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CUPRIOR 150 mg FILM-COATED TABLETS

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About the medicine

How to use CUPRIOR 150 mg FILM-COATED TABLETS

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Patient Information: Summary of Product Characteristics

Cuprior 150 mg film-coated tablets

trientine

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What is Cuprior and what is it used for
  1. What you need to know before you take Cuprior
  2. How to take Cuprior
  3. Possible side effects
  4. Storage of Cuprior
  1. Contents of the pack and further information

1. What is Cuprior and what is it used for

Cuprior is a medicine used to treat Wilson's disease that contains the active substance trientine.

Wilson's disease is a hereditary disease in which the body cannot transport copper in the normal way or cannot eliminate copper in the normal way in the form of liver secretion into the intestine. For this reason, the small amounts of copper ingested with food and drinks accumulate in excessive levels, which can cause liver damage and problems in the nervous system. This medicine works mainly by binding to copper in the body, which can then be eliminated in the urine, helping to reduce copper levels. It can also bind to copper in the intestine, reducing the amount of copper absorbed by the body.

Cuprior is administered to adults, adolescents, and children aged 5 years or older who cannot tolerate another medicine used to treat this disease called penicillamine.

Doctor consultation

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2. What you need to know before you take Cuprior

Do not take Cuprior

  • if you are allergic to trientine or any of the other ingredients of this medicine (listed in section 6).

Warnings and precautions

Consult your doctor or pharmacist before starting to take Cuprior.

If you were already taking another medicine with trientine, your doctor may change your daily dose, the number of tablets, or the number of intakes per day when replacing your treatment with Cuprior.

Your symptoms may worsen when you start treatment. In this case, you should inform your doctor.

Your doctor will perform periodic blood and urine tests to ensure you are receiving the correct dose of Cuprior to control your symptoms and copper levels.

You should inform your doctor if you experience any side effects, as this could indicate that your dose of Cuprior needs to be adjusted upwards or downwards.

This medicine can also reduce iron levels in the blood, so your doctor may prescribe iron supplements (see section "Other medicines and Cuprior" below).

If you have kidney problems, your doctor will periodically check that the treatment dose is suitable and not affecting kidney function.

The combination of trientine with another medicine containing zinc is not recommended.

Pseudolupus reactions (with symptoms such as persistent skin rash, fever, joint pain, and fatigue) have been reported in some patients who switched to trientine after receiving the medicine penicillamine. However, it was not possible to determine whether the reaction was caused by trientine or by previous treatment with penicillamine.

Children and adolescents

Your doctor will perform more frequent reviews to ensure that your copper levels are maintained at an adequate level for growth and mental development. This medicine is not recommended in children under 5 years of age.

Other medicines and Cuprior

Tell your doctor if you are taking, have recently taken, or might take any other medicines.

In particular, you should inform your doctor if you are already taking iron supplements or if you take any remedy for indigestion (medicines that reduce discomfort after eating). If you are taking these medicines, you will need to take Cuprior at a different time of day, otherwise, Cuprior will not be effective. If you take iron supplements, make sure that at least two hours have passed between taking Cuprior and taking the iron supplements.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.

It is very important that you continue treatment to reduce copper levels during pregnancy. You should discuss the possible benefits of treatment with your doctor, taking into account the risks that may exist. Your doctor will advise you on the best treatment and dose in your situation.

If you are pregnant and taking Cuprior, you will be monitored throughout your pregnancy to detect any effects on the baby or any changes in your copper levels. When your child is born, the copper level in the baby's blood will also be checked.

It is not known whether Cuprior passes into breast milk. It is important that you inform your doctor if you are breastfeeding or planning to breastfeed. Your doctor will help you decide whether to stop breastfeeding or stop taking Cuprior, considering the benefit of breastfeeding for the baby and the benefit of Cuprior for the mother. Your doctor will decide on the best treatment and dose in your situation.

Driving and using machines

Cuprior is not expected to affect your ability to drive or use tools or machines.

Cuprior contains sodium

This medicine contains less than 1 mmol of sodium (23 mg) per dose; this is essentially "sodium-free".

3. How to take Cuprior

Follow exactly the administration instructions of this medicine given by your doctor or pharmacist. If you are unsure, consult your doctor or pharmacist again.

