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ISOVORIN 175 mg Injectable Solution

Prescription review online

Prescription review online

A doctor will review your case and decide whether a prescription is medically appropriate.

Talk to a doctor about this medicine

Talk to a doctor about this medicine

Discuss your symptoms and possible next steps in a quick online consultation.

Doctor
5.0(38)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a General Practitioner with specialized training in chronic pain. He provides online consultations for adult patients in Spain and other European countries.

Dr. Popov understands that seeking help with weight-related concerns or pain that has persisted for months can be difficult. Many patients come to him after trying different approaches without feeling truly heard. During the consultation, the doctor creates a comfortable and supportive, non-judgmental environment where the patient’s medical history can be discussed in detail, questions can be answered, and the next steps can be decided together.

Weight Management and Metabolic Health

Dr. Popov can help assess overweight, obesity, and related conditions such as hypertension, diabetes, or metabolic disorders. During the consultation, the patient’s medical history, test results, current medications, and previous treatments will be reviewed.

If you would like to learn about possible medication options or have already started treatment, the doctor can assess your situation, review the effectiveness and tolerability of the therapy, and clearly explain its benefits, potential risks, and alternatives.

Not every patient requires the same treatment. A consultation does not guarantee a prescription — it provides an objective medical assessment and a plan tailored to your individual situation.

Pain and General Medicine

You can also consult Dr. Popov regarding:

* chronic pain, migraines, neuralgia, and fibromyalgia;

* back, neck, lower back, or joint pain;

* hypertension, diabetes, and follow-up of chronic conditions;

* review of test results, medical reports, and current treatment;

* preventive medicine and a second medical opinion.

How the Consultation Works

The video consultation lasts up to 30 minutes. The doctor will listen carefully, review the information you provide, and explain the next steps in clear and understandable language.

If additional tests, an in-person consultation, or urgent medical care are required, the doctor will inform you directly.

Dr. Popov’s goal is to make sure the patient feels heard and leaves the consultation with a clear understanding of their condition and the next steps they can take.

Book a video appointment
€86
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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use ISOVORIN 175 mg POWDER FOR INJECTABLE SOLUTION AND FOR INFUSION

Contents of the leaflet

  1. Introduction
  2. What Isovorin is and what it is used for
  3. What you need to know before you use Isovorin
  4. How to use Isovorin
  5. Possible side effects
  6. Storage of Isovorin
  7. Contents of the pack and further information

Introduction

Package Leaflet: Information for the Patient

Isovorin 175 mg Powder for Solution for Injection and Infusion

Levofolinic Acid

Read all of this leaflet carefully before you start using this medicine, because it contains important information for you.Keep this leaflet, you may need to read it again.

  • Keep this leaflet, you may need to read it again.

If you have any further questions, ask your doctor, pharmacist, or nurse.

  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.
  • If you experience any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the Package Leaflet

  1. What Isovorin is and what it is used for
  2. What you need to know before you use Isovorin
  3. How to use Isovorin
  4. Possible side effects

5. Storage of Isovorin

  1. Contents of the pack and further information

1. What Isovorin is and what it is used for

Isovorin contains levofolinic acid, which is the active form of folic acid. Levofolinic acid acts as an antidote to folic acid antagonists and belongs to the group of medicines called detoxifying agents for the treatment of tumors.

This medicine is used in the following cases:

  • To reduce the side effects and treat overdose of certain cancer medicines such as methotrexate (and other folic acid antagonists).
  • Used in combination with 5-fluorouracil, as it increases the effect of the latter, in the treatment of patients with cancer.
Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you use Isovorin

Do not use Isovorin:

  • if you are allergic to levofolinic acid or any of the other ingredients of this medicine (listed in section 6).
  • if you have anemia (a disorder characterized by a decrease in the number of red blood cells and/or hemoglobin in the blood), whether pernicious or other megaloblastic anemias secondary to vitamin B12 deficiency.
  • if you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant.

Warnings and precautions

Talk to your doctor, pharmacist, or nurse before starting to use Isovorin.

Your doctor will inform you about the benefits and risks of treatment with Isovorin, as well as the symptoms that may indicate possible toxicity due to the medicine.

