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ZAFIRON

ZAFIRON

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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use ZAFIRON

INSTRUCTIONS for medical use of the medicinal product ISONIAZID-DARNITSA

Composition

active substance: isoniazid; 1 tablet contains 300 mg of isoniazid; excipients: microcrystalline cellulose, methylcellulose, sodium croscarmellose, calcium stearate.

Pharmaceutical form

Tablets.

Main physical and chemical properties

Tablets of round shape with a flat surface, white or white with a creamy tint, with a notch and a facet.

Pharmacotherapeutic group

Anti-tuberculosis drugs. ATC code J04A C01.

Pharmacological properties

Pharmacodynamics

Isoniazid-Darnitsa inhibits DNA-dependent RNA polymerase and inhibits the synthesis of mycolic acids of the cell wall of tuberculosis mycobacteria. The drug has high bacteriostatic activity against tuberculosis mycobacteria, slowing their growth at a concentration of 0.03 mcg/ml. It is especially active against rapidly multiplying microorganisms. It has a weak effect on the causative agents of other infectious diseases.

Pharmacokinetics

Well absorbed from the gastrointestinal tract, easily penetrates the blood-brain barrier. The time to reach the maximum concentration in the blood (Tmax) is 1-4 hours. Binding to plasma proteins is up to 10%. The volume of distribution is 0.56-0.76 L/kg. The tuberculostatic concentration after a single dose is maintained for 6-24 hours. It is widely distributed in the tissues and fluids of the body, including cerebrospinal fluid, pleural effusion, ascitic fluid, skin, lungs, sputum, saliva, and caseous masses. It penetrates through the placenta and is excreted in breast milk.

Clinical characteristics

Indications
  • In combination with 3-4 other anti-tuberculosis drugs - for the treatment of active tuberculosis of all forms and localizations;
  • as monotherapy - for the treatment of latent tuberculosis infection;
  • as monotherapy - for the prevention of tuberculosis in individuals who have been or are in close contact with patients with tuberculosis.
Contraindications

Increased sensitivity to isoniazid or to the excipients of the drug.

Epilepsy and other diseases that are accompanied by a tendency to seizures, severe psychoses, poliomyelitis (including in the anamnesis), toxic hepatitis in the anamnesis due to the use of hydrazide derivatives of isonicotinic acid (ftivazid), pronounced atherosclerosis, acute liver and/or kidney failure.

Interaction with other medicinal products and other types of interactions

Antacid drugs - reduction of isoniazid absorption (the interval between their administration should be at least 1 hour).

Indirect anticoagulants, benzodiazepines, phenytoin, carbamazepine, theophylline, MAO inhibitors - isoniazid potentiates the effects of these drugs (including toxic ones).

Isoniazid may reduce the hepatic metabolism of benzodiazepines (e.g., diazepam, flurazepam, triazolam, midazolam), leading to an increase in their concentration in plasma. Patients should be carefully monitored for signs of benzodiazepine toxicity, and the doses of benzodiazepines should be adjusted accordingly.

Special instructions

As a result of monotherapy with isoniazid, resistant strains of mycobacteria are formed, so it should be used in combination with other anti-tuberculosis drugs. In the case of mixed infection, antibiotics with a broad spectrum of action, fluoroquinolones, and sulfonamides should be prescribed simultaneously with isoniazid.

Use during pregnancy or breastfeeding

During pregnancy, the use of the drug is contraindicated at a dose higher than 10 mg/kg per day. At a dose of up to 10 mg/kg of body weight per day, the use of isoniazid is possible, taking into account the benefit/risk ratio.

Method of administration and dosage

The daily and course dose is determined individually, depending on the course and form of the disease, the degree of inactivation of isoniazid, the effectiveness of therapy, and the tolerance of the drug.

Overdose

Symptoms: in case of overdose, 0.5-3 hours after administration of the drug, disorders of the digestive tract (including liver) may occur - nausea, vomiting, anorexia, metabolic acidosis, acetonuria, hyperglycemia, glucosuria, neurotoxic manifestations (dizziness, fever, headache, visual and hearing disturbances, indistinct speech, weakness, disorientation, visual hallucinations, hyperreflexia, respiratory failure, and depression of the central nervous system, which rapidly progress, stupor, seizures, coma).

Adverse reactions

From the organs of vision: neuritis of the optic nerve, atrophy of the optic nerve.

From the organs of hearing and the vestibular apparatus: hearing loss and tinnitus in patients with terminal stage renal failure.

Reports of suspected adverse reactions

Reports of suspected adverse reactions after registration of the medicinal product are an important procedure.

Shelf life

5 years.

Storage conditions

Store in the original packaging at a temperature not exceeding 25 °C.

Packaging

10 tablets in a contour cell pack; 5 contour cell packs in a pack; 1000, 1500, or 2500 tablets in containers.

Release category

By prescription.

Manufacturer

PrJSC "Pharmaceutical firm "Darnitsa".

Location of the manufacturer and address of the place of its activity

Ukraine, 02093, Kyiv, Borispylska street, 13.

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