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IRUXOL NEO OINTMENT

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Talk to a doctor about this medicine

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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use IRUXOL NEO OINTMENT

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

Iruxol Neo Ointment

Read the entire package leaflet carefully before starting to use the medicine

  • Keep this package leaflet, as you may need to read it again.
  • If you have any doubts, consult your doctor or pharmacist.
  • This medicine has been prescribed to you and should not be given to others, even if they have the same symptoms, as it may harm them.
  • If you consider that any of the side effects you are suffering from is serious or if you notice any side effect not mentioned in this package leaflet, inform your doctor or pharmacist.

Contents of the Package Leaflet

  1. What is Iruxol Neo and what is it used for
  2. Before using Iruxol Neo
  3. How to use Iruxol Neo
  4. Possible side effects
  5. Storage of Iruxol Neo
  6. Additional information

1. What is Iruxol Neo and what is it used for

The active ingredients are proteolytic enzymes that act on components of ulcers and skin wounds, and an aminoglycoside antibiotic. It is indicated in adults for the debridement (cleaning and removal) of necrotic tissue in small skin ulcers of various origins and reduction of the number of superficial bacteria.

Doctor consultation

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Discuss your symptoms and treatment with a doctor online.

2. Before using Iruxol Neo

Do not use Iruxol Neo

-If you are allergic (hypersensitive) to the active ingredients, to other aminoglycoside antibiotics, or to any of the other components of this medicine.

Be careful with Iruxol Neo

-Iruxol Neo should not be used on large areas, as neomycin could be absorbed through the skin and have adverse effects on other parts of the body. This is more likely if you have kidney disease or are being treated with an aminoglycoside antibiotic orally or by another route (e.g., amikacin, tobramycin, or gentamicin).

-If you notice that you have an infection in the lesion or that superinfections by resistant microorganisms may have occurred, consult your doctor, who will apply the appropriate treatment. There are antibiotics that cannot be used with this medicine in the same area (see section Use of other medicines).

-If you use some soaps or antiseptics with the ointment, they may eliminate the effect of this medicine (see section Use of other medicines).

-You should avoid contact between the ointment and the eyes or mucous membranes (e.g., the genital area).

-If you are weakened, caution is required, and you should consult your doctor due to the risk of spreading an infection.

-In children, this medicine should not be used, as its safety and efficacy have not been established in them.

Use of other medicines

Inform your doctor or pharmacist if you are using or have recently used other medicines, including those purchased without a prescription.

  • Aminoglycoside antibiotics (e.g., amikacin, tobramycin, or gentamicin): if you are being treated with an antibiotic of this type, orally or by another route, it may increase the risk of adverse reactions in other areas of the body.

-The following products should not be used in conjunction with Iruxol Neo because they may reduce or suppress its activity:

-Locally applied antibiotics such as tyrothricin, gramicidin, and tetracyclines

-Detergents, soaps, acidic solutions, or antiseptics such as hexachlorophene or those containing heavy metals (e.g., mercurochrome).

-Other enzymatic preparations.

-However, the following products can be used in conjunction with Iruxol Neo: - Antibiotics such as neomycin, bacitracin, polymyxin B, and framicetin.

Pregnancy and breastfeeding

Consult your doctor or pharmacist before using any medicine.

To avoid any risk to the child, you should not use Iruxol Neo if you are pregnant or breastfeeding, unless your doctor indicates it, weighing the benefits against the possible risks.

Driving and using machines

No effects of Iruxol Neo on driving or using machines have been described.

3. How to use Iruxol Neo

Follow your doctor's instructions for administering Iruxol Neo exactly. Consult your doctor or pharmacist if you have doubts.

Topical use.

To pierce the sealed tube, press using the back of the cap. The normal dose is:

Adults

Apply a layer of ointment approximately 2 mm thick, once a day, directly to the area to be treated, lightly moistened with hydrogel or physiological serum. It can also be applied to a sterile gauze or dressing placed over the wound. Occasionally, it may be necessary to apply the ointment twice a day.

Strict aseptic conditions (cleanliness) must be maintained. Before each application, the lesion should be gently cleaned with a gauze impregnated with physiological serum or another cleaning solution compatible with the ointment to remove necrotic tissue.

In general, the medicine should not be used for more than one week, unless the doctor decides to extend it longer. If a reduction in necrotic tissue is not observed after 14 days from the start of treatment, you should inform your doctor, who will interrupt and replace it with another.

