CUFENCE 200 mg Hard Capsules

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Talk to a doctor about this medicine

Discuss your symptoms and possible next steps in a quick online consultation.

Doctor
5.0(36)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

Book a video appointment
€86
This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use CUFENCE 200 mg HARD CAPSULES

Contents of the leaflet

  1. Introduction
  2. What is Cufence and what is it used for
  3. What you need to know before you take Cufence
  4. How to take Cufence
  5. Possible side effects
  6. Storing Cufence
  7. Contents of the pack and other information

Introduction

Package Leaflet: Information for the Patient

Cufence 100 mg Hard Capsules

Cufence 200 mg Hard Capsules

trientine

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor, pharmacist, or nurse.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What is Cufence and what is it used for
  2. What you need to know before you take Cufence
  3. How to take Cufence
  4. Possible side effects
  5. Storing Cufence
  6. Contents of the pack and other information

1. What is Cufence and what is it used for

Cufence is indicated for the treatment of Wilson's disease in adults, adolescents, and children aged 5 years and older. It is used in patients who cannot take another medicine, D-penicillamine, due to side effects.

Cufence contains the active substance trientine, a copper-chelating agent used to remove excess copper from the body. Cufence binds to copper, which is then excreted from the body.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you take Cufence

Do not take Cufence

If you are allergic to trientine or any of the other ingredients of this medicine (listed in section 6).

Signs of an allergic reaction include, among others, skin rash, itching, swelling of the face, fainting, and breathing difficulties.

Warnings and precautions

Your doctor will need to regularly check your symptoms of the disease and your copper levels in blood and urine. Regular monitoring is especially important at the start of treatment or when changing the dose, in growing children, and in pregnant women, to ensure that copper levels are maintained at an adequate level. Your doctor may need to increase or decrease the dose of Cufence.

Problems in the nervous system (such as tremors, lack of coordination, difficulty speaking, muscle stiffness, and worsening of muscle spasms) may occur, especially in patients who have just started treatment with Cufence. If you notice any of these while taking Cufence, you should inform your doctor immediately.

Pseudolupus reactions (symptoms could include persistent skin rash, fever, joint pain, and fatigue) have been described in some patients who have switched to trientine after penicillamine. However, it has not been possible to determine whether the reaction was due to trientine or previous treatment with penicillamine.

Other medicines and Cufence

Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.

If you are taking iron tablets or medicines that neutralize stomach acid, leave at least 2 hours before or after taking Cufence, as they may reduce its effect. It is recommended to take trientine at least 1 hour before or after any other medicine.

Taking Cufence with food and drinks

Take this medicine only with water. Do not take it with other drinks, milk, or food, as they may reduce the effect of the medicine. Avoid eating or drinking (except water) for 2 hours before and 1 hour after taking the medicine.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. It is very important that you continue treatment to maintain normal copper levels during pregnancy. You should discuss the possible benefits of treatment with your doctor, taking into account any risks that may exist. Your doctor will advise you on the best treatment and dose for your situation. If you become pregnant while taking Cufence, talk to your doctor.

If you are pregnant and taking Cufence, you will be monitored throughout your pregnancy to detect any effects on the baby or any changes in your copper levels.

The limited information available indicates that Cufence is not excreted in breast milk, but there is no certainty that the baby is risk-free. It is important that you inform your doctor if you are breastfeeding or plan to breastfeed. Your doctor will help you decide whether to stop breastfeeding or stop taking Cufence, considering the benefit of breastfeeding for the child and the benefit of Cufence for the mother. Your doctor will advise you on the best treatment and dose for your situation.

Driving and using machines

Cufence is unlikely to affect your ability to drive or use tools or machines.

3. How to take Cufence

Follow exactly the administration instructions of this medicine given by your doctor or pharmacist. If you are unsure, ask your doctor or pharmacist again.

Adults (including elderly patients)

The usual dose is between 800 and 1600 mg per day, taken orally.

Use in children and adolescents (5 to 17 years old)

The dose in children and adolescents depends on age and body weight, and will be adjusted by the doctor. At the start of treatment, the dose varies between 400 and 1000 mg per day.

Method of administration

Your doctor will decide the correct dose for you.

The total daily dose may be divided into 2 to 4 smaller doses, as indicated by the doctor. Swallow the capsules whole with water, on an empty stomach, at least 1 hour before or 2 hours after meals.

Patients who have difficulty swallowing should contact their doctor.

If you take more Cufence than you should

If you take more medicine than you should, you may experience nausea, vomiting, and dizziness. You should contact your doctor or another healthcare professional immediately.

If you forget to take Cufence

If you forget to take a dose, take the next dose at the scheduled time.

Do not take a double dose to make up for forgotten doses.

If you stop taking Cufence

This medicine is intended for long-term use because Wilson's disease is a lifelong condition. Do not stop or change treatment without discussing it with your doctor, even if you feel better.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Sometimes (frequency not known; cannot be estimated from the available data) treatment with this medicine may cause inflammation of the small intestine or colon. If you experience any of the following side effects, contact your doctor immediately:

  • Severe stomach pain
  • Persistent diarrhea
  • Nervous system problems (such as tremors, lack of coordination, difficulty speaking, muscle stiffness, and worsening of muscle spasms).

Other side effects may include:

Common (may affect up to 1 in 10 people)

  • Nausea (especially when starting treatment)

Uncommon (may affect up to 1 in 100 people)

  • Skin rashes
  • Anemia (you may feel unusually tired)

Reporting of side effects

If you experience any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly through the national reporting system listed in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storing Cufence

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the outer packaging after EXP. The expiry date is the last day of the month stated.

Use within 3 months of first opening the bottle. Keep the bottle tightly closed to protect it from moisture. Do not use if the capsules become sticky or damp.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. Contents of the pack and other information

Composition of Cufence

The active substance is trientine.

  • Each hard capsule of Cufence 100 mg contains 150 mg of trientine dihydrochloride equivalent to 100 mg of trientine.
  • Each hard capsule of Cufence 200 mg contains 300 mg of trientine dihydrochloride equivalent to 200 mg of trientine.

The other ingredients are:

  • Capsule content: magnesium stearate and anhydrous colloidal silica
  • Capsule shell: gelatin and titanium dioxide (E171)
  • Printing ink: shellac, propylene glycol (E1520), titanium dioxide (E171), black iron oxide (E172), and yellow iron oxide (E172)

Appearance and packaging

Cufence 100 mg, hard capsules

Opaque white HDPE bottle with a child-resistant screw cap and induction-sealed with a dry silica gel sachet as a desiccant. Each hard capsule is white, oval-shaped, size 3 (15.8 mm x 5.85 mm), and printed with "Cufence" in gray ink.

Pack size: one bottle of 200 hard capsules

Cufence 200 mg, hard capsules

Ambber glass bottle with a polypropylene cap and induction-sealed with a dry silica gel sachet as a desiccant. Each hard capsule is white, oval-shaped, size 0 (21.8 mm x 7.66 mm), and printed with "Cufence" in gray ink.

Pack size: one bottle of 100 hard capsules.

Not all pack sizes may be marketed.

Marketing authorization holder

Univar Solutions BV

Schouwburgplein 30

3012 CL Rotterdam

Netherlands

Manufacturer

Aesica Pharmaceuticals GmbH

Alfred-Nobel Strasse 10

40789 Monheim

Germany

Date of last revision of this leaflet: <{MM/AAAA}><{month AAAA}>.

Other sources of information

Detailed information on this medicine is available on the European Medicines Agency website: http://www.ema.europa.eu. There are also links to other websites on rare diseases and orphan medicines.

Online doctors for CUFENCE 200 mg HARD CAPSULES

Discuss questions about CUFENCE 200 mg HARD CAPSULES, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

Doctor
5.0(36)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

Book a video appointment
€86
Doctor
5.0(19)

Nuno Tavares Lopes

Family medicineGeneral medicine18 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies
  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management
  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses
  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment
  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance
  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis
  • Pain management: acute and chronic pain, post-surgical care
  • Public health: prevention, health screenings, long-term monitoring
  • Sick leave (Baixa médica) connected to Segurança Social in Portugal
  • IMT medical certificates for driving licence exchange
Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.

Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

Book a video appointment
€70
Doctor
0.0(0)

Hocine Lokchiri

General medicine21 years of experience

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
Book a video appointment
€64
Doctor
0.0(0)

Muhammad Tayyab Altaf

General medicine3 years of experience

Dr. Muhammad Tayyab Altaf is a primary care physician with extensive international experience, offering online consultations for adults and children. His background includes clinical practice in Policlinico San Matteo Hospital Pavia in Italy, Mount Sinai Hospital in New York, United States and other healthcare settings, allowing him to manage a wide range of acute and chronic medical conditions with confidence and clarity.

His clinical expertise spans multi-system conditions, preventive care and long-term management of chronic diseases. Dr. Altaf combines hands-on experience with a strong research background in both medical and surgical fields, enabling him to provide accurate assessments and structured, evidence-based treatment plans. Patients value his ability to explain diagnoses clearly, outline next steps and support them in making informed healthcare decisions.

Online consultations with Dr. Altaf are suitable for many everyday and acute situations where a timely medical opinion can help determine the safest next steps. He evaluates and treats conditions affecting the cardiovascular, respiratory, gastrointestinal, neurological, haematological and endocrine systems. Common examples include:

  • hypertension and other blood pressure issues
  • ischaemic heart disease and angina
  • asthma, COPD and emphysema
  • pneumonia and lung fibrosis
  • gastroenteritis and digestive infections
  • liver conditions, including alcohol-related disease
  • epilepsy, seizures and post-stroke symptoms
  • dementia and cognitive decline
  • anaemia and other haematological changes
  • diabetes, thyroid disorders and pituitary disease
Many patients reach out when they experience new or worsening symptoms, fluctuations in blood pressure, non-severe chest discomfort, breathing symptoms, digestive issues, suspected infections, chronic fatigue or concerns that affect daily life. He also helps patients understand test results, adjust existing treatment plans and navigate long-term health strategies safely and effectively.

When clinically appropriate, Dr. Altaf can also provide health and fitness certificates, including documentation required for physical activity, sports participation or gym use, based on the patient’s health status and medical indications.

Some conditions are not suitable for online care. Severe chest pain, loss of consciousness, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack require immediate attention from local emergency services. Dr. Altaf prioritises patient safety and will guide you accordingly if your situation needs urgent in-person care.

In all consultations, Dr. Muhammad Tayyab Altaf focuses on clear communication, accurate diagnosis and patient-centred decision-making. His approach ensures that individuals and families feel informed, supported and confident in their next steps, no matter where they are.

Book a video appointment
€71

Get CUFENCE 200 mg HARD CAPSULES Prescription Online

1

Fill in a 2-min form

Tell us your symptoms, history, and what medicine you're requesting.

2

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3

Doctor reviews your case

Usually within 30 minutes. They may ask follow-up questions via chat.

4

Collect from any pharmacy

Electronic prescription sent to your email — valid across Spain.

Frequently Asked Questions

Is a prescription required for CUFENCE 200 mg HARD CAPSULES?

CUFENCE 200 mg HARD CAPSULES requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

What is the active substance in CUFENCE 200 mg HARD CAPSULES?

The active ingredient in CUFENCE 200 mg HARD CAPSULES is trientine. This information helps identify medicines with the same composition but different brand names.

Who manufactures CUFENCE 200 mg HARD CAPSULES?

CUFENCE 200 mg HARD CAPSULES is manufactured by Univar Solutions B.V.. Pharmacy brands and packaging may differ depending on the distributor.

Which doctors can assess the use of CUFENCE 200 mg HARD CAPSULES online?

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether CUFENCE 200 mg HARD CAPSULES is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

How to buy CUFENCE 200 mg HARD CAPSULES in Spain?

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy CUFENCE 200 mg HARD CAPSULES in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

What are the alternatives to CUFENCE 200 mg HARD CAPSULES?

Other medicines with the same active substance (trientine) include CUPRIOR 150 mg FILM-COATED TABLETS, TRIENTINE WAYMADE 200 mg HARD CAPSULES, AMMONAPS 500 mg TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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