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PRODERMA 200 mg HARD CAPSULES

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About the medicine

How to use PRODERMA 200 mg HARD CAPSULES

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

Proderma 200 mg Hard Capsules

Doxycycline

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet.

Contents of the pack

  1. What Proderma 200 mg Hard Capsules is and what it is used for
  2. What you need to know before you take Proderma 200 mg Hard Capsules
  3. How to take Proderma 200 mg Hard Capsules
  4. Possible side effects
  5. Storage of Proderma 200 mg Hard Capsules
  6. Contents of the pack and other information

1. What Proderma 200 mg Hard Capsules is and what it is used for

Doxycycline belongs to a group of medicines called tetracyclines, which are broad-spectrum antibiotics, active against multiple microorganisms.

Text on a white background explaining the use of antibiotics and the importance of following medical instructionsDoxycycline is indicated primarily in infections of the skin and soft tissues, respiratory tract infections, and genitourinary infections, such as:

  • Atypical pneumonia.
  • Psittacosis (disease transmitted to humans by certain birds that occurs as pneumonia accompanied by fever and cough).
  • Typhus and other infections caused by microorganisms called rickettsias.
  • Sexually transmitted diseases.
  • Brucellosis (Malta fever).
  • Cholera.
  • Early stages of Lyme disease (disease transmitted by ticks).
  • Fever transmitted by lice and ticks.
  • Malaria.
  • Severe acne vulgaris.
Doctor consultation

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2. What you need to know before you take Proderma 200 mg Hard Capsules

Do not take Proderma 200 mg Hard Capsules

If you are allergic to doxycycline, tetracyclines, or any of the other components of Proderma 200 mg (listed in section 6).

Warnings and precautions

Consult your doctor or pharmacist before starting to take Proderma 200 mg.

Children

Proderma 200 mg should not be administered during the dentition period (second half of pregnancy, lactation, and children under 8 years), as it may cause permanent tooth discoloration, as well as delayed bone development.

General

  • Bulging of the fontanelles (unossified space in the skull) has been reported in children and intracranial hypertension (increased pressure of the cerebrospinal fluid in the brain) in both children and adults (see section 4. Possible side effects).
  • If you experience diarrhea while receiving treatment with doxycycline, consult your doctor.
  • If you take this medication while lying down, or without sufficient water, ulcers may appear in the digestive system, so it is essential to follow the administration instructions (see section 3. How to take Proderma 200 mg Hard Capsules and section 4. Possible side effects).
  • If you have liver or kidney disease, consult your doctor.
  • In prolonged treatments, the doctor will perform checks on renal and hepatic function.
  • If you have systemic lupus erythematosus, you should avoid using this medication.
  • In case of direct exposure to the sun, skin redness may occur; if this happens, you should consult your doctor.
  • If you suffer from myasthenia gravis (a form of muscle weakness), consult your doctor before taking this medication.
  • If you are going to have any urine tests, you should inform the healthcare staff that you are being treated with this medication, as doxycycline may interfere with the results.

Using Proderma 200 mg Hard Capsules with other medicines

Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including those obtained without a prescription.

Like all medicines, Proderma 200 mg can interact with some medicines, such as:

  • Aluminum, calcium, and magnesium antacids, as they decrease the absorption of Proderma 200 mg.
  • Antibiotics, as they may decrease the effectiveness of Proderma 200 mg.
  • Methoxyflurane, along with tetracyclines and Proderma 200 mg, may produce kidney toxicity, which can be severe.
  • Anticoagulants (such as warfarin), as Proderma 200 mg may alter the effect of these anticoagulants, so you should consult your doctor.
  • Medicines for the treatment of epilepsy, such as carbamazepine and phenytoin.
  • Oral contraceptives and barbiturates, as Proderma 200 mg may decrease their effectiveness.
  • Chronic alcohol consumption may decrease the effectiveness of Proderma 200 mg.

In case of doubt, consult your doctor or pharmacist.

Taking Proderma 200 mg Hard Capsules with food and drinks:

  • During treatment with doxycycline, alcohol consumption should be avoided.
  • Proderma 200 mg should be administered with food or water to avoid esophageal irritation (see section 3. How to take Proderma 200 mg Hard Capsules and section 4. Possible side effects).

Pregnancy and lactation

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medicine.

Breastfeeding

You should avoid taking this medication during breastfeeding.

Driving and using machines

There is no evidence that Proderma 200 mg alters the ability to drive or use machines.

Proderma 200 mg Hard Capsules contains sucrose.If your doctor has told you that you have an intolerance to certain sugars, consult with them before taking this medicine.

