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CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS

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Doctor

Maria Martelli

Anaesthesiology 12 years exp.

Dr Maria Martelli is a medical doctor specialising in anaesthesiology and pain medicine. She provides online consultations for adults, focusing on the assessment and management of acute, chronic, and complex pain conditions, as well as supportive care in serious illness. She graduated from the Medical University of Silesia in Katowice and completed her specialisation in Anaesthesiology and Intensive Care. Alongside hospital work, she has extensive experience in home and inpatient hospice care, supporting patients with severe pain and advanced disease. Since 2021, she has been a certified specialist and continues to work in anaesthesiology, intensive care, and pain treatment. Patients consult her for: 

  • Chronic pain lasting more than 3 months (musculoskeletal, neuropathic, mixed pain).
  • Acute pain requiring medical assessment and treatment planning.
  • Post-operative pain and recovery support.
  • Cancer-related pain and symptom relief.
  • Palliative care support and quality-of-life improvement.
  • Adjustment and optimisation of pain medication.
  • Second opinions for complex or treatment-resistant pain.

Dr Martelli takes a structured, evidence-based approach, carefully analysing symptoms, previous treatments, and overall health status. Her consultations focus on realistic pain control goals, safety of therapy, and improving daily functioning. She is especially attentive to patients living with long-term pain or serious illness, providing clear explanations, compassionate guidance, and medically sound recommendations adapted to each individual situation.

This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Leaflet: information for the user

cinfamar caffeine 50mg/50mg coated tablets

dimenhydrinate/caffeine

Read the entire leaflet carefully before starting to take this medicine, as it contains important information for you.

  • Follow the administration instructions for the medicine contained in this leaflet or as indicated by your doctor or pharmacist.
  • Keep this leaflet, as you may need to read it again.
  • If you need advice or more information, consult your pharmacist.
  • If you experience side effects, consult your doctor or pharmacist, even if they are not listed in this leaflet. See section 4.
  • You should consult a doctor if it worsens or does not improve after 7 days.

Contents of the leaflet

  1. What is cinfamar caffeine and what is it used for
  2. What you need to know before taking cinfamar caffeine
  3. How to take cinfamar caffeine
  4. Possible side effects
  5. Storage of cinfamar caffeine
  6. Package contents and additional information

1. What is cinfamar caffeine and what is it used for

cinfamar caffeine is a medicine that contains two active substances: dimenhydrinate and caffeine. Dimenhydrinate is an active ingredient that acts against motion sickness.

Caffeine has a stimulating effect on the nervous system, so it counteracts the drowsiness effect that dimenhydrinate can cause.

cinfamar caffeine is a medicine that is indicated for the prevention and treatment of symptoms of motion sickness caused by land, sea, or air travel, such as nausea, vomiting, and/or vertigo for adults and children over 12 years old.

You should consult a doctor if it worsens or does not improve after 7 days.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before taking cinfamar caffeine

Do not take cinfamar caffeine

  • If you are allergic to dimenhydrinate, diphenhydramine, caffeine (or its derivatives, such as aminophylline, theophylline, etc.) or any of the other components of this medicine (listed in section 6).
  • If you have porphyria (a rare, usually hereditary disorder in which a large amount of porphyrin is eliminated in urine and feces).
  • If you have asthma attacks.
  • If you have mental disorders that cause nervous excitement or convulsive crises, with or without loss of consciousness (epilepsy).
  • If you have anxiety or insomnia (difficulty sleeping).
  • If you have severe liver or heart disorders.
  • If you have stomach or duodenal ulcers.
  • If you have high blood pressure.

Warnings and precautions

Consult your doctor or pharmacist before starting to take cinfamar caffeine.

