Bg pattern

DIFFERINE 1 mg/g CREAM

This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use DIFFERINE 1 mg/g CREAM

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

Show translation

Introducción

P

Differine 1mg/g crema

Adapaleno

Lea todo el prospecto detenidamente antes de empezar a usar el medicamento, porque contiene información importante para usted.

  • Conserve este prospecto, ya que puede tener que volver a leerlo.
  • Si tiene alguna duda, consulte a su médico o farmacéutico.
  • Este medicamento se le ha recetado solamente a usted y no debe dárselo a otras personas aunque tengan los mismos síntomas que usted, ya que puede perjudicarles.
  • Si experimenta efectos adversos, consulte a su médico o farmacéutico, incluso si se trata de efectos adversos que no aparecen en este prospecto.Ver sección 4.
Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

Contenido del prospecto

  1. Qué es Differine crema y para qué se utiliza
  2. Qué necesita saber antes de empezar a usar Differine crema
  3. Cómo usar Differine crema
  4. Posibles efectos adversos
  5. Conservación de Differine crema

Contenido del envase e información adicional

1. Qué es Differine crema y para qué se utiliza

Differine crema está indicado para el tratamiento del acné vulgar, en el que predominan los comedones, pápulas y pústulas. Es apropiado para el tratamiento del acné de la cara, pecho y espalda.

Differine crema pertenece a un grupo de medicamentos llamados antiacnéicos.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

2. Qué necesita saber antes de empezar a usar Differine crema

No use Differine crema:

  • Si está embarazada.
  • Si planea quedarse embarazada.
  • Si es alérgico al principio activo o a cualquiera de los demás componentes de este medicamento (incluido en la sección 6).

Advertencias y precauciones

Consulte a su médico o farmacéutico antes de empezar a usar Differine crema.

  • Asegúrese de que Differine no entra en contacto con los ojos, labios, alas de la nariz o membranas mucosas. Si accidentalmente entrara en contacto con los ojos, lavarlos inmediatamente con agua templada.
  • Si después de aplicar el producto experimenta irritación (enrojecimiento y picor) en el lugar de aplicación, se debe interrumpir el tratamiento, consulte a su médico por si se puede disminuir la frecuencia de la aplicación, interrumpir la medicación temporalmente o permanentemente.
  • No utilice Differine crema sobre piel dañada (cortes o heridas), quemaduras solares o sobre piel eczematosa (piel descamada, enrojecida, con ampollas, y con dolor).
  • Evite la exposición excesiva a luz solar o a radiación U.V.

Si utiliza cosméticos estos deben ser no grasos ni resecantes para la piel.

Niños y adolescentes

La seguridad y eficacia no se ha establecido en niños menores de 12 años.

Otros medicamentos y Differine Crema

Informe a su médico o farmacéutico si está utilizando, o ha utilizado recientemente otros medicamentos, incluso los adquiridos sin receta.

  • No utilice otros productos para el acné (que contengan retinoides) al mismo tiempo que Differine.
  • Evite utilizar Differine al mismo tiempo que cosméticos que sean irritantes, resequen o descamen la piel.
  • El tratamiento con Differine no afecta la eficacia de anticonceptivos orales ni antibióticos administrados por vía oral.
  • Si está en tratamiento con otros productos antiacné como soluciones de eritromicina al 4% o de clindamicina fosfato al 1% (como base), o geles en base acuosa de peróxido de benzoilo hasta el 10%, podrá aplicar estos productos por la mañana y Differine por la noche.

Embarazo y lactancia:

NO use Differine si està embarazada o tiene intención de quedarse embarazada.Su médico puede darle más información.

Differine puede utilizarse durante la lactancia. Para evitar exposición por contacto del lactante, se debe evitar aplicar Differine en el pecho ya que no se sabe si Differine pasa o no a la leche materna.

Consulte a su médico o farmacéutico antes de utilizar cualquier medicamento.

Conducción y uso de máquinas:

El tratamiento con Differine no afecta a la capacidad de conducir o utilizar maquinaria.

Differine cremacontieneparahidroxibenzoato de metilo(E218) y parahidroxibenzoato de propilo (E216)como excipientes, por lo que puede causar reacciones alérgicas (posiblemente retardadas).

3. Cómo usar Differine crema

Siga exactamente las instrucciones de administración de este medicamento indicadas por su médico. Consulte a su médico o farmacéutico, si tiene dudas.

