Package Insert: Information for the User

Transtec70 micrograms/hour Transdermal Patch

Buprenorphine

Read this package insert carefully before starting to use this medication,because it contains important information for you.

• Keep this package insert, as you may need to read it again.
• If you have any questions, consult your doctor or pharmacist.
• This medication has been prescribed only for you, and you should not give it to others, even if they have the same symptoms as you, as it may harm them.
• If you experience any adverse effects, consult your doctor or pharmacist,eveniftheydo not appear in this package insert.See section 4.

Transtecis an analgesic (a pain-relieving medication) indicated for the relief of moderate to severe oncological pain and severe pain that does not respond to other types of analgesics. Transtecacts through the skin. When the transdermal patch is applied to the skin, the active substance buprenorphine passes through it into the bloodstream. Buprenorphine is an opioid (a medication for intense pain relief) that reduces pain by acting on the central nervous system (on specific nerve cells in the spinal cord and the brain). The effect of the transdermal patch lasts for up to a maximum of four days. Transtec is not ideal for the treatment of acute pain (short duration).

No useTranstec

• If you are allergic to buprenorphine or any of the other components of this medication (listed in section 6),
• If you are addicted to powerful analgesics (opioids),
• If you have a condition where you have great difficulty breathing or where this may occur,
• If you are taking monoamine oxidase inhibitors (certain medications for depression treatment) or have taken them in the last two weeks before treatment with Transtec (see “Use of Transtec with other medications”),
• In case of myasthenia gravis (a severe type of muscle weakness),
• In case of delirium tremens (confusion and tremors caused by alcohol withdrawal after excessive consumption or during an episode of high alcohol consumption),
• In case of pregnancy.

Transtec should not be used to treat withdrawal syndrome in drug-dependent individuals.

Warnings and precautions

Tolerance, dependence, and addiction

This medication contains buprenorphine, an opioid substance. Repeated use of opioids may reduce the effectiveness of the medication (your body becomes accustomed to the medication, which is known as tolerance). Repeated use of Transtec may also cause dependence, abuse, and addiction, which may lead to a potentially fatal overdose. The risk of adverse effects may increase with a higher dose and longer duration of use.

Dependence or addiction may make you feel like you no longer have control over the amount of medication you need to take or how often you need to take it.

The risk of becoming dependent or addicted varies from person to person. You may be at a higher risk of becoming dependent or addicted to Transtec if:

- You or a family member has a history of alcohol abuse, prescription medication abuse, or illicit substance abuse (“addiction”).

- You are a smoker.

- You have had problems with your mood (depression, anxiety, or personality disorder) or have received treatment from a psychiatrist for other mental health conditions.

If you notice any of the following signs while taking Transtec, it could be a sign that you have become dependent or addicted:

- You need to take the medication for a longer period than recommended by your doctor.

- You need to take more doses than recommended.

- You are using the medication for reasons other than those prescribed, such as “to calm down” or “to help you sleep”.

- You have made repeated and unsuccessful attempts to stop or control the use of the medication.

- You do not feel well when you stop taking the medication and feel better when you take it again (“withdrawal symptoms”).

If you notice any of these signs, talk to your doctor to address the most suitable treatment strategy for your case, including when it is appropriate to stop taking it and how to do it safely (see section 3 “If you interrupt treatment with Transtec”).

Consult your doctor or pharmacist before starting to use Transtec

• If you have recently consumed a lot of alcohol,
• If you have seizures or convulsions (attacks),
• If you have altered consciousness (feeling dizzy or fainting),
• If you are in shock (a sign may be cold sweat),
• If you have increased intracranial pressure (for example, after head trauma or brain disease), without the possibility of artificial respiration,
• If you have difficulty breathing or are taking another medication that may make you breathe more slowly or weakly (see “Use of Transtec with other medications”),
• If you have depression or other conditions treated with antidepressants.

The use of these medications with Transtec may cause serotonin syndrome, a potentially fatal condition (see “Use of Transtec with other medications”),

• If you have liver problems.