If you are in any of the following situations, consult your doctor before using this medicine:

  • If you have pernicious anemia and other megaloblastic anemias resulting from vitamin B12 deficiency.
  • If you have blood problems caused by cancer medicines.
  • If you are being treated with methotrexate or 5-fluorouracil. It is essential that you strictly follow the dose of Isovorin prescribed by your doctor, as non-compliance may cause excessive toxicity or lack of efficacy of methotrexate.
  • If you have diarrhea, as this may be a symptom of gastrointestinal toxicity.
  • If you have received prior radiotherapy.
  • If you have taken an accidental overdose of methotrexate.
  • If you are epileptic and are being treated with phenobarbital, phenytoin, primidone, and succinimides, as there is a risk of increased frequency of seizures (see section "Other medicines and Isovorin").

Levofolinic acid should not be administered intrathecally (in the spinal cord).

Children and adolescents

There are no data on the efficacy and safety in children and adolescents under 18 years of age.

Other medicines and Isovorin

Tell your doctor or pharmacist if you are using, have recently used, or might use any other medicines.

In particular, tell your doctor if you are using the following medicines:

  • Folic acid antagonist medicines such as cotrimoxazole, pyrimethamine, or chloramphenicol, as levofolinic acid may reduce their efficacy.
  • Antiepileptic medicines (such as phenobarbital, phenytoin, succinimides, or primidone), as high doses may partially reduce their effect and increase the frequency of seizures (see section "Warnings and precautions").
  • Medicines such as methotrexate or 5-fluorouracil. Folinic acid calcium should only be used with methotrexate or 5-fluorouracil under the direct supervision of an experienced doctor in the use of cancer chemotherapeutic agents.

Pregnancy, breastfeeding, and fertility

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medicine. No adequate and well-controlled clinical studies have been conducted in pregnant or breastfeeding women.

It is unknown whether calcium levofolinate passes into breast milk. Your doctor will decide whether it is necessary for you to take this medicine according to the therapeutic indications.

No fertility studies have been conducted with calcium folinate.

Driving and using machines

This medicine has no effects on the ability to drive vehicles or use machines.

This medicine contains sodium

This medicine contains less than 1 mmol (23 mg of sodium) per dose unit; i.e., it is essentially "sodium-free".

3. How to use Isovorin

Your doctor will determine the dose and duration of treatment, as well as the most suitable route of administration for you, according to your condition and response to treatment.

This medicine should not be administered intrathecally (in the spinal cord).

This medicine should only be administered intravenously or intramuscularly. In the case of intravenous administration, no more than 160 mg of calcium levofolinate should be injected per minute due to the calcium content of the solution.

Rescue with calcium levofolinate in methotrexate therapy

If you have been administered a dose of methotrexate greater than 500 mg/m2, you should receive levofolinate thereafter. When administering methotrexate doses between 100 mg/m2 - 500 mg/m2, your doctor may consider rescue administration.

Rescue with levofolinate will be started 12-24 hours after the start of methotrexate infusion, with doses of 7.5 mg (approximately 5 mg/m2) of levofolinate every 6 hours, for 72 hours.

Combined treatment with 5-fluorouracil

Since calcium levofolinate increases the activity and toxicity of 5-fluorouracil, treatment with the combination of both should be supervised by an experienced doctor in the use of cancer chemotherapeutic agents.

Antidote for folic acid antagonists

This medicine can be used to reverse toxicity due to trimetrexate, trimethoprim, or pyrimethamine. Your doctor will determine the treatment regimen.

If you use more Isovorin than you should

This medicine will be administered to you in the hospital, so it is unlikely that you will receive more than you should; no significant harm has been reported in patients who have received significantly higher doses of calcium levofolinate than recommended.

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or call the Toxicology Information Service, phone: 91 562 04 20, indicating the medicine and the amount ingested.

If you forget to use Isovorin

Your doctor or nurse has the instructions for when to administer your medicine. It is unlikely that you will not be administered the medicine as prescribed. If you are aware that you have not been administered your dose, contact your doctor or pharmacist immediately.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

The following side effects are uncommon (may affect up to 1 in 100 people):

  • Fever.

The following side effects are rare (may affect up to 1 in 1,000 people):

  • Seizures and/or fainting.
  • Depression.
  • Agitation.
  • Digestive problems.
  • Difficulty sleeping (insomnia).

The following side effects are very rare (may affect up to 1 in 10,000 people):

  • Severe allergic reaction: you may experience a sudden rash with itching (urticaria), swelling of the hands, feet, ankles, face, lips, mouth, or throat (which may cause difficulty swallowing or breathing), and you may feel like you are going to faint. This is a serious side effect. You may need urgent medical attention.