Adults

In adults of all ages, the recommended daily dose is 3 to 6 tablets and a half per day (which corresponds to a total of 450 to 975 mg). This total daily dose will be divided into 2 to 4 smaller doses taken throughout the day. Your doctor will indicate how many tablets you should take and how often during the day. The tablets can be divided in half if necessary.

Use in children and adolescents (5 to 18 years)

The dose for children and adolescents will normally be lower than the dose corresponding to adults and will depend on age and body weight.

The usual total daily dose is between 225 and 600 mg (between 1 and a half and 4 tablets per day), which will be divided into 2 to 4 smaller doses taken throughout the day. Your doctor will indicate how many tablets you should take and how often during the day. The tablets can be split in half if necessary.

Once you have started treatment, your doctor may adjust the dose depending on your response to treatment.

Swallow the tablets with water. Take this medicine on an empty stomach, at least one hour before or two hours after mealsand at least one hour apart from other medicines, food, or milk.

If you take iron supplements, take them at least two hours after the dose of Cuprior.

If you take more Cuprior than you should

Take Cuprior only as prescribed by your doctor. If you think you have taken more Cuprior than you should, consult your doctor or pharmacist.

If you take more than you should, you may experience nausea, vomiting, and dizziness.

If you forget to take Cuprior

Do not take a double dose to make up for forgotten doses. Skip the missed dose and take the next dose at the usual time.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

If you stop taking Cuprior

This medicine is indicated for long-term treatment. Do not stop treatment unless your doctor tells you to, even if you feel better, as Wilson's disease is a lifelong condition.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

Medicine questions

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4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

The following side effects have been reported:

Common (may affect up to 1 in 10 people)

  • nausea

Uncommon (may affect up to 1 in 100 people)

  • skin rash
  • redness of the skin (erythema)
  • itching
  • anemia

Frequency not known (cannot be estimated from the available data)

  • stomach discomfort and upset, such as severe stomach pain (duodenitis)
  • inflammation of the intestine that can cause, for example, abdominal pain, recurrent diarrhea, and blood in the stool (colitis)
  • reduction in the number of red blood cells due to low iron levels in the blood (iron deficiency anemia)
  • hives (urticaria).

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist, even if they are not listed in this leaflet. You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Cuprior

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the carton and blister after EXP. The expiry date is the last day of the month stated.

This medicine does not require any special storage conditions.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. Contents of the pack and further information

Composition of Cuprior

  • The active substance is trientine. Each film-coated tablet contains trientine tetrahydrochloride equivalent to 150 mg of trientine.
  • The other ingredients are:

Core of the tablet: mannitol, colloidal anhydrous silica, and dibehenate of glycerol.

Coating of the tablet: polyvinyl alcohol, talc, titanium dioxide (E171), glycerol monocaprylocaprate (type I), yellow iron oxide (E172), and sodium lauryl sulfate (see section 2 "Cuprior contains sodium").

Appearance of the product and pack size

Cuprior are film-coated tablets, yellow, elongated, 16 x 8 mm in size, with a score line on each face.

Cuprior is available in blister packs of 72 or 96 film-coated tablets.

Not all pack sizes may be marketed.

Marketing authorisation holder

Orphalan

226 Boulevard Voltaire

75011 Paris

France

Manufacturer

Delpharm Evreux

5 rue du Guesclin

27000 Evreux

France

Date of last revision of this leaflet:

You can also find this information by scanning the QR code below with a mobile phone or on the website QR codehttp://www.cuprior.com

Other sources of information

Detailed information on this medicine is available on the European Medicines Agency website: http://www.ema.europa.eu. There are also links to other websites on rare diseases and orphan medicines.

Online doctors for CUPRIOR 150 mg FILM-COATED TABLETS

Discuss questions about CUPRIOR 150 mg FILM-COATED TABLETS, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

5.0 (5)
Doctor

Tomasz Grzelewski

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques. For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance. Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults. In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions. Patients commonly seek his care for: 

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
  • urticaria, atopic dermatitis and skin reactions
  • recurrent infections in children
  • sports-related health questions
  • general family medicine concerns

Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.

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5.0 (181)
Doctor

Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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Doctor

Joao Silva

General medicine 6 years exp.

