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BESTER COMPLEX Hard Capsules

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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use BESTER COMPLEX Hard Capsules

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

Bester Complex Hard Capsules

Thiamine Hydrochloride / Pyridoxine Hydrochloride / Hydroxocobalamin Acetate

Read the entire package leaflet carefully before starting to take this medication, as it contains important information for you.

Follow exactly the administration instructions of the medication contained in this package leaflet or as indicated by your doctor or pharmacist.

  • Keep this package leaflet, as you may need to read it again.
  • If you need advice or more information, consult your pharmacist.
  • If you experience side effects, consult your doctor or pharmacist, even if they are side effects not listed in this package leaflet. See section 4.
  • You should consult a doctor if your condition worsens or does not improve after 7 days.

Contents of the Package Leaflet

  1. What is Bester Complex and what is it used for
  2. What you need to know before taking Bester Complex
  3. How to take Bester Complex
  4. Possible side effects
  5. Storage of Bester Complex
  6. Package Contents and Additional Information

1. What is Bester Complex and what is it used for

It is an association of the water-soluble vitamins of the B group: thiamine (vitamin B1), pyridoxine (vitamin B6), and hydroxocobalamin (vitamin B12), which are involved in numerous human metabolic processes.

It is indicated in: Prevention and treatment of states of deficiency of vitamins B1, B6, and B12, due to increased needs, reduced consumption, or absorption, which could manifest as symptoms such as back pain, among others; convalescences; insufficient diets.

Bester Complex is indicated for adults and adolescents over 14 years of age.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before taking Bester Complex

Do not take Bester Complex

  • if you are allergic to thiamine, pyridoxine, hydroxocobalamin, or other cobalamins (e.g., cyanocobalamin), cobalt, or any of the other components of this medication (listed in section 6).
  • if you are being treated with levodopa (a medication used for Parkinson's disease).

Due to the high doses it contains:

  • if you have kidney or liver disease.
  • if you are pregnant or breastfeeding.
  • children under 14 years of age.

Warnings and Precautions

Consult your doctor or pharmacist before starting to take Bester Complex.

  • Do not take a higher dose than recommended or for a longer period than recommended. When high doses of pyridoxine (vitamin B6) are administered continuously, adverse effects of a neurological type (headache, tingling sensation, etc.) may occur.
  • If you have a blood disease, such as anemia, your doctor should check the cause before taking vitamin B12.
  • If you have conditions such as uremia (urea accumulation in the blood), infections, iron or folic acid deficiency, or are being treated with medications that have a suppressive effect on the bone marrow (e.g., chloramphenicol), the effect of vitamin B12 may be reduced.
  • There have been cases of dependence and withdrawal when taking 200 mg of pyridoxine for a month.
  • You should be cautious with sun exposure or avoid it and ultraviolet (UVA) lamp exposure while using this medication, as pyridoxine can cause sun sensitivity (photosensitivity).
  • If you have previously had an allergy to vitamin B1 on skin contact (contact dermatitis) for professional reasons, you may experience a relapse when taking this medication.
  • Interference with analytical tests: If you are going to undergo any diagnostic test (including blood tests, urine tests, skin tests using allergens, etc.), inform your doctor that you are taking this medication, as it may alter the results. In some determinations of urobilinogen, theophylline, and uric acid, false results may be produced.

Children

  • Bester Complex is contraindicated in children under 14 years of age (see "Do not take Bester Complex" section).

Other Medications and Bester Complex

Inform your doctor or pharmacist if you are using, have recently used, or may need to use any other medication.

