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DIFFERINE 1 mg/g CREAM

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About the medicine

How to use DIFFERINE 1 mg/g CREAM

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

P

Differine 1mg/g cream

Adapalene

Read the entire leaflet carefully before starting to use the medicine, as it contains important information for you.

  • Keep this leaflet, as you may need to read it again.
  • If you have any doubts, consult your doctor or pharmacist.
  • This medicine has been prescribed to you only, and you should not give it to others, even if they have the same symptoms as you, as it may harm them.
  • If you experience side effects, consult your doctor or pharmacist, even if they are side effects not listed in this leaflet. See section 4.
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Contents of the leaflet

  1. What is Differine cream and what is it used for
  2. What you need to know before starting to use Differine cream
  3. How to use Differine cream
  4. Possible side effects
  5. Storage of Differine cream

Contents of the package and additional information

1. What is Differine cream and what is it used for

Differine cream is indicated for the treatment of vulgar acne, where comedones, papules, and pustules predominate. It is suitable for the treatment of acne on the face, chest, and back.

Differine cream belongs to a group of medicines called anti-acne agents.

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2. What you need to know before starting to use Differine cream

Do not use Differine cream:

  • If you are pregnant.
  • If you plan to become pregnant.
  • If you are allergic to the active ingredient or to any of the other components of this medicine (listed in section 6).

Warnings and precautions

Consult your doctor or pharmacist before starting to use Differine cream.

  • Make sure Differine does not come into contact with the eyes, lips, nostrils, or mucous membranes. If it accidentally comes into contact with the eyes, rinse them immediately with warm water.
  • If after applying the product you experience irritation (redness and itching) at the application site, you should interrupt treatment, consult your doctor to see if the application frequency can be reduced, or the medication temporarily or permanently discontinued.
  • Do not use Differine cream on damaged skin (cuts or wounds), sunburned skin, or eczematous skin (scaly, red, blistered, and painful skin).
  • Avoid excessive exposure to sunlight or UV radiation.

If you use cosmetics, they should be non-greasy and non-drying for the skin.

Children and adolescents

Safety and efficacy have not been established in children under 12 years of age.

Other medicines and Differine cream

Tell your doctor or pharmacist if you are using, or have recently used, other medicines, including those purchased without a prescription.

  • Do not use other acne products (containing retinoids) at the same time as Differine.
  • Avoid using Differine at the same time as cosmetics that are irritating, drying, or scaling to the skin.
  • Treatment with Differine does not affect the efficacy of oral contraceptives or antibiotics administered orally.
  • If you are being treated with other anti-acne products such as 4% erythromycin solutions or 1% clindamycin phosphate (as a base), or aqueous-based gels of benzoyl peroxide up to 10%, you can apply these products in the morning and Differine at night.

Pregnancy and breastfeeding:

DO NOT use Differine if you are pregnant or plan to become pregnant. Your doctor may provide more information.

Differine can be used during breastfeeding. To avoid contact exposure to the infant, you should avoid applying Differine to the breast, as it is not known whether Differine passes into breast milk.

Consult your doctor or pharmacist before using any medicine.

Driving and using machines:

Treatment with Differine does not affect the ability to drive or use machinery.

Differine creamcontainsmethylparaben (E218) and propylparaben (E216)as excipients, which may cause allergic reactions (possibly delayed).

3. How to use Differine cream

Follow the administration instructions for this medicine exactly as indicated by your doctor. Consult your doctor or pharmacist if you have any doubts.

Apply the cream to the affected acne areas once a day, before bedtime:

  • Before applying the cream, wash and dry the affected area
  • Make sure the areas to be treated are dry before application
  • Apply a thin layer of cream
  • Perform a gentle massage
  • Avoid getting the cream into contact with the eyes and lips.

Use in children

It cannot be used in children under 12 years of age.

If you use more Differine cream than you should

This medicine should not be ingested. It is for external use only.