Also, be aware of the following precautions:

• Fever and heat may cause higher-than-normal levels of buprenorphine in the blood. Heat may also prevent the transdermal patch from adhering properly. Therefore, consult your doctor if you have a fever and do not expose yourself to heat sources (e.g., sauna, infrared lamps, electric blankets, or hot water bags).

Inform athletes that this medication may result in a positive test in doping control tests.

Respiratory disorders related to sleep

Transtec may cause respiratory disorders related to sleep such as sleep apnea (pauses in breathing during sleep) and sleep-related hypoxemia (low oxygen levels in the blood). Symptoms may include pauses in breathing during sleep, nocturnal awakenings due to difficulty breathing, difficulty maintaining sleep, or excessive daytime somnolence. Contact your doctor if you or someone else observes these symptoms. Your doctor may consider reducing the dose.

Children and adolescents

Transtec should not be used in individuals under 18 years old, as there is no experience to date in this age group.

Use of Transtec with other medications

Inform your doctor or pharmacist if you are using, have used recently, or may need to use any other medication.

• Transtec should not be used with monoamine oxidase inhibitors (certain medications for depression treatment), or if you have taken them in the last two weeks.

• Transtec may cause drowsiness, vomiting, dizziness, or make you breathe more slowly or weakly in some patients. These adverse effects may intensify if taken at the same time as other medications that may produce the same effects. These other medications include other powerful analgesics (opioids), certain sleep medications, anesthetics, and medications for the treatment of certain psychological conditions such as tranquilizers, antidepressants, neuroleptics, and gabapentin or pregabalin used to treat epilepsy or pain due to nerve problems (neuropathic pain).

Inform your doctor or pharmacist if you are taking:

• allergy medications and anti-nausea medications for travel (antihistamines or antiemetics);
• psychiatric disorder medications (antipsychotics or neuroleptics);
• muscle relaxants;
• parkinson's disease medications.

The concomitant use of Transtec with sedatives or sleep medications (such as benzodiazepines) increases the risk of drowsiness, respiratory difficulties (respiratory depression), coma, and may be potentially fatal. Therefore, only consider concomitant use when other treatment options are not possible. However, if your doctor prescribes Transtec with sedatives, you should limit the dose and duration of concomitant treatment. Inform your doctor about all sedatives you are taking and follow your doctor's dose recommendation strictly. It may be helpful to inform your friends and family about the signs and symptoms mentioned above. Inform your doctor if you experience any of these symptoms.

• If Transtec is used with some medications, the action of the transdermal patch may be intensified. These medications include, for example, certain antibiotics and antifungals (e.g., those containing erythromycin or ketoconazole) or HIV medications (e.g., those containing ritonavir).

• If Transtec is used with other medications, the action of the transdermal patch may be reduced. These medications include, for example, dexamethasone, certain epilepsy medications (e.g., those containing carbamazepine or phenytoin) or tuberculosis medications (e.g., rifampicin).

• Some medications may increase the side effects of Transtec and, in some cases, may cause severe reactions. Do not take any other medication while using Transtec without consulting your doctor first, especially antidepressants such as citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, duloxetine, venlafaxine, amitriptyline, doxepin, or trimipramine. These medications may interact with Transtec and you may experience symptoms such as involuntary muscle contractions, including those that control eye movement, agitation, hallucinations, coma, excessive sweating, tremors, exaggerated reflexes, increased muscle tension, body temperature above 38°C. Contact your doctor if you experience these symptoms.

Use of Transtec with food, drinks, and alcohol

Do not drink alcohol while using Transtec. Alcohol may intensify certain adverse effects of the transdermal patch and you may not feel well.

Taking grapefruit juice during treatment may intensify the effects of Transtec.

Pregnancy, breastfeeding, and fertility

If you are pregnant or breastfeeding, or if you think you may be pregnant, consult your doctor or pharmacist before using this medication.

