Logo
Bg pattern

DIFFERINE 1 mg/g CREAM

Prescription review online

Prescription review online

A doctor will review your case and decide whether a prescription is medically appropriate.

Talk to a doctor about this medicine

Talk to a doctor about this medicine

Discuss your symptoms and possible next steps in a quick online consultation.

This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use DIFFERINE 1 mg/g CREAM

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

Show original

Contents of the leaflet

  1. Introduction
  2. What is Differine cream and what is it used for
  3. What you need to know before starting to use Differine cream
  4. How to use Differine cream
  5. Possible side effects
  6. Storage of Differine cream
  7. Contents of the package and additional information

Introduction

P

Differine 1mg/g cream

Adapalene

Read the entire leaflet carefully before starting to use the medicine, as it contains important information for you.

  • Keep this leaflet, as you may need to read it again.
  • If you have any doubts, consult your doctor or pharmacist.
  • This medicine has been prescribed to you only, and you should not give it to others, even if they have the same symptoms as you, as it may harm them.
  • If you experience side effects, consult your doctor or pharmacist, even if they are side effects not listed in this leaflet. See section 4.
Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

Contents of the leaflet

  1. What is Differine cream and what is it used for
  2. What you need to know before starting to use Differine cream
  3. How to use Differine cream
  4. Possible side effects
  5. Storage of Differine cream

Contents of the package and additional information

1. What is Differine cream and what is it used for

Differine cream is indicated for the treatment of vulgar acne, where comedones, papules, and pustules predominate. It is suitable for the treatment of acne on the face, chest, and back.

Differine cream belongs to a group of medicines called anti-acne agents.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before starting to use Differine cream

Do not use Differine cream:

  • If you are pregnant.
  • If you plan to become pregnant.
  • If you are allergic to the active ingredient or to any of the other components of this medicine (listed in section 6).

Warnings and precautions

Consult your doctor or pharmacist before starting to use Differine cream.

  • Make sure Differine does not come into contact with the eyes, lips, nostrils, or mucous membranes. If it accidentally comes into contact with the eyes, rinse them immediately with warm water.
  • If after applying the product you experience irritation (redness and itching) at the application site, you should interrupt treatment, consult your doctor to see if the application frequency can be reduced, or the medication temporarily or permanently discontinued.
  • Do not use Differine cream on damaged skin (cuts or wounds), sunburned skin, or eczematous skin (scaly, red, blistered, and painful skin).
  • Avoid excessive exposure to sunlight or UV radiation.

If you use cosmetics, they should be non-greasy and non-drying for the skin.

Children and adolescents

Safety and efficacy have not been established in children under 12 years of age.

Other medicines and Differine cream

Tell your doctor or pharmacist if you are using, or have recently used, other medicines, including those purchased without a prescription.

  • Do not use other acne products (containing retinoids) at the same time as Differine.
  • Avoid using Differine at the same time as cosmetics that are irritating, drying, or scaling to the skin.
  • Treatment with Differine does not affect the efficacy of oral contraceptives or antibiotics administered orally.
  • If you are being treated with other anti-acne products such as 4% erythromycin solutions or 1% clindamycin phosphate (as a base), or aqueous-based gels of benzoyl peroxide up to 10%, you can apply these products in the morning and Differine at night.

Pregnancy and breastfeeding:

DO NOT use Differine if you are pregnant or plan to become pregnant. Your doctor may provide more information.

Differine can be used during breastfeeding. To avoid contact exposure to the infant, you should avoid applying Differine to the breast, as it is not known whether Differine passes into breast milk.

Consult your doctor or pharmacist before using any medicine.

Driving and using machines:

Treatment with Differine does not affect the ability to drive or use machinery.

Differine creamcontainsmethylparaben (E218) and propylparaben (E216)as excipients, which may cause allergic reactions (possibly delayed).

3. How to use Differine cream

Follow the administration instructions for this medicine exactly as indicated by your doctor. Consult your doctor or pharmacist if you have any doubts.

