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LEGALON 150 mg CAPSULES

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About the medicine

How to use LEGALON 150 mg CAPSULES

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the Patient

Legalon 150 mg Capsules

(Silymarin)

Read the entire package leaflet carefully before starting to take this medication, as it contains important information for you.

  • Keep this package leaflet, as you may need to read it again.
  • If you have any questions, consult your doctor or pharmacist.
  • This medication has been prescribed to you only, and you should not give it to others, even if they have the same symptoms as you, as it may harm them.
  • If you experience side effects, consult your doctor or pharmacist, even if they are not listed in this package leaflet. See section 4.

Contents of the Package Leaflet:

  1. What is Legalon 150 mg Capsules and what is it used for
  2. What you need to know before taking Legalon 150 mg Capsules
  3. How to take Legalon 150 mg Capsules
  4. Possible side effects
  5. Storage of Legalon 150 mg Capsules
  6. Package Contents and Additional Information

1. What is Legalon 150 mg Capsules and what is it used for

Legalon 150 mg Capsules belongs to a group of medications called "Hepatic Therapy, Lipotropics" with therapeutic activity on liver lesions, and its active ingredient is silymarin.

Legalon 150 mg Capsules is indicated for the treatment of liver lesions such as those caused by chronic alcohol consumption and hepatotoxic medications, hepatic steatosis (fatty liver), alcoholic hepatitis, and hepatic cirrhosis.

Doctor consultation

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2. What you need to know before taking Legalon 150 mg Capsules

Do not take Legalon 150 mg Capsules

If you are allergic to the active ingredient, silymarin, or to any of the other components of this medication (listed in section 6).

Warnings and Precautions

Treatment with dry extract of milk thistle fruit does not replace abstinence from the causes of liver damage (e.g., alcohol).

In case of jaundice (yellowish discoloration of the skin, yellowish discoloration of the whites of the eyes), consult your doctor.

The use of this medication for long periods of time should be monitored by your doctor.

Consult your doctor or pharmacist before starting to take Legalon 150 mg Capsules.

Other Medications and Legalon 150 mg Capsules:

Tell your doctor or pharmacist that you are using, have recently used, or may need to use any other medication.

Taking Legalon 150 mg Capsules with Food and Drinks:

No interaction has been described between the use of this medication and the consumption of food and drinks.

Pregnancy, Breastfeeding, and Fertility

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medication.

Pregnancy:

Since there are no studies in pregnant women, this medication will only be used during pregnancy when, in the strict medical opinion, the benefits justify the potential risks.

Breastfeeding:

It is unknown whether silymarin passes into breast milk, so it will only be used during breastfeeding when, in the strict medical opinion, the benefits justify the potential risks.

Driving and Using Machines

The influence of Legalon 150 mg Capsules on the ability to drive and use machines is nil.

Legalon 150 mg Capsules contains Sodium

This medication contains less than 23 mg of sodium (1 mmol) per capsule, which is essentially "sodium-free".

3. How to take Legalon 150 mg Capsules

Follow the administration instructions for this medication exactly as indicated by your doctor or pharmacist. If you have any doubts, consult your doctor or pharmacist again.

Adults

The recommended oral dose is 1 capsule (150 mg) three times a day, after the main meals.

The treatment period is established at 4 to 6 weeks, and as a maintenance dose, 1 capsule 2 times a day, unless otherwise medically indicated.

Use in Children and Adolescents

No data are available for this age group.

Use in the Elderly

No specific problems have been described in this age group.

Method of Administration

Swallow the capsules with a little liquid after the main meals.

If you take more Legalon 150 mg Capsules than you should:

In case of overdose or accidental ingestion, consult the Toxicology Information Service. Phone 91 562 04 20.

If you forget to take Legalon 150 mg Capsules

Do not take a double dose to make up for the forgotten doses.

If you interrupt treatment with Legalon 150 mg Capsules

Consult your doctor.

If you have any other questions about the use of this medication, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible Side Effects

Like all medications, Legalon 150 mg may cause side effects, although not everyone will experience them.

The adverse reactions of Legalon 150 mg are infrequent.

Uncommon (affecting 1 to 10 out of 1000 patients)

Gastrointestinal disorders: stomach pain and diarrhea.

Very rare (affecting less than 1 patient in 10,000)

Immune system disorders: allergic reactions.

Respiratory, thoracic, and mediastinal disorders: dyspnea.

Skin and subcutaneous tissue disorders: skin rash.

If you experience side effects, consult your doctor or pharmacist, even if they are not listed in this package leaflet.

Reporting Side Effects

If you experience any type of side effect, consult your doctor or pharmacist, even if it is a possible side effect not listed in this package leaflet. You can also report them directly through the Spanish Medication Pharmacovigilance System, https://www.notificaRAM.es. By reporting side effects, you can contribute to providing more information on the safety of this medication.