There is no sufficient experience to date with the use of Transtec in pregnant women. Therefore, Transtec should not be used during pregnancy.

Buprenorphine, the active ingredient contained in the transdermal patch, passes into breast milk and inhibits its production. Therefore, Transtec should not be used during breastfeeding.

Driving and operating machinery

Transtec may make you feel dizzy, drowsy, or have double vision or blurred vision and may alter your reflexes so that you do not react quickly or adequately in unexpected situations.

This applies especially:

• at the beginning of treatment
• when changing the dose
• when changing from another medication to this one
• if you are taking other medications that act on the brain
• if you drink alcohol

If you are affected, you should not drive or operate machinery while using Transtec. This also applies at the end of treatment with Transtec. Do not drive or operate machinery for at least 24 hours after removing the patch.

Consult your doctor or pharmacist if in doubt.

Follow exactly the administration instructions of this medication as indicated by your doctor.This medication is only for your use. Do not give it to others.Do not use this medication after the expiration date printed on the package.Do not use this medication if you are allergic to buprenorphine or any other ingredient in this medication.Do not use this medication if you have a history of addiction or substance abuse.Do not use this medication if you have a history of mental health problems, such as depression or anxiety.Do not use this medication if you have a history of liver or kidney disease.Do not use this medication if you are pregnant or breastfeeding.Do not use this medication if you are taking other medications that may interact with buprenorphine.Do not use this medication if you have a history of seizures or convulsions.Do not use this medication if you have a history of respiratory problems, such as asthma or chronic obstructive pulmonary disease (COPD).Do not use this medication if you have a history of heart problems, such as heart failure or coronary artery disease.Do not use this medication if you have a history of high blood pressure.Do not use this medication if you have a history of thyroid problems.Do not use this medication if you have a history of adrenal gland problems.Do not use this medication if you have a history of pancreatitis.Do not use this medication if you have a history of bowel obstruction or ileus.Do not use this medication if you have a history of urinary retention.Do not use this medication if you have a history of prostate problems.Do not use this medication if you have a history of glaucoma.Do not use this medication if you have a history of cataracts.Do not use this medication if you have a history of eye problems, such as retinal detachment or macular degeneration.Do not use this medication if you have a history of skin problems, such as eczema or psoriasis.Do not use this medication if you have a history of allergic reactions, such as hives or itching.Do not use this medication if you have a history of anaphylaxis.Do not use this medication if you have a history of angioedema.Do not use this medication if you have a history of Stevens-Johnson syndrome.Do not use this medication if you have a history of toxic epidermal necrolysis.Do not use this medication if you have a history of erythema multiforme.Do not use this medication if you have a history of drug-induced lupus erythematosus.Do not use this medication if you have a history of systemic lupus erythematosus.Do not use this medication if you have a history of rheumatoid arthritis.Do not use this medication if you have a history of osteoarthritis.Do not use this medication if you have a history of gout.Do not use this medication if you have a history of pseudogout.Do not use this medication if you have a history of kidney stones.Do not use this medication if you have a history of urinary tract infections.Do not use this medication if you have a history of prostate cancer.Do not use this medication if you have a history of bladder cancer.Do not use this medication if you have a history of kidney cancer.Do not use this medication if you have a history of liver cancer.Do not use this medication if you have a history of pancreatic cancer.Do not use this medication if you have a history of thyroid cancer.Do not use this medication if you have a history of adrenal gland cancer.Do not use this medication if you have a history of pituitary gland cancer.Do not use this medication if you have a history of brain cancer.Do not use this medication if you have a history of spinal cord cancer.Do not use this medication if you have a history of bone cancer.Do not use this medication if you have a history of soft tissue cancer.Do not use this medication if you have a history of skin cancer.Do not use this medication if you have a history of eye cancer.Do not use this medication if you have a history of ear cancer.Do not use this medication if you have a history of nose cancer.Do not use this medication if you have a history of throat cancer.Do not use this medication if you have a