ISOVORIN 5 mg Tablets

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Doctor
5.0(36)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

Book a video appointment
€86
This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use ISOVORIN 5 mg TABLETS

Contents of the leaflet

  1. Introduction
  2. What Isovorin is and what it is used for
  3. What you need to know before you take Isovorin
  4. How to Take Isovorin
  5. Possible Side Effects
  6. Conservation of Isovorin
  7. Contents of the Pack and Further Information

Introduction

Package Leaflet: Information for the Patient

Isovorin 5 mg Tablets

Levofolinic Acid

Read this package leaflet carefully before you start using this medicine, as it contains important information for you.Keep this package leaflet, you may need to read it again.

  • Keep this package leaflet, you may need to read it again.

If you have any further questions, ask your doctor, pharmacist, or nurse.

  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.
  • If you experience any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this package leaflet. See section 4.

Contents of the Package Leaflet

  1. What Isovorin is and what it is used for
  2. What you need to know before you take Isovorin
  3. How to take Isovorin
  4. Possible side effects

5 Conservation of Isovorin

  1. Contents of the pack and further information

1. What Isovorin is and what it is used for

Isovorin contains levofolinic acid in the form of calcium levofolinate. Levofolinic acid is the active form of folic acid. Levofolinic acid acts in processes that involve folate deficiency and as an antidote to folic acid antagonists (it belongs to the group of medicines called detoxifying agents for the treatment of tumors).

This medicine is used in the following cases:

  • Treatment of disorders that involve folate deficiency (megaloblastic anemia, alcoholism, malabsorption syndrome, nutritional deficiency in children and/or the elderly).
  • Antidote to folic acid antagonists such as Methotrexate.
Doctor consultation

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2. What you need to know before you take Isovorin

Do not take Isovorin

  • if you are allergic to levofolinic acid or any of the other ingredients of this medicine (listed in section 6).
  • if you have anemia (a disorder characterized by a decrease in the number of red blood cells and/or hemoglobin in the blood), whether pernicious or other megaloblastic anemia secondary to vitamin B12 deficiency.

Warnings and Precautions

Talk to your doctor, pharmacist, or nurse before taking Isovorin tablets.

Your doctor will inform you about the benefits and risks of treatment with Isovorin tablets, as well as the symptoms that may indicate possible toxicity due to the medicine.

If you are in any of the following situations, consult your doctor before taking this medicine:

  • If you are epileptic and are being treated with phenobarbital, phenytoin, primidone, and succinimides, as there is a risk of increased frequency of seizures (see section "Other Medicines and Isovorin").
  • If you are taking folic acid antagonist medicines such as chloramphenicol (an antibiotic).
  • If you are being treated with methotrexate or 5-fluorouracil. It is essential that you strictly follow the dose of Isovorin prescribed by your doctor, as non-compliance may cause excessive toxicity or lack of efficacy of methotrexate.
  • If you have pernicious anemia and other megaloblastic anemia resulting from vitamin B12 deficiency.
  • If you are being treated with cytotoxic medicines that directly or indirectly inhibit DNA synthesis, such as hydroxyurea, cytarabine, mercaptopurine, or thioguanine, and have presented microcytosis.

Other Medicines and Isovorin

Tell your doctor or pharmacist if you are using, have recently used, or might use any other medicines.

In particular, tell your doctor if you are using the following medicines:

  • Folic acid antagonist medicines such as cotrimoxazole, pyrimethamine, or chloramphenicol, as levofolinic acid may reduce their efficacy.
  • Antiepileptic medicines (such as phenobarbital, phenytoin, succinimides, or primidone), as high doses may partially reduce their effect and increase the frequency of seizures (see section "Warnings and Precautions").
  • Medicines such as methotrexate or 5-fluorouracil. Calcium folinate should only be used with methotrexate or 5-fluorouracil under the direct supervision of an experienced doctor in the use of cancer chemotherapeutic agents.