  • If you are allergic to any allergy medicine, you may also be allergic to dimenhydrinate.
  • If you have asthma or severe respiratory diseases (chronic obstructive pulmonary disease, emphysema, chronic bronchitis), as it can cause thickening of secretions and alter expectoration.
  • If you have a disease in which there is an abnormal increase in thyroid gland activity (hyperthyroidism), increased intraocular pressure (glaucoma), prostate enlargement (prostatic hypertrophy), or any disease that causes obstruction of the urinary or gastrointestinal tract.
  • If you are over 65 years old, dry mouth, urinary retention, nausea, sedation, confusion, and low blood pressure (hypotension) may occur.
  • If you are using any medicine that produces ear toxicity, which manifests with symptoms such as ringing in the ears, dizziness, or vertigo, as this medicine may mask the symptoms of those toxic effects.
  • If you are diabetic, you should be aware that caffeine can raise blood sugar levels.
  • If you have any liver, kidney, stomach, or duodenal ulcer disease, or stomach inflammation (gastritis), you should consult your doctor before taking this medicine.
  • You should consult your doctor before taking this medicine if you have or have had heart diseases (cardiac arrhythmia, myocardial ischemia, etc.), especially when engaging in physical exercise or being in high-altitude areas.
  • If you are sensitive to caffeine or other xanthines, such as theophylline, aminophylline, or others, you should consult your doctor before taking this medicine.
  • If you suspect you may have appendicitis symptoms such as nausea, vomiting, or abdominal cramps, it is recommended to see a doctor to rule out the presence or absence of appendicitis, as dimenhydrinate can make it difficult to diagnose this disease.
  • It is recommended to avoid exposure to very high temperatures and follow adequate hygiene and dietary measures, such as proper ventilation and hydration.
  • Avoid exposure to the sun (even on cloudy days) and UVA lamps (ultraviolet rays) while taking this medicine.
  • The simultaneous use of tobacco with the caffeine contained in this medicine can increase the degradation of caffeine.

Children

Children under 12 years old should not take this medicine.

Taking cinfamar caffeine with other medicines

Tell your doctor or pharmacist if you are taking, have recently taken, or may need to take any other medicine.

In particular, if you are using any of the following medicines, it may be necessary to modify the dose of cinfamar caffeine or not take it:

Medicines that primarily interfere with dimenhydrinate:

  • Anesthetics and other substances with a central nervous system depressant effect.
  • Antibiotics of the aminoglycoside group.
  • Antidepressants, such as monoamine oxidase inhibitors (MAOIs).
  • Antiparkinsonian agents.
  • Neuroleptics (used to calm agitation and neuromuscular hyperactivity).
  • Ototoxic medicines (which can affect the ear) (see Warnings and Precautions section).
  • Medicines that can cause photosensitivity (skin reactions due to sensitivity to sunlight).

Medicines that primarily interfere with caffeine:

  • Oral contraceptives.
  • Anti-infectives of the quinolone group (e.g., pipemidic acid, ciprofloxacin), linezolid, and erythromycin.
  • Barbiturates (used as anticonvulsants).
  • Adrenergic bronchodilators and theophylline (used to combat bronchial asthma).
  • Calcium.
  • Cimetidine (used for the treatment of excessive gastric secretion and stomach ulcers).
  • Disulfiram (used in alcohol withdrawal treatments).
  • Phenytoin (used for the treatment of epilepsy).
  • Iron (used for the treatment of anemia. Caffeine decreases iron absorption, so it should be taken at least 2 hours apart).
  • Lithium (antidepressant).
  • Mexiletine: used for heart rhythm disorders (cardiac arrhythmias).
  • Procarbazine (anticancer).
  • Selegiline (used for the treatment of Parkinson's disease).
  • Thyroxine (used for the treatment of thyroid diseases).

Interference with diagnostic tests

If you are going to have any analytical tests (blood tests, urine tests, etc.), tell your doctor that you are taking this medicine, as it may alter the results of these tests.

If you are going to have any allergy tests, including skin tests, it is recommended to stop treatment 72 hours before starting the test, to avoid altering the results.

Additionally, diabetic patients should be aware that caffeine can increase blood glucose levels.

Taking cinfamar caffeine with food, drinks, and alcohol

It is not recommended to consume alcohol while taking this medicine.

Limit the consumption of beverages that contain caffeine (coffee, tea, chocolate, and cola drinks) while taking this medicine.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medicine.