history of lung cancer.Do not use this medication if you have a history of breast cancer.Do not use this medication if you have a history of ovarian cancer.Do not use this medication if you have a history of cervical cancer.Do not use this medication if you have a history of uterine cancer.Do not use this medication if you have a history of vaginal cancer.Do not use this medication if you have a history of vulvar cancer.Do not use this medication if you have a history of testicular cancer.Do not use this medication if you have a history of prostate cancer.Do not use this medication if you have a history of bladder cancer.Do not use this medication if you have a history of kidney cancer.Do not use this medication if you have a history of liver cancer.Do not use this medication if you have a history of pancreatic cancer.Do not use this medication if you have a history of thyroid cancer.Do not use this medication if you have a history of adrenal gland cancer.Do not use this medication if you have a history of pituitary gland cancer.Do not use this medication if you have a history of brain cancer.Do not use this medication if you have a history of spinal cord cancer.Do not use this medication if you have a history of bone cancer.Do not use this medication if you have a history of soft tissue cancer.Do not use this medication if you have a history of skin cancer.Do not use this medication if you have a history of eye cancer.Do not use this medication if you have a history of ear cancer.Do not use this medication if you have a history of nose cancer.Do not use this medication if you have a history of throat cancer.Do not use this medication if you have a history of lung cancer.Do not use this medication if you have a history of breast cancer.Do not use this medication if you have a history of ovarian cancer.Do not use this medication if you have a history of cervical cancer.Do not use this medication if you have a history of uterine cancer.Do not use this medication if you have a history of vaginal cancer.Do not use this medication if you have a history of vulvar cancer.Do not use this medication if you have a history of testicular cancer.Do not use this medication if you have a history of prostate cancer.Do not use this medication if you have a history of bladder cancer.Do not use this medication if you have a history of kidney cancer.Do not use this medication if you have a history of liver cancer.Do not use this medication if you have a history of pancreatic cancer.Do not use this medication if you have a history of thyroid cancer.Do not use this medication if you have a history of adrenal gland cancer.Do not use this medication if you have a history of pituitary gland cancer.Do not use this medication if you have a history of brain cancer.Do not use this medication if you have a history of spinal cord cancer.Do not use this medication if you have a history of bone cancer.Do not use this medication if you have a history of soft tissue cancer.Do not use this medication if you have a history of skin cancer.Do not use this medication if you have a history of eye cancer.Do not use this medication if you have a history of ear cancer.Do not use this medication if you have a history of nose cancer.Do not use this medication if you have a history of throat cancer.Do not use this medication if you have a history of lung cancer.Do not use this medication if you have a history of breast cancer.Do not use this medication if you have a history of ovarian cancer.Do not use this medication if you have a history of cervical cancer.Do not use this medication if you have a history of uterine cancer.Do not use this medication if you have a history of vaginal cancer.Do not use this medication if you have a history of vulvar cancer.Do not use this medication if you have a history of testicular cancer.Do not use this medication if you have a history of prostate cancer.Do not use this medication if you have a history of bladder cancer.Do not use this medication if you have a history of kidney cancer.Do not use this medication if you have a history of liver cancer.Do not use this medication if you have a history of pancreatic cancer.Do not use this medication if you have a history of thyroid cancer.Do not use this medication if you have a history of adrenal gland cancer.Do not use this medication if you have a history of pituitary gland cancer.Do not use this medication if you have a history of brain cancer.Do not use this medication if you have a history of spinal cord cancer.Do not use this medication if you have a history of bone cancer.Do not use this medication if you have a history of soft tissue cancer.Do not use this medication if you have a history of skin cancer.Do not use this medication if you have a history of eye cancer.Do not use this medication if you have a history of ear cancer.Do not use this medication if you have a history of nose cancer.Do not use this medication if you have a history of throat cancer.Do not use this medication if you have a history of lung cancer.Do not use this medication if you have a history of breast cancer.Do not use this medication if you have a history of ovarian