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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use BESTER COMPLEX Hard Capsules

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

Bester Complex Hard Capsules

Thiamine Hydrochloride / Pyridoxine Hydrochloride / Hydroxocobalamin Acetate

Read the entire package leaflet carefully before starting to take this medication, as it contains important information for you.

Follow exactly the administration instructions of the medication contained in this package leaflet or as indicated by your doctor or pharmacist.

  • Keep this package leaflet, as you may need to read it again.
  • If you need advice or more information, consult your pharmacist.
  • If you experience side effects, consult your doctor or pharmacist, even if they are side effects not listed in this package leaflet. See section 4.
  • You should consult a doctor if your condition worsens or does not improve after 7 days.

Contents of the Package Leaflet

  1. What is Bester Complex and what is it used for
  2. What you need to know before taking Bester Complex
  3. How to take Bester Complex
  4. Possible side effects
  5. Storage of Bester Complex
  6. Package Contents and Additional Information

1. What is Bester Complex and what is it used for

It is an association of the water-soluble vitamins of the B group: thiamine (vitamin B1), pyridoxine (vitamin B6), and hydroxocobalamin (vitamin B12), which are involved in numerous human metabolic processes.

It is indicated in: Prevention and treatment of states of deficiency of vitamins B1, B6, and B12, due to increased needs, reduced consumption, or absorption, which could manifest as symptoms such as back pain, among others; convalescences; insufficient diets.

Bester Complex is indicated for adults and adolescents over 14 years of age.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before taking Bester Complex

Do not take Bester Complex

  • if you are allergic to thiamine, pyridoxine, hydroxocobalamin, or other cobalamins (e.g., cyanocobalamin), cobalt, or any of the other components of this medication (listed in section 6).
  • if you are being treated with levodopa (a medication used for Parkinson's disease).

Due to the high doses it contains:

  • if you have kidney or liver disease.
  • if you are pregnant or breastfeeding.
  • children under 14 years of age.

Warnings and Precautions

Consult your doctor or pharmacist before starting to take Bester Complex.

  • Do not take a higher dose than recommended or for a longer period than recommended. When high doses of pyridoxine (vitamin B6) are administered continuously, adverse effects of a neurological type (headache, tingling sensation, etc.) may occur.
  • If you have a blood disease, such as anemia, your doctor should check the cause before taking vitamin B12.
  • If you have conditions such as uremia (urea accumulation in the blood), infections, iron or folic acid deficiency, or are being treated with medications that have a suppressive effect on the bone marrow (e.g., chloramphenicol), the effect of vitamin B12 may be reduced.
  • There have been cases of dependence and withdrawal when taking 200 mg of pyridoxine for a month.
  • You should be cautious with sun exposure or avoid it and ultraviolet (UVA) lamp exposure while using this medication, as pyridoxine can cause sun sensitivity (photosensitivity).
  • If you have previously had an allergy to vitamin B1 on skin contact (contact dermatitis) for professional reasons, you may experience a relapse when taking this medication.
  • Interference with analytical tests: If you are going to undergo any diagnostic test (including blood tests, urine tests, skin tests using allergens, etc.), inform your doctor that you are taking this medication, as it may alter the results. In some determinations of urobilinogen, theophylline, and uric acid, false results may be produced.

Children

  • Bester Complex is contraindicated in children under 14 years of age (see "Do not take Bester Complex" section).

Other Medications and Bester Complex

Inform your doctor or pharmacist if you are using, have recently used, or may need to use any other medication.

Bester Complex may interact with the following medications:

  • Levodopa (medication for Parkinson's disease): may decrease its antiparkinsonian effect.
  • Phenobarbital, phenytoin (medications for epilepsy).
  • Amiodarone (medication used for the heart).
  • Altretamine or 5-fluorouracil (for cancer treatment).
  • Neuromuscular blocking medications (used in anesthesia for surgery).
  • Various medications can interfere with pyridoxine (vitamin B6) and may reduce its levels, including: antibiotics for tuberculosis treatment (isoniazid, cycloserine, ethionamide), penicillamine (for rheumatic diseases), hydralazine (for hypertension), theophylline (for asthma and other respiratory diseases), immunosuppressants such as corticosteroids or cyclosporine (used in organ transplantation).
  • Various medications can decrease the absorption of vitamin B12 or reduce its effect, such as: ascorbic acid (vitamin C), aminoglycoside antibiotics like neomycin, colchicine (for gout treatment), H-2 antagonists (medications against stomach acidity or ulcers, such as ranitidine, cimetidine, etc.), aminosalicylic acid (for intestinal diseases), omeprazole (for stomach acidity or ulcers), medications for epilepsy, metformin (for diabetes), chloramphenicol (antibiotic), or cobalt radiation.
  • Oral contraceptives can reduce the levels of both vitamin B6 and vitamin B12.

Taking Bester Complex with Food and Drinks

Excessive alcohol consumption reduces the absorption of vitamins.

Pregnancy and Breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medication.

Due to the high doses of vitamin B in this medication, which are much higher than those recommended during pregnancy and breastfeeding, it is contraindicated during these periods.

Driving and Using Machines

This medication can cause drowsiness in a small proportion of patients, who should not drive and/or operate machines during treatment.

3. How to Take Bester Complex

Follow exactly the administration instructions of the medication contained in this package leaflet or as indicated by your doctor or pharmacist. In case of doubt, ask your doctor or pharmacist.

Adults and Adolescents Over 14 Years of Age

The recommended dose is 1 capsule per day.

In general, treatment should not exceed two weeks, although your doctor may recommend administration for more than 15 days.

If symptoms do not improve after 7 days of treatment, you should consult your doctor.

Oral route.

It is recommended to take the capsules with the help of water.

Patient with Hepatic or Renal Insufficiency

These patients should not take Bester Complex.

If You Take More Bester Complex Than You Should

If you have taken more Bester Complex than you should (high doses), you may experience symptoms such as: digestive disorders (diarrhea, nausea, and vomiting) and headache. You may also experience sun sensitivity with skin lesions; drowsiness, difficulty breathing, among other effects, depending on the dose, increased liver enzyme levels, decreased folic acid levels in the blood.

In rare cases, a severe allergic reaction (anaphylactic shock) may occur.

You may also experience sensitivity alterations, tingling, etc., in prolonged treatments.

In children, accidental ingestion of very high doses of vitamin B6 can also cause deep sedation, weakness, and difficulty breathing.

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or go to a medical center, or call the Toxicological Information Service, phone 91 562 04 20, indicating the medication and the amount taken.

If You Forget to Take Bester Complex

Do not take a double dose to make up for forgotten doses.

If you have any other doubts about the use of this medication, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible Side Effects

Like all medications, this medication can cause side effects, although not everyone experiences them.

Uncommon side effects (may affect up to 1 in 100 people): nausea, vomiting, headache, drowsiness, tingling sensation in the skin (paresthesia) or sensitivity alterations, and skin rash. Allergic reactions (hypersensitivity reactions) to vitamins B1, B6, and B12 have also been described.

Other side effects that have been reported, with an unknown frequency (cannot be estimated from available data), are: digestive disorders, diarrhea, loss of appetite, photosensitivity with skin lesions such as blisters; changes in urine color, dizziness, restlessness, occasional insomnia; disorder with reduced sensitivity and tingling, numbness of feet or hands, which generally decrease when treatment is discontinued; a pyridoxine withdrawal syndrome more likely at high doses and in treatments of more than one month; in rare cases, anaphylactic reaction with itching, swelling, difficulty breathing, etc., late allergic reaction to vitamin B1 (see "Warnings and Precautions" in section 2).

If an allergic reaction occurs, you should discontinue treatment and receive treatment for the symptoms.

Reporting Side Effects

If you experience any type of side effect, consult your doctor or pharmacist, even if it is a possible side effect not listed in this package leaflet. You can also report them directly through the Spanish Medication Surveillance System for Human Use: https://www.notificaram.es. By reporting side effects, you can contribute to providing more information on the safety of this medication.

5. Storage of Bester Complex

Keep this medication out of the sight and reach of children.

No special storage conditions are required.

