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About the medicine

How to use ROCURONIUM AGUETTANT 10 mg/mL Injectable Solution in Pre-filled Syringe

Contents of the leaflet

  1. Introduction
  2. What is Rocuronium Aguettant and what is it used for
  3. What you need to know before you use Rocuronium Aguettant
  4. How to use Rocuronium Aguettant
  5. Possible side effects
  6. Conservation of Rocuronium Aguettant
  7. Contents of the pack and further information

Introduction

Package Leaflet:information for the user

Rocuronium Aguettant10mg/ml solution for injection in a pre-filled syringe

Rocuronium bromide

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • If you experience any side effects, talk to your doctor or pharmacist, even if it is not listed in this leaflet. See section 4.

Contents of the pack

  1. What is Rocuronium Aguettant and what is it used for
  2. What you need to know before you use Rocuronium Aguettant
  3. How to use Rocuronium Aguettant
  4. Possible side effects

5 Conservation of Rocuronium Aguettant

  1. Contents of the pack and further information

1. What is Rocuronium Aguettant and what is it used for

Rocuronium is a muscle relaxantused in adults and children from 2 years of age. Muscle relaxants are used during surgical procedures as adjuncts during general anesthesia. During a surgical procedure, your muscles must be completely relaxed. This makes it easier for the surgeon to perform the surgical procedure. Normally, nerves send messages to your muscles. Rocuronium works by temporarily blocking these signals, causing muscle relaxation. Since the muscles needed for breathing also relax, you will be given artificial respiration until you can breathe on your own again. During the surgical procedure, the effect of the muscle relaxant will be constantly monitored, and if necessary, more medication will be administered. At the end of the operation, the effects of rocuronium will be allowed to disappear, and you will be able to start breathing on your own. Sometimes, another medication will be given to speed up this process. Rocuronium can also be used in the Intensive Care Unit.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you use Rocuronium Aguettant

Do not use Rocuronium Aguettant

  • if you are allergic to rocuronium or any of the other ingredients of this medicine (listed in section 6).

Consult your doctor if this applies to you.

Warnings and precautions

Your medical history may affect how Rocuronium Aguettant is administered to you. Inform your doctor if you have or have had any of the following diseases:

  • allergy to muscle relaxants
  • renal impairment (renal failure) or kidney disease
  • cardiovascular disease
  • edema formation (fluid retention, e.g., in the ankles)
  • liver disease, gallbladder disease, or bile duct disease, or impaired liver function.
  • diseases that affect the nerves and muscles.
  • history of malignant hyperthermia (sudden fever with rapid heart rate, rapid breathing, and muscle stiffness, pain, and/or weakness).

Certain medical conditions may affect how Rocuronium Aguettant works. For example:

  • low potassium levels in the blood (hypokalemia)
  • high magnesium levels in the blood (hypermagnesemia), e.g., when treating pregnancy toxemia with magnesium salts
  • low calcium levels in the blood (hypocalcemia)
  • low protein levels in the blood (hypoproteinemia)
  • fluid deficiency (dehydration)
  • excess acid in the blood (acidosis)
  • excess carbon dioxide in the blood (hypercapnia)
  • general poor health
  • overweight
  • burns

If any of these conditions apply to you, your doctor will take them into account when deciding on the appropriate dose of Rocuronium Aguettant for you.

Children and adolescentsRocuronium Aguettant can be used in children (2-11 years) and adolescents (12-17 years). However, the maintenance dose is not indicated in the pediatric population under 12 years.

Rocuronium Aguettant should not be administered to children under 2 years because the sub-graduation of the pre-filled syringe does not allow for precise administration of the product in these populations.

Other medicines and Rocuronium Aguettant

Tell your doctor if you are using, have recently used, or might use any other medicines. This will help your doctor determine the correct dose of Rocuronium Aguettant for you.

The following medicines may affect the effect of Rocuronium Aguettant:

Medicines that increase the effect of Rocuronium Aguettant:

  • certain anesthetics
  • medicines used as muscle relaxants (suxamethonium)
  • certain medicines used to treat bacterial infections (antibiotics)
  • certain medicines used to treat manic-depressive illness (lithium)
  • certain medicines for heart diseases or high blood pressure (quinidine, calcium antagonists, beta-blockers)
  • certain medicines used to treat malaria (quinine)
  • medicines that cause increased urine production (diuretics)
  • magnesium salts
  • local anesthetics (lidocaine and bupivacaine)
  • short-term use of medicines for the treatment of epilepsy (phenytoin), such as during an operation.

