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CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS

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About the medicine

How to use CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Leaflet: information for the user

cinfamar caffeine 50mg/50mg coated tablets

dimenhydrinate/caffeine

Read the entire leaflet carefully before starting to take this medicine, as it contains important information for you.

  • Follow the administration instructions for the medicine contained in this leaflet or as indicated by your doctor or pharmacist.
  • Keep this leaflet, as you may need to read it again.
  • If you need advice or more information, consult your pharmacist.
  • If you experience side effects, consult your doctor or pharmacist, even if they are not listed in this leaflet. See section 4.
  • You should consult a doctor if it worsens or does not improve after 7 days.

Contents of the leaflet

  1. What is cinfamar caffeine and what is it used for
  2. What you need to know before taking cinfamar caffeine
  3. How to take cinfamar caffeine
  4. Possible side effects
  5. Storage of cinfamar caffeine
  6. Package contents and additional information

1. What is cinfamar caffeine and what is it used for

cinfamar caffeine is a medicine that contains two active substances: dimenhydrinate and caffeine. Dimenhydrinate is an active ingredient that acts against motion sickness.

Caffeine has a stimulating effect on the nervous system, so it counteracts the drowsiness effect that dimenhydrinate can cause.

cinfamar caffeine is a medicine that is indicated for the prevention and treatment of symptoms of motion sickness caused by land, sea, or air travel, such as nausea, vomiting, and/or vertigo for adults and children over 12 years old.

You should consult a doctor if it worsens or does not improve after 7 days.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before taking cinfamar caffeine

Do not take cinfamar caffeine

  • If you are allergic to dimenhydrinate, diphenhydramine, caffeine (or its derivatives, such as aminophylline, theophylline, etc.) or any of the other components of this medicine (listed in section 6).
  • If you have porphyria (a rare, usually hereditary disorder in which a large amount of porphyrin is eliminated in urine and feces).
  • If you have asthma attacks.
  • If you have mental disorders that cause nervous excitement or convulsive crises, with or without loss of consciousness (epilepsy).
  • If you have anxiety or insomnia (difficulty sleeping).
  • If you have severe liver or heart disorders.
  • If you have stomach or duodenal ulcers.
  • If you have high blood pressure.

Warnings and precautions

Consult your doctor or pharmacist before starting to take cinfamar caffeine.

  • If you are allergic to any allergy medicine, you may also be allergic to dimenhydrinate.
  • If you have asthma or severe respiratory diseases (chronic obstructive pulmonary disease, emphysema, chronic bronchitis), as it can cause thickening of secretions and alter expectoration.
  • If you have a disease in which there is an abnormal increase in thyroid gland activity (hyperthyroidism), increased intraocular pressure (glaucoma), prostate enlargement (prostatic hypertrophy), or any disease that causes obstruction of the urinary or gastrointestinal tract.
  • If you are over 65 years old, dry mouth, urinary retention, nausea, sedation, confusion, and low blood pressure (hypotension) may occur.
  • If you are using any medicine that produces ear toxicity, which manifests with symptoms such as ringing in the ears, dizziness, or vertigo, as this medicine may mask the symptoms of those toxic effects.
  • If you are diabetic, you should be aware that caffeine can raise blood sugar levels.
  • If you have any liver, kidney, stomach, or duodenal ulcer disease, or stomach inflammation (gastritis), you should consult your doctor before taking this medicine.
  • You should consult your doctor before taking this medicine if you have or have had heart diseases (cardiac arrhythmia, myocardial ischemia, etc.), especially when engaging in physical exercise or being in high-altitude areas.
  • If you are sensitive to caffeine or other xanthines, such as theophylline, aminophylline, or others, you should consult your doctor before taking this medicine.
  • If you suspect you may have appendicitis symptoms such as nausea, vomiting, or abdominal cramps, it is recommended to see a doctor to rule out the presence or absence of appendicitis, as dimenhydrinate can make it difficult to diagnose this disease.
  • It is recommended to avoid exposure to very high temperatures and follow adequate hygiene and dietary measures, such as proper ventilation and hydration.
  • Avoid exposure to the sun (even on cloudy days) and UVA lamps (ultraviolet rays) while taking this medicine.
  • The simultaneous use of tobacco with the caffeine contained in this medicine can increase the degradation of caffeine.

Children

Children under 12 years old should not take this medicine.

Taking cinfamar caffeine with other medicines

Tell your doctor or pharmacist if you are taking, have recently taken, or may need to take any other medicine.

In particular, if you are using any of the following medicines, it may be necessary to modify the dose of cinfamar caffeine or not take it:

Medicines that primarily interfere with dimenhydrinate:

  • Anesthetics and other substances with a central nervous system depressant effect.
  • Antibiotics of the aminoglycoside group.
  • Antidepressants, such as monoamine oxidase inhibitors (MAOIs).
  • Antiparkinsonian agents.
  • Neuroleptics (used to calm agitation and neuromuscular hyperactivity).
  • Ototoxic medicines (which can affect the ear) (see Warnings and Precautions section).
  • Medicines that can cause photosensitivity (skin reactions due to sensitivity to sunlight).

Medicines that primarily interfere with caffeine:

  • Oral contraceptives.
  • Anti-infectives of the quinolone group (e.g., pipemidic acid, ciprofloxacin), linezolid, and erythromycin.
  • Barbiturates (used as anticonvulsants).
  • Adrenergic bronchodilators and theophylline (used to combat bronchial asthma).
  • Calcium.
  • Cimetidine (used for the treatment of excessive gastric secretion and stomach ulcers).
  • Disulfiram (used in alcohol withdrawal treatments).
  • Phenytoin (used for the treatment of epilepsy).
  • Iron (used for the treatment of anemia. Caffeine decreases iron absorption, so it should be taken at least 2 hours apart).
  • Lithium (antidepressant).
  • Mexiletine: used for heart rhythm disorders (cardiac arrhythmias).
  • Procarbazine (anticancer).
  • Selegiline (used for the treatment of Parkinson's disease).
  • Thyroxine (used for the treatment of thyroid diseases).

Interference with diagnostic tests

If you are going to have any analytical tests (blood tests, urine tests, etc.), tell your doctor that you are taking this medicine, as it may alter the results of these tests.

If you are going to have any allergy tests, including skin tests, it is recommended to stop treatment 72 hours before starting the test, to avoid altering the results.

Additionally, diabetic patients should be aware that caffeine can increase blood glucose levels.

Taking cinfamar caffeine with food, drinks, and alcohol

It is not recommended to consume alcohol while taking this medicine.

Limit the consumption of beverages that contain caffeine (coffee, tea, chocolate, and cola drinks) while taking this medicine.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medicine.

Breastfeeding

Women who are breastfeeding should not take this medicine without first consulting their doctor or pharmacist, as this medicine passes into breast milk.

Driving and using machines

While being treated with this medicine, do not drive or operate hazardous machinery, as this medicine can cause drowsiness or decreased reaction capacity at the recommended doses.

cinfamar caffeine contains sodium

This medicine contains less than 23 mg of sodium (1 mmol) per tablet; it is essentially "sodium-free".

3. How to take cinfamar caffeine

Follow the administration instructions for the medicine contained in this leaflet or as indicated by your doctor or pharmacist. In case of doubt, ask your doctor or pharmacist.

The recommended dose is:

Adults and children over 12 years old

1 or 2 tablets per dose. If necessary, repeat the dose every 4-6 hours.

Do not take more than 8 tablets per day (corresponding to 400 mg of dimenhydrinate and 400 mg of caffeine).

Patients with liver disease

They should consult their doctor before taking this medicine, as it may be necessary to adjust the dose.

Use in children

Children under 12 years old should not take this medicine.

cinfamar caffeine is administered orally.

The first dose should be taken at least 30 minutes before starting the trip (preferably 1 or 2 hours before), leaving at least 4 hours between one dose and the next. It is recommended to take the tablets with food, water, or milk to minimize gastric irritation.

The last dose should not be taken in the 6 hours prior to bedtime, to avoid possible insomnia, especially in patients with difficulty sleeping.

If it worsens or if the symptoms persist for more than 7 days, you should consult your doctor.

If you take more cinfamar caffeine than you should

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or call the Toxicology Information Service, phone 91 562 04 20, indicating the medicine and the amount taken.

The symptoms of overdose include mainly: dilated pupils, red face, excitement, hallucinations, confusion, stomach and intestinal irritation with nausea, vomiting, and diarrhea, movement disorders, convulsions, deep loss of consciousness (coma), sudden decrease in respiratory and cardiac functions (cardiorespiratory collapse), and death. The symptoms may take more than 2 hours to appear after the overdose.

If you have any other doubts about the use of this medicine, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everyone gets them.

Side effects usually occur at the beginning of treatment.

During the use of dimenhydrinate, the following adverse reactions have been observed, whose frequency could not be established with precision:

  • Nausea, vomiting, constipation, diarrhea, stomach pain.
  • Lack of appetite and dry mouth.
  • Sleepiness and sedation (drowsiness).
  • Headache, dizziness, and vertigo.
  • Increased viscosity of mucus in the bronchi, making breathing difficult.
  • Urinary retention and impotence.
  • Glaucoma (increased intraocular pressure).
  • Pupil dilation, blurred vision, or double vision.
  • Allergic reactions on the skin and sensitivity to sunlight after intense exposure, which can cause hives, itching, and skin redness.
  • Decrease in the blood of the number of red blood cells, white blood cells, leukocytes, and platelets.
  • Porphyria (a rare, usually hereditary disorder in which a large amount of porphyrin is eliminated in feces and urine).
  • Hypotension (decreased blood pressure).
  • Tachycardia, palpitations, and/or cardiac arrhythmias.
  • Hyperexcitability may occur, especially in children, with symptoms such as insomnia, nervousness, confusion, tremors, irritability, euphoria, delirium, palpitations, and even convulsions.

Additionally, due to caffeine, the following may appear:

  • Excitement, agitation, and/or difficulty sleeping.
  • Ringing in the ears.
  • Disorientation.
  • Rapid breathing.
  • Hot flashes.
  • Abundant urine elimination.
  • Hyperglycemia or hypoglycemia (increased or decreased glucose in the blood).

Reporting side effects

If you experience any type of side effect, consult your doctor or pharmacist, even if it is a possible side effect that is not listed in this leaflet. You can also report them directly through the Spanish Medicines and Health Products Agency (AEMPS) https://www.notificaram.es. By reporting side effects, you can contribute to providing more information on the safety of this medicine.

5. Storage of cinfamar caffeine

Keep this medicine out of the sight and reach of children.

This medicine does not require special storage conditions.

Do not use this medicine after the expiration date shown on the packaging, after EXP. The expiration date is the last day of the month indicated.

Medicines should not be disposed of through wastewater or household waste. Deposit the packaging and medicines that are no longer needed in the pharmacy's SIGRE point. If in doubt, ask your pharmacist how to dispose of the packaging and medicines that are no longer needed. This will help protect the environment.

6. Package contents and additional information

Composition of cinfamar caffeine

  • Each tablet contains 50 milligrams of dimenhydrinate and 50 milligrams of caffeine as active ingredients.
  • The other components are:
    • Core: Cornstarch, anhydrous colloidal silica, microcrystalline cellulose, calcium phosphate dihydrate, magnesium stearate, sodium carboxymethyl starch (potato) (type A), povidone, talc.
    • Coating: Macrogol 6000, hypromellose 606, hypromellose 615.

Appearance of the product and package contents

cinfamar caffeine are white, cylindrical, biconvex, and scored on one side coated tablets.

They come in packages containing 4 or 10 coated tablets.

Marketing authorization holder and manufacturer

Laboratorios Cinfa, S.A.

Carretera Olaz-Chipi, 10. Polígono Industrial Areta

31620 Huarte (Navarra) – Spain

Date of the last revision of this leaflet:December 2020

Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es/

Online doctors for CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS

Discuss questions about CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Даниэль Чики

Family medicine 24 years exp.