Do not use this medication after the expiration date shown on the package after CAD. The expiration date is the last day of the month indicated.

Medications should not be disposed of through wastewater or household waste. Deposit the packages and medications you no longer need at the SIGRE Point in the pharmacy. If in doubt, ask your pharmacist how to dispose of the packages and medications you no longer need. This will help protect the environment.

6. Package Contents and Additional Information

Bester Complex Composition

  • The active ingredients are Thiamine Hydrochloride (vitamin B1), Pyridoxine Hydrochloride (vitamin B6), and Hydroxocobalamin Acetate (vitamin B12). Each capsule contains 100 mg of thiamine hydrochloride, 150 mg of pyridoxine hydrochloride, and 1,500 micrograms of hydroxocobalamin acetate.
  • The other components are dibasic calcium phosphate dihydrate, sodium carboxymethylcellulose, microcrystalline cellulose, magnesium stearate, colloidal silicon dioxide, cornstarch; the capsule colorants are: erythrosine (E127), indigotine (E132), quinoline (E104), titanium dioxide (E171).

Product Appearance and Package Contents

Bester Complex is presented in hard capsules, orange and brown in color.

Each package contains 30 capsules.

Marketing Authorization Holder and Manufacturer

LABORATORIOS SALVAT, S.A.

Gall, 30-36.

08950 Esplugues de Llobregat (Barcelona) Spain

Date of the Last Revision of this Package Leaflet:October/2017.

Detailed information about this medication is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es/

Online doctors for BESTER COMPLEX Hard Capsules

Discuss questions about BESTER COMPLEX Hard Capsules, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Andrei Popov

General medicine 7 years exp.

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

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Dr. Agami received clinical training and worked in leading medical institutions in Israel (Kaplan Medical Center, Barzilai Medical Center, Wolfson Medical Center) and Portugal (European Healthcare City, Viscura Internacional, Hospital Dr. José Maria Grande, Hospital Vila Franca de Xira). His approach combines international medical standards with individualised attention to each patient.

Main areas of consultation:

  • Diagnosis and treatment of acute and chronic conditions (high blood pressure, diabetes, respiratory infections, cardiovascular symptoms)
  • Evaluation of symptoms and guidance on further diagnostic testing
  • Preventive check-ups and regular health monitoring
  • Medical support during travel or after relocation
  • Treatment adjustments and lifestyle recommendations based on your personal history
Dr. Agami provides medical support for patients using GLP-1 medications (such as Ozempic or Mounjaro) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Portugal and Israel.

Dr. Agami is committed to evidence-based, patient-centred care, ensuring that each person receives trusted medical support tailored to their health goals.

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Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies
  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management
  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses
  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment
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  • Pain management: acute and chronic pain, post-surgical care
  • Public health: prevention, health screenings, long-term monitoring
  • Sick leave (Baixa médica) connected to Segurança Social in Portugal
  • IMT medical certificates for driving licence exchange
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Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

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She currently works as a physician at the Canary Islands Emergency Service (Servicio de Urgencias Canario – SUC), where she is responsible for the assessment and care of patients in medical emergency situations, performing the initial diagnosis, patient stabilization, and coordination with hospital services when necessary.

She has also developed her professional activity within the Primary Care Management Service, providing consultations in general medicine. In this setting she is responsible for patient follow-up, management of acute and chronic conditions, as well as health promotion and disease prevention.

She has also worked as a physician in a mobile ICU unit, providing medical assistance in out-of-hospital emergencies, treating critical patients and participating in medicalized patient transport.

In addition, she has collaborated with the Red Cross, participating in healthcare support units, providing medical assistance at events and supporting emergency interventions.

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Throughout his career, he has participated in various medical and academic projects, including a research fellowship in Spain, where he contributed to evidence-based studies in the field of family medicine. This experience allowed him to broaden his global perspective on healthcare and comprehensive patient care.

Dr. Correa Bellido has worked with several healthcare providers in Spain, focusing particularly on patient-centered care and public health initiatives aimed at communities with limited access to healthcare services.

In addition, he actively participates in international medical conferences and workshops, which allows him to stay up to date with the latest medical advances and collaborate with healthcare professionals from different countries.