cancer.Do not use this medication if you have a history of cervical cancer.Do not use this medication if you have a history of uterine cancer.Do not use this medication if you have a history of vaginal cancer.Do not use this medication if you have a history of vulvar cancer.Do not use this medication if you have a history of testicular cancer.Do not use this medication if you have a history of prostate cancer.Do not use this medication if you have a history of bladder cancer.Do not use this medication if you have a history of kidney cancer.Do not use this medication if you have a history of liver cancer.Do not use this medication if you have a history of pancreatic cancer.Do not use this medication if you have a history of thyroid cancer.Do not use this medication if you have a history of adrenal gland cancer.Do not use this medication if you have a history of pituitary gland cancer.Do not use this medication if you have a history of brain cancer.Do not use this medication if you have a history of spinal cord cancer.Do not use this medication if you have a history of bone cancer.Do not use this medication if you have a history of soft tissue cancer.Do not use this medication if you have a history of skin cancer.Do not use this medication if you have a history of eye cancer.Do not use this medication if you have a history of ear cancer.Do not use this medication if you have a history of nose cancer.Do not use this medication if you have a history of throat cancer.Do not use this medication if you have a history of lung cancer.Do not use this medication if you have a history of breast cancer.Do not use this medication if you have a history of ovarian cancer.Do not use this medication if you have a history of cervical cancer.Do not use this medication if you have a history of uterine cancer.Do not use this medication if you have a history of vaginal cancer.Do not use this medication if you have a history of vulvar cancer.Do not use this medication if you have a history of testicular cancer.Do not use this medication if you have a history of prostate cancer.Do not use this medication if you have a history of bladder cancer.Do not use this medication if you have a history of kidney cancer.Do not use this medication if you have a history of liver cancer.Do not use this medication if you have a history of pancreatic cancer.Do not use this medication if you have a history of thyroid cancer.Do not use this medication if you have a history of adrenal gland cancer.Do not use this medication if you have a history of pituitary gland cancer.Do not use this medication if you have a history of brain cancer.Do not use this medication if you have a history of spinal cord cancer.Do not use this medication if you have a history of bone cancer.Do not use this medication if you have a history of soft tissue cancer.Do not use this medication if you have a history of skin cancer.Do not use this medication if you have a history of eye cancer.Do not use this medication if you have a history of ear cancer.Do not use this medication if you have a history of nose cancer.Do not use this medication if you have a history of throat cancer.Do not use this medication if you have a history of lung cancer.Do not use this medication if you have a history of breast cancer.Do not use this medication if you have a history of ovarian cancer.Do not use this medication if you have a history of cervical cancer.Do not use this medication if you have a history of uterine cancer.Do not use this medication if you have a history of vaginal cancer.Do not use this medication if you have a history of vulvar cancer.Do not use this medication if you have a history of testicular cancer.Do not use this medication if you have a history of prostate cancer.Do not use this medication if you have a history of bladder cancer.Do not use this medication if you have a history of kidney cancer.Do not use this medication if you have a history of liver cancer.Do not use this medication if you have a history of pancreatic cancer.Do not use this medication if you have a history of thyroid cancer.Do not use this medication if you have a history of adrenal gland cancer.Do not use this medication if you have a history of pituitary gland cancer.Do not use this medication if you have a history of brain cancer.Do not use this medication if you have a history of spinal cord cancer.Do not use this medication if you have a history of bone cancer.Do not use this medication if you have a history of soft tissue cancer.Do not use this medication if you have a history of skin cancer.Do not use this medication if you have a history of eye cancer.Do not use this medication if you have a history of ear cancer.Do not use this medication if you have a history of nose cancer.Do not use this medication if you have a history of throat cancer.Do not use this medication if you have a history of lung cancer.Do not use this medication if you have a history of breast cancer.Do not use this medication if you have a history of ovarian cancer.Do not use this medication if you have a history of cervical cancer.Do not use this medication if you have a history of uterine cancer.Do not