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Cafergot 1 mg/100 mg comprimidos

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Abdullah Alhasan

General medicineCardiology11 years of experience

Dr. Abdullah Alhasan is a physician specialising in cardiology and general medicine, with international clinical experience and a commitment to evidence-based care. He offers online consultations for adults, focusing on both acute symptoms and long-term health management.

Main areas of consultation:

  • Chest pain, shortness of breath, heart palpitations, high blood pressure
  • Hypertension control and cardiovascular disease prevention
  • Interpretation of ECG, blood tests, and Holter monitor results
  • Management of heart failure and coronary artery disease
  • General medical issues: infections, fever, fatigue, gastrointestinal symptoms
  • Guidance on diagnostics, treatment plans, and medication adjustments
Dr. Alhasan’s approach is based on thorough assessment, clear communication, and personalised care – helping patients understand their health and make informed decisions about their treatment.
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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use CAFERGOT 1 mg/100 mg TABLETS

Contents of the leaflet

  1. Introduction
  2. What Cafergot is and what it is used for
  3. What you need to know before you take Cafergot
  5. How to take Cafergot
  6. Possible side effects
  7. Storing Cafergot
  8. Contents of the pack and other information

Introduction

Package Leaflet: Information for the User

Cafergot 1 mg/100 mg Tablets

Ergotamine, tartrate/caffeine

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor, pharmacist, or nurse.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack:

  1. What Cafergot is and what it is used for
  2. What you need to know before you take Cafergot
  3. How to take Cafergot
  4. Possible side effects
  5. Storing Cafergot
  6. Contents of the pack and other information

1. What Cafergot is and what it is used for

Ergotamine, the active substance of Cafergot, belongs to a group of medicines known as ergot alkaloids. This substance constricts the dilated blood vessels in the brain that are responsible for the painful sensation, thus cutting off migraine attacks. Caffeine accelerates and increases the absorption of ergotamine in the body.

Cafergot is indicated for the treatment of acute migraine attacks with or without "aura" (i.e., visual, sensory, or language problems that some people have shortly before the attack and that may also appear during and after the attack).

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2. What you need to know before you take Cafergot

Do not take Cafergot

  • - If you are allergic to the active substance or to any of the other ingredients of this medicine (listed in section 6).
  • - If you suffer from circulatory disorders, e.g., Raynaud's syndrome (a condition that affects blood supply to certain parts of the body, usually the fingers and toes), hyperthyroidism, vascular disease that reduces blood flow to the arms and legs (peripheral vascular disease), heart disease due to reduced blood flow to the heart (ischemic heart disease), uncontrolled high blood pressure, or generalized infection (sepsis or shock).
  • - If you suffer from severe liver or kidney failure.
  • - If you suffer from inflammatory disease of the temporal artery (the main artery in the head)
  • - If you suffer from migraines accompanied by neurological symptoms such as balance disturbance, speech disturbance, vision disturbance, tingling sensation in fingers and toes, and around the mouth (hemiplegic or basilar migraine).
  • - If you are pregnant or breastfeeding.

Warnings and precautions

Consult your doctor, pharmacist, or nurse before starting to take Cafergot

  • - Cafergot is only indicated for the treatment of acute migraine attacks and not as a preventive treatment.
  • - Continuous use of Cafergot or use at doses higher than recommended should be avoided, as higher doses than recommended may cause vasospasm (contraction of the arteries that can lead to cerebral and cardiac disorders), and after prolonged treatment, changes in the pleura (membrane that covers the lungs), peritoneum (membrane that covers the intestinal loops), or, more rarely, heart valves, cardiac fibrosis, pulmonary fibrosis (a respiratory disease in which scars form in lung tissue), and pleural fibrosis (a condition in which the tissue covering the lungs becomes thick and rigid) and ergotism (a long-term poisoning effect of ergot) may appear, including severe symptoms of vasoconstriction, which may result in death.
  • - Caution is recommended in patients with anemia.
  • - Patients with rare hereditary disorders such as galactose intolerance or glucose-galactose malabsorption should not take this medicine.
  • - If symptoms such as tingling in fingers and toes appear, treatment should be discontinued immediately and the doctor consulted.
  • People with mild or moderate liver function impairment should be monitored (by their doctor).

Children and adolescents

Cafergot is not recommended for children and adolescents under 18 years of age.

Use in elderly patients

As this medicine contains ergotamine, caution is recommended in these patients, as they are more likely to have vascular disease that reduces blood flow to the arms and legs and, therefore, to experience adverse events related to reduced diameter of blood vessels in the arms and legs than younger adults. The risk of reduced blood flow in the heart's blood vessels is also higher in older people.