The adverse reactions when administering levofolinic acid in combination with 5-fluorouracil are:

The following side effects are very common (may affect more than 1 in 10 patients):

  • Nausea, vomiting, diarrhea.
  • Inflammation of the mucous membranes of the intestine and mouth (in some cases fatal).
  • Decrease in the number of blood cells (in some cases fatal).

The following side effects are common (may affect up to 1 in 10 patients):

  • Redness and swelling on the palms of the hands or soles of the feet, which can cause the skin to peel (hand-foot syndrome).

The following side effects have a frequency that cannot be estimated from the available data:

  • Increased ammonia levels in the blood.

Reporting of side effects:

If you experience any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly through the Spanish Medicines and Healthcare Products Agency (AEMPS) website: www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Isovorin

Keep this medicine out of the sight and reach of children.

Do not store above 30°C and protect from light.

Do not use this medicine after the expiry date stated on the packaging after EXP. The expiry date is the last day of the month indicated.

6. Contents of the pack and further information

Composition of Isovorin

  • The active substance is folinic acid. Each vial contains 175 mg of levofolinic acid in the form of calcium levofolinate.
  • The other ingredients (excipients) are mannitol, hydrochloric acid, and sodium hydroxide.

Appearance of Isovorin and contents of the pack

White to pale yellow lyophilized powder in a Type I transparent glass vial with a bromobutyl rubber stopper and a green aluminum/plastic flip-off cap.

It is available in a single format of 1 vial.

Marketing authorization holder:

Wyeth Farma, S.A.

Carretera A-1, Km. 23. Desvío Algete, Km. 1

28700 San Sebastián de los Reyes, Madrid

Spain

Manufacturer

Wyeth Lederle S.r.l.

Via Franco Gorgone, Zona Industriale

95100 Catania

Italy

Local representative

Pfizer, S.L.

Avda. de Europa, 20-B

Parque Empresarial La Moraleja

28108 Alcobendas (Madrid)

Date of the last revision of this leaflet: October 2023

Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Healthcare Products (AEMPS) http://www.aemps.gob.es/

IMPORTANT INFORMATION FOR HEALTHCARE PROFESSIONALS

Instructions for the correct reconstitution of the medicine

Each vial should be reconstituted in 17.5 ml of sterile diluent to obtain a concentration of levofolinic acid of 10 mg per ml. This medicine does not contain preservatives.

Reconstitution can be done in the following media:

  • 9 mg/ml (0.9%) bacteriostatic saline (containing benzyl alcohol)
  • 9 mg/ml (0.9%) saline
  • 50 mg/ml (5%) glucose solution
  • Glucosaline (50 mg/ml (5%) glucose in saline)

Reconstitution with water for injection alone is not recommended, as it does not provide an isotonic solution.

The use of 9 mg/ml (0.9%) bacteriostatic saline is not recommended for administering doses greater than 10 mg/m2, due to its benzyl alcohol content. If high doses are required, the medicine should be reconstituted in 9 mg/ml (0.9%) saline.

The reconstituted solutions can, in turn, be diluted to concentrations ranging from:

  • 0.5 mg/ml to 5 mg/ml, in 9 mg/ml (0.9%) saline
  • 50 mg/ml (5%) glucose solution
  • 50 mg/ml (5%) glucose in saline (glucosaline)

Instructions for the correct storage of the reconstituted medicine

  • The solutions reconstituted with 9 mg/ml (0.9%) bacteriostatic saline, which contain benzyl alcohol, are chemically and physically stable for one week at room temperature or for four weeks under refrigeration.
  • The solutions reconstituted with 9 mg/ml (0.9%) saline, 5% glucose solution, or glucosaline (5% glucose in saline) should be used within 24 hours, stored under refrigeration, for reasons of sterility (the vial does not contain preservatives).
  • The reconstituted and subsequently diluted solutions in 0.9% saline, 5% glucose solution, or glucosaline (5% glucose in saline), if stored in PVC bags, are chemically and physically stable for at least 14 days at room temperature or under refrigeration. However, it is recommended to use them within 24 hours, stored under refrigeration, for reasons of sterility.

After reconstitution and before administration, the solution should be visually inspected. The solution for injection or infusion should be clear and yellowish and should be discarded if it is cloudy or particles are observed inside. Each vial is designed for single use.

Disposal of unused medicine and all materials that have come into contact with it will be carried out in accordance with local regulations.