Bester Complex may interact with the following medications:

  • Levodopa (medication for Parkinson's disease): may decrease its antiparkinsonian effect.
  • Phenobarbital, phenytoin (medications for epilepsy).
  • Amiodarone (medication used for the heart).
  • Altretamine or 5-fluorouracil (for cancer treatment).
  • Neuromuscular blocking medications (used in anesthesia for surgery).
  • Various medications can interfere with pyridoxine (vitamin B6) and may reduce its levels, including: antibiotics for tuberculosis treatment (isoniazid, cycloserine, ethionamide), penicillamine (for rheumatic diseases), hydralazine (for hypertension), theophylline (for asthma and other respiratory diseases), immunosuppressants such as corticosteroids or cyclosporine (used in organ transplantation).
  • Various medications can decrease the absorption of vitamin B12 or reduce its effect, such as: ascorbic acid (vitamin C), aminoglycoside antibiotics like neomycin, colchicine (for gout treatment), H-2 antagonists (medications against stomach acidity or ulcers, such as ranitidine, cimetidine, etc.), aminosalicylic acid (for intestinal diseases), omeprazole (for stomach acidity or ulcers), medications for epilepsy, metformin (for diabetes), chloramphenicol (antibiotic), or cobalt radiation.
  • Oral contraceptives can reduce the levels of both vitamin B6 and vitamin B12.

Taking Bester Complex with Food and Drinks

Excessive alcohol consumption reduces the absorption of vitamins.

Pregnancy and Breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medication.

Due to the high doses of vitamin B in this medication, which are much higher than those recommended during pregnancy and breastfeeding, it is contraindicated during these periods.

Driving and Using Machines

This medication can cause drowsiness in a small proportion of patients, who should not drive and/or operate machines during treatment.

3. How to Take Bester Complex

Follow exactly the administration instructions of the medication contained in this package leaflet or as indicated by your doctor or pharmacist. In case of doubt, ask your doctor or pharmacist.

Adults and Adolescents Over 14 Years of Age

The recommended dose is 1 capsule per day.

In general, treatment should not exceed two weeks, although your doctor may recommend administration for more than 15 days.

If symptoms do not improve after 7 days of treatment, you should consult your doctor.

Oral route.

It is recommended to take the capsules with the help of water.

Patient with Hepatic or Renal Insufficiency

These patients should not take Bester Complex.

If You Take More Bester Complex Than You Should

If you have taken more Bester Complex than you should (high doses), you may experience symptoms such as: digestive disorders (diarrhea, nausea, and vomiting) and headache. You may also experience sun sensitivity with skin lesions; drowsiness, difficulty breathing, among other effects, depending on the dose, increased liver enzyme levels, decreased folic acid levels in the blood.

In rare cases, a severe allergic reaction (anaphylactic shock) may occur.

You may also experience sensitivity alterations, tingling, etc., in prolonged treatments.

In children, accidental ingestion of very high doses of vitamin B6 can also cause deep sedation, weakness, and difficulty breathing.

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or go to a medical center, or call the Toxicological Information Service, phone 91 562 04 20, indicating the medication and the amount taken.

If You Forget to Take Bester Complex

Do not take a double dose to make up for forgotten doses.

If you have any other doubts about the use of this medication, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible Side Effects

Like all medications, this medication can cause side effects, although not everyone experiences them.

Uncommon side effects (may affect up to 1 in 100 people): nausea, vomiting, headache, drowsiness, tingling sensation in the skin (paresthesia) or sensitivity alterations, and skin rash. Allergic reactions (hypersensitivity reactions) to vitamins B1, B6, and B12 have also been described.

Other side effects that have been reported, with an unknown frequency (cannot be estimated from available data), are: digestive disorders, diarrhea, loss of appetite, photosensitivity with skin lesions such as blisters; changes in urine color, dizziness, restlessness, occasional insomnia; disorder with reduced sensitivity and tingling, numbness of feet or hands, which generally decrease when treatment is discontinued; a pyridoxine withdrawal syndrome more likely at high doses and in treatments of more than one month; in rare cases, anaphylactic reaction with itching, swelling, difficulty breathing, etc., late allergic reaction to vitamin B1 (see "Warnings and Precautions" in section 2).

If an allergic reaction occurs, you should discontinue treatment and receive treatment for the symptoms.

Reporting Side Effects

If you experience any type of side effect, consult your doctor or pharmacist, even if it is a possible side effect not listed in this package leaflet. You can also report them directly through the Spanish Medication Surveillance System for Human Use: https://www.notificaram.es. By reporting side effects, you can contribute to providing more information on the safety of this medication.

5. Storage of Bester Complex

Keep this medication out of the sight and reach of children.

No special storage conditions are required.

