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About the medicine

How to use HBVAXPRO 10 micrograms INJECTABLE SUSPENSION

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

HBVAXPRO 10 micrograms, suspension for injection

Hepatitis B vaccine (rDNA)

Read all of this leaflet carefully before you are vaccinated because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor, pharmacist or nurse.
  • If you experience any side effects, talk to your doctor, pharmacist or nurse, even if they are not listed in this leaflet. See section 4.

Contents of the pack

  1. What HBVAXPRO 10 micrograms is and what it is used for
  2. What you need to know before you are given HBVAXPRO 10 micrograms
  3. How HBVAXPRO 10 micrograms is given
  4. Possible side effects
  5. Storage of HBVAXPRO 10 micrograms
  6. Contents of the pack and other information

1. What HBVAXPRO 10 micrograms is and what it is used for

This vaccine is indicated for active immunization against hepatitis B virus infection caused by all known subtypes, in individuals from 16 years of age considered at risk of exposure to hepatitis B virus.

It can be expected that immunization with HBVAXPRO will also prevent hepatitis D, since hepatitis D does not occur in the absence of hepatitis B infection.

The vaccine does not prevent infections caused by other agents such as hepatitis A, hepatitis C, and hepatitis E, or by other pathogens known to infect the liver.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you are given HBVAXPRO 10 micrograms

Do not use HBVAXPRO 10 micrograms

  • if you are allergic to hepatitis B surface antigen or to any of the other components of HBVAXPRO (see section 6).
  • if you have a severe illness with fever.

Warnings and precautions

It can cause severe allergic reactions because it contains latex in the packaging. Consult your doctor, pharmacist or nurse before receiving HBVAXPRO 10 micrograms.

Other vaccines and HBVAXPRO 10 micrograms

HBVAXPRO can be given at the same time as hepatitis B immunoglobulin, in different injection sites.

HBVAXPRO can be used to complete a primary immunization cycle or as a booster dose in individuals who have previously received another hepatitis B vaccine.

HBVAXPRO can be given at the same time as other vaccines, using different injection sites and syringes.

Tell your doctor, pharmacist or nurse if you are taking or have recently taken any other medicines, including those obtained without a prescription.

Pregnancy and lactation

Caution should be exercised when prescribing the vaccine to pregnant or breastfeeding women.

Consult your doctor, pharmacist or nurse before using any medicine.

Driving and using machines

HBVAXPRO is not expected to have a significant effect on the ability to drive and use machines.

HBVAXPRO 10 micrograms contains sodium: this medicine contains less than 23 mg of sodium (1 mmol) per dose; it is essentially "sodium-free".

3. How HBVAXPRO 10 micrograms is given

Dose

The recommended dose per injection (1 ml) is 10 micrograms in individuals from 16 years of age.

A vaccination cycle should include at least three injections.

Two vaccination schedules can be recommended:

  • two injections with a one-month interval followed by a third injection six months after the first administration (0, 1, 6 months).
  • if rapid immunity is required: three injections with a one-month interval and a fourth dose one year later (0, 1, 2, 12 months).

In the event of recent exposure to hepatitis B virus, the first dose of HBVAXPRO can be given along with the appropriate dose of immunoglobulin.

Some local vaccination schedules currently recommend a booster dose. Your doctor, pharmacist or nurse will inform you if you need a booster dose.

HBVAXPRO 10 micrograms is not indicated in individuals under 16 years of age.

The appropriate dose for administration to individuals from birth to 15 years of age is HBVAXPRO 5 micrograms.

Method of administration

The vial should be shaken well until a slightly opaque white suspension is obtained. The doctor or nurse will administer the vaccine by injection into the muscle. The preferred injection site in adults and adolescents is the muscle of the upper arm.

This vaccine should never be administered into a blood vessel.

Exceptionally, the vaccine can be administered subcutaneously in patients with thrombocytopenia (decreased blood platelets) or in individuals at risk of bleeding.

If you miss a dose of HBVAXPRO 10 micrograms

If you miss a scheduled injection, consult your doctor, pharmacist or nurse. Your doctor or nurse will decide when to administer the missed dose.

