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CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS

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About the medicine

How to use CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Leaflet: information for the user

cinfamar caffeine 50mg/50mg coated tablets

dimenhydrinate/caffeine

Read the entire leaflet carefully before starting to take this medicine, as it contains important information for you.

  • Follow the administration instructions for the medicine contained in this leaflet or as indicated by your doctor or pharmacist.
  • Keep this leaflet, as you may need to read it again.
  • If you need advice or more information, consult your pharmacist.
  • If you experience side effects, consult your doctor or pharmacist, even if they are not listed in this leaflet. See section 4.
  • You should consult a doctor if it worsens or does not improve after 7 days.

Contents of the leaflet

  1. What is cinfamar caffeine and what is it used for
  2. What you need to know before taking cinfamar caffeine
  3. How to take cinfamar caffeine
  4. Possible side effects
  5. Storage of cinfamar caffeine
  6. Package contents and additional information

1. What is cinfamar caffeine and what is it used for

cinfamar caffeine is a medicine that contains two active substances: dimenhydrinate and caffeine. Dimenhydrinate is an active ingredient that acts against motion sickness.

Caffeine has a stimulating effect on the nervous system, so it counteracts the drowsiness effect that dimenhydrinate can cause.

cinfamar caffeine is a medicine that is indicated for the prevention and treatment of symptoms of motion sickness caused by land, sea, or air travel, such as nausea, vomiting, and/or vertigo for adults and children over 12 years old.

You should consult a doctor if it worsens or does not improve after 7 days.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before taking cinfamar caffeine

Do not take cinfamar caffeine

  • If you are allergic to dimenhydrinate, diphenhydramine, caffeine (or its derivatives, such as aminophylline, theophylline, etc.) or any of the other components of this medicine (listed in section 6).
  • If you have porphyria (a rare, usually hereditary disorder in which a large amount of porphyrin is eliminated in urine and feces).
  • If you have asthma attacks.
  • If you have mental disorders that cause nervous excitement or convulsive crises, with or without loss of consciousness (epilepsy).
  • If you have anxiety or insomnia (difficulty sleeping).
  • If you have severe liver or heart disorders.
  • If you have stomach or duodenal ulcers.
  • If you have high blood pressure.

Warnings and precautions

Consult your doctor or pharmacist before starting to take cinfamar caffeine.

  • If you are allergic to any allergy medicine, you may also be allergic to dimenhydrinate.
  • If you have asthma or severe respiratory diseases (chronic obstructive pulmonary disease, emphysema, chronic bronchitis), as it can cause thickening of secretions and alter expectoration.
  • If you have a disease in which there is an abnormal increase in thyroid gland activity (hyperthyroidism), increased intraocular pressure (glaucoma), prostate enlargement (prostatic hypertrophy), or any disease that causes obstruction of the urinary or gastrointestinal tract.
  • If you are over 65 years old, dry mouth, urinary retention, nausea, sedation, confusion, and low blood pressure (hypotension) may occur.
  • If you are using any medicine that produces ear toxicity, which manifests with symptoms such as ringing in the ears, dizziness, or vertigo, as this medicine may mask the symptoms of those toxic effects.
  • If you are diabetic, you should be aware that caffeine can raise blood sugar levels.
  • If you have any liver, kidney, stomach, or duodenal ulcer disease, or stomach inflammation (gastritis), you should consult your doctor before taking this medicine.
  • You should consult your doctor before taking this medicine if you have or have had heart diseases (cardiac arrhythmia, myocardial ischemia, etc.), especially when engaging in physical exercise or being in high-altitude areas.
  • If you are sensitive to caffeine or other xanthines, such as theophylline, aminophylline, or others, you should consult your doctor before taking this medicine.
  • If you suspect you may have appendicitis symptoms such as nausea, vomiting, or abdominal cramps, it is recommended to see a doctor to rule out the presence or absence of appendicitis, as dimenhydrinate can make it difficult to diagnose this disease.
  • It is recommended to avoid exposure to very high temperatures and follow adequate hygiene and dietary measures, such as proper ventilation and hydration.
  • Avoid exposure to the sun (even on cloudy days) and UVA lamps (ultraviolet rays) while taking this medicine.
  • The simultaneous use of tobacco with the caffeine contained in this medicine can increase the degradation of caffeine.

Children

Children under 12 years old should not take this medicine.

Taking cinfamar caffeine with other medicines

Tell your doctor or pharmacist if you are taking, have recently taken, or may need to take any other medicine.