Medicines that decrease the effect of Rocuronium Aguettant:

  • prolonged use of corticosteroids (anti-inflammatory) or medicines for epilepsy (phenytoin and carbamazepine)
  • medicines for pancreatitis, blood coagulation problems, and acute blood loss (protease inhibitors: gabexate, ulinastatin)
  • Calcium chloride, potassium chloride.

Medicines with a variable effect on Rocuronium Aguettant:

  • other medicines used to relax muscles.

Rocuronium Aguettant may affect the effects of the following medicines:

  • May increase the effect of local anesthetics (such as lidocaine).

Pregnancy, breast-feeding and fertility

If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before using this medicine.

There are limited data on the use of rocuronium bromide during human pregnancy, and no data on women during breast-feeding. Rocuronium Aguettant should only be administered to pregnant and breast-feeding women when the doctor decides that the benefits outweigh the risks.

This medicine can be administered during a cesarean section.

Driving and using machines

Your doctor will inform you when you can drive or use hazardous machines after the administration of Rocuronium Aguettant.

Rocuronium Aguettant contains sodium

This medicine contains less than 1 mmol of sodium (23 mg) per pre-filled syringe; it is essentially "sodium-free"

3. How to use Rocuronium Aguettant

Dosage

Your doctor will determine the dose of Rocuronium Aguettant based on:

  • the type of anesthesia used
  • the expected duration of the surgical procedure
  • other medicines you are using
  • your age and health status.

A healthcare professional will administer Rocuronium Aguettant to you before and/or during the surgical procedure. The usual dose is 0.6 mg of rocuronium bromide per kilogram of body weight, and the effect lasts for 30 to 40 minutes. During the procedure, it will be checked if rocuronium is still working. If necessary, additional doses will be administered.

How Rocuronium Aguettant is administered

Rocuronium is not intended for self-administration. Rocuronium will be injected into a vein. It will be administered as a single injection or through an infusion.

If you use more Rocuronium Aguettant than you should

Since the medical staff will carefully monitor your condition, it is unlikely that you will be given too much rocuronium. However, if this happens, artificial respiration will be maintained until you are able to breathe on your own again. It is possible to counteract the effects of (excess) rocuronium and speed up your recovery by administering a medicine that counteracts the effects of rocuronium.

Medicine questions

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Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. If these side effects occur during anesthesia, they will be observed and treated by your doctor.

The following side effects may occur:

Rare or uncommon (may affect less than 1 in 100/1,000 people)

  • increased heart rate (tachycardia)
  • decreased blood pressure (hypotension)
  • absence, increase, or decrease of the effect of Rocuronium Aguettant
  • pain at the injection site
  • redness or itching at the injection site
  • prolongation of the muscle relaxant effect of Rocuronium Aguettant
  • delayed recovery from anesthesia

Very rare (may affect less than 1 in 10,000 people)

  • allergic reactions such as difficulty breathing, changes in blood pressure or heart rate, shock (abrupt drop in blood pressure) due to insufficient blood circulation, or skin changes (e.g., fluid accumulation, redness, or rash)
  • excessive and prolonged contraction of the muscles of the airways, causing difficulty breathing (bronchospasm)
  • muscle weakness or paralysis
  • sudden accumulation of fluid in the skin and mucous membranes (e.g., throat or tongue), breathing difficulties, and/or itching or rash, often with an allergic reaction (angioedema)
  • fluid accumulation (edema) in the face
  • breathing difficulties due to anesthesia
  • skin rash, sometimes with intense itching and hives (urticaria)
  • redness of the skin
  • flushing

Unknown frequency (cannot be estimated from the available data)

  • allergic spasm and severe coronary artery vasospasm (Kounis syndrome) causing chest pain (angina) or heart attack (myocardial infarction).
  • dilated pupils (mydriasis) or fixed pupils that do not change size with light or other stimuli

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist, even if it is not listed in this leaflet. You can also report side effects directly through the Spanish Medicines Agency's website: www.notificaRAM.es/. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Conservation of Rocuronium Aguettant

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the label, blister, and carton.