Apply the cream to the affected acne areas once a day, before bedtime:

  • Before applying the cream, wash and dry the affected area
  • Make sure the areas to be treated are dry before application
  • Apply a thin layer of cream
  • Perform a gentle massage
  • Avoid getting the cream into contact with the eyes and lips.

Use in children

It cannot be used in children under 12 years of age.

If you use more Differine cream than you should

This medicine should not be ingested. It is for external use only.

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately, go to a medical center, or call the Toxicology Information Service, phone: 91 562 04 20, indicating the medicine and the amount ingested.

If it is used excessively, it will not produce better or faster results, and it may cause intense redness, scaling, or discomfort on the skin.

If you forget to use Differine cream

Do not apply a double dose to make up for forgotten doses.

If you interrupt treatment with Differine cream

If you have any other doubts about using this leaflet, ask your doctor or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everyone gets them.

Differine may cause the following side effects at the application site.

Contact your doctor immediately if you notice any of the following symptoms, as you may need urgent medical treatment: Swelling of the face, lips, or throat that makes swallowing or breathing difficult, skin rash, itching, hives, and dizziness. This could be a sign of angioedema or a severe allergic reaction (frequency not known, cannot be estimated from available data).

Common side effects (may affect up to 1 in 10 people) - Dryness of the skin

  • Skin irritation
  • Burning sensation on the skin
  • Redness of the skin (erythema)

Uncommon side effects (may affect up to 1 in 100 people)

  • Local skin reaction (contact dermatitis)
  • Discomfort on the skin
  • Sunburn
  • Itching on the skin (pruritus)
  • Worsening of acne

Side effects of unknown frequency (cannot be estimated from available data)

  • Contact allergic reactions

- Pain or swelling of the skin

  • Irritation, redness, itching, or swelling of the eyelids
  • Darkening of light skin
  • Lightening of darker skin
  • Burn at the application site

Burns have been reported at the application site (mainly superficial but also second-degree or severe burns).

Reporting side effects

If you experience any type of side effect, consult your doctor or pharmacist, even if it is a possible side effect not listed in this leaflet. You can also report them directly through the Spanish Medicines and Health Products Agency (AEMPS) website: https://www.notificaRAM.es. By reporting side effects, you can contribute to providing more information on the safety of this medicine.

5. Storage of Differine cream

Keep this medicine out of sight and reach of children.

Do not store above 25°C.

Do not use this medicine after the expiration date stated on the box after CAD or EXP. The expiration date is the last day of the month indicated.

Medicines should not be disposed of through wastewater or household waste. Deposit the packaging and unused medicines in the SIGRE collection point at the pharmacy. If in doubt, ask your pharmacist how to dispose of the packaging and unused medicines. This will help protect the environment.

6. Contents of the package and additional information

Composition of Differine cream

The active ingredient is adapalene. Each gram of cream contains 1 milligram of adapalene.

The other excipients are carbomer 934P, polyethylene glycol-20 methylglucose sesquiestearate, methylglucose sesquiestearate, glycerol, squalene, methylparaben (E218), propylparaben (E216), disodium edetate, phenoxyethanol, cyclomethicone, sodium hydroxide, and purified water.

Appearance of the product and contents of the package

Differine is a cream, white and shiny.

Differine cream is available in packages containing 30 g and 50 g of cream.

Marketing authorization holder and manufacturer:

Marketing authorization holder:

Laboratorios Galderma, S.A.

Serrano Galvache, 56

28033 Madrid

Spain

Manufacturer:

Laboratoires Galderma

Alby-sur-Chéran

(France)

Date of the last revision of this leaflet:07/2019

Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es

Online doctors for DIFFERINE 1 mg/g CREAM

Discuss questions about DIFFERINE 1 mg/g CREAM, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

0.0 (2)
Doctor

Nikita Savin

Paediatrics 5 years exp.

Dr. Nikita Savin is a paediatrician providing online consultations for children of all ages. He offers comprehensive medical care with a focus on preventive health, proper development, and long-term management of chronic and complex conditions.