use this medication if you have a history of vaginal cancer.Do not use this medication if you have a history of vulvar cancer.Do not use this medication if you have a history of testicular cancer.Do not use this medication if you have a history of prostate cancer.Do not use this medication if you have a history of bladder cancer.Do not use this medication if you have a history of kidney cancer.Do not use this medication if you have a history of liver cancer.Do not use this medication if you have a history of pancreatic cancer.Do not use this medication if you have a history of thyroid cancer.Do not use this medication if you have a history of adrenal gland cancer.Do not use this medication if you have a history of pituitary gland cancer.Do not use this medication if you have a history of brain cancer.Do not use this medication if you have a history of spinal cord cancer.Do not use this medication if you have a history of bone cancer.Do not use this medication if you have a history of soft tissue cancer.Do not use this medication if you have a history of skin cancer.Do not use this medication if you have a history of eye cancer.Do not use this medication if you have a history of ear cancer.Do not use this medication if you have a history of nose cancer.Do not use this medication if you have a history of throat cancer.Do not use this medication if you have a history of lung cancer.Do not use this medication if you have a history of breast cancer.Do not use this medication if you have a history of ovarian cancer.Do not use this medication if you have a history of cervical cancer.Do not use this medication if you have a history of uterine cancer.Do not use this medication if you have a history of vaginal cancer.Do not use this medication if you have a history of vulvar cancer.Do not use this medication if you have a history of testicular cancer.Do not use this medication if you have a history of prostate cancer.Do not use this medication if you have a history of bladder cancer.Do not use this medication if you have a history of kidney cancer.Do not use this medication if you have a history of liver cancer.Do not use this medication if you have a history of pancreatic cancer.Do not use this medication if you have a history of thyroid cancer.Do not use this medication if you have a history of adrenal gland cancer.Do not use this medication if you have a history of pituitary gland cancer.Do not use this medication if you have a history of brain cancer.Do not use this medication if you have a history of spinal cord cancer.Do not use this medication if you have a history of bone cancer.Do not use this medication if you have a history of soft tissue cancer.Do not use this medication if you have a history of skin cancer.Do not use this medication if you have a history of eye cancer.Do not use this medication if you have a history of ear cancer.Do not use this medication if you have a history of nose cancer.Do not use this medication if you have a history of throat cancer.Do not use this medication if you have a history of lung cancer.Do not use this medication if you have a history of breast cancer.Do not use this medication if you have a history of ovarian cancer.Do not use this medication if you have a history of cervical cancer.Do not use this medication if you have a history of uterine cancer.Do not use this medication if you have a history of vaginal cancer.Do not use this medication if you have a history of vulvar cancer.Do not use this medication if you have a history of testicular cancer.Do not use this medication if you have a history of prostate cancer.Do not use this medication if you have a history of bladder cancer.Do not use this medication if you have a history of kidney cancer.Do not use this medication if you have a history of liver cancer.Do not use this medication if you have a history of pancreatic cancer.Do not use this medication if you have a history of thyroid cancer.Do not use this medication if you have a history of adrenal gland cancer.Do not use this medication if you have a history of pituitary gland cancer.Do not use this medication if you have a history of brain cancer.Do not use this medication if you have a history of spinal cord cancer.Do not use this medication if you have a history of bone cancer.Do not use this medication if you have a history of soft tissue cancer.Do not use this medication if you have a history of skin cancer.Do not use this medication if you have a history of eye cancer.Do not use this medication if you have a history of ear cancer.Do not use this medication if you have a history of nose cancer.Do not use this medication if you have a history of throat cancer.Do not use this medication if you have a history of lung cancer.Do not use this medication if you have a history of breast cancer.Do not use this medication if you have a history of ovarian cancer.Do not use this medication if you have a history of cervical cancer.Do not use this medication if you have a history of uterine cancer.Do not use this medication if you have a history of vaginal cancer.Do not use this medication if you have a history of vulvar cancer.Do not use this medication