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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use P-TOLUENDIAMINE SMARTPRACTICE 10 mg/g (1%) OINTMENT

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Leaflet: information for the patient

p-toluendiamina SmartPractice10mg/g (1%) ointment

2,5-diaminotoluene

Read the entire leaflet carefully before starting to use this medication, as it contains important information for you.

  • Keep this leaflet, as you may need to read it again.
  • If you have any questions, consult your doctor or pharmacist.
  • If you experience side effects, consult your doctor or nurse, even if they are side effects not listed in this leaflet. See section 4.

Contents of the leaflet

  1. What is p-toluendiamina SmartPractice and what is it used for
  2. What you need to know before starting to use p-toluendiamina SmartPractice
  3. How to use p-toluendiamina SmartPractice
  4. Possible side effects

5 Conservation of p-toluendiamina SmartPractice

  1. Package contents and additional information

1. What is p-toluendiamina SmartPractice and what is it used for

p-toluendiamina SmartPractice is a diagnostic agent. It contains p-toluendiamina, which can trigger contact allergies on the skin.

Contact allergic dermatitis is an inflammatory skin response caused by repeated exposure to foreign substances to which you are allergic.

The test is performed in the doctor's office.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before starting to use p-toluendiamina SmartPractice

Do not use p-toluendiamina SmartPractice

  • If your general state of health is significantly affected (e.g., you have an infection).
  • If you are allergic to any of the components of this medication (listed in section 6).
  • If, at the time of the test, you have severe or widespread dermatitis. The test area must be free of any skin condition for 14 days before performing the patch test.
  • If your skin has been exposed to UV radiation (sun) in the test area in the last 4 weeks.

Warnings and precautions

Consult your doctor or nurse before starting to use p-toluendiamina SmartPractice.

  • Before applying the patch test, your doctor will ensure that the test area is free of any ongoing skin condition that may interfere with the results.
  • Avoid strenuous physical exercise and excessive sweating while wearing the test patch.
  • Avoid showers and baths, as moisture can cause the test panel to come off.
  • Refrain from taking medications such as steroids, which inhibit the immune system, as they may cause false-negative reactions.
  • If you have previously had anaphylactoid reactions. The use of p-toluendiamina SmartPractice should be carefully considered.
  • If you are allergic to p-toluendiamina, you may also be allergic to other chemicals with a similar structure, such as those found in some hair dyes. Your doctor may decide to perform additional tests to identify these chemicals.

Other medications and p-toluendiamina SmartPractice

Tell your doctor or nurse if you are using, have recently used, or may need to use any other medication, including those purchased without a prescription, before applying p-toluendiamina SmartPractice. Remember that your doctor may not know what medications you are taking.

  • Steroids can cause false-negative results in the test. Your doctor will decide whether to interrupt steroid treatment before the test. If you are unsure whether any of your medications contain steroids, talk to your doctor.
  • If you are undergoing treatment with cytotoxic medications or immunosuppressive therapy, the patch test should be postponed.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or nurse before using this medication.

The patch test for allergies should not be performed during pregnancy or breastfeeding, unless it is considered absolutely necessary. Your doctor will decide whether you should perform the patch test or not.

Driving and using machines

It is unlikely that this medication will affect your ability to drive or use machines. Talk to your doctor if you have any concerns about this.

3. How to use p-toluendiamina SmartPractice

Method of administration

During the patch test, the healthcare professional will perform the following steps:

  • For the allergy test, a 5 mm strip of ointment is applied directly to the designated area of the test panel.
  • Then, the test panel is applied to healthy, dry skin (usually on the back or upper arm).

Duration of treatment

  • The patch test will be removed 48 hours after application.
  • Your doctor will read the test result 30 minutes after removal and again after 1 and 2 days, when allergic reactions have fully developed and possible irritant reactions have disappeared.
  • The evaluation of skin reactions will be performed by the doctor following an established protocol. The instructions for this evaluation are found in the information for healthcare professionals (see section "Interpretation").
  • If you experience severe discomfort in the test area, contact your doctor. Your doctor may decide to remove the test.

Use in children and adolescents

Clinical trial data in children are limited.

Children under 12 years old should only undergo the test with p-toluendiamina SmartPractice when there is a strong suspicion of contact allergy to p-toluendiamina. Your doctor will decide whether to perform the test.

The patch test can be removed after 24 hours to reduce irritant reactions.

If you use more p-toluendiamina SmartPractice than you should

If the test is used correctly, overdose is not possible. If used incorrectly, it can cause a stronger allergic reaction, including blisters on the skin. In these cases, the doctor will take the necessary measures.