Aplicar la crema sobre las áreas afectadas de acné, una vez al día, antes de acostarse:

  • Antes de aplicar la crema, lave y seque la zona afectada
  • Asegúrese que las zonas a tratar estén secas antes de la aplicación
  • Aplique una fina capa de crema
  • Efectúe un ligero masaje
  • Evite que la crema entre en contacto con los ojos y los labios.

Uso en niños

No puede ser utilizado en niños menores de 12 años de edad.

Si usa más Differine Crema del que debe

Este medicamento no debe ser ingerido. Es solamente para uso externo.

En caso de sobredosis o ingestión accidental, consulte inmediatamente con su médico o farmacéutico, acuda a un centro médico, o llame al Servicio de Información Toxicológica, teléfono: 91 562 04 20, indicando el medicamento y la cantidad ingerida.

Si se emplea de forma excesiva no se producirán resultados mejores ni más rápido y en cambio puede causar enrojecimiento intenso, descamación o malestar en la piel.

Si olvidó usarDifferine Crema

No aplique una dosis doble para compensar las dosis olvidadas.

Si interrumpe el tratamiento con Differine Crema

Si tiene cualquier otra duda sobre el uso de este prospecto, pregunte a su médico o farmacéutico.

4. Posibles efectos adversos

Al igual que todos los medicamentos, este medicamento puede producir efectos adversos, aunque no todas las personas los sufran.

Differine puede causar los siguientes efectos adversos en el lugar de aplicación.

Comuníquese con su médico de inmediato si nota alguno de los siguientes síntomas, es posible que necesite tratamiento médico de urgencia: Hinchazón de la cara, labios o garganta que dificulta la deglución o la respiración, erupción cutánea, picazón, urticaria y mareos. Esto podría ser un signo de angioedema o una reacción alérgica grave (frecuencia no conocida, no puede estimarse a partir de los datos disponibles).

Efectos adversos frecuentes (puede afectar hasta 1 de cada 10 personas)- Sequedad de la piel

  • Irritación de la piel
  • Sensación de quemazón en la piel
  • Enrojecimiento de la piel (eritema)

Efectos adversos poco frecuentes (puede afectar hasta 1 de cada 100 personas)

  • Reacción local en la piel (dermatitis de contacto)
  • Malestar en la piel
  • Quemadura solar
  • Picor en la piel (prurito)
  • Empeoramiento del acné

Efectos adversos de frecuencia no conocida (no puede estimarse a partir de los datos disponibles)

  • Reacciones alérgicas de contacto

-Dolor o hinchazón de la piel

  • Irritación, enrojecimiento, picor o hinchazón de los párpados
  • Oscurecimiento de la piel clara
  • Aclaramiento de la piel más oscura
  • Quemadura en el lugar de aplicación

Se han notificado quemaduras en el lugar de aplicación (principalmente quemaduras superficiales pero también quemaduras de segundo grado o quemaduras graves).

Comunicación de efectos adversos

Si experimenta cualquier tipo de efecto adverso, consulte a su médico o farmacéutico, incluso si se trata de posibles efectos adversos que no aparecen en este prospecto. También puede comunicarlos directamente a través del Sistema Español de Farmacovigilancia de medicamentos de Uso Humano: https://www.notificaRAM.es. Mediante la comunicación de efectos adversos usted puede contribuir a proporcionar más información sobre la seguridad de este medicamento.

5. Conservación de Differine crema

Mantener este medicamento fuera de la vista y del alcance de los niños.

No conservar a temperatura superior a 25ºC.

No utilice este medicamento después de la fecha de caducidad que aparece en la caja después de CAD o EXP. La fecha de caducidad es el último día del mes que se indica.

Los medicamentos no se deben tirar por los desagües ni a la basura. Deposite los envases y los medicamentos que no necesita en el Punto SIGRE de la farmacia. En caso de duda pregunte a su farmacéutico cómo deshacerse de los envases y los medicamentos que no necesita. De esta forma ayudará a proteger el medio ambiente.

6. Contenido del envase e información adicional

Composición de Differine crema

El principio activo es adapaleno. Cada gramo de crema contiene 1 miligramo de adapaleno.

