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URSOBILANE 300 mg CAPSULES

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About the medicine

How to use URSOBILANE 300 mg CAPSULES

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

Ursobilane 300 mg Capsules

Ursodeoxycholic Acid

Read this entire leaflet carefully before starting to take this medicine, as it contains important information for you.

  • Keep this leaflet, as you may need to read it again.
  • If you have any questions, ask your doctor or pharmacist.
  • This medicine has been prescribed to you only, and you should not give it to others, even if they have the same symptoms as you, as it may harm them.
  • If you experience side effects, consult your doctor or pharmacist, even if they are not listed in this leaflet. See section 4.

Contents of the Package Leaflet:

  1. What Ursobilane 300 mg Capsules are and what they are used for
  2. What you need to know before taking Ursobilane 300 mg Capsules
  3. How to take Ursobilane 300 mg Capsules
  4. Possible side effects
  5. Storage of Ursobilane 300 mg Capsules
  6. Package Contents and Additional Information

1. What Ursobilane 300 mg Capsules are and what they are used for

The active ingredient of Ursobilane 300 mg Capsules is ursodeoxycholic acid, which belongs to a group of medicines called bile stone dissolvers.

It is used to dissolve cholesterol gallstones, provided they are radiotransparent and the gallbladder is functioning (which should have been verified by a test called oral cholecystography). Ursobilane is also used to treat a rare disease of the bile ducts and liver called primary biliary cirrhosis.

Doctor consultation

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2. What you need to know before taking Ursobilane 300 mg Capsules

Do not take Ursobilane 300 mg Capsules:

  • If you are allergic to ursodeoxycholic acid or any of the other ingredients of this medicine (listed in section 6).
  • If you have a stomach or duodenal ulcer.
  • If you have a non-functioning gallbladder or if you have calcified cholesterol gallstones, radio-opaque gallstones, or radiotransparent bile pigment gallstones.
  • If you have liver or intestinal disorders that may interfere with the circulation of bile salts.
  • If you are breastfeeding.

Warnings and Precautions

Consult your doctor before taking Ursobilane 300 mg Capsules:

  • If you are taking medicines that may cause a buildup of cholesterol in the bile, such as estrogens and hormonal contraceptives.
  • If you are being treated with medicines that may be toxic to the liver.

Other Medicines and Ursobilane 300 mg Capsules

Ursobilane 300 mg Capsules may interact with other medicines, such as:

  • Antacids containing aluminum.
  • Colestyramine or colestipol, or other medicines for treating high cholesterol.
  • Antibiotics: neomycin.
  • Hormonal contraceptives, such as estrogens or progestogens.

Taking Ursobilane 300 mg Capsules with Food, Drinks, and Alcohol

No special considerations.

Pregnancy, Breastfeeding, and Fertility

Before starting treatment, your doctor should know if you are or suspect you may be pregnant, or if you plan to become pregnant. Your doctor will then decide whether or not to use Ursobilane 300 mg Capsules.

This medicine should not be used during breastfeeding.

Driving and Using Machines

Ursobilane 300 mg Capsules do not affect the ability to drive vehicles or use machinery.

3. How to Take Ursobilane 300 mg Capsules

Follow the instructions for taking this medicine exactly as indicated by your doctor or pharmacist. If you have any doubts, consult your doctor or pharmacist again.

Remember to take your medicine.

Depending on the nature of your illness, age, and weight, your doctor will prescribe the correct dose and indicate the duration of treatment. Do not stop treatment prematurely, as this may not achieve the desired effect.

Your doctor will advise you to follow a moderate calorie and cholesterol diet during treatment with Ursobilane 300 mg Capsules.

If you think the effect of Ursobilane 300 mg Capsules is too strong or too weak, inform your doctor or pharmacist.

The capsules should be swallowed whole, without chewing, with a little liquid. If you have difficulty swallowing, you can disperse the powder contained in the capsules in a liquid.

Take Ursobilane 300 mg Capsules preferably with meals.

For the treatment of gallstones, the usual doses are as follows:

Adults: 2 capsules per day (8-10 mg/kg/day), divided into several doses.

It is essential that you visit your doctor regularly to check the progress of your illness. While taking this medicine, you will need to have laboratory tests every few months to check that the gallstones are dissolving and that your liver is functioning correctly.

For the treatment of primary biliary cirrhosis, the usual doses are:

Adults: 3-4 capsules per day (13-15 mg/kg/day), divided into several doses.

If you take more Ursobilane 300 mg Capsules than you should

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately, or call the Toxicology Information Service, telephone 91 562 04 20, indicating the medicine and the amount ingested.

The symptom of overdose of Ursobilane 300 mg Capsules is mainly the appearance of diarrhea. It is recommended that during treatment with Ursobilane 300 mg Capsules, regular monitoring of liver function be carried out.

If you forget to take Ursobilane 300 mg Capsules

Do not take a double dose to make up for forgotten doses.

If you have any other questions about the use of this medicine, ask your doctor or pharmacist.

Medicine questions

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4. Possible Side Effects

Like all medicines, this medicine can cause side effects, although not everyone gets them.

These side effects may occur with certain frequencies, which are defined below: Very common: may affect more than 1 in 10 patients.

Common: may affect between 1 and 10 in 100 patients.

Uncommon: may affect between 1 and 10 in 1,000 patients.

Rare: may affect between 1 and 10 in 10,000 patients.

Very rare: may affect less than 1 in 10,000 patients.

Frequency not known: the frequency cannot be estimated from the available data.