Store in a refrigerator (2°C - 8°C).

Do not freeze.

Store the pre-filled syringe in its blister pack until use.

Once opened, the medicine must be used immediately.

This medicine can be stored at a temperature up to 30°C for a maximum of 12 weeks. In all cases, once removed from the refrigerator, the medicine must be discarded after 12 weeks.

The product must not be re-introduced into the refrigerator once stored outside. The shelf life cannot exceed the expiry date stated on the packaging.

Do not use this medicine if you notice visible signs of deterioration.

Any pre-filled syringe, even if partially used, must be disposed of properly after use.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. Contents of the pack and further information

Composition of Rocuronium Aguettant

  • The active substance is rocuronium bromide.

Each ml of solution contains 10 mg of rocuronium bromide.

Each 5 ml pre-filled syringe contains 50 mg of rocuronium bromide (50 mg/5 ml).

  • The other ingredients are sodium acetate trihydrate (E 262), sodium chloride, glacial acetic acid (E260), and water for injections.

Appearance of the product and pack contents

Rocuronium Aguettant is a solution for injection or infusion, from colorless to pale yellowish-brown, in a 5 ml pre-filled syringe, with a transparent graduated label (sub-graduations of 0.2 ml, from 0 to 5 ml). Each pre-filled syringe is packaged individually in a transparent blister pack.

Pack size: cardboard boxes of 10 pre-filled syringes.

Marketing authorization holder and manufacturer

Marketing authorization holder

Laboratoire Aguettant

1 rue Alexander Fleming,

69007 Lyon

France

Manufacturer

Laboratoire Aguettant

1, rue Alexander Fleming

69007 LYON

France

Laboratoire Aguettant

Lieu Dit Chantecaille

07340 Champagne

France

This medicine is authorized in the Member States of the European Economic Area under the following names:

AT: Rocuroniumbromid Aguettant

FR, DE, IS, PL, RO: Rocuronium Aguettant

BE, DK, FI, LU, NO, SE: Rocuronium bromide Aguettant

IT: Rocuronio bromuro Aguettant

NL: Rocuroniumbromide Aguettant

PT: Brometo de Rocurónio Aguettant

ES: Rocuronio Aguettant 10mg/ml solution for injection in a pre-filled syringe

IE: Rocuronium bromide

Date of last revision of this leaflet: May 2025.

Detailed information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es

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This information is intended only for healthcare professionals:

The pre-filled syringe is not suitable for the precise administration of the product in children under 2 years.

The pre-filled syringe is for single patient use only. Discard the syringe after use. Do not reuse.

Appearance of the solution

The product should be visually inspected for particles and color changes before administration. Only a clear solution from colorless to pale yellowish-brown without particles or precipitates should be used.

Incompatibilities of the solution

Rocuronium bromide is physically incompatible with solutions of the following medicines: amphotericin, amoxicillin, azathioprine, cefazolin, cloxacillin, dexamethasone, diazepam, enoximone, erythromycin, famotidine, furosemide, sodium hydrocortisone succinate, insulin, methohexital, methylprednisolone, prednisolone sodium succinate, thiopental, trimethoprim, and vancomycin.

Rocuronium bromide is also incompatible with intralipid.

Use of the pre-filled syringe

The content of an unopened and undamaged blister is sterile, and the blister should not be opened until the syringe is ready for use.

The pre-filled syringe is for single patient use only. Discard the syringe after use. Do not reuse.

The pre-filled syringe is not suitable for the precise administration of the product in children under 2 years.

The product should not be used if the security seal of the syringe is broken.

Do not use this medicine if you notice visible signs of deterioration.

Please prepare the syringe carefully as follows

The outer surface of the syringe is sterile until the blister is opened. The blister should not be opened until use.

If handled with an aseptic method, this medicine can be placed in a sterile field once removed from the blister.

  1. Remove the pre-filled syringe from the blister.

Hand holding a syringe with exposed needle and retracted plunger showing the numerical graduation of the cylinder

  1. Push the plunger to release the piston. The sterilization process may have caused the piston to stick to the syringe body.