Los demás excipientes son carbomer 934P, polietilenglicol-20 metilglucosa sesquiestearato, metilglucosa sesquiestearato, glicerol, escualeno, parahidroxibenzoato de metilo (E218), parahidroxibenzoato de propilo (E216), edetato disódico, fenoxietanol, ciclometicona, hidróxido de sodio y agua purificada.

Aspecto del producto y contenido del envase

Differine es una crema, blanca y brillante.

Differine crema está disponible en envases que contienen 30 g y 50 g de crema.

Titular de la autorización de comercialización y responsable de la fabricación:

Titular de la autorización de comercialización:

Laboratorios Galderma, S.A.

Serrano Galvache, 56

28033 Madrid

España

Responsable de la fabricación:

Laboratoires Galderma

Alby-sur-Chéran

(Francia)

Fecha de la última revisión de este prospecto:07/2019

La información detallada y actualizada de este medicamento está disponible en la página Web de la Agencia Española de Medicamentos y Productos Sanitarios (AEMPS) http://www.aemps.gob.es

Online doctors for DIFFERINE 1 mg/g CREAM

Discuss questions about DIFFERINE 1 mg/g CREAM, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

0.0 (0)
Doctor

Sviatoslav Chekhun

Oncology 13 years exp.

Dr. Sviatoslav Chekhun is a medical oncologist with international clinical and research experience, specializing in modern medical oncology and a personalized approach to cancer treatment.

Currently (since 2025), he works as a Medical Oncologist at Institut Català d’Oncologia (Girona, Spain). Previously, he completed his residency in Medical Oncology and was involved in clinical research at Hospital Universitari Germans Trias i Pujol.

Dr. Chekhun has a strong academic and scientific background. He served as a lecturer in Internal Medicine at O.O. Bohomolets National Medical University and conducted research in experimental oncology at the R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology.

Earlier in his career, he worked as a medical oncologist at the Kyiv City Clinical Oncological Center and contributed to regulatory evaluation of medicinal products at the State Expert Center of the Ministry of Health of Ukraine.

When to consult Dr. Chekhun:

  •  for diagnosis or clarification of a cancer diagnosis
  •  to obtain a second opinion on an existing treatment plan 
  •  when you need a personalized treatment strategy 
  •  for interpretation of test results, CT, MRI, PET-CT, and biopsies 
  •  when choosing between treatment options (chemotherapy, targeted therapy, immunotherapy) 
  •  in case of doubts about treatment strategy or disease progression 

Consultation format

Dr. Chekhun provides online consultations, where you can receive:

  •  expert second opinion 
  •  detailed case review 
  •  recommendations based on current international treatment guidelines 
  •  personalized treatment and follow-up plan 

Important:
Prescription and monitoring of medications must be carried out by your treating physician in an in-person (offline) setting. An online consultation does not replace a face-to-face visit but helps you make more informed decisions about your treatment.

Dr. Sviatoslav Chekhun combines clinical practice, research, and international experience, enabling him to provide patients with modern, evidence-based approaches in oncology.

5.0 (194)
Doctor

Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

5.0 (43)
Doctor

Dmytro Horobets

Family medicine 7 years exp.

Dr. Dmytro Horobets is a licensed family medicine physician in Poland, specialising in endocrinology, diabetology, obesity management, gastroenterology, pediatrics, general surgery, and pain medicine. He offers online consultations for adults and children, providing personalised medical support for a wide range of acute and chronic health concerns.

Areas of expertise:

  • Endocrinology: diabetes type 1 and type 2, prediabetes, thyroid disorders, metabolic syndrome, hormonal imbalance.
  • Obesity medicine: structured weight management plans, nutritional counselling, obesity-related health risks.
  • Gastroenterology: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), liver and biliary conditions.
  • Pediatric care: infections, respiratory symptoms, digestive issues, growth and development monitoring.
  • General surgery support: pre- and post-surgical consultations, wound care, rehabilitation.
  • Pain management: chronic and acute pain, back pain, joint pain, post-traumatic pain syndromes.
  • Cardiovascular health: hypertension, cholesterol control, risk assessment for heart disease.
  • Preventive medicine: regular check-ups, health screenings, long-term management of chronic conditions.

Dr. Horobets combines evidence-based medicine with a patient-centred approach. He carefully evaluates each patient’s medical history and symptoms, offering clear explanations and structured treatment plans adapted to individual needs.