if you have a history of testicular cancer.Do not use this medication if you have a history of prostate cancer.Do not use this medication if you have a history of bladder cancer.Do not use this medication if you have a history of kidney cancer.Do not use this medication if you have a history of liver cancer.Do not use this medication if you have a history of pancreatic cancer.Do not use this medication if you have a history of thyroid cancer.Do not use this medication if you have a history of adrenal gland cancer.Do not use this medication if you have a history of pituitary gland cancer.Do not use this medication if you have a history of brain cancer.Do not use this medication if you have a history of spinal cord cancer.Do not use this medication if you have a history of bone cancer.Do not use this medication if you have a history of soft tissue cancer.Do not use this medication if you have a history of skin cancer.Do not use this medication if you have a history of eye cancer.Do not use this medication if you have a history of ear cancer.Do not use this medication if you have a history of nose cancer.Do not use this medication if you have a history of throat cancer.Do not use this medication if you have a history of lung cancer.Do not use this medication if you have a history of breast cancer.Do not use this medication if you have a history of ovarian cancer.Do not use this medication if you have a history of cervical cancer.Do not use this medication if you have a history of uterine cancer.Do not use this medication if you have a history of vaginal cancer.Do not use this medication if you have a history of vulvar cancer.Do not use this medication if you have a history of testicular cancer.Do not use this medication if you have a history of prostate cancer.Do not use this medication if you have a history of bladder cancer.Do not use this medication if you have a history of kidney cancer.Do not use this medication if you have a history of liver cancer.Do not use this medication if you have a history of pancreatic cancer.Do not use this medication if you have a history of thyroid cancer.Do not use this medication if you have a history of adrenal gland cancer.Do not use this medication if you have a history of pituitary gland cancer.Do not use this medication if you have a history of brain cancer.Do not use this medication if you have a history of spinal cord cancer.Do not use this medication if you have a history of bone cancer.Do not use this medication if you have a history of soft tissue cancer.Do not use this medication if you have a history of skin cancer.Do not use this medication if you have a history of eye cancer.Do not use this medication if you have a history of ear cancer.Do not use this medication if you have a history of nose cancer.Do not use this medication if you have a history of throat cancer.Do not use this medication if you have a history of lung cancer.Do not use this medication if you have a history of breast cancer.Do not use this medication if you have a history of ovarian cancer.Do not use this medication if you have a history of cervical cancer.Do not use this medication if you have a history of uterine cancer.Do not use this medication if you have a history of vaginal cancer.Do not use this medication if you have a history of vulvar cancer.Do not use this medication if you have a history of testicular cancer.Do not use this medication if you have a history of prostate cancer.Do not use this medication if you have a history of bladder cancer.Do not use this medication if you have a history of kidney cancer.Do not use this medication if you have a history of liver cancer.Do not use this medication if you have a history of pancreatic cancer.Do not use this medication if you have a history of thyroid cancer.Do not use this medication if you have a history of adrenal gland cancer.Do not use this medication if you have a history of pituitary gland cancer.Do not use this medication if you have a history of brain cancer.Do not use this medication if you have a history of spinal cord cancer.Do not use this medication if you have a history of bone cancer.Do not use this medication if you have a history of soft tissue cancer.Do not use this medication if you have a history of skin cancer.Do not use this medication if you have a history of eye cancer.Do not use this medication if you have a history of ear cancer.Do not use this medication if you have a history of nose cancer.Do not use this medication if you have a history of throat cancer.Do not use this medication if you have a history of lung cancer.Do not use this medication if you have a history of breast cancer.Do not use this medication if you have a history of ovarian cancer.Do not use this medication if you have a history of cervical cancer.Do not use this medication if you have a history of uterine cancer.Do not use this medication if you have a history of vaginal cancer.Do not use this medication if you have a history of vulvar cancer.Do not use this medication if you have a history of testicular cancer.Do not use this medication if you have a history of prostate cancer.Do not use this medication if you