If you have any further questions about the use of this product, consult your doctor, pharmacist or nurse.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this vaccine can cause side effects, although not everybody gets them.

As with other hepatitis B vaccines, in many cases, a causal relationship between the side effects and the vaccine has not been established.

The most frequently observed side effects are reactions at the injection site: discomfort, redness, and induration.

Other side effects reported very rarely are:

  • Low platelet count, Lymph node disease
  • Allergic reactions
  • Nervous system disorders such as Tingling, Facial paralysis, Inflammations of the nerves including Guillain-Barré syndrome, Optic neuritis causing vision disturbances, Brain inflammation, Exacerbation of multiple sclerosis, Multiple sclerosis, Seizures, Headache, Dizziness, and Fainting
  • Low blood pressure, Inflammation of blood vessels
  • Symptoms similar to asthma
  • Vomiting, Nausea, Diarrhea, Abdominal pain
  • Skin reactions such as Eczema, Rash, Itching, Hives, and Blistering of the skin, Hair loss
  • Joint pain, Arthritis, Muscle pain, Pain in a limb
  • Fatigue, Fever, Undiagnosed illness, Flu-like symptoms
  • Elevation of liver enzymes
  • Inflammation of the eyes causing pain and redness

Reporting of side effects

If you experience any side effects, talk to your doctor, pharmacist or nurse, even if they are not listed in this leaflet. You can also report side effects directly through the national reporting system listed in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of HBVAXPRO 10 micrograms

Keep this vaccine out of the sight and reach of children.

Do not use this vaccine after the expiry date which is stated on the label.

Store in a refrigerator (between 2°C and 8°C).

Do not freeze.

Store in the original packaging to protect from light.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. Contents of the pack and other information

Composition of HBVAXPRO 10 micrograms

The active substance is:

Recombinant hepatitis B surface antigen (HBsAg)*……..10 micrograms

Adsorbed on amorphous aluminum hydroxyphosphate sulfate (0.50 milligrams Al+)

  • produced in yeast Saccharomyces cerevisiae (strain 2150-2-3) using recombinant DNA technology.

The adjuvant is included in this vaccine to accelerate, enhance, and/or prolong the protective effects of the vaccine.

The other ingredients are sodium chloride (NaCl), sodium borate, and water for injections.

Appearance and packaging of HBVAXPRO 10 micrograms

HBVAXPRO 10 micrograms is a suspension for injection in a vial. Pack sizes of 1 and 10 vials.

Not all pack sizes may be marketed.

Marketing Authorisation Holder and Manufacturer

Merck Sharp & Dohme B.V., Waarderweg 39, 2031 BN Haarlem, Netherlands

For further information about this vaccine, please contact the local representative of the Marketing Authorisation Holder.

België/Belgique/Belgien

MSD Belgium

Tél/Tel: +32(0)27766211

[email protected]

Lietuva

UAB Merck Sharp & Dohme

Tel.: +370.5.2780.247

[email protected]

Text in Bulgarian language with company name Мерк Шарп и Доум България ЕООД and phone number +359 2 819 3737

[email protected]

Luxembourg/Luxemburg

MSD Belgium

Tél/Tel: +32(0)27766211

[email protected]

Ceská republika

Merck Sharp & Dohme s.r.o.

Tel.: +420 233 010 111

[email protected]

Magyarország

MSD Pharma Hungary Kft.

Tel.: + 36.1.888.5300

[email protected]

Danmark

MSD Danmark ApS

Tlf: + 45 4482 4000

[email protected]

Malta

Merck Sharp & Dohme Cyprus Limited.

Tel: 8007 4433 (+356 99917558)

[email protected]

Deutschland

MSD Sharp & Dohme GmbH

Tel: 0800 673 673 673 (+49 (0) 89 4561 0)

[email protected]

Nederland

Merck Sharp & Dohme B.V.

Tel: 0800 9999000 (+31 23 5153153)

[email protected]

Eesti

Merck Sharp & Dohme OÜ,

Tel: +372.614.4200

[email protected]

Norge

MSD (Norge) AS

Tlf: +47 32 20 73 00

[email protected]

Ελλáδα

MSD Α.Φ.Β.Ε.Ε.