In particular, if you are using any of the following medicines, it may be necessary to modify the dose of cinfamar caffeine or not take it:

Medicines that primarily interfere with dimenhydrinate:

  • Anesthetics and other substances with a central nervous system depressant effect.
  • Antibiotics of the aminoglycoside group.
  • Antidepressants, such as monoamine oxidase inhibitors (MAOIs).
  • Antiparkinsonian agents.
  • Neuroleptics (used to calm agitation and neuromuscular hyperactivity).
  • Ototoxic medicines (which can affect the ear) (see Warnings and Precautions section).
  • Medicines that can cause photosensitivity (skin reactions due to sensitivity to sunlight).

Medicines that primarily interfere with caffeine:

  • Oral contraceptives.
  • Anti-infectives of the quinolone group (e.g., pipemidic acid, ciprofloxacin), linezolid, and erythromycin.
  • Barbiturates (used as anticonvulsants).
  • Adrenergic bronchodilators and theophylline (used to combat bronchial asthma).
  • Calcium.
  • Cimetidine (used for the treatment of excessive gastric secretion and stomach ulcers).
  • Disulfiram (used in alcohol withdrawal treatments).
  • Phenytoin (used for the treatment of epilepsy).
  • Iron (used for the treatment of anemia. Caffeine decreases iron absorption, so it should be taken at least 2 hours apart).
  • Lithium (antidepressant).
  • Mexiletine: used for heart rhythm disorders (cardiac arrhythmias).
  • Procarbazine (anticancer).
  • Selegiline (used for the treatment of Parkinson's disease).
  • Thyroxine (used for the treatment of thyroid diseases).

Interference with diagnostic tests

If you are going to have any analytical tests (blood tests, urine tests, etc.), tell your doctor that you are taking this medicine, as it may alter the results of these tests.

If you are going to have any allergy tests, including skin tests, it is recommended to stop treatment 72 hours before starting the test, to avoid altering the results.

Additionally, diabetic patients should be aware that caffeine can increase blood glucose levels.

Taking cinfamar caffeine with food, drinks, and alcohol

It is not recommended to consume alcohol while taking this medicine.

Limit the consumption of beverages that contain caffeine (coffee, tea, chocolate, and cola drinks) while taking this medicine.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medicine.

Breastfeeding

Women who are breastfeeding should not take this medicine without first consulting their doctor or pharmacist, as this medicine passes into breast milk.

Driving and using machines

While being treated with this medicine, do not drive or operate hazardous machinery, as this medicine can cause drowsiness or decreased reaction capacity at the recommended doses.

cinfamar caffeine contains sodium

This medicine contains less than 23 mg of sodium (1 mmol) per tablet; it is essentially "sodium-free".

3. How to take cinfamar caffeine

Follow the administration instructions for the medicine contained in this leaflet or as indicated by your doctor or pharmacist. In case of doubt, ask your doctor or pharmacist.

The recommended dose is:

Adults and children over 12 years old

1 or 2 tablets per dose. If necessary, repeat the dose every 4-6 hours.

Do not take more than 8 tablets per day (corresponding to 400 mg of dimenhydrinate and 400 mg of caffeine).

Patients with liver disease

They should consult their doctor before taking this medicine, as it may be necessary to adjust the dose.

Use in children

Children under 12 years old should not take this medicine.

cinfamar caffeine is administered orally.

The first dose should be taken at least 30 minutes before starting the trip (preferably 1 or 2 hours before), leaving at least 4 hours between one dose and the next. It is recommended to take the tablets with food, water, or milk to minimize gastric irritation.

The last dose should not be taken in the 6 hours prior to bedtime, to avoid possible insomnia, especially in patients with difficulty sleeping.

If it worsens or if the symptoms persist for more than 7 days, you should consult your doctor.

If you take more cinfamar caffeine than you should

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or call the Toxicology Information Service, phone 91 562 04 20, indicating the medicine and the amount taken.

The symptoms of overdose include mainly: dilated pupils, red face, excitement, hallucinations, confusion, stomach and intestinal irritation with nausea, vomiting, and diarrhea, movement disorders, convulsions, deep loss of consciousness (coma), sudden decrease in respiratory and cardiac functions (cardiorespiratory collapse), and death. The symptoms may take more than 2 hours to appear after the overdose.

If you have any other doubts about the use of this medicine, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everyone gets them.

Side effects usually occur at the beginning of treatment.

During the use of dimenhydrinate, the following adverse reactions have been observed, whose frequency could not be established with precision:

  • Nausea, vomiting, constipation, diarrhea, stomach pain.
  • Lack of appetite and dry mouth.
  • Sleepiness and sedation (drowsiness).
  • Headache, dizziness, and vertigo.
  • Increased viscosity of mucus in the bronchi, making breathing difficult.
  • Urinary retention and impotence.
  • Glaucoma (increased intraocular pressure).
  • Pupil dilation, blurred vision, or double vision.
  • Allergic reactions on the skin and sensitivity to sunlight after intense exposure, which can cause hives, itching, and skin redness.
  • Decrease in the blood of the number of red blood cells, white blood cells, leukocytes, and platelets.
  • Porphyria (a rare, usually hereditary disorder in which a large amount of porphyrin is eliminated in feces and urine).
  • Hypotension (decreased blood pressure).
  • Tachycardia, palpitations, and/or cardiac arrhythmias.
  • Hyperexcitability may occur, especially in children, with symptoms such as insomnia, nervousness, confusion, tremors, irritability, euphoria, delirium, palpitations, and even convulsions.