Use in children

The safety and efficacy of Iruxol Neo have not been established in children, so it should not be used in this age group.

If you use more Iruxol Neo than you should

If you use more Iruxol Neo than recommended, on large areas of eroded skin (e.g., in ulcers) or for prolonged periods, neomycin could be absorbed in sufficient quantities to produce adverse effects such as hearing loss, kidney damage, and muscle relaxation (neuromuscular blockade). Rarely, severe cases of dermatitis have occurred due to the local use of neomycin, one of the active ingredients of this medicine. In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or go to a medical center, or call the Toxicology Information Service, phone: 91 562 04 20, indicating the medicine and the amount ingested.

If you forget to use Iruxol Neo

Do not use more ointment to make up for forgotten doses. If you have forgotten a dose, apply it as soon as possible and continue with your regular schedule.

If you interrupt treatment with Iruxol Neo

Do not interrupt treatment before your doctor indicates it, or the desired results will not be achieved.

If you have any other doubts about using this product, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, Iruxol Neo can cause side effects, although not everyone gets them.

The assessment of side effects is based on the following frequencies:

Very common: may affect more than 1 in 10 people.

Common: may affect between 1 and 10 in 100 people.

Side effects such as pain, itching, irritation, inflammation, or redness of the skin have been observed, which usually do not require interruption of treatment.

Frequent hypersensitivity reactions to neomycin have been observed, especially if used for prolonged periods, including: inflammation, burning, rash, appearance of hives (urticaria); rarely, anaphylactic reactions (exaggerated allergic reaction) may occur.

For the case of excessive use of the medicine, see section If you use more Iruxol Neo than you should.

If you consider that any of the side effects you are suffering from is serious or if you notice any side effect not mentioned in this package leaflet, inform your doctor or pharmacist.

Reporting side effects:

If you experience any type of side effect, consult your doctor or pharmacist, even if it is a possible side effect not listed in this package leaflet. You can also report them directly through the Spanish Medicines and Health Products Agency (AEMPS) website: https://www.notificaram.es. By reporting side effects, you can contribute to providing more information on the safety of this medicine.

5. Storage of Iruxol Neo

Keep out of the reach and sight of children.

Do not use Iruxol Neo after the expiration date stated on the packaging after CAD. The expiration date is the last day of the month indicated.

Do not store above 25°C.

Medicines should not be disposed of through wastewater or household waste. Ask your pharmacist how to dispose of the packaging and medicines you no longer need. This will help protect the environment.

6. Additional information

Composition of Iruxol Neo ointment

  • The active ingredients are: Clostridiopeptidase A (Collagenase) 0.6 UI/g and Neomycin (as sulfate) 3.5 mg/g.
  • The other components are: liquid paraffin and white vaseline.

Appearance of the product and packaging contents

Iruxol Neo is presented as a white or slightly brown ointment. Each package contains 15 or 30 g of ointment in an aluminum tube.

Marketing authorization holder

Smith & Nephew GmbH

Friesenweg 30, 22763 Hamburg, Germany.

Manufacturer

Nordmark Pharma GmbH

Pinnauallee 4, 25436 Uetersen, Germany.

You can request more information about this medicine by contacting the local representative of the marketing authorization holder:

Local representative

Smith & Nephew, S.A.U

Fructuós Gelabert, 2-4

08970 Sant Joan Despí Barcelona, Spain

Tel: +34 93 373 7301

Fax: +34 93 373 7453

This package leaflet was approved in April 2018.

Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.es/

Online doctors for IRUXOL NEO OINTMENT

Discuss questions about IRUXOL NEO OINTMENT, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

5.0 (808)
Doctor

Alina Tsurkan

Family medicine 13 years exp.

Dr. Alina Tsurkan is a licensed family medicine physician based in Portugal, offering online consultations for adults and children. She provides professional primary care, with a focus on prevention, accurate diagnosis, and long-term management of acute and chronic conditions.

Dr. Tsurkan supports patients with a wide range of health issues, including:

  • Respiratory infections: cold, flu, bronchitis, pneumonia, and lingering coughs.
  • ENT conditions: sinusitis, tonsillitis, otitis (ear infections), sore throat, allergic rhinitis.
  • Eye conditions: allergic or infectious conjunctivitis, red eyes, irritation.
  • Digestive issues: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), constipation, bloating, nausea.
  • Urinary and reproductive health: urinary tract infections (UTIs), cystitis, prevention of recurrent infections.
  • Chronic diseases: hypertension, elevated cholesterol, weight management.
  • Neurological complaints: headaches, migraines, sleep disturbances, fatigue, general weakness.
  • Children’s health: fever, infections, digestive issues, follow-ups, vaccination guidance.