Τηλ: +30 210 98 97 300

[email protected]

Österreich

Merck Sharp & Dohme Ges.m.b.H.

Tel: +43 (0) 1 26 044

[email protected]

España

Merck Sharp & Dohme de España, S.A.

Tel: +34 91 321 06 00

[email protected]

Polska

MSD Polska Sp. z o.o.

Tel.: +48.22.549.51.00

[email protected]

France

MSD France

Tél: +33 (0)1 80 46 40 40

Portugal

Merck Sharp & Dohme, Lda

Tel: +351 21 4465700

[email protected]

Hrvatska

Merck Sharp & Dohme d.o.o.

Tel: +385 1 66 11 333

[email protected]

România

Merck Sharp & Dohme Romania S.R.L

Tel: + 4021 529 29 00

[email protected]

Ireland

Merck Sharp & Dohme Ireland (Human Health)

Limited

Tel: +353 (0)1 2998700

[email protected]

Slovenija

Merck Sharp & Dohme, inovativna zdravila

d.o.o.

Tel: +386.1.520.4201

[email protected]

Ísland

Vistor hf.

Sími: + 354 535 7000

Slovenská republika

Merck Sharp & Dohme, s. r. o

Tel: +421 2 58282010

[email protected]

Italia

MSD Italia S.r.l.

Tel: 800 23 99 89 (+39 06 361911)

[email protected]

Suomi/Finland

MSD Finland Oy

Puh/Tel: +358 (0)9 804 650

[email protected]

Κ?προς

Merck Sharp & Dohme Cyprus Limited

Τηλ: 800 00 673 (+357 22866700)

[email protected]

Sverige

Merck Sharp & Dohme (Sweden) AB

Tel: +46 77 5700488

[email protected]

Latvija

SIA Merck Sharp & Dohme Latvija

Tel: +371.67364.224

[email protected]

United Kingdom (Northern Ireland)

Merck Sharp & Dohme Ireland (Human Health)

Limited

Tel: +353 (0)1 2998700

[email protected]

This leaflet was approved on

Detailed information on this medicine is available on the European Medicines Agency website: http://www.ema.europa.eu.

This information is intended for healthcare professionals only:

Instructions

A visual inspection of the vaccine should be performed to detect any foreign particles and/or unusual physical appearance of the contents before administration. The vial should be shaken well until a slightly opaque white suspension is obtained.

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Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.

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Frequently Asked Questions

Is a prescription required for HBVAXPRO 10 micrograms INJECTABLE SUSPENSION?

HBVAXPRO 10 micrograms INJECTABLE SUSPENSION requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

What is the active substance in HBVAXPRO 10 micrograms INJECTABLE SUSPENSION?

The active ingredient in HBVAXPRO 10 micrograms INJECTABLE SUSPENSION is hepatitis B, purified antigen. This information helps identify medicines with the same composition but different brand names.

Who manufactures HBVAXPRO 10 micrograms INJECTABLE SUSPENSION?

HBVAXPRO 10 micrograms INJECTABLE SUSPENSION is manufactured by Merck Sharp & Dohme B.V.. Pharmacy brands and packaging may differ depending on the distributor.

Which doctors can assess the use of HBVAXPRO 10 micrograms INJECTABLE SUSPENSION online?

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether HBVAXPRO 10 micrograms INJECTABLE SUSPENSION is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

How to buy HBVAXPRO 10 micrograms INJECTABLE SUSPENSION in Spain?

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy HBVAXPRO 10 micrograms INJECTABLE SUSPENSION in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

What are the alternatives to HBVAXPRO 10 micrograms INJECTABLE SUSPENSION?

Other medicines with the same active substance (hepatitis B, purified antigen) include ENGERIX-B 20 micrograms/1 ml, PRE-FILLED SYRINGE SUSPENSION FOR INJECTION, ENGERIX-B JUNIOR 10 micrograms/0.5 ml, PRE-FILLED SYRINGE SUSPENSION, FENDRIX, INJECTABLE SUSPENSION. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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