Additionally, due to caffeine, the following may appear:

  • Excitement, agitation, and/or difficulty sleeping.
  • Ringing in the ears.
  • Disorientation.
  • Rapid breathing.
  • Hot flashes.
  • Abundant urine elimination.
  • Hyperglycemia or hypoglycemia (increased or decreased glucose in the blood).

Reporting side effects

If you experience any type of side effect, consult your doctor or pharmacist, even if it is a possible side effect that is not listed in this leaflet. You can also report them directly through the Spanish Medicines and Health Products Agency (AEMPS) https://www.notificaram.es. By reporting side effects, you can contribute to providing more information on the safety of this medicine.

5. Storage of cinfamar caffeine

Keep this medicine out of the sight and reach of children.

This medicine does not require special storage conditions.

Do not use this medicine after the expiration date shown on the packaging, after EXP. The expiration date is the last day of the month indicated.

Medicines should not be disposed of through wastewater or household waste. Deposit the packaging and medicines that are no longer needed in the pharmacy's SIGRE point. If in doubt, ask your pharmacist how to dispose of the packaging and medicines that are no longer needed. This will help protect the environment.

6. Package contents and additional information

Composition of cinfamar caffeine

  • Each tablet contains 50 milligrams of dimenhydrinate and 50 milligrams of caffeine as active ingredients.
  • The other components are:
    • Core: Cornstarch, anhydrous colloidal silica, microcrystalline cellulose, calcium phosphate dihydrate, magnesium stearate, sodium carboxymethyl starch (potato) (type A), povidone, talc.
    • Coating: Macrogol 6000, hypromellose 606, hypromellose 615.

Appearance of the product and package contents

cinfamar caffeine are white, cylindrical, biconvex, and scored on one side coated tablets.

They come in packages containing 4 or 10 coated tablets.

Marketing authorization holder and manufacturer

Laboratorios Cinfa, S.A.

Carretera Olaz-Chipi, 10. Polígono Industrial Areta

31620 Huarte (Navarra) – Spain

Date of the last revision of this leaflet:December 2020

Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es/

Online doctors for CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS

Discuss questions about CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Doctor

Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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€58
5.0 (5)
Doctor

Tomasz Grzelewski

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques. For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance. Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults. In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions. Patients commonly seek his care for: 

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
  • urticaria, atopic dermatitis and skin reactions
  • recurrent infections in children
  • sports-related health questions
  • general family medicine concerns

Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.

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€80
5.0 (1056)
Doctor

Andrei Popov

General medicine 7 years exp.

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

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€80
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Doctor

Joao Silva

General medicine 6 years exp.

Dr. João Silva is a physician with training and experience in the field of General and Family Medicine, dedicated to providing healthcare focused on the well-being and quality of life of his patients. Throughout his professional career, he has developed broad clinical competencies, striving to maintain a medical practice based on scientific evidence and continuous knowledge updates.

Between 2013 and 2019, he completed the Integrated Master's Degree in Medicine at the Abel Salazar Institute of Biomedical Sciences in Porto, where he acquired a solid academic and clinical education.

Subsequently, between January 2021 and December 2021, he completed the General Internship at the Entre Douro e Vouga Hospital Center in Santa Maria da Feira, where he had the opportunity to work in different hospital settings and deepen his competencies in several areas of medicine.

From January 2022 until March 2026, he works as a Resident Physician in General and Family Medicine at USF Salvador Machado in Oliveira de Azeméis, developing clinical activities in primary healthcare, follow-up of chronic patients, and health promotion in the community.

Complementing his medical training, Dr. João Silva also completed a Postgraduate Degree in Continuing and Palliative Care at CESPU, strengthening his preparation in the comprehensive approach to patient care, especially in situations requiring prolonged care and multidisciplinary support.

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€55

Frequently Asked Questions

Is a prescription required for CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS?
CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS does not require a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS?
The active ingredient in CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS is diphenhydramine, combinations. This information helps identify medicines with the same composition but different brand names.
Who manufactures CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS?
CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS is manufactured by Laboratorios Cinfa S.A.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS?
Other medicines with the same active substance (diphenhydramine, combinations) include BIODRAMINA CAFFEINE COATED TABLETS, BIODRAMINA 20 mg CHEWABLE MEDICATED LOZENGES, BIODRAMINA 50 mg TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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