Dr. João Silva is a physician with training and experience in the field of General and Family Medicine, dedicated to providing healthcare focused on the well-being and quality of life of his patients. Throughout his professional career, he has developed broad clinical competencies, striving to maintain a medical practice based on scientific evidence and continuous knowledge updates.

Between 2013 and 2019, he completed the Integrated Master's Degree in Medicine at the Abel Salazar Institute of Biomedical Sciences in Porto, where he acquired a solid academic and clinical education.

Subsequently, between January 2021 and December 2021, he completed the General Internship at the Entre Douro e Vouga Hospital Center in Santa Maria da Feira, where he had the opportunity to work in different hospital settings and deepen his competencies in several areas of medicine.

From January 2022 until March 2026, he works as a Resident Physician in General and Family Medicine at USF Salvador Machado in Oliveira de Azeméis, developing clinical activities in primary healthcare, follow-up of chronic patients, and health promotion in the community.

Complementing his medical training, Dr. João Silva also completed a Postgraduate Degree in Continuing and Palliative Care at CESPU, strengthening his preparation in the comprehensive approach to patient care, especially in situations requiring prolonged care and multidisciplinary support.

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€55
0.0 (0)
Doctor

Bulat Garipov

General medicine 15 years exp.

Dr. Bulat Garipov is a radiologist with more than 15 years of experience, specializing in magnetic resonance imaging (MRI). Throughout his professional career, he has worked in leading diagnostic imaging centers, both in on-site practice and teleradiology, which has allowed him to develop a broad and versatile approach to radiology.

Over the years, he has gained solid experience in interpreting MRI studies in various areas, including:

  •  Neuroimaging
  •  Musculoskeletal system (MSK)
  •  Angiography
  •  Abdomen and pelvis
  •  Soft tissues

Additionally, Dr. Garipov is open to new collaboration opportunities in radiology and teleradiology projects. He offers his expertise in MRI, providing both first and second readings of studies, as well as advanced image interpretation, ensuring accurate and high-quality diagnostics.

You could consult Dr. Bulat Garipov in cases where accurate interpretation of MRI studies or a second expert opinion is required. His expertise is especially valuable in cases of suspected neurological conditions, back and joint pain, vascular disorders, as well as in the diagnosis of abdominal and pelvic diseases. The doctor also provides support in complex or unclear clinical situations, including the review of previously performed studies, which helps improve diagnostic accuracy and determine the optimal treatment strategy. A teleradiology format is available, allowing you to receive a professional opinion remotely.

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€80
5.0 (41)
Doctor

Anna Biriukova

General medicine 6 years exp.

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

  • High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
  • Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
  • Leg swelling, chronic fatigue, reduced exercise tolerance.
  • EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
  • Post-COVID-19 cardiac monitoring and care.
Endocrinology – Diabetes, thyroid, metabolism:
  • Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
  • Individual treatment plans including oral medications and insulin therapy.
  • GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
  • Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
  • Metabolic syndrome – obesity, lipid disorders, insulin resistance.
Gastroenterology – Digestive health:
  • Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
  • Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
  • Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).
General internal medicine and preventive care:
  • Respiratory infections – cough, colds, bronchitis.
  • Lab test analysis, therapy adjustments, medication management.
  • Adult vaccinations – planning, contraindications assessment.
  • Cancer prevention – screening strategies and risk assessment.
  • Holistic approach – symptom relief, complication prevention, and quality of life improvement.
Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.
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€60

Frequently Asked Questions

Is a prescription required for CUPRIOR 150 mg FILM-COATED TABLETS?
CUPRIOR 150 mg FILM-COATED TABLETS requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in CUPRIOR 150 mg FILM-COATED TABLETS?
The active ingredient in CUPRIOR 150 mg FILM-COATED TABLETS is trientine. This information helps identify medicines with the same composition but different brand names.
Who manufactures CUPRIOR 150 mg FILM-COATED TABLETS?
CUPRIOR 150 mg FILM-COATED TABLETS is manufactured by Orphalan. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of CUPRIOR 150 mg FILM-COATED TABLETS online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether CUPRIOR 150 mg FILM-COATED TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to CUPRIOR 150 mg FILM-COATED TABLETS?
Other medicines with the same active substance (trientine) include CUFENCE 200 mg HARD CAPSULES, TRIENTINE WAYMADE 200 mg HARD CAPSULES, AMMONAPS 500 mg TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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