Dr. Correa Bellido provides comprehensive care for a wide variety of medical conditions, including:

  • respiratory infections
  • gastrointestinal disorders
  • cardiovascular problems
  • endocrine and metabolic diseases
  • musculoskeletal and dermatological conditions
  • as well as mental health conditions such as anxiety and depression.

He also treats infectious and allergic diseases, general health concerns, and provides guidance on prevention and healthy lifestyle habits.

His services include virtual consultations, diagnosis and management of acute and chronic diseases, prescription renewals, and personalized medical advice.

With a patient-centered approach and a strong commitment to continuous learning, Dr. Correa Bellido provides accessible and high-quality healthcare to patients both in Spain and around the world.

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  • acute respiratory symptoms (cough, sore throat, runny nose, fever)
  • viral illnesses such as colds and seasonal infections
  • gastrointestinal complaints (nausea, diarrhoea, abdominal pain, gastroenteritis)
  • sudden changes in how a child or adult feels
  • questions about existing treatment and whether adjustments are needed
  • renewal of prescriptions when clinically appropriate

Dr. Shalko works specifically with urgent and short-term problems, providing practical recommendations and helping patients determine the safest next step. She explains symptoms clearly, guides patients through decision-making and offers straightforward medical advice for everyday acute issues.She does not provide long-term management of chronic conditions, ongoing follow-up or comprehensive care plans for complex long-term illnesses. Her consultations are designed for acute symptoms, sudden concerns and situations where timely medical input is important.With clinical experience in both paediatrics and general medicine, Dr. Shalko confidently supports adults and children. Her communication style is clear, simple and reassuring, helping patients feel informed and supported throughout the consultation.

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Daniel Cichi

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Dr Daniel Cichi is a family medicine doctor with over 20 years of clinical experience. He provides online consultations for adults, supporting patients with acute symptoms, chronic conditions, and everyday health concerns that require timely medical guidance. His background includes work in emergency care, ambulance services, and family medicine, which allows him to assess symptoms quickly, identify warning signs, and help patients choose the safest next steps – whether that means home care, treatment adjustment, or in-person evaluation. Patients commonly consult Dr Daniel Cichi for: 

  • acute symptoms: fever, infections, flu-like illness, cough, sore throat, shortness of breath;
  • chest discomfort, palpitations, dizziness, fatigue, and blood pressure concerns;
  • digestive problems: abdominal pain, nausea, diarrhoea, constipation, reflux;
  • sexually transmitted infections, erectile dysfunction;
  • muscle, joint, and back pain, minor injuries, post-traumatic symptoms;
  • chronic conditions: hypertension, diabetes, high cholesterol, thyroid disorders, weight loss, hair loss;
  • review and interpretation of lab tests, imaging reports, and medical documents;
  • medication review and treatment adjustment;
  • medical advice while travelling or living abroad;
  • second opinions and guidance on whether in-person care is needed.

Dr Cichi’s consultations are structured and practical. He focuses on clear explanations, risk assessment, and actionable recommendations, helping patients understand their symptoms and make informed decisions about their health.

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Tell us your symptoms, history, and what medicine you're requesting.

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Electronic prescription sent to your email — valid across Spain.

Frequently Asked Questions

Is a prescription required for BESTER COMPLEX Hard Capsules?

BESTER COMPLEX Hard Capsules does not require a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

Who manufactures BESTER COMPLEX Hard Capsules?

BESTER COMPLEX Hard Capsules is manufactured by Laboratorios Salvat S.A.. Pharmacy brands and packaging may differ depending on the distributor.

Which doctors can assess the use of BESTER COMPLEX Hard Capsules online?

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether BESTER COMPLEX Hard Capsules is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

How to buy BESTER COMPLEX Hard Capsules in Spain?

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy BESTER COMPLEX Hard Capsules in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

What are the alternatives to BESTER COMPLEX Hard Capsules?

Other medicines with the same active substance () include BENEXOL B1-B6-B12 FILM-COATED TABLETS, HYDROXIL B1-B6-B12 FILM-COATED TABLETS, NEUROMADE Hard Capsules. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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