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately, go to a medical center, or call the Toxicology Information Service, phone: 91 562 04 20, indicating the medicine and the amount ingested.

If it is used excessively, it will not produce better or faster results, and it may cause intense redness, scaling, or discomfort on the skin.

If you forget to use Differine cream

Do not apply a double dose to make up for forgotten doses.

If you interrupt treatment with Differine cream

If you have any other doubts about using this leaflet, ask your doctor or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everyone gets them.

Differine may cause the following side effects at the application site.

Contact your doctor immediately if you notice any of the following symptoms, as you may need urgent medical treatment: Swelling of the face, lips, or throat that makes swallowing or breathing difficult, skin rash, itching, hives, and dizziness. This could be a sign of angioedema or a severe allergic reaction (frequency not known, cannot be estimated from available data).

Common side effects (may affect up to 1 in 10 people) - Dryness of the skin

  • Skin irritation
  • Burning sensation on the skin
  • Redness of the skin (erythema)

Uncommon side effects (may affect up to 1 in 100 people)

  • Local skin reaction (contact dermatitis)
  • Discomfort on the skin
  • Sunburn
  • Itching on the skin (pruritus)
  • Worsening of acne

Side effects of unknown frequency (cannot be estimated from available data)

  • Contact allergic reactions

- Pain or swelling of the skin

  • Irritation, redness, itching, or swelling of the eyelids
  • Darkening of light skin
  • Lightening of darker skin
  • Burn at the application site

Burns have been reported at the application site (mainly superficial but also second-degree or severe burns).

Reporting side effects

If you experience any type of side effect, consult your doctor or pharmacist, even if it is a possible side effect not listed in this leaflet. You can also report them directly through the Spanish Medicines and Health Products Agency (AEMPS) website: https://www.notificaRAM.es. By reporting side effects, you can contribute to providing more information on the safety of this medicine.

5. Storage of Differine cream

Keep this medicine out of sight and reach of children.

Do not store above 25°C.

Do not use this medicine after the expiration date stated on the box after CAD or EXP. The expiration date is the last day of the month indicated.

Medicines should not be disposed of through wastewater or household waste. Deposit the packaging and unused medicines in the SIGRE collection point at the pharmacy. If in doubt, ask your pharmacist how to dispose of the packaging and unused medicines. This will help protect the environment.

6. Contents of the package and additional information

Composition of Differine cream

The active ingredient is adapalene. Each gram of cream contains 1 milligram of adapalene.

The other excipients are carbomer 934P, polyethylene glycol-20 methylglucose sesquiestearate, methylglucose sesquiestearate, glycerol, squalene, methylparaben (E218), propylparaben (E216), disodium edetate, phenoxyethanol, cyclomethicone, sodium hydroxide, and purified water.

Appearance of the product and contents of the package

Differine is a cream, white and shiny.

Differine cream is available in packages containing 30 g and 50 g of cream.

Marketing authorization holder and manufacturer:

Marketing authorization holder:

Laboratorios Galderma, S.A.

Serrano Galvache, 56

28033 Madrid

Spain

Manufacturer:

Laboratoires Galderma

Alby-sur-Chéran

(France)

Date of the last revision of this leaflet:07/2019

Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es

Online doctors for DIFFERINE 1 mg/g CREAM

Discuss questions about DIFFERINE 1 mg/g CREAM, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Doctor

Tomasz Grzelewski

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques. For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance. Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults. In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions. Patients commonly seek his care for: 

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
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  • sports-related health questions
  • general family medicine concerns

Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.

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Andreea Mateescu

Paediatrics 8 years exp.

Dr Andreea Mateescu is a board-certified paediatrician with 7 years of clinical experience. She graduated from Carol Davila University of Medicine and Pharmacy in Bucharest, Romania, and completed her paediatric residency at INSMC Alessandrescu-Rusescu. She also holds additional training in general ultrasound diagnostics.