Breastfeeding

Women who are breastfeeding should not take this medicine without first consulting their doctor or pharmacist, as this medicine passes into breast milk.

Driving and using machines

While being treated with this medicine, do not drive or operate hazardous machinery, as this medicine can cause drowsiness or decreased reaction capacity at the recommended doses.

cinfamar caffeine contains sodium

This medicine contains less than 23 mg of sodium (1 mmol) per tablet; it is essentially "sodium-free".

3. How to take cinfamar caffeine

Follow the administration instructions for the medicine contained in this leaflet or as indicated by your doctor or pharmacist. In case of doubt, ask your doctor or pharmacist.

The recommended dose is:

Adults and children over 12 years old

1 or 2 tablets per dose. If necessary, repeat the dose every 4-6 hours.

Do not take more than 8 tablets per day (corresponding to 400 mg of dimenhydrinate and 400 mg of caffeine).

Patients with liver disease

They should consult their doctor before taking this medicine, as it may be necessary to adjust the dose.

Use in children

Children under 12 years old should not take this medicine.

cinfamar caffeine is administered orally.

The first dose should be taken at least 30 minutes before starting the trip (preferably 1 or 2 hours before), leaving at least 4 hours between one dose and the next. It is recommended to take the tablets with food, water, or milk to minimize gastric irritation.

The last dose should not be taken in the 6 hours prior to bedtime, to avoid possible insomnia, especially in patients with difficulty sleeping.

If it worsens or if the symptoms persist for more than 7 days, you should consult your doctor.

If you take more cinfamar caffeine than you should

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or call the Toxicology Information Service, phone 91 562 04 20, indicating the medicine and the amount taken.

The symptoms of overdose include mainly: dilated pupils, red face, excitement, hallucinations, confusion, stomach and intestinal irritation with nausea, vomiting, and diarrhea, movement disorders, convulsions, deep loss of consciousness (coma), sudden decrease in respiratory and cardiac functions (cardiorespiratory collapse), and death. The symptoms may take more than 2 hours to appear after the overdose.

If you have any other doubts about the use of this medicine, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everyone gets them.

Side effects usually occur at the beginning of treatment.

During the use of dimenhydrinate, the following adverse reactions have been observed, whose frequency could not be established with precision:

  • Nausea, vomiting, constipation, diarrhea, stomach pain.
  • Lack of appetite and dry mouth.
  • Sleepiness and sedation (drowsiness).
  • Headache, dizziness, and vertigo.
  • Increased viscosity of mucus in the bronchi, making breathing difficult.
  • Urinary retention and impotence.
  • Glaucoma (increased intraocular pressure).
  • Pupil dilation, blurred vision, or double vision.
  • Allergic reactions on the skin and sensitivity to sunlight after intense exposure, which can cause hives, itching, and skin redness.
  • Decrease in the blood of the number of red blood cells, white blood cells, leukocytes, and platelets.
  • Porphyria (a rare, usually hereditary disorder in which a large amount of porphyrin is eliminated in feces and urine).
  • Hypotension (decreased blood pressure).
  • Tachycardia, palpitations, and/or cardiac arrhythmias.
  • Hyperexcitability may occur, especially in children, with symptoms such as insomnia, nervousness, confusion, tremors, irritability, euphoria, delirium, palpitations, and even convulsions.

Additionally, due to caffeine, the following may appear:

  • Excitement, agitation, and/or difficulty sleeping.
  • Ringing in the ears.
  • Disorientation.
  • Rapid breathing.
  • Hot flashes.
  • Abundant urine elimination.
  • Hyperglycemia or hypoglycemia (increased or decreased glucose in the blood).

Reporting side effects

If you experience any type of side effect, consult your doctor or pharmacist, even if it is a possible side effect that is not listed in this leaflet. You can also report them directly through the Spanish Medicines and Health Products Agency (AEMPS) https://www.notificaram.es. By reporting side effects, you can contribute to providing more information on the safety of this medicine.

5. Storage of cinfamar caffeine

Keep this medicine out of the sight and reach of children.