His areas of expertise include:

  • Preventive care and vaccination planning, including catch-up schedules for children.
  • Assessment of psychomotor, emotional, and physical development.
  • Diagnosis, treatment planning, and clinical monitoring for paediatric conditions.
  • Nutritional guidance for infants, including the choice of adapted milk formulas tailored to medical needs.
  • Early identification of rare and orphan diseases.
  • Ongoing care for children with chronic or complex health conditions.
By combining paediatrics with a personalised approach, Dr. Savin ensures professional support that addresses both the physical health and overall well-being of children, while guiding parents at every stage of their child’s growth.
Camera Book a video appointment
€79
5.0 (140)
Doctor

Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.
Camera Book a video appointment
€50
5.0 (51)
Doctor

Taisiya Minorskaya

Family medicine 13 years exp.

Dr Taisiya Minorskaya is a family medicine doctor with an official licence to practise in Spain and over 12 years of clinical experience. She provides online consultations for adults and children, combining evidence-based medicine with a personalised, modern European approach.

She helps with:

  • Viral infections and cold symptoms (flu, sore throat, cough, runny nose)
  • Review and adjustment of antibiotics
  • Skin rashes and allergic reactions
  • Chronic condition flare-ups, high blood pressure, headaches, fatigue
  • Lab and test interpretation
  • Medication review and adaptation to European standards
  • Patient navigation: what tests are needed, which specialists to see, when an in-person visit is required
Dr Minorskaya also specialises in the diagnosis and management of gastrointestinal conditions, including bloating, abdominal pain, chronic nausea, IBS, and SIBO. She supports patients with unexplained physical symptoms that may be linked to somatisation or stress, helping them find relief and improve quality of life.

She offers care for people undergoing GLP-1 therapy (Ozempic, Mounjaro, and others) for weight management. Her support follows Spanish clinical guidelines, from treatment planning and side effect counselling to regular follow-ups and coordination with private or public healthcare providers.
Camera Book a video appointment
€65
5.0 (11)
Doctor

Mar Tabeshadze

Endocrinology 11 years exp.

Dr. Mar Tabeshadze is a licensed endocrinologist and general practitioner in Spain. She provides online consultations for adults, offering medical support for a wide range of endocrine conditions and related health concerns.

  • Diagnostic consultations for suspected endocrine disorders
  • Management of thyroid conditions, including in pregnant women
  • Early detection and treatment of type 1 and type 2 diabetes, with personalised therapy plans
  • Obesity treatment: identifying underlying causes of weight gain, combining medication and non-pharmacological strategies, and long-term support
  • Diagnosis and treatment of endocrine-related skin, hair, and nail issues
  • Ongoing care for patients with osteoporosis, pituitary, and adrenal gland disorders
Dr. Tabeshadze takes a patient-centred approach based on evidence-based medicine. Her goal is to help patients achieve hormonal balance, manage chronic conditions effectively, and improve overall well-being through targeted, personalised care.
Camera Book a video appointment
€55
5.0 (21)
Doctor

Giorgi Eremeishvili

Urology 22 years exp.

Giorgi Eremeishvili is a top-category urologist, a Candidate of Medical Sciences, and a licensed physician in Spain. He provides expert assistance in the diagnosis and treatment of a wide range of urological conditions in both men and women, employing a comprehensive approach and evidence-based principles.

Key areas of expertise:

  • Erectile dysfunction, decreased libido, premature ejaculation.
  • Male infertility: comprehensive diagnosis and modern treatment methods.
  • Prostate gland diseases: acute and chronic prostatitis, prostatic adenoma (benign prostatic hyperplasia), prostate cancer.
  • Inflammatory diseases of the genitourinary system: acute and chronic cystitis, pyelonephritis, epididymitis, orchitis, urethritis.
  • Sexually transmitted infections (STIs): chlamydia, ureaplasmosis, mycoplasmosis, gardnerellosis, candidiasis, herpetic infections, HPV, CMV, trichomoniasis, and others.
  • Urination disorders: urinary retention, frequent urination, urinary incontinence, overactive bladder, neurogenic bladder.
  • Neoplasms: cysts, tumors of the kidneys, bladder, testicles, prostate gland (including prostate cancer).
  • Surgical interventions: determining indications and selecting optimal minimally invasive methods.