Do not use this medication after the expiration date shown on the package after CAD. The expiration date is the last day of the month indicated.

Medications should not be disposed of through wastewater or household waste. Deposit the packages and medications you no longer need at the SIGRE Point in the pharmacy. If in doubt, ask your pharmacist how to dispose of the packages and medications you no longer need. This will help protect the environment.

6. Package Contents and Additional Information

Bester Complex Composition

  • The active ingredients are Thiamine Hydrochloride (vitamin B1), Pyridoxine Hydrochloride (vitamin B6), and Hydroxocobalamin Acetate (vitamin B12). Each capsule contains 100 mg of thiamine hydrochloride, 150 mg of pyridoxine hydrochloride, and 1,500 micrograms of hydroxocobalamin acetate.
  • The other components are dibasic calcium phosphate dihydrate, sodium carboxymethylcellulose, microcrystalline cellulose, magnesium stearate, colloidal silicon dioxide, cornstarch; the capsule colorants are: erythrosine (E127), indigotine (E132), quinoline (E104), titanium dioxide (E171).

Product Appearance and Package Contents

Bester Complex is presented in hard capsules, orange and brown in color.

Each package contains 30 capsules.

Marketing Authorization Holder and Manufacturer

LABORATORIOS SALVAT, S.A.

Gall, 30-36.

08950 Esplugues de Llobregat (Barcelona) Spain

Date of the Last Revision of this Package Leaflet:October/2017.

Detailed information about this medication is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es/

Online doctors for BESTER COMPLEX Hard Capsules

Discuss questions about BESTER COMPLEX Hard Capsules, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

0.0 (0)
Doctor

Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
Camera Book a video appointment
€58
5.0 (25)
Doctor

Lina Travkina

Family medicine 13 years exp.

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
  • Medical advice and follow-up consultations.
  • Test interpretation and diagnostic guidance.
  • Structured support for undiagnosed complaints.
  • Second opinion on diagnoses and treatment plans.
  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
  • Post-operative recovery support and pain management.
  • Preconception counselling and postpartum support.
  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

Camera Book a video appointment
€70
5.0 (760)
Doctor

Alina Tsurkan

Family medicine 13 years exp.

Dr. Alina Tsurkan is a licensed family medicine physician based in Portugal, offering online consultations for adults and children. She provides professional primary care, with a focus on prevention, accurate diagnosis, and long-term management of acute and chronic conditions.

Dr. Tsurkan supports patients with a wide range of health issues, including:

  • Respiratory infections: cold, flu, bronchitis, pneumonia, and lingering coughs.
  • ENT conditions: sinusitis, tonsillitis, otitis (ear infections), sore throat, allergic rhinitis.
  • Eye conditions: allergic or infectious conjunctivitis, red eyes, irritation.
  • Digestive issues: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), constipation, bloating, nausea.
  • Urinary and reproductive health: urinary tract infections (UTIs), cystitis, prevention of recurrent infections.
  • Chronic diseases: hypertension, elevated cholesterol, weight management.
  • Neurological complaints: headaches, migraines, sleep disturbances, fatigue, general weakness.
  • Children’s health: fever, infections, digestive issues, follow-ups, vaccination guidance.

She also provides:

  • IMT medical certificates for driving licence exchange in Portugal.
  • Personalised preventive care and wellness consultations.
  • Interpretation of test results and medical reports.
  • Follow-up care and medication review.
  • Support in managing multiple coexisting conditions.
  • Remote prescription management and medical documentation.

Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

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€55

Frequently Asked Questions

Is a prescription required for BESTER COMPLEX Hard Capsules?
BESTER COMPLEX Hard Capsules does not require a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
Who manufactures BESTER COMPLEX Hard Capsules?
BESTER COMPLEX Hard Capsules is manufactured by Laboratorios Salvat S.A.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of BESTER COMPLEX Hard Capsules online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether BESTER COMPLEX Hard Capsules is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to BESTER COMPLEX Hard Capsules?
Other medicines with the same active substance () include BENEXOL B1-B6-B12 FILM-COATED TABLETS, HYDROXIL B1-B6-B12 FILM-COATED TABLETS, NEUROMADE Hard Capsules. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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