Whether you need help managing diabetes, tackling weight-related health issues, interpreting lab results, or receiving general family medicine support, Dr. Horobets provides professional online care tailored to your specific health goals.

0.0 (13)
Doctor

Daria Portnova

Psychiatry 31 years exp.

Dr Daria Portnova is a psychiatrist and psychotherapist with over 30 years of clinical experience. She works with adults and adolescents aged 14 and over, providing online psychiatric and psychotherapeutic consultations. In her practice, Dr Portnova supports patients facing the onset of mental health conditions, chronic psychiatric disorders, psychotic symptoms, trauma-related states, and complex emotional crises. Her work is structured and safety-focused, with an emphasis on stabilisation, accurate diagnosis, and long-term improvement in quality of life. Patients consult Dr Daria Portnova for the following concerns: 

  • existential crises and complex life situations;
  • loss, grief, and emotional exhaustion;
  • relationship difficulties, separation, and divorce;
  • psychological and psychiatric trauma, including complex PTSD (cPTSD);
  • anxiety disorders: generalised anxiety disorder and panic disorder;
  • social anxiety and social phobia;
  • obsessive-compulsive disorder (OCD);
  • sleep disorders;
  • depressive disorders;
  • bipolar affective disorder;
  • schizoaffective disorder;
  • schizophrenia;
  • personality disorders.

Dr Portnova combines psychiatric assessment with a psychotherapeutic approach. She works with evidence-based methods, including cognitive behavioural therapy (CBT) and third-wave approaches such as ACT, FACT, and CFT. Consultations are focused on clear clinical understanding, practical recommendations, and ongoing support over time.

0.0 (0)
Doctor

Bulat Garipov

Radiology 15 years exp.

Dr. Bulat Garipov is a radiologist with more than 15 years of experience, specializing in magnetic resonance imaging (MRI). Throughout his professional career, he has worked in leading diagnostic imaging centers, both in on-site practice and teleradiology, which has allowed him to develop a broad and versatile approach to radiology.

Over the years, he has gained solid experience in interpreting MRI studies in various areas, including:

  •  Neuroimaging
  •  Musculoskeletal system (MSK)
  •  Angiography
  •  Abdomen and pelvis
  •  Soft tissues

Additionally, Dr. Garipov is open to new collaboration opportunities in radiology and teleradiology projects. He offers his expertise in MRI, providing both first and second readings of studies, as well as advanced image interpretation, ensuring accurate and high-quality diagnostics.

You could consult Dr. Bulat Garipov in cases where accurate interpretation of MRI studies or a second expert opinion is required. His expertise is especially valuable in cases of suspected neurological conditions, back and joint pain, vascular disorders, as well as in the diagnosis of abdominal and pelvic diseases. The doctor also provides support in complex or unclear clinical situations, including the review of previously performed studies, which helps improve diagnostic accuracy and determine the optimal treatment strategy. A teleradiology format is available, allowing you to receive a professional opinion remotely.

...
4

Get DIFFERINE 1 mg/g CREAM Prescription Online

1

Fill in a 2-min form

Tell us your symptoms, history, and what medicine you're requesting.

2

Pick a doctor or let us assign

Choose a specialist or we'll match you with the next available doctor.

3

Doctor reviews your case

Usually within 30 minutes. They may ask follow-up questions via chat.

4

Collect from any pharmacy

Electronic prescription sent to your email — valid across Spain.

Frequently Asked Questions

Is a prescription required for DIFFERINE 1 mg/g CREAM?

DIFFERINE 1 mg/g CREAM requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

Who manufactures DIFFERINE 1 mg/g CREAM?

DIFFERINE 1 mg/g CREAM is manufactured by Laboratorios Galderma S.A.. Pharmacy brands and packaging may differ depending on the distributor.

Which doctors can assess the use of DIFFERINE 1 mg/g CREAM online?

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether DIFFERINE 1 mg/g CREAM is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

How to buy DIFFERINE 1 mg/g CREAM in Spain?

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy DIFFERINE 1 mg/g CREAM in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

What are the alternatives to DIFFERINE 1 mg/g CREAM?

Other medicines with the same active substance () include ACNIDUO 1 mg/g + 25 mg/g GEL, AKLIEF 50 micrograms/g cream, DIFFERINE 1 mg/g GEL. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

bg-pattern-dark

Stay informed about Oladoctor

News about new services, product updates and useful information for patients.

Follow us on social media