Online doctors for ISOVORIN 175 mg POWDER FOR INJECTABLE SOLUTION AND FOR INFUSION

Discuss questions about ISOVORIN 175 mg POWDER FOR INJECTABLE SOLUTION AND FOR INFUSION, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

Doctor
5.0(38)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a General Practitioner with specialized training in chronic pain. He provides online consultations for adult patients in Spain and other European countries.

Dr. Popov understands that seeking help with weight-related concerns or pain that has persisted for months can be difficult. Many patients come to him after trying different approaches without feeling truly heard. During the consultation, the doctor creates a comfortable and supportive, non-judgmental environment where the patient’s medical history can be discussed in detail, questions can be answered, and the next steps can be decided together.

Weight Management and Metabolic Health

Dr. Popov can help assess overweight, obesity, and related conditions such as hypertension, diabetes, or metabolic disorders. During the consultation, the patient’s medical history, test results, current medications, and previous treatments will be reviewed.

If you would like to learn about possible medication options or have already started treatment, the doctor can assess your situation, review the effectiveness and tolerability of the therapy, and clearly explain its benefits, potential risks, and alternatives.

Not every patient requires the same treatment. A consultation does not guarantee a prescription — it provides an objective medical assessment and a plan tailored to your individual situation.

Pain and General Medicine

You can also consult Dr. Popov regarding:

* chronic pain, migraines, neuralgia, and fibromyalgia;

* back, neck, lower back, or joint pain;

* hypertension, diabetes, and follow-up of chronic conditions;

* review of test results, medical reports, and current treatment;

* preventive medicine and a second medical opinion.

How the Consultation Works

The video consultation lasts up to 30 minutes. The doctor will listen carefully, review the information you provide, and explain the next steps in clear and understandable language.

If additional tests, an in-person consultation, or urgent medical care are required, the doctor will inform you directly.

Dr. Popov’s goal is to make sure the patient feels heard and leaves the consultation with a clear understanding of their condition and the next steps they can take.

Book a video appointment
€86
More times
Doctor
5.0(12)

Yevgen Yakovenko

General medicine12 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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5.0(3)

Lina Travkina

General medicine13 years of experience

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.

  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.

  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.

  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.

  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.

  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.

  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.

  • Medical advice and follow-up consultations.

  • Test interpretation and diagnostic guidance.

  • Structured support for undiagnosed complaints.

  • Second opinion on diagnoses and treatment plans.

  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.

  • Post-operative recovery support and pain management.

  • Preconception counselling and postpartum support.

  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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€75
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Doctor
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Abdullah Alhasan

General medicineCardiology11 years of experience

Dr. Abdullah Alhasan is a physician specialising in cardiology and general medicine, with international clinical experience and a commitment to evidence-based care. He offers online consultations for adults, focusing on both acute symptoms and long-term health management.

Main areas of consultation:

  • Chest pain, shortness of breath, heart palpitations, high blood pressure
  • Hypertension control and cardiovascular disease prevention
  • Interpretation of ECG, blood tests, and Holter monitor results
  • Management of heart failure and coronary artery disease
  • General medical issues: infections, fever, fatigue, gastrointestinal symptoms
  • Guidance on diagnostics, treatment plans, and medication adjustments
Dr. Alhasan’s approach is based on thorough assessment, clear communication, and personalised care – helping patients understand their health and make informed decisions about their treatment.
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€45
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Nuno Tavares Lopes

General medicine18 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies

  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management

  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses

  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment

  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance

  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis

  • Pain management: acute and chronic pain, post-surgical care

  • Public health: prevention, health screenings, long-term monitoring

  • Sick leave (Baixa médica) connected to Segurança Social in Portugal

  • IMT medical certificates for driving licence exchange

Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

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€70
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Doctor
5.0(7)

Mar Tabeshadze

EndocrinologyGeneral medicine11 years of experience

Dr. Mar Tabeshadze is a licensed endocrinologist and general practitioner in Spain. She provides online consultations for adults, offering medical support for a wide range of endocrine conditions and related health concerns.