If you have any further questions about the use of this medication, ask your doctor or nurse.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medications, this medication can cause side effects, although not everyone will experience them.

Class effects for epicutaneous patch tests (frequency cannot be estimated from available data):

  • Anaphylactic reaction (systemic reaction, possibly with a drop in blood pressure that can be fatal). If you experience sweating, dizziness, or other discomfort immediately after applying the test panel, inform your doctor or nurse immediately.
  • Sensitization to the substance being tested.
  • Skin reactions at the test site. Reactions include itching, skin redness, and possibly blisters. These reactions are expected and may indicate a contact allergy.
  • Type I allergic reactions (mild to moderate allergic reactions).

Emergency measures in case of side effects

Rarely, patch tests can cause severe allergic reactions, including systemic reactions (anaphylactic shock). Warning signs of an anaphylactic shock reaction are burning, itching, and a feeling of heat in and under the tongue, throat, palms of the hands, and soles of the feet. Inform your doctor or nurse immediately if you experience any of these reactions.

Reporting side effects

If you experience any side effects, consult your doctor or nurse, even if they are side effects not listed in this leaflet. You can also report them directly through the Spanish Medication Surveillance System for Human Use: https://www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medication.

5. Conservation of p-toluendiamina SmartPractice

Keep in the refrigerator (between 2 °C and 8 °C).

Keep this medication out of the sight and reach of children.

Do not use this medication after the expiration date shown on the label after CAD. The expiration date is the last day of the month indicated.

Medications should not be disposed of through wastewater or household waste. Ask your pharmacist how to dispose of the packaging and any unused medication. This will help protect the environment.

6. Package contents and additional information

Composition of p-toluendiamina SmartPractice

  • The active ingredient is p-toluendiamina.
  • The excipient is white petrolatum.

Appearance of the product and package contents

  • Brown-red to purple ointment in a syringe.
  • Package size: a 5ml syringe with 5 ml (4.7 g) of ointment.

Marketing authorization holder and manufacturer

SmartPractice Europe GmbH

Bövemannstr. 8

48268 Greven

Germany

This medication is authorized in the Member States of the European Economic Area with the following names:

Germany: p-Toluylendiamin 1%, Testsalbe

France: p-toluènediamine SmartPractice 1%, pommade

Spain: p-toluendiamina SmartPractice 10 mg/g (1%), ointment

Sweden: p-toluendiamin SmartPractice 1%, salva

Date of the last revision of this leaflet:02//2022

Detailed information about this medication is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) (http://www.aemps.gob.es/)

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This information is intended only for healthcare professionals:

Interpretation

The interpretation of the patch test reaction should be performed according to the method of interpretation recommended by the International Contact Dermatitis Research Group (ICDRG).

Symbol

Morphology

Assessment

-

No reaction

Negative reaction

?

Only weak erythema

Doubtful reaction

+

Erythema, infiltration, possible papules

Weak positive reaction

++

Erythema, infiltration, papules, vesicles

Strong positive reaction

+++

Intense erythema, infiltration, coalescent vesicles

Extreme positive reaction

RI

Various morphologies (e.g., soap effect, blister, necrosis)

Irritant reaction

NA

An allergen contained in a test block but not tested

Not analyzed

Online doctors for P-TOLUENDIAMINE SMARTPRACTICE 10 mg/g (1%) OINTMENT

Discuss questions about P-TOLUENDIAMINE SMARTPRACTICE 10 mg/g (1%) OINTMENT, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Sergey Ilyasov

Psychiatry 7 years exp.

Dr Sergey Ilyasov is an experienced neurologist and qualified psychiatrist who provides online consultations for adults and adolescents. Combining deep neurological expertise with a modern psychiatric approach, he ensures comprehensive diagnostics and effective treatment for a wide range of conditions affecting both physical and mental health.

Dr. Ilyasov helps patients in the following cases:

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Thanks to his dual specialization in neurology and psychiatry, Dr Sergey Ilyasov offers integrated and evidence-based care for complex conditions requiring a multidisciplinary approach. His consultations focus on accurate diagnosis, development of an individualized treatment plan (including pharmacotherapy and psychotherapeutic methods), and long-term support adapted to each patient's unique needs.

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Alina Tsurkan

Family medicine 13 years exp.

Dr. Alina Tsurkan is a licensed family medicine physician based in Portugal, offering online consultations for adults and children. She provides professional primary care, with a focus on prevention, accurate diagnosis, and long-term management of acute and chronic conditions.