This medicine does not require special storage conditions.

Do not use this medicine after the expiration date shown on the packaging, after EXP. The expiration date is the last day of the month indicated.

Medicines should not be disposed of through wastewater or household waste. Deposit the packaging and medicines that are no longer needed in the pharmacy's SIGRE point. If in doubt, ask your pharmacist how to dispose of the packaging and medicines that are no longer needed. This will help protect the environment.

6. Package contents and additional information

Composition of cinfamar caffeine

  • Each tablet contains 50 milligrams of dimenhydrinate and 50 milligrams of caffeine as active ingredients.
  • The other components are:
    • Core: Cornstarch, anhydrous colloidal silica, microcrystalline cellulose, calcium phosphate dihydrate, magnesium stearate, sodium carboxymethyl starch (potato) (type A), povidone, talc.
    • Coating: Macrogol 6000, hypromellose 606, hypromellose 615.

Appearance of the product and package contents

cinfamar caffeine are white, cylindrical, biconvex, and scored on one side coated tablets.

They come in packages containing 4 or 10 coated tablets.

Marketing authorization holder and manufacturer

Laboratorios Cinfa, S.A.

Carretera Olaz-Chipi, 10. Polígono Industrial Areta

31620 Huarte (Navarra) – Spain

Date of the last revision of this leaflet:December 2020

Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es/

Online doctors for CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS

Discuss questions about CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

0.0 (0)
Doctor

Maria Martelli

Anaesthesiology 12 years exp.

Dr Maria Martelli is a medical doctor specialising in anaesthesiology and pain medicine. She provides online consultations for adults, focusing on the assessment and management of acute, chronic, and complex pain conditions, as well as supportive care in serious illness. She graduated from the Medical University of Silesia in Katowice and completed her specialisation in Anaesthesiology and Intensive Care. Alongside hospital work, she has extensive experience in home and inpatient hospice care, supporting patients with severe pain and advanced disease. Since 2021, she has been a certified specialist and continues to work in anaesthesiology, intensive care, and pain treatment. Patients consult her for: 

  • Chronic pain lasting more than 3 months (musculoskeletal, neuropathic, mixed pain).
  • Acute pain requiring medical assessment and treatment planning.
  • Post-operative pain and recovery support.
  • Cancer-related pain and symptom relief.
  • Palliative care support and quality-of-life improvement.
  • Adjustment and optimisation of pain medication.
  • Second opinions for complex or treatment-resistant pain.

Dr Martelli takes a structured, evidence-based approach, carefully analysing symptoms, previous treatments, and overall health status. Her consultations focus on realistic pain control goals, safety of therapy, and improving daily functioning. She is especially attentive to patients living with long-term pain or serious illness, providing clear explanations, compassionate guidance, and medically sound recommendations adapted to each individual situation.

5.0 (198)
Doctor

Taisiia Proida

Family medicine 7 years exp.

Taisiia Proida is a general practitioner with a specialization in mental health and a cognitive behavioral therapist (CBT), a member of the European Psychiatric Association. She offers online consultations for adults aged 18 and over, combining evidence-based medicine with an individualised approach to mental health care. She specialises in consultations and ongoing support for a wide range of mental health concerns, including: 

  • Mood disorders: depression, bipolar disorder, postpartum depression.
  • Anxiety disorders: generalised anxiety, OCD, panic attacks, phobias.
  • Post-traumatic stress disorder (PTSD) and complex PTSD.
  • Attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Assessment is provided only after an initial psychiatric evaluation and during a follow-up appointment.
  • Personality disorders and emotional instability.
  • Cyclothymia and mood fluctuations.
  • Schizophrenia spectrum and related conditions.

Dr. Proida combines clinical expertise with an empathetic approach, offering structured support based on evidence-based practices. Her work integrates CBT techniques with medical management, with a focus on anxiety and depressive disorders. She works with clients from different countries and cultural backgrounds, adapting her communication style and recommendations to individual needs. With experience in international clinical trials (Pfizer, Merck), she values clarity, trust, and collaborative partnership in patient care.