Dr Mateescu focuses on providing high-quality, evidence-based medical care for children, with a strong emphasis on prevention, healthy development, and long-term wellbeing. She believes that clear, empathetic communication with both children and parents is essential for building trust and ensuring effective care.

Online consultations with Dr Mateescu are suitable for:

  • preventive check-ups and monitoring of growth and development;
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Dr Mateescu works with patience, empathy, and professionalism, ensuring that each child receives attentive, individualised care. Her goal is to support healthy, balanced development while helping parents feel confident and well-informed at every stage of their child’s care.
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Chikeluo Okeke

General medicine 4 years exp.

Dr Chikeluo Okeke is an internal medicine doctor with extensive international clinical experience. Originally from Nigeria, he has worked across multiple European healthcare systems and currently practises in Sweden. This professional path has given him a strong understanding of different medical approaches and the ability to work effectively with patients from diverse cultural and linguistic backgrounds.

Dr Okeke focuses on general internal medicine and adult primary care, combining clinical accuracy with careful attention to lifestyle, personal context, and everyday health concerns. His consultations are particularly well suited for people who seek medical advice online, live abroad, or need clear guidance without unnecessary complexity.

He provides online consultations covering symptom assessment, prevention, and long-term management of chronic conditions, helping patients understand what is happening and decide on appropriate next steps.

Common reasons for consultation:

  • General internal medicine concerns and initial health assessment.
  • Acute symptoms such as fever, cough, infections, pain, or weakness.
  • Chronic conditions and treatment adjustment.
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Online consultations with Dr Chikeluo Okeke offer reliable internal medicine care without geographic limitations, focused on medical relevance, clarity, and patient comfort.

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Doctor

Lina Travkina

Family medicine 13 years exp.

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
  • Medical advice and follow-up consultations.
  • Test interpretation and diagnostic guidance.
  • Structured support for undiagnosed complaints.
  • Second opinion on diagnoses and treatment plans.
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  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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€70
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Doctor

Alina Tsurkan

Family medicine 13 years exp.

Dr. Alina Tsurkan is a licensed family medicine physician based in Portugal, offering online consultations for adults and children. She provides professional primary care, with a focus on prevention, accurate diagnosis, and long-term management of acute and chronic conditions.

Dr. Tsurkan supports patients with a wide range of health issues, including:

  • Respiratory infections: cold, flu, bronchitis, pneumonia, and lingering coughs.
  • ENT conditions: sinusitis, tonsillitis, otitis (ear infections), sore throat, allergic rhinitis.
  • Eye conditions: allergic or infectious conjunctivitis, red eyes, irritation.
  • Digestive issues: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), constipation, bloating, nausea.
  • Urinary and reproductive health: urinary tract infections (UTIs), cystitis, prevention of recurrent infections.
  • Chronic diseases: hypertension, elevated cholesterol, weight management.
  • Neurological complaints: headaches, migraines, sleep disturbances, fatigue, general weakness.
  • Children’s health: fever, infections, digestive issues, follow-ups, vaccination guidance.

She also provides:

  • IMT medical certificates for driving licence exchange in Portugal.
  • Personalised preventive care and wellness consultations.
  • Interpretation of test results and medical reports.
  • Follow-up care and medication review.
  • Support in managing multiple coexisting conditions.
  • Remote prescription management and medical documentation.

Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

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Frequently Asked Questions

Is a prescription required for DIFFERINE 1 mg/g CREAM?
DIFFERINE 1 mg/g CREAM requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
Who manufactures DIFFERINE 1 mg/g CREAM?
DIFFERINE 1 mg/g CREAM is manufactured by Laboratorios Galderma S.A.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of DIFFERINE 1 mg/g CREAM online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether DIFFERINE 1 mg/g CREAM is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to DIFFERINE 1 mg/g CREAM?
Other medicines with the same active substance () include ACNIDUO 1 mg/g + 25 mg/g GEL, AKLIEF 50 micrograms/g cream, DIFFERINE 1 mg/g GEL. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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