Dr. Tsurkan supports patients with a wide range of health issues, including:

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Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

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Alexander Nazarchuk

Allergology 7 years exp.

Dr. Alexander Nazarchuk is a physician specialising in allergology and internal medicine. He provides online consultations for adults, following the principles of evidence-based medicine — no outdated treatments or unnecessary tests, with clear explanations and a personalised approach. He helps patients with a wide range of allergic and therapeutic conditions, from common day-to-day complaints to complex cases involving allergies, gastrointestinal issues, cardiovascular concerns, respiratory symptoms, and more.

You can consult Dr. Nazarchuk for:

  • Test interpretation and guidance on diagnostic plans.
  • Allergic rhinitis, hay fever, bronchial asthma (including severe cases).
  • Food and drug allergies, skin rashes, angioedema.
  • Atopic dermatitis, urticaria, contact allergies.
  • Allergen-specific immunotherapy (AIT) – initiation and ongoing management.
  • Abdominal pain, bloating, changes in bowel habits, nausea, heartburn.
  • High blood pressure and adjustment of baseline antihypertensive therapy.
  • Hyperlipidaemia and elevated cholesterol.
  • Cough, nasal congestion, fever, sore throat.
  • Anaemia, including iron deficiency and related conditions.
  • Other issues related to allergology and internal medicine.

During consultations, Dr. Nazarchuk takes a thorough, structured approach — analysing symptoms, identifying potential causes, and helping patients make informed decisions. Whether treatment, further investigation, or monitoring is needed, he explains each step clearly so you understand your health and how best to manage it.

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Tomasz Grzelewski

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques. For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance. Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults. In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions. Patients commonly seek his care for: 

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
  • urticaria, atopic dermatitis and skin reactions
  • recurrent infections in children
  • sports-related health questions
  • general family medicine concerns

Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.

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Marta Reguero Capilla

Allergology 8 years exp.

Dr Marta Reguero Capilla is an allergist and immunologist who works with both adults and children. She specialises in the diagnosis, treatment, and ongoing management of allergic and immune-related conditions through online consultations. In her practice, Dr Reguero Capilla helps patients understand the causes of their symptoms, review test results, and choose appropriate treatment or monitoring strategies. Her consultations are suitable both for first-time assessments and for follow-up care over time. Patients commonly consult Dr Marta Reguero Capilla for: 

  • allergic rhinitis, seasonal allergies, and perennial allergy symptoms;
  • allergic conditions in adults and children;
  • bronchial asthma and allergy-related respiratory symptoms;
  • urticaria (acute and chronic) and angioedema;
  • food allergies and reactions to foods, additives, or medications;
  • atopic dermatitis, allergic rashes, and persistent itching;
  • unexplained or recurrent allergic reactions;
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  • immune system concerns, frequent infections, and reduced immune response;
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Dr Reguero Capilla works in a structured and attentive manner, explaining medical decisions clearly and helping patients make informed choices about their own health or their child’s care. When clinically appropriate, she may provide recommendations for further tests or referrals that patients can use within Spanish medical networks, including Sanitas and DKV, in accordance with the terms and conditions of those services.

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Frequently Asked Questions

Is a prescription required for P-TOLUENDIAMINE SMARTPRACTICE 10 mg/g (1%) OINTMENT?

P-TOLUENDIAMINE SMARTPRACTICE 10 mg/g (1%) OINTMENT requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

Who manufactures P-TOLUENDIAMINE SMARTPRACTICE 10 mg/g (1%) OINTMENT?

P-TOLUENDIAMINE SMARTPRACTICE 10 mg/g (1%) OINTMENT is manufactured by Smartpractice Europe Gmbh. Pharmacy brands and packaging may differ depending on the distributor.

Which doctors can assess the use of P-TOLUENDIAMINE SMARTPRACTICE 10 mg/g (1%) OINTMENT online?

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether P-TOLUENDIAMINE SMARTPRACTICE 10 mg/g (1%) OINTMENT is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

How to buy P-TOLUENDIAMINE SMARTPRACTICE 10 mg/g (1%) OINTMENT in Spain?

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy P-TOLUENDIAMINE SMARTPRACTICE 10 mg/g (1%) OINTMENT in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

What are the alternatives to P-TOLUENDIAMINE SMARTPRACTICE 10 mg/g (1%) OINTMENT?

Other medicines with the same active substance () include ANTICUDE, APULCO ACOMETH 0.3%/0.3%/0.3% MEDICINAL COMPRESSED GAS, APULCO COHE 0.28%/9.5% MEDICINAL COMPRESSED GAS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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