Hand holding syringe with needle inserted into the skin showing angle of injection and direction of the needle

  1. Unscrew the cap from the end to break the seal. Do not touch the exposed luer connection to avoid contamination.

Needle with bevel showing angle and insertion into a circle representing the skin

  1. Check that the tip of the syringe cap has been completely removed. If not, replace the cap and unscrew it again.

Hand holding a transparent syringe with dark liquid and needle pointing upwards in a vertical position

  1. Expel any air by gently pushing the plunger.
  1. Connect the syringe to the vascular access device using a luer/luer lock system. Slowly push the plunger to inject the required volume. Administer the product through the appropriate administration route.

The pre-filled syringe is not suitable for syringe drivers. The pre-filled syringe is a ready-to-administer product and is not suitable for dilution in an infusion bag.

No syringe that has been damaged or manipulated without respecting the conditions of sterility should be used.

Any unused product or waste material should be disposed of in accordance with local regulations.

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As a licensed physician fully integrated with the Spanish electronic prescription system, Dr. Andrada can issue legally valid e-prescriptions following a medical assessment during an online consultation. Whether you need help with an acute illness, prescription renewal, neurological symptoms, or travel-related healthcare, she offers convenient, patient-centered medical care without the need to visit a clinic.

Dr. Andrada combines extensive emergency medicine experience with advanced expertise in neurology, epilepsy, sleep medicine, and headache disorders. Her international clinical background includes several years working in Switzerland, where she collaborated with multidisciplinary teams in emergency departments and neurology services. This experience strengthened her commitment to evidence-based medicine, compassionate communication, and high-quality patient care.

She graduated in Medicine from the University of Seville and completed her residency in Clinical Neurophysiology at Hospital Virgen de la Salud and the National Hospital for Paraplegics in Toledo. She currently works as a Clinical Neurophysiology Specialist at Hospital San Pedro in Logroño.

To further expand her expertise, Dr. Andrada completed several postgraduate qualifications, including Master's degrees in Sleep Physiology and Medicine, Medical Professionalism and Clinical Practice, Epilepsy, and Clinical Management.

Patients appreciate her thorough consultations, practical treatment recommendations, and empathetic approach. She speaks Spanish, French, and Portuguese, allowing her to communicate comfortably with patients from different backgrounds.

Conditions Dr. Cristina Andrada Treats Online

Dr. Andrada provides online consultations for a wide range of common medical conditions, including:

  • Fever, flu, COVID-19 symptoms, sore throat and respiratory infections
  • Sinusitis, bronchitis, cough and seasonal allergies
  • Urinary tract infections (UTIs)
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  • Dizziness and vertigo
  • Epilepsy and seizure follow-up
  • Sleep disorders, including insomnia and circadian rhythm disturbances
  • Heartburn, gastritis, diarrhea and constipation
  • Back pain, muscle injuries and joint pain
  • Minor skin infections and allergic reactions
  • Fatigue and general medical assessment
  • Prescription renewals for appropriate chronic treatments
  • Follow-up consultations after surgery or previous medical treatment
  • Travel medicine advice and preventive healthcare
  • Interpretation of laboratory results and medical reports

If your condition requires urgent in-person assessment or emergency care, Dr. Andrada will advise you on the most appropriate next steps.

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Frequently Asked Questions

ROCURONIUM AGUETTANT 10 mg/mL Injectable Solution in Pre-filled Syringe requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

The active ingredient in ROCURONIUM AGUETTANT 10 mg/mL Injectable Solution in Pre-filled Syringe is rocuronium bromide. This information helps identify medicines with the same composition but different brand names.

ROCURONIUM AGUETTANT 10 mg/mL Injectable Solution in Pre-filled Syringe is manufactured by Laboratoire Aguettant. Pharmacy brands and packaging may differ depending on the distributor.

Doctors such as Endocrinologists, Rheumatologists, Neurologists, General medicine doctors may assess whether ROCURONIUM AGUETTANT 10 mg/mL Injectable Solution in Pre-filled Syringe is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

The prescription is issued by a doctor after assessing your health. In Spain, ROCURONIUM AGUETTANT 10 mg/mL Injectable Solution in Pre-filled Syringe is then dispensed in pharmacies with that prescription. An online consultation does not guarantee that a prescription will be issued: the decision always rests with the doctor.

To request an assessment, you can use Oladoctor:

Other medicines with the same active substance (rocuronium bromide) include ESMERON 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION, ROCURONIUM B. BRAUN 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION, ROCURONIUM HIKMA 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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