5.0 (939)
Doctor

Alina Tsurkan

Family medicine 13 years exp.

Dr. Alina Tsurkan is a licensed family medicine physician based in Portugal, offering online consultations for adults and children. She provides professional primary care, with a focus on prevention, accurate diagnosis, and long-term management of acute and chronic conditions.

Dr. Tsurkan supports patients with a wide range of health issues, including:

  • Respiratory infections: cold, flu, bronchitis, pneumonia, and lingering coughs.
  • ENT conditions: sinusitis, tonsillitis, otitis (ear infections), sore throat, allergic rhinitis.
  • Eye conditions: allergic or infectious conjunctivitis, red eyes, irritation.
  • Digestive issues: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), constipation, bloating, nausea.
  • Urinary and reproductive health: urinary tract infections (UTIs), cystitis, prevention of recurrent infections.
  • Chronic diseases: hypertension, elevated cholesterol, weight management.
  • Neurological complaints: headaches, migraines, sleep disturbances, fatigue, general weakness.
  • Children’s health: fever, infections, digestive issues, follow-ups, vaccination guidance.

She also provides:

  • IMT medical certificates for driving licence exchange in Portugal.
  • Personalised preventive care and wellness consultations.
  • Interpretation of test results and medical reports.
  • Follow-up care and medication review.
  • Support in managing multiple coexisting conditions.
  • Remote prescription management and medical documentation.

Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

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€55
5.0 (2)
Doctor

Alexander Nazarchuk

Allergology 7 years exp.

Dr. Alexander Nazarchuk is a physician specialising in allergology and internal medicine. He provides online consultations for adults, following the principles of evidence-based medicine — no outdated treatments or unnecessary tests, with clear explanations and a personalised approach. He helps patients with a wide range of allergic and therapeutic conditions, from common day-to-day complaints to complex cases involving allergies, gastrointestinal issues, cardiovascular concerns, respiratory symptoms, and more.

You can consult Dr. Nazarchuk for:

  • Test interpretation and guidance on diagnostic plans.
  • Allergic rhinitis, hay fever, bronchial asthma (including severe cases).
  • Food and drug allergies, skin rashes, angioedema.
  • Atopic dermatitis, urticaria, contact allergies.
  • Allergen-specific immunotherapy (AIT) – initiation and ongoing management.
  • Abdominal pain, bloating, changes in bowel habits, nausea, heartburn.
  • High blood pressure and adjustment of baseline antihypertensive therapy.
  • Hyperlipidaemia and elevated cholesterol.
  • Cough, nasal congestion, fever, sore throat.
  • Anaemia, including iron deficiency and related conditions.
  • Other issues related to allergology and internal medicine.

During consultations, Dr. Nazarchuk takes a thorough, structured approach — analysing symptoms, identifying potential causes, and helping patients make informed decisions. Whether treatment, further investigation, or monitoring is needed, he explains each step clearly so you understand your health and how best to manage it.

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€66
5.0 (5)
Doctor

Tomasz Grzelewski

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques. For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance. Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults. In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions. Patients commonly seek his care for: 

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
  • urticaria, atopic dermatitis and skin reactions
  • recurrent infections in children
  • sports-related health questions
  • general family medicine concerns

Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.

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€86

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Frequently Asked Questions

Is a prescription required for CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS?

CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS does not require a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

What is the active substance in CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS?

The active ingredient in CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS is diphenhydramine, combinations. This information helps identify medicines with the same composition but different brand names.

Who manufactures CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS?

CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS is manufactured by Laboratorios Cinfa S.A.. Pharmacy brands and packaging may differ depending on the distributor.

Which doctors can assess the use of CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS online?

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

How to buy CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS in Spain?

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

What are the alternatives to CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS?

Other medicines with the same active substance (diphenhydramine, combinations) include BIODRAMINA CAFFEINE COATED TABLETS, BIODRAMINA 20 mg CHEWABLE MEDICATED LOZENGES, BIODRAMINA 50 mg TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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