3. How to take Proderma 200 mg Hard Capsules

Follow the administration instructions of Proderma 200 mg exactly as indicated by your doctor. In case of doubt, consult your doctor or pharmacist again.

Remember to take your medicine.

Consult your doctor or pharmacist if you think the effect of doxycycline is too strong or too weak.

IMPORTANT:

This medication should be taken during a meal, accompanied by a large glass of water.

It is essential that, after taking the medication, you wait at least one hour before lying down or going to bed to sleep.

The above recommendations are intended to prevent the appearance of digestive problems, especially stomach ulcers.

Your doctor will indicate the duration of treatment with Proderma 200 mg. Do not stop treatment early, even if you have started to improve.

Adults:the usual dose of doxycycline is 200 mg in one or two doses on the first day of treatment, followed by a maintenance dose of 100 mg/day. For the treatment of more severe infections, 200 mg/day should be administered throughout the treatment period. In general, treatment should continue until at least 24 to 48 hours after the disappearance of symptoms and fever.

Children over 8 years old:children over 8 years old who weigh 45 kg or less, the usual dose is 4 mg/kg body weight on the first day of treatment, administered in a single dose or in two equal doses every 12 hours. In severe infections: 4 mg/kg body weight every 24 hours, maintaining the same dose throughout treatment. Treatment should continue for 24 to 48 hours after symptoms have disappeared.

If you take more Proderma 200 mg Hard Capsules than you should

If you have taken more capsules than you should, consult your doctor or pharmacist immediately.

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or call the Toxicology Information Service. Phone (91) 562 04 20, indicating the medication and the amount ingested.

If you forget to take Proderma 200 mg Hard Capsules

If you forget to take a dose, take the next one when it is due. Do not take a double dose to make up for the forgotten dose.

Medicine questions

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Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, Proderma 200 mg can cause side effects, although not everybody gets them.

The following side effects have been detected after taking Proderma 200 mg:

Blood and lymphatic system disorders:blood disorders after administration of tetracyclines are very rare. However, cases of hemolytic anemia (consequence of high destruction of red blood cells), thrombocytopenia (decrease in the number of platelets), neutropenia (decrease in the number of neutrophils), and eosinophilia (increase in the number of eosinophils) have been reported.

Nervous system disorders:infrequently, intracranial hypertension characterized by headache, nausea, vomiting, dizziness, tinnitus, and visual disturbances occurs. These symptoms resolve after withdrawal of the drug. Bulging of the fontanelles in children has also been reported.

Gastrointestinal disorders:it is possible to experience digestive alterations such as esophageal ulcers (see section 3. How to take Proderma 200 mg Hard Capsules), nausea, stomach pain, diarrhea, loss of appetite, tongue inflammation, intestinal inflammation, and anogenital candidiasis (infection by a microscopic fungus).

Permanent tooth discoloration may also occur if doxycycline is used during dental development (second half of pregnancy, lactation, and children under 8 years).

Liver disorders:treatment with high doses may produce hepatitis and liver function disorders.

Skin and subcutaneous tissue disorders:urticaria, maculopapular rash (spots and small elevations of the skin), exudative erythema (redness and spots on the skin), multiform eruptions (redness and swelling of the skin), photosensitivity skin reactions, exceptionally exfoliative dermatitis (inflammation and peeling of the skin), and rarely Stevens-Johnson syndrome.

Frequency not known: photoonycholysis (nail pigmentation).

Musculoskeletal and connective tissue disorders:joint pain and muscle pain may occur, as well as delayed growth in children.

Kidney disorders:like all tetracyclines, doxycycline may produce elevated blood urea nitrogen.

General disorders:occasionally, severe hypersensitivity reactions (allergies) may occur, exceptionally urticaria, angioedema (fluid retention in the vessels), hypotension (decrease in blood pressure), pericarditis (inflammation of the tissue surrounding the heart), worsening of systemic lupus erythematosus, angioedema, serum sickness (allergic reaction to serum), and very rarely anaphylactic shock (unusual or exaggerated allergic reaction).

Jarisch-Herxheimer reaction: which occurs with fever, chills, headache, muscle pain, and skin rash, and usually resolves spontaneously. It occurs shortly after starting treatment with doxycycline for spirochetal infections, such as Lyme disease.

If you think any of the side effects you are experiencing is serious, or if you notice any side effect not mentioned in this leaflet, tell your doctor or pharmacist.

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist, even if they are not listed in this leaflet. You can also report them directly through the Spanish Medicines and Healthcare Products Agency Website: www.notificaRAM.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Proderma 200 mg Hard Capsules

Keep out of the sight and reach of children.

No special storage conditions are required.

Do not use this medicine after the expiry date stated on the carton after EXP. The expiry date is the last day of the month indicated.