She also provides:

  • IMT medical certificates for driving licence exchange in Portugal.
  • Personalised preventive care and wellness consultations.
  • Interpretation of test results and medical reports.
  • Follow-up care and medication review.
  • Support in managing multiple coexisting conditions.
  • Remote prescription management and medical documentation.

Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

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€55
0.0 (0)
Doctor

Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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€58
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Doctor

Daniel Cichi

Family medicine 24 years exp.

Dr Daniel Cichi is a family medicine doctor with over 20 years of clinical experience. He provides online consultations for adults, supporting patients with acute symptoms, chronic conditions, and everyday health concerns that require timely medical guidance. His background includes work in emergency care, ambulance services, and family medicine, which allows him to assess symptoms quickly, identify warning signs, and help patients choose the safest next steps – whether that means home care, treatment adjustment, or in-person evaluation. Patients commonly consult Dr Daniel Cichi for: 

  • acute symptoms: fever, infections, flu-like illness, cough, sore throat, shortness of breath;
  • chest discomfort, palpitations, dizziness, fatigue, and blood pressure concerns;
  • digestive problems: abdominal pain, nausea, diarrhoea, constipation, reflux;
  • sexually transmitted infections, erectile dysfunction;
  • muscle, joint, and back pain, minor injuries, post-traumatic symptoms;
  • chronic conditions: hypertension, diabetes, high cholesterol, thyroid disorders, weight loss, hair loss;
  • review and interpretation of lab tests, imaging reports, and medical documents;
  • medication review and treatment adjustment;
  • medical advice while travelling or living abroad;
  • second opinions and guidance on whether in-person care is needed.

Dr Cichi’s consultations are structured and practical. He focuses on clear explanations, risk assessment, and actionable recommendations, helping patients understand their symptoms and make informed decisions about their health.

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€55
5.0 (32)
Doctor

Dmytro Horobets

Family medicine 7 years exp.

Dr. Dmytro Horobets is a licensed family medicine physician in Poland, specialising in endocrinology, diabetology, obesity management, gastroenterology, pediatrics, general surgery, and pain medicine. He offers online consultations for adults and children, providing personalised medical support for a wide range of acute and chronic health concerns.

Areas of expertise:

  • Endocrinology: diabetes type 1 and type 2, prediabetes, thyroid disorders, metabolic syndrome, hormonal imbalance.
  • Obesity medicine: structured weight management plans, nutritional counselling, obesity-related health risks.
  • Gastroenterology: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), liver and biliary conditions.
  • Pediatric care: infections, respiratory symptoms, digestive issues, growth and development monitoring.
  • General surgery support: pre- and post-surgical consultations, wound care, rehabilitation.
  • Pain management: chronic and acute pain, back pain, joint pain, post-traumatic pain syndromes.
  • Cardiovascular health: hypertension, cholesterol control, risk assessment for heart disease.
  • Preventive medicine: regular check-ups, health screenings, long-term management of chronic conditions.

Dr. Horobets combines evidence-based medicine with a patient-centred approach. He carefully evaluates each patient’s medical history and symptoms, offering clear explanations and structured treatment plans adapted to individual needs.

Whether you need help managing diabetes, tackling weight-related health issues, interpreting lab results, or receiving general family medicine support, Dr. Horobets provides professional online care tailored to your specific health goals.

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€60

Frequently Asked Questions

Is a prescription required for IRUXOL NEO OINTMENT?
IRUXOL NEO OINTMENT requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in IRUXOL NEO OINTMENT?
The active ingredient in IRUXOL NEO OINTMENT is collagenase, combinations. This information helps identify medicines with the same composition but different brand names.
Who manufactures IRUXOL NEO OINTMENT?
IRUXOL NEO OINTMENT is manufactured by Smith & Nephew Gmbh. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of IRUXOL NEO OINTMENT online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether IRUXOL NEO OINTMENT is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to IRUXOL NEO OINTMENT?
Other medicines with the same active substance (collagenase, combinations) include IRUXOL MONO OINTMENT, NEXOBRID 2 g powder and gel for gel, NEXOBRID 5 g powder and gel for gel. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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