Dr. Eremeishvili applies an integrated approach to each case. This includes thorough preoperative preparation, postoperative observation, and regular dynamic follow-up during the treatment process to achieve the best possible outcomes. All diagnostic and therapeutic recommendations are based on current evidence-based medicine and comply with the recommendations of the European Association of Urology, guaranteeing high-quality and effective care.

If you are seeking qualified assistance in diagnosing or treating urological conditions, book an online consultation with Dr. Giorgi Eremeishvili. Get expert support, accurate diagnosis, and a personalized treatment plan from the comfort of your home.
Camera Book a video appointment
€60
5.0 (29)
Doctor

Anna Biriukova

General medicine 6 years exp.

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

  • High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
  • Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
  • Leg swelling, chronic fatigue, reduced exercise tolerance.
  • EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
  • Post-COVID-19 cardiac monitoring and care.
Endocrinology – Diabetes, thyroid, metabolism:
  • Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
  • Individual treatment plans including oral medications and insulin therapy.
  • GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
  • Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
  • Metabolic syndrome – obesity, lipid disorders, insulin resistance.
Gastroenterology – Digestive health:
  • Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
  • Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
  • Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).
General internal medicine and preventive care:
  • Respiratory infections – cough, colds, bronchitis.
  • Lab test analysis, therapy adjustments, medication management.
  • Adult vaccinations – planning, contraindications assessment.
  • Cancer prevention – screening strategies and risk assessment.
  • Holistic approach – symptom relief, complication prevention, and quality of life improvement.
Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.
Camera Book a video appointment
€60
0.0 (0)
Doctor

Katia Benko

Paediatrics 10 years exp.

Dr Katia Benko is a paediatrician with over 9 years of clinical experience and international training. She completed her medical education and residency in Argentina and is fully licensed to practise in Spain. Her work spans newborns, children and adolescents, with a focus on whole-person care that integrates physical, emotional and developmental health.

Areas of expertise:

  • online consultations for newborns, children and teens
  • evaluation and treatment of acute symptoms: fever, cough, infections, bronchiolitis, earache, etc.
  • long-term care for chronic paediatric conditions
  • preventive care at every stage of growth and development
  • child wellness visits and routine health check-ups
  • vaccination guidance according to standard and special schedules
  • assessment of neurodevelopment in infants and toddlers
  • feeding concerns: picky eating, food refusal, healthy habits, eating disorders
  • parental support in everyday health, emotional wellbeing and prevention
  • guidance for teenagers on healthy habits, self-care and risk prevention
Dr Benko sees paediatrics as a space for partnership with families – not only to treat illness, but to guide each child’s health journey with clarity, empathy and trust. Her goal is for every family to feel supported in making confident, informed decisions for their child’s wellbeing.
Camera Book a video appointment
€59
5.0 (29)
Doctor

Dmytro Horobets

Family medicine 7 years exp.

Dr. Dmytro Horobets is a licensed family medicine physician in Poland, specialising in endocrinology, diabetology, obesity management, gastroenterology, pediatrics, general surgery, and pain medicine. He offers online consultations for adults and children, providing personalised medical support for a wide range of acute and chronic health concerns.

Areas of expertise:

  • Endocrinology: diabetes type 1 and type 2, prediabetes, thyroid disorders, metabolic syndrome, hormonal imbalance.
  • Obesity medicine: structured weight management plans, nutritional counselling, obesity-related health risks.
  • Gastroenterology: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), liver and biliary conditions.
  • Pediatric care: infections, respiratory symptoms, digestive issues, growth and development monitoring.
  • General surgery support: pre- and post-surgical consultations, wound care, rehabilitation.
  • Pain management: chronic and acute pain, back pain, joint pain, post-traumatic pain syndromes.
  • Cardiovascular health: hypertension, cholesterol control, risk assessment for heart disease.
  • Preventive medicine: regular check-ups, health screenings, long-term management of chronic conditions.