Medicines should not be disposed of via wastewater or household waste. Place the empty packaging and any unused medication in the SIGRE collection point at your pharmacy. If you have any doubts, ask your pharmacist how to dispose of the packaging and any unused medication. This will help protect the environment.

6. Contents of the pack and other information

Composition of Proderma 200 mg Hard Capsules

  • The active ingredient is doxycycline. Each capsule contains 200 mg of doxycycline (as hyclate).
  • The other ingredients (excipients) are: sucrose, cornstarch, crospovidone, polyaminomethacrylate (Eudragit E100), talc, gelatin, carmine indigo (E132), erythrosine (E127), and titanium dioxide (E171).

Appearance of the product and contents of the pack

Proderma 200 mg is presented in packs of 42 capsules.

Other presentations:

Proderma 50 mg Hard Capsules

Proderma 100 mg Hard Capsules

Marketing authorization holder

INDUSTRIAL FARMACÉUTICA CANTABRIA, S.A.

Carretera de Cazoña-Adarzo, s/n.

39011, Santander

Manufacturer

INDUSTRIAL FARMACÉUTICA CANTABRIA, S.A.

C/ Pirita, 9 28850 Torrejón de Ardoz (Madrid)

Spain

or

TOLL MANUFACTURING SERVICES, S.L.

Aragoneses 2,

28108 Alcobendas

Spain

This leaflet was approved in June 2022.

Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Healthcare Products (AEMPS) http://www.aemps.gob.es/

Online doctors for PRODERMA 200 mg HARD CAPSULES

Discuss questions about PRODERMA 200 mg HARD CAPSULES, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Doctor

Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
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  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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Doctor

Tomasz Grzelewski

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques.

For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance.

Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults.

In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions.

Patients commonly seek his care for:

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
  • urticaria, atopic dermatitis and skin reactions
  • recurrent infections in children
  • sports-related health questions
  • general family medicine concerns
Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.
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Doctor

Lina Travkina

Family medicine 13 years exp.

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
  • Medical advice and follow-up consultations.
  • Test interpretation and diagnostic guidance.
  • Structured support for undiagnosed complaints.
  • Second opinion on diagnoses and treatment plans.
  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
  • Post-operative recovery support and pain management.
  • Preconception counselling and postpartum support.
  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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€70
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Doctor

Alina Tsurkan

Family medicine 13 years exp.

Dr. Alina Tsurkan is a licensed family medicine physician based in Portugal, offering online consultations for adults and children. She provides professional primary care, with a focus on prevention, accurate diagnosis, and long-term management of acute and chronic conditions.

Dr. Tsurkan supports patients with a wide range of health issues, including:

  • Respiratory infections: cold, flu, bronchitis, pneumonia, and lingering coughs.
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  • Eye conditions: allergic or infectious conjunctivitis, red eyes, irritation.
  • Digestive issues: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), constipation, bloating, nausea.
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  • Chronic diseases: hypertension, elevated cholesterol, weight management.
  • Neurological complaints: headaches, migraines, sleep disturbances, fatigue, general weakness.
  • Children’s health: fever, infections, digestive issues, follow-ups, vaccination guidance.

She also provides:

  • IMT medical certificates for driving licence exchange in Portugal.
  • Personalised preventive care and wellness consultations.
  • Interpretation of test results and medical reports.
  • Follow-up care and medication review.
  • Support in managing multiple coexisting conditions.
  • Remote prescription management and medical documentation.

Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

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€55
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Doctor

Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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€50

Frequently Asked Questions

Is a prescription required for PRODERMA 200 mg HARD CAPSULES?
PRODERMA 200 mg HARD CAPSULES requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in PRODERMA 200 mg HARD CAPSULES?
The active ingredient in PRODERMA 200 mg HARD CAPSULES is doxycycline. This information helps identify medicines with the same composition but different brand names.
How much does PRODERMA 200 mg HARD CAPSULES cost in pharmacies?
The average pharmacy price for PRODERMA 200 mg HARD CAPSULES is around 14.42 EUR. Prices may vary depending on the manufacturer and dosage form.
Who manufactures PRODERMA 200 mg HARD CAPSULES?
PRODERMA 200 mg HARD CAPSULES is manufactured by Industrial Farmaceutica Cantabria S.A.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of PRODERMA 200 mg HARD CAPSULES online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether PRODERMA 200 mg HARD CAPSULES is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to PRODERMA 200 mg HARD CAPSULES?
Other medicines with the same active substance (doxycycline) include DOSIL 100 mg HARD CAPSULES, DOXICICLINA NORMON 100 mg FILM-COATED TABLETS, DOXICLAT 100 mg FILM-COATED TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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