Gastrointestinal Disorders

Rare: nausea and vomiting, difficulty in digestion, alterations in taste, biliary pain, abdominal pain, sensation of gas, and constipation.

Very rare: diarrhea.

Reporting Side Effects

If you experience any side effects, consult your doctor or pharmacist, even if they are not listed in this leaflet. You can also report them directly through the Spanish Medicines Monitoring System: https://www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Ursobilane 300 mg Capsules

Keep this medicine out of the sight and reach of children.

No special storage conditions are required.

Do not use this medicine after the expiration date stated on the box after EXP. The expiration date is the last day of the month indicated.

Medicines should not be disposed of via wastewater or household waste. Place the packaging and any unused medicines in the SIGRE collection point at your pharmacy. If you have any doubts, ask your pharmacist how to dispose of the packaging and any unused medicines. This will help protect the environment.

6. Package Contents and Additional Information

Composition of Ursobilane 300 mg Capsules

The active ingredient is ursodeoxycholic acid. Each capsule contains 300 mg of ursodeoxycholic acid.

The other excipients are magnesium stearate, powdered cellulose, colloidal silica, and sodium carboxymethyl starch (type A) (from potato).

The components of the capsule are: gelatin, titanium dioxide (E-171), quinoline yellow (E-104), and indigotine (indigo carmine) (E-132).

Appearance of the Product and Package Contents

Green and yellow capsules.

Aluminum-PVC blister packs containing 60 capsules.

Marketing Authorization Holder and Manufacturer

Marketing Authorization Holder

Laboratorio Estedi S.L.

Montseny, 41

08012 Barcelona - Spain

Manufacturer

Laboratorio Estedi, S.L.

Leopoldo Alas, 7

08012 Barcelona - Spain

You can request more information about this medicine from the local representative of the Marketing Authorization Holder:

Laboratorio Aldo-Unión, S.L.

C/ Baronesa de Maldá, 73

08950 Esplugues de Llobregat

(Barcelona) Spain

Date of the Last Revision of this Leaflet:January 2012

Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) (http://www.aemps.gob.es/)

Online doctors for URSOBILANE 300 mg CAPSULES

Discuss questions about URSOBILANE 300 mg CAPSULES, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Doctor

Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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€58
5.0 (3)
Doctor

Tomasz Grzelewski

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques.

For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance.

Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults.

In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions.

Patients commonly seek his care for:

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
  • urticaria, atopic dermatitis and skin reactions
  • recurrent infections in children
  • sports-related health questions
  • general family medicine concerns
Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.
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€80
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Doctor

Lina Travkina

Family medicine 13 years exp.

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
  • Medical advice and follow-up consultations.
  • Test interpretation and diagnostic guidance.
  • Structured support for undiagnosed complaints.
  • Second opinion on diagnoses and treatment plans.
  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
  • Post-operative recovery support and pain management.
  • Preconception counselling and postpartum support.
  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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€70
5.0 (760)
Doctor

Alina Tsurkan

Family medicine 13 years exp.

Dr. Alina Tsurkan is a licensed family medicine physician based in Portugal, offering online consultations for adults and children. She provides professional primary care, with a focus on prevention, accurate diagnosis, and long-term management of acute and chronic conditions.

Dr. Tsurkan supports patients with a wide range of health issues, including:

  • Respiratory infections: cold, flu, bronchitis, pneumonia, and lingering coughs.
  • ENT conditions: sinusitis, tonsillitis, otitis (ear infections), sore throat, allergic rhinitis.
  • Eye conditions: allergic or infectious conjunctivitis, red eyes, irritation.
  • Digestive issues: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), constipation, bloating, nausea.
  • Urinary and reproductive health: urinary tract infections (UTIs), cystitis, prevention of recurrent infections.
  • Chronic diseases: hypertension, elevated cholesterol, weight management.
  • Neurological complaints: headaches, migraines, sleep disturbances, fatigue, general weakness.
  • Children’s health: fever, infections, digestive issues, follow-ups, vaccination guidance.

She also provides:

  • IMT medical certificates for driving licence exchange in Portugal.
  • Personalised preventive care and wellness consultations.
  • Interpretation of test results and medical reports.
  • Follow-up care and medication review.
  • Support in managing multiple coexisting conditions.
  • Remote prescription management and medical documentation.

Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

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€55
5.0 (140)
Doctor

Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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€50

Frequently Asked Questions

Is a prescription required for URSOBILANE 300 mg CAPSULES?
URSOBILANE 300 mg CAPSULES requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in URSOBILANE 300 mg CAPSULES?
The active ingredient in URSOBILANE 300 mg CAPSULES is ursodeoxycholic acid. This information helps identify medicines with the same composition but different brand names.
How much does URSOBILANE 300 mg CAPSULES cost in pharmacies?
The average pharmacy price for URSOBILANE 300 mg CAPSULES is around 14.85 EUR. Prices may vary depending on the manufacturer and dosage form.
Who manufactures URSOBILANE 300 mg CAPSULES?
URSOBILANE 300 mg CAPSULES is manufactured by Laboratorio Estedi S.L.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of URSOBILANE 300 mg CAPSULES online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether URSOBILANE 300 mg CAPSULES is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to URSOBILANE 300 mg CAPSULES?
Other medicines with the same active substance (ursodeoxycholic acid) include URSODESOXYCHOLIC ACID GRINDEKS 250 mg HARD CAPSULES, ADISOCOL 150 mg TABLETS, ADISOCOL 250 mg HARD CAPSULES. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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