Dr. Horobets combines evidence-based medicine with a patient-centred approach. He carefully evaluates each patient’s medical history and symptoms, offering clear explanations and structured treatment plans adapted to individual needs.

Whether you need help managing diabetes, tackling weight-related health issues, interpreting lab results, or receiving general family medicine support, Dr. Horobets provides professional online care tailored to your specific health goals.
Camera Book a video appointment
€60
0.0 (0)
Doctor

Karim BenHarbi

General medicine 9 years exp.

Dr. Karim Ben Harbi is a licensed general practitioner based in Italy. He provides online consultations for adults and children, combining international clinical experience with evidence-based medicine. His care approach is focused on accurate diagnosis, preventive care, and personalised health guidance.

Dr. Ben Harbi received his medical degree from Sapienza University in Rome. His training included hands-on experience in diverse settings — tropical medicine, rural healthcare, and urban outpatient practice. He also conducted clinical research in microbiology, exploring the role of the gut microbiome in chronic gastrointestinal issues.

You can consult Dr. Ben Harbi for:

  • General health concerns, prevention, and primary care.
  • Hypertension, type 1 and type 2 diabetes, metabolic issues.
  • Cold, cough, flu, respiratory infections, sore throat, fever.
  • Chronic digestive issues: bloating, gastritis, IBS, microbiome imbalance.
  • Skin rashes, mild allergic reactions, basic dermatological complaints.
  • Medication guidance, treatment adjustments, prescription review.
  • Paediatric concerns — fever, infections, general well-being.
  • Lifestyle optimisation: stress, sleep, weight, and diet counselling.

Dr. Ben Harbi offers reliable, accessible medical support through online consultations, helping patients make informed decisions about their health with a clear, structured, and compassionate approach.
Camera Book a video appointment
€79
0.0 (2)
Doctor

Marianna Neshta

Endocrinology 25 years exp.

Marianna Neshta is a medical doctor specialising in endocrinology and ultrasound diagnostics. She provides online consultations for adults, focusing on the diagnosis, treatment, and long-term management of endocrine disorders. Her approach includes personalised care plans, analysis of lab results and ultrasound scans, and evidence-based treatment.

Key areas of expertise:

  • Type 1 and Type 2 diabetes – diagnosis, therapy adjustment, CGM interpretation, and prevention of chronic complications
  • Obesity – treatment using both medication and lifestyle strategies, including modern GLP-1 medications and tailored follow-up plans
  • Thyroid disorders – ultrasound assessment, treatment planning, and management during pregnancy
  • Male hypogonadism – age-related or hormonal, including diagnostics and therapy
  • Metabolic syndrome, prediabetes, lipid disorders – risk assessment, lifestyle recommendations, and medical treatment
  • Calcium metabolism disorders – diagnosis and management of osteoporosis, hyperparathyroidism, and hypoparathyroidism
Dr Neshta applies current clinical guidelines and diagnostic tools, offering medical support adapted to each patient’s individual needs — all in an accessible online format.
Camera Book a video appointment
€45
4

Frequently Asked Questions

Is a prescription required for DIFFERINE 1 mg/g CREAM?
DIFFERINE 1 mg/g CREAM requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
Who manufactures DIFFERINE 1 mg/g CREAM?
DIFFERINE 1 mg/g CREAM is manufactured by Laboratorios Galderma S.A.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of DIFFERINE 1 mg/g CREAM online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether DIFFERINE 1 mg/g CREAM is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to DIFFERINE 1 mg/g CREAM?
Other medicines with the same active substance () include ACNIDUO 1 mg/g + 25 mg/g GEL, AKLIEF 50 micrograms/g cream, DIFFERINE 1 mg/g GEL. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
bg-pattern-dark

Stay informed about Oladoctor

News about new services, product updates and useful information for patients.
Follow us on social media