Pregnancy, Breastfeeding, and Fertility

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medicine. There have been no adequate and well-controlled clinical studies in pregnant or breastfeeding women.

It is not known whether calcium folinate is excreted in breast milk. Levofolinic acid calcium can be used during breastfeeding if considered necessary according to therapeutic indications.

No fertility studies have been conducted with calcium folinate.

Driving and Using Machines

This medicine has no effects on the ability to drive vehicles or use machines.

This Medicine Contains Lactose and Sodium

This medicine contains lactose. If your doctor has told you that you have an intolerance to some sugars, consult them before taking this medicine.

This medicine contains less than 1 mmol of sodium (23 mg) per dose; this is essentially "sodium-free".

3. How to Take Isovorin

Follow exactly the administration instructions of this medicine indicated by your doctor or pharmacist. In case of doubt, consult your doctor or pharmacist again.

The tablet can be taken on an empty stomach or after meals.

Treatment of Folate Deficiencies

The recommended dose is 2.5 mg to 5 mg per day (generally one tablet per day), administered orally.

Your doctor will indicate the dose and duration of treatment, taking into account your situation.

Antidote to Folic Acid Antagonists

Rescue of high doses of Methotrexate: It will be done with doses of 7.5 mg (approximately 5 mg/m2) of levofolinic acid administered intravenously, intramuscularly, or orally if tablets are used, every 6 hours for 72 hours and with a total of 10 doses. Treatment will start 24 hours after the start of methotrexate infusion. The dose will be individual for each patient and may be modified by your doctor depending on the severity of the condition and the patient's response.

Overdose of Methotrexate: Rescue should be started as soon as possible after accidental overdose and within 24 hours after methotrexate administration when there is a delay in its elimination. Levofolinic acid doses of 5 mg/m2 will be administered intravenously, intramuscularly, or orally, every 6 hours, until the methotrexate level in plasma is less than 0.5 µmol/l.

Trimetrexate, Trimethoprim, and Pyrimethamine:

  • Trimethoprim toxicity: After stopping trimethoprim, a dose of 1.5 to 5 mg of calcium levofolinate should be administered daily until a normal blood count is recovered.
  • Pyrimethamine toxicity: In case of administration of high doses or prolonged treatment with low doses of pyrimethamine, 2.5 to 25 mg of calcium levofolinate should be administered simultaneously, based on the results of peripheral blood counts.
  • Trimetrexate toxicity:
    • Prevention: Calcium levofolinate should be administered every day during treatment with trimetrexate and for 72 hours after the last dose of trimetrexate.

Calcium levofolinate can be administered orally with four doses of 20 mg/m2 administered at equal intervals. The daily doses of calcium levofolinate should be adjusted depending on the hematological toxicity of trimetrexate.

  • Overdose (possibly with trimetrexate doses higher than 90 mg/m2 without concomitant administration of calcium folinate): After stopping trimetrexate, 20 mg/m2 of calcium levofolinate should be administered every 6 hours for 3 days.

If You Take More Isovorin Than You Should

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or call the Toxicology Information Service, phone: 91 562 04 20, indicating the medicine and the amount ingested.

If You Forget to Take Isovorin

Do not take a dose to make up for forgotten doses.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible Side Effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Rare side effects (may affect up to 1 in 1,000 people) include:

  • Seizures and/or fainting.
  • Depression.
  • Agitation.
  • Digestive problems.
  • Difficulty sleeping (insomnia).

Very rare side effects (may affect up to 1 in 10,000 people) include:

  • Severe allergic reaction: You may experience a sudden rash with itching (urticaria), swelling of the hands, feet, ankles, face, lips, mouth, or throat (which may cause difficulty swallowing or breathing) and may feel like you are going to faint. This is a serious side effect. You may need urgent medical attention.

Side effects of unknown frequency (cannot be estimated from the available data) include:

  • Fever.

Reporting of Side Effects:

If you experience any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this package leaflet. You can also report side effects directly through the Spanish Medicines and Healthcare Products Agency (AEMPS) website: www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Conservation of Isovorin

Keep this medicine out of the sight and reach of children.