  • Diagnostic consultations for suspected endocrine disorders
  • Management of thyroid conditions, including in pregnant women
  • Early detection and treatment of type 1 and type 2 diabetes, with personalised therapy plans
  • Obesity treatment: identifying underlying causes of weight gain, combining medication and non-pharmacological strategies, and long-term support
  • Diagnosis and treatment of endocrine-related skin, hair, and nail issues
  • Ongoing care for patients with osteoporosis, pituitary, and adrenal gland disorders
Dr. Tabeshadze takes a patient-centred approach based on evidence-based medicine. Her goal is to help patients achieve hormonal balance, manage chronic conditions effectively, and improve overall well-being through targeted, personalised care.
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€66
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Doctor
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Sergio Correa

General medicineGeriatrics8 years of experience

Dr. Sergio Correa is a licensed general practitioner, aesthetic medicine specialist, and trichologist with experience in emergency care and preventive health. He offers online consultations in English and Spanish, supporting adult patients with a wide range of medical concerns – from acute symptoms to chronic condition management.His areas of focus include:

  • General and urgent care: fever, fatigue, infections, digestive issues, respiratory symptoms, and other common concerns
  • Chronic condition support: hypertension, high cholesterol, diabetes, thyroid issues
  • Aesthetic medicine and dermatology: acne, skin ageing, hyperpigmentation, personalised skincare guidance
  • Trichology: hair loss, scalp conditions, treatment strategies for men and women
  • Preventive care: health check-ups, lifestyle advice, second opinions

Dr. Correa combines medical knowledge with an aesthetic and holistic approach to help patients improve both health and quality of life.

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€56
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Antonio Cayatte

General medicine44 years of experience

Dr Antonio Cayatte is a physician in General and Acute Medicine with over 30 years of experience across clinical care, medical research, and education. He offers online consultations for adults with a wide range of symptoms, both acute and chronic. His clinical background includes: 

  • assessment of sudden or unclear symptoms
  • ongoing care for chronic conditions
  • follow-up after hospital discharge
  • interpretation of test results
  • medical support while abroad

Dr Cayatte earned his degree from the University of Lisbon and taught internal medicine at Boston University School of Medicine. He holds active medical registrations in both Portugal and the UK and is a Fellow of the American Heart Association. Consultations are available in English and Portuguese. Patients value his clarity, professionalism, and balanced approach to evidence-based care.

Dr. Antonio Cayatte provides comprehensive care for a broad spectrum of common health concerns, including:

  • Respiratory & ENT: acute bronchitis, concerns related to pneumonia, sinusitis, tonsillitis, ear infections, sore throat conditions, and allergic rhinitis
  • Eye Health: allergic and infectious conjunctivitis, as well as red or irritated eyes
  • Digestive & Urinary: gastroesophageal reflux disease (GERD), gastritis, urinary tract infections, and cystitis
  • Chronic Conditions: hypertension, elevated cholesterol, and structured weight management planning
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€66
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Doctor
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Ngozi Precious Okwuosa

General medicine6 years of experience

Dr. Ngozi Precious Okwuosa is a Primary Care Physician with over 5 years of clinical experience in Hungary, Sweden, and Nigeria. A graduate of the University of Szeged (cum laude), she offers online consultations for adults in the areas of internal medicine, women’s health, and postoperative care.

Key areas of consultation:

  • Preventive and family medicine
  • Women’s health, including gynaecology and obstetrics
  • Chronic disease management: hypertension, diabetes, and more
  • Mental health support, anxiety, and counselling
  • Postoperative care and lab test interpretation
She has conducted research on the genetic background of stroke and is skilled in communicating with patients from diverse cultural backgrounds. Her approach combines clinical expertise with empathy and clear communication.
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€56
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Doctor
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Hocine Lokchiri

General medicine21 years of experience

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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Get ISOVORIN 175 mg POWDER FOR INJECTABLE SOLUTION AND FOR INFUSION Prescription Online

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Electronic prescription sent to your email — valid across Spain.

Frequently Asked Questions

ISOVORIN 175 mg POWDER FOR INJECTABLE SOLUTION AND FOR INFUSION requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

The active ingredient in ISOVORIN 175 mg POWDER FOR INJECTABLE SOLUTION AND FOR INFUSION is calcium levofolinate. This information helps identify medicines with the same composition but different brand names.

ISOVORIN 175 mg POWDER FOR INJECTABLE SOLUTION AND FOR INFUSION is manufactured by Wyeth Farma S.A.. Pharmacy brands and packaging may differ depending on the distributor.

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether ISOVORIN 175 mg POWDER FOR INJECTABLE SOLUTION AND FOR INFUSION is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy ISOVORIN 175 mg POWDER FOR INJECTABLE SOLUTION AND FOR INFUSION in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

Other medicines with the same active substance (calcium levofolinate) include ISOVORIN 5 mg TABLETS, ISOVORIN 7.5 mg TABLETS, CARDIOXANE 500 mg POWDER FOR SOLUTION FOR INFUSION. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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