5. Storage of Legalon 150 mg Capsules

Keep this medication out of sight and reach of children. Store in the outer packaging.

Do not use Legalon 150 mg Capsules after the expiration date stated on the packaging after CAD or EXP. The expiration date is the last day of the month indicated.

Medications should not be disposed of through wastewater or household waste. Deposit the packaging and medications you no longer need at the SIGRE point in the pharmacy. If you have any doubts, ask your pharmacist how to dispose of the packaging and medications you no longer need. This will help protect the environment.

6. Package Contents and Additional Information

Composition of Legalon 150 mg Capsules:

The active ingredient is silymarin. Each capsule contains 196 mg of silymarin extract equivalent to 150 mg of silybinin.

The other components are: Mannitol (E-421), Polysorbate 80, Polyvinylpyrrolidone, Colloidal Anhydrous Silica, Magnesium Stearate, and Sodium Carboxymethylcellulose Type A.

The capsule is composed of: Red and Yellow Iron Oxides (E-172), Erythrosine (E-127), and Titanium Dioxide (E-171).

Appearance of the Product and Package Contents

Legalon 150 mg Capsules are presented in blisters containing 30 hard red capsules.

Marketing Authorization Holder:

Cooper Consumer Health B.V.

Verrijn Stuartweg 60,

1112 AX Diemen,

Netherlands

Manufacturer:

Alcalá Farma, S.L.

Avenida de Madrid 82

28802 Alcalá de Henares – Spain

You can request more information about this medication by contacting the local representative of the marketing authorization holder:

Vemedia Pharma Hispania, S.A.

C/ Aragón, 182, 5th floor

08011 - Barcelona

Spain

Date of Last Revision of this Package Leaflet: February 2025

Detailed and updated information about this medication is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) https://www.aemps.es/

Online doctors for LEGALON 150 mg CAPSULES

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Chikeluo Okeke

General medicine 4 years exp.

Dr Chikeluo Okeke is an internal medicine doctor with extensive international clinical experience. Originally from Nigeria, he has worked across multiple European healthcare systems and currently practises in Sweden. This professional path has given him a strong understanding of different medical approaches and the ability to work effectively with patients from diverse cultural and linguistic backgrounds.

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Tomasz Grzelewski

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques. For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance. Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults. In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions. Patients commonly seek his care for: 

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Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.

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Yevgen Yakovenko

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Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

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Joao Silva

General medicine 6 years exp.

Dr. João Silva is a physician with training and experience in the field of General and Family Medicine, dedicated to providing healthcare focused on the well-being and quality of life of his patients. Throughout his professional career, he has developed broad clinical competencies, striving to maintain a medical practice based on scientific evidence and continuous knowledge updates.

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Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

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He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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Bulat Garipov

General medicine 15 years exp.

Dr. Bulat Garipov is a radiologist with more than 15 years of experience, specializing in magnetic resonance imaging (MRI). Throughout his professional career, he has worked in leading diagnostic imaging centers, both in on-site practice and teleradiology, which has allowed him to develop a broad and versatile approach to radiology.

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Additionally, Dr. Garipov is open to new collaboration opportunities in radiology and teleradiology projects. He offers his expertise in MRI, providing both first and second readings of studies, as well as advanced image interpretation, ensuring accurate and high-quality diagnostics.

You could consult Dr. Bulat Garipov in cases where accurate interpretation of MRI studies or a second expert opinion is required. His expertise is especially valuable in cases of suspected neurological conditions, back and joint pain, vascular disorders, as well as in the diagnosis of abdominal and pelvic diseases. The doctor also provides support in complex or unclear clinical situations, including the review of previously performed studies, which helps improve diagnostic accuracy and determine the optimal treatment strategy. A teleradiology format is available, allowing you to receive a professional opinion remotely.

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Frequently Asked Questions

Is a prescription required for LEGALON 150 mg CAPSULES?
LEGALON 150 mg CAPSULES requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in LEGALON 150 mg CAPSULES?
The active ingredient in LEGALON 150 mg CAPSULES is silymarin. This information helps identify medicines with the same composition but different brand names.
Who manufactures LEGALON 150 mg CAPSULES?
LEGALON 150 mg CAPSULES is manufactured by Cooper Consumer Health B.V.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of LEGALON 150 mg CAPSULES online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether LEGALON 150 mg CAPSULES is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to LEGALON 150 mg CAPSULES?
Other medicines with the same active substance (silymarin) include SILARINE 80 mg HARD CAPSULES, CHENODEOXYCHOLIC ACID LEADIANT 250 mg HARD CAPSULES, URSODESOXYCHOLIC ACID GRINDEKS 250 mg HARD CAPSULES. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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