This medicine does not require special storage conditions. Store below 25°C and protected from light.

Do not use this medicine after the expiry date which is stated on the packaging after EXP. The expiry date is the last day of the month indicated.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. Contents of the Pack and Further Information

Composition of Isovorin

  • The active substance is folinic acid. Each tablet contains 5 mg of levofolinic acid in the form of calcium levofolinate.
  • The other ingredients (excipients) are lactose, microcrystalline cellulose, sodium starch glycolate, silicon dioxide, and magnesium stearate.

Appearance of Isovorin and Contents of the Pack

Oval, biconvex tablets, white, marked with "L L" on the lower face and "I 7" on the upper face, packaged in blisters.

Pack containing 30 tablets.

Marketing Authorization Holder:

Pfizer, S.L.

Avda. de Europa, 20-B

Parque Empresarial La Moraleja

28108 Alcobendas (Madrid)

Manufacturer

Farmasierra Manufacturing, S.L.

Carretera de Irún, Km. 26,200

28700 San Sebastián de los Reyes (Madrid)

Date of Last Revision of this Package Leaflet: October 2023

Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Healthcare Products (AEMPS) http://www.aemps.gob.es/

Online doctors for ISOVORIN 5 mg TABLETS

Discuss questions about ISOVORIN 5 mg TABLETS, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

Doctor
5.0(36)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

Book a video appointment
€86
Doctor
5.0(12)

Yevgen Yakovenko

Family medicine12 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

Book a video appointment
€72
Doctor
5.0(3)

Lina Travkina

Family medicine13 years of experience

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
  • Medical advice and follow-up consultations.
  • Test interpretation and diagnostic guidance.
  • Structured support for undiagnosed complaints.
  • Second opinion on diagnoses and treatment plans.
  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
  • Post-operative recovery support and pain management.
  • Preconception counselling and postpartum support.
  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

Book a video appointment
€75
Doctor
5.0(19)

Nuno Tavares Lopes

Family medicineGeneral medicine18 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies
  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management
  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses
  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment
  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance
  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis
  • Pain management: acute and chronic pain, post-surgical care
  • Public health: prevention, health screenings, long-term monitoring
  • Sick leave (Baixa médica) connected to Segurança Social in Portugal
  • IMT medical certificates for driving licence exchange
Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.

Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

Book a video appointment
€70

Get ISOVORIN 5 mg TABLETS Prescription Online

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Electronic prescription sent to your email — valid across Spain.

Frequently Asked Questions

Is a prescription required for ISOVORIN 5 mg TABLETS?

ISOVORIN 5 mg TABLETS requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

What is the active substance in ISOVORIN 5 mg TABLETS?

The active ingredient in ISOVORIN 5 mg TABLETS is calcium levofolinate. This information helps identify medicines with the same composition but different brand names.

How much does ISOVORIN 5 mg TABLETS cost in pharmacies?

The average pharmacy price for ISOVORIN 5 mg TABLETS is around 16.86 EUR. Prices may vary depending on the manufacturer and dosage form.

Who manufactures ISOVORIN 5 mg TABLETS?

ISOVORIN 5 mg TABLETS is manufactured by Pfizer S.L.. Pharmacy brands and packaging may differ depending on the distributor.

Which doctors can assess the use of ISOVORIN 5 mg TABLETS online?

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether ISOVORIN 5 mg TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

How to buy ISOVORIN 5 mg TABLETS in Spain?

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy ISOVORIN 5 mg TABLETS in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

What are the alternatives to ISOVORIN 5 mg TABLETS?

Other medicines with the same active substance (calcium levofolinate) include ISOVORIN 175 mg POWDER FOR INJECTABLE SOLUTION AND FOR INFUSION, ISOVORIN 7.5 mg TABLETS, CARDIOXANE 500 mg POWDER FOR SOLUTION FOR INFUSION. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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