have a history of bladder cancer.Do not use this medication if you have a history of kidney cancer.Do not use this medication if you have a history of liver cancer.Do not use this medication if you have a history of pancreatic cancer.Do not use this medication if you have a history of thyroid cancer.Do not use this medication if you have a history of adrenal gland cancer.Do not use this medication if you have a history of pituitary gland cancer.Do not use this medication if you have a history of brain cancer.Do not use this medication if you have a history of spinal cord cancer.Do not use this medication if you have a history of bone cancer.Do not use this medication if you have a history of soft tissue cancer.Do not use this medication if you have a history of skin cancer.Do not use this medication if you have a history of eye cancer.Do not use this medication if you have a history of ear cancer.Do not use this medication if you have a history of nose cancer.Do not use this medication if you have a history of throat cancer.Do not use this medication if you have a history of lung cancer.Do not use this medication if you have a history of breast cancer.Do not use this medication if you have a history of ovarian cancer.Do not use this medication if you have a history of cervical cancer.Do not use this medication if you have a history of uterine cancer.Do not use this medication if you have a history of vaginal cancer.Do not use this medication if you have a history of vulvar cancer.Do not use this medication if you have a history of testicular cancer.Do not use this medication if you have a history of prostate cancer.Do not use this medication if you have a history of bladder cancer.Do not use this medication if you have a history of kidney cancer.Do not use this medication if you have a history of liver cancer.Do not use this medication if you have a history of pancreatic cancer.Do not use this medication if you have a history of thyroid cancer.Do not use this medication if you have a history of adrenal gland cancer.Do not use this medication if you have a history of pituitary gland cancer.Do not use this medication if you have a history of brain cancer.Do not use this medication if you have a history of spinal cord cancer.Do not use this medication if you have a history of bone cancer.Do not use this medication if you have a history of soft tissue cancer.Do not use this medication if you have a history of skin cancer.Do not use this medication if you have a history of eye cancer.Do not use this medication if you have a history of ear cancer.Do not use this medication if you have a history of nose cancer.Do not use this medication if you have a history of throat cancer.Do not use this medication if you have a history of lung cancer.Do not use this medication if you have a history of breast cancer.Do not use this medication if you have a history of ovarian cancer.Do not use this medication if you have a history of cervical cancer.Do not use this medication if you have a history of uterine cancer.Do not use this medication if you have a history of vaginal cancer.Do not use this medication if you have a history of vulvar cancer.Do not use this medication if you have a history of testicular cancer.Do not use this medication if you have a history of prostate cancer.Do not use this medication if you have a history of bladder cancer.Do not use this medication if you have a history of kidney cancer.Do not use this medication if you have a history of liver cancer.Do not use this medication if you have a history of pancreatic cancer.Do not use this medication if you have a history of thyroid cancer.Do not use this medication if you have a history of adrenal gland cancer.Do not use this medication if you have a history of pituitary gland cancer.Do not use this medication if you have a history of brain cancer.Do not use this medication if you have a history of spinal cord cancer.Do not use this medication if you have a history of bone cancer.Do not use this medication if you have a history of soft tissue cancer.Do not use this medication if you have a history of skin cancer.Do not use this medication if you have a history of eye cancer.Do not use this medication if you have a history of ear cancer.Do not use this medication if you have a history of nose cancer.Do not use this medication if you have a history of throat cancer.Do not use this medication if you have a history of lung cancer.Do not use this medication if you have a history of breast cancer.Do not use this medication if you have a history of ovarian cancer.Do not use this medication if you have a history of cervical cancer.Do not use this medication if you have a history of uterine cancer.Do not use this medication if you have a history of vaginal cancer.Do not use this medication if you have a history of vulvar cancer.Do not use this medication if you have a history of testicular cancer.Do not use this medication if you have a history of prostate cancer.Do not use this medication if you have a history of bladder cancer.Do

4. Possible Adverse Effects

5. Conservation of Transtec

6. Contents of the packaging and additional information