Dr Daniel Cichi is a family medicine doctor with over 20 years of clinical experience. He provides online consultations for adults, supporting patients with acute symptoms, chronic conditions, and everyday health concerns that require timely medical guidance.

His background includes work in emergency care, ambulance services, and family medicine, which allows him to assess symptoms quickly, identify warning signs, and help patients choose the safest next steps – whether that means home care, treatment adjustment, or in-person evaluation.

Patients commonly consult Dr Daniel Cichi for:

  • acute symptoms: fever, infections, flu-like illness, cough, sore throat, shortness of breath;
  • chest discomfort, palpitations, dizziness, fatigue, and blood pressure concerns;
  • digestive problems: abdominal pain, nausea, diarrhoea, constipation, reflux;
  • muscle, joint, and back pain, minor injuries, post-traumatic symptoms;
  • chronic conditions: hypertension, diabetes, high cholesterol, thyroid disorders;
  • review and interpretation of lab tests, imaging reports, and medical documents;
  • medication review and treatment adjustment;
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Dr Cichi’s consultations are structured and practical. He focuses on clear explanations, risk assessment, and actionable recommendations, helping patients understand their symptoms and make informed decisions about their health.
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Doctor

Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
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Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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Doctor

Lina Travkina

Family medicine 13 years exp.

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
  • Medical advice and follow-up consultations.
  • Test interpretation and diagnostic guidance.
  • Structured support for undiagnosed complaints.
  • Second opinion on diagnoses and treatment plans.
  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
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  • Preconception counselling and postpartum support.
  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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Doctor

Alina Tsurkan

Family medicine 13 years exp.

Dr. Alina Tsurkan is a licensed family medicine physician based in Portugal, offering online consultations for adults and children. She provides professional primary care, with a focus on prevention, accurate diagnosis, and long-term management of acute and chronic conditions.

Dr. Tsurkan supports patients with a wide range of health issues, including:

  • Respiratory infections: cold, flu, bronchitis, pneumonia, and lingering coughs.
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  • Eye conditions: allergic or infectious conjunctivitis, red eyes, irritation.
  • Digestive issues: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), constipation, bloating, nausea.
  • Urinary and reproductive health: urinary tract infections (UTIs), cystitis, prevention of recurrent infections.
  • Chronic diseases: hypertension, elevated cholesterol, weight management.
  • Neurological complaints: headaches, migraines, sleep disturbances, fatigue, general weakness.
  • Children’s health: fever, infections, digestive issues, follow-ups, vaccination guidance.

She also provides:

  • IMT medical certificates for driving licence exchange in Portugal.
  • Personalised preventive care and wellness consultations.
  • Interpretation of test results and medical reports.
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Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

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Doctor

Anna Biriukova

General medicine 6 years exp.

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

  • High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
  • Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
  • Leg swelling, chronic fatigue, reduced exercise tolerance.
  • EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
  • Post-COVID-19 cardiac monitoring and care.
Endocrinology – Diabetes, thyroid, metabolism:
  • Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
  • Individual treatment plans including oral medications and insulin therapy.
  • GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
  • Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
  • Metabolic syndrome – obesity, lipid disorders, insulin resistance.
Gastroenterology – Digestive health:
  • Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
  • Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
  • Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).
General internal medicine and preventive care:
  • Respiratory infections – cough, colds, bronchitis.
  • Lab test analysis, therapy adjustments, medication management.
  • Adult vaccinations – planning, contraindications assessment.
  • Cancer prevention – screening strategies and risk assessment.
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Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.
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€60

Frequently Asked Questions

Is a prescription required for CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS?
CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS does not require a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS?
The active ingredient in CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS is diphenhydramine, combinations. This information helps identify medicines with the same composition but different brand names.
Who manufactures CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS?
CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS is manufactured by Laboratorios Cinfa S.A.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to CINFAMAR CAFFEINE 50 mg/50 mg FILM-COATED TABLETS?
Other medicines with the same active substance (diphenhydramine, combinations) include BIODRAMINA CAFFEINE COATED TABLETS, BIODRAMINA 20 mg CHEWABLE MEDICATED LOZENGES, BIODRAMINA 50 mg TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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