Taking Cafergot with other medicines

Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines. The administration of macrolide antibiotics (erythromycin, clarithromycin), tetracycline (an antibiotic used to treat bacterial infections), medications for the treatment of HIV infection (e.g., ritonavir, indinavir, nelfinavir, amprenavir, delavirdine, saquinavir, atazanavir, and efavirenz), or medications for the treatment of fungal infections (e.g., ketoconazole, itraconazole, voriconazole) with Cafergot may cause a lack of blood flow, as they increase ergotamine levels in the blood. Other medications that may cause interactions are: medications for the treatment of heart diseases and blood pressure, such as propranolol, other preparations containing ergot alkaloids, nicotine (e.g., excessive smoking), and medications for the treatment of migraine, such as sumatriptan.

  • There is a higher risk of vasospasm (arterial contraction that can lead to cerebral and cardiac disorders) observed with triptans, such as almotriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan, and eletriptan. A higher risk of hypertension.
  • Fluoroquinolones (broad-spectrum antibiotics), mexiletine (used to treat irregular heartbeats), fluvoxamine (a medication used in depression), and oral contraceptives may increase plasma caffeine exposure. Caffeine interactions with sympathomimetics (e.g., epinephrine) may lead to increased blood pressure.
  • Moderate to weak CYP3A4 inhibitors, such as cimetidine, fluvoxamine, grapefruit juice, quinupristin/dalfopristin, and zileuton, may also increase ergotamine exposure, and caution is required for concomitant use.
  • The concomitant use of ergotamine with serotonin reuptake inhibitors (e.g., amitriptyline), including selective agents (e.g., sertraline), may lead to serotonin syndrome (a potentially life-threatening pharmacological interaction) and should be used with caution.
  • Drugs (e.g., nevirapine, rifampicin) that induce CYP3A4 may lead to a decrease in the pharmacological action of ergotamine.
  • Quinupristin-dalfopristin (combination): ergotism with possible necrosis (cell damage) of the limbs.
  • Stiripentol: ergotism with possible necrosis (cell damage) of the limbs.
  • Dopaminergic ergot alkaloids (bromocriptine, cabergoline, pergolide, lisuride): risk of vasoconstriction and/or hypertensive crisis (a severe increase in blood pressure that can lead to a stroke).
  • Alpha sympathomimetics (oral and/or nasal) (e.g., etilefrine, midodrine, nafazoline, oxymetazoline, phenylephrine, synephrine, tetrisoline, tuaminoheptane, timazoline): risk of vasoconstriction and/or hypertensive crisis.
  • Taking it with reboxetine may cause high blood pressure.
  • Enoxacin (fluoroquinolones): significant increase in caffeine concentrations in the body, which may lead to excitement and hallucinations.
  • Fluoroquinolones (ciprofloxacin, norfloxacin): significant increase in caffeine concentrations in the body, which may lead to excitement and hallucinations.

Taking Cafergot with food, drinks, and alcohol

Cafergot can be taken with or without food.

Pregnancy, breastfeeding, and fertility

Do not take Cafergot if you are pregnant or breastfeeding.

If you think you might be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

In male rats that received the combination of ergotamine and caffeine orally, fertility was not altered.

Driving and using machines

Patients with a history of vertigo or other cerebral disorders should not drive or operate machines. Patients should not drive a vehicle or operate machinery if they experience visual disturbances.

This medicine may cause dizziness. You should be aware that some symptoms, such as drowsiness, dizziness, and weakness, caused by the migraine attack itself, may affect your ability to drive or use machines.

Important information about some of the ingredients of Cafergot

Athletes are informed that this medicine contains a component that may result in a positive doping test.

Medicine questions

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3. How to take Cafergot

Follow exactly the administration instructions of this medicine given by your doctor or pharmacist. If you are in doubt, consult your doctor or pharmacist again.

Your doctor will indicate the duration of your treatment with Cafergot. Do not stop treatment before consulting your doctor.

Oral use.

Cafergot should be administered when the first symptoms of a migraine attack appear.

The recommended dose is:

Adults

If it is the first time you take Cafergot, a dose of 2 tablets is recommended. If the pain has not subsided within the first half hour, another tablet can be taken. This can be repeated at half-hour intervals without exceeding the maximum daily dose.

Subsequent crises: depending on the doses that were necessary in previous crises, the initial dose can be increased to 3 tablets. If necessary, additional doses of one tablet can be administered at half-hour intervals until the maximum dose is reached.

Use in children and adolescents

Cafergot is not recommended for children and adolescents (under 18 years of age).

Maximum daily dose:

Adults: 6 mg of ergotamine tartrate = 6 tablets.

Maximum weekly dose

Adults: 10 mg of ergotamine tartrate = 10 tablets.

If you take more Cafergot than you should

In case of overdose or accidental ingestion, inform your doctor or pharmacist immediately or consult the Toxicology Information Service, phone 91 562 04 20, indicating the medicine and the amount ingested. It is recommended to bring the package leaflet and the medicine packaging to the healthcare professional.

The symptoms caused by Cafergot overdose are: nausea, vomiting, drowsiness, confusion, tachycardia (increased heart rate), dizziness, numbness, tingling, and pain in fingers and toes. Reduced respiratory rate and coma may occur.

If you forget to take Cafergot

Do not take a double dose to make up for forgotten doses.

If you stop taking Cafergot

If you have any further questions on the use of this medicine, ask your doctor, pharmacist, or nurse.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

If you experience any of the following side effects, contact your doctor immediately:

  • Severe allergic reactions such as rash or itching, swelling of the face, eyelids, lips, urticaria, difficulty breathing.

Other side effects:

Common: May affect up to 1 in 10 people

Dizziness, nausea, and vomiting not related to migraine, and abdominal pain.

Uncommon: May affect up to 1 in 100 people

Numbness and tingling of fingers and toes, blue discoloration of the skin, diarrhea, pain and weakness in arms and legs. Blue discoloration of the skin due to poor blood circulation.

Rare: May affect up to 1 in 1,000 people

Acceleration or slowing of heart rate, increased blood pressure, skin rash, swelling of the face, urticaria, muscle pain, lack of pulse, and difficulty breathing, headache, vertigo, muscle spasms, ergotism (long-term poisoning effect of ergot).

Very rare: May affect up to 1 in 10,000 people

Myocardial infarction (heart attack) or angina pectoris (chest pain), gangrene (death of body tissue due to lack of blood flow or bacterial infection).

Not known: Frequency cannot be estimated from the available data

Endocardial fibrosis (a form of heart disorder in which the heart walls are rigid and the heart is unable to stretch and fill with blood properly), pleural fibrosis (a condition in which the tissue covering the lungs becomes thick and rigid), retroperitoneal fibrosis (a rare condition in which the ducts that carry urine from the kidneys to the bladder are blocked by masses located in the back of the abdominal cavity), rectal ulcer, anal ulcer, drug-induced headache.

Reporting of side effects:

If you experience any side effects, talk to your doctor, pharmacist, or nurse, even if it is possible side effects not listed in this leaflet. You can also report side effects directly through the Spanish Pharmacovigilance System for Human Use Medicines: https://www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storing Cafergot

Keep this medicine out of the sight and reach of children.

Store in the original packaging to protect from light.

Do not store above 25°C. Do not use this medicine after the expiry date stated on the packaging after EXP. The expiry date is the last day of the month indicated.

Medicines should not be disposed of via wastewater or household waste. Place the packaging and any unused medicine in the SIGRE Pointof the pharmacy. If you are unsure, ask your pharmacist how to dispose of the packaging and any unused medicine. This will help protect the environment.

6. Contents of the pack and other information

Composition of Cafergot

The active substances are ergotamine (DOE) tartrate 1 mg and anhydrous caffeine 100 mg.

The other ingredients of the tablet are: tartaric acid, magnesium stearate, talc, cornstarch, microcrystalline cellulose, yellow iron oxide (E172).

Appearance and packaging of the product

Cafergot is presented in tablet form. Cafergot is available in aluminum/PVC/PVDC blister packs of 10 tablets. The score line is only for breaking and facilitating swallowing but not for dividing into equal parts.

Marketing authorization holder and manufacturer

Marketing authorization holder

Amdipharm Limited

Temple Chambers,

3 Burlington Road,

Dublin 4, Ireland

Manufacturer

CENEXI 52 rue Marcel et Jacques Gaucher (Fontenay Sous Bois) - 94120 - France

You can request more information about this medicine by contacting the local representative of the marketing authorization holder:

Local representative

Ferrer Internacional, S.A.

Gran Vía Carlos III, 94

08028 – Barcelona

Revision date of this leaflet: July 2022

Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS)http://www.aemps.gob.es/

Online doctors for CAFERGOT 1 mg/100 mg TABLETS

Discuss questions about CAFERGOT 1 mg/100 mg TABLETS, including use, safety considerations and whether a prescription is appropriate, subject to medical assessment and local regulations.

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Main areas of consultation:

  • Chest pain, shortness of breath, heart palpitations, high blood pressure
  • Hypertension control and cardiovascular disease prevention
  • Interpretation of ECG, blood tests, and Holter monitor results
  • Management of heart failure and coronary artery disease
  • General medical issues: infections, fever, fatigue, gastrointestinal symptoms
  • Guidance on diagnostics, treatment plans, and medication adjustments
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She currently works as a physician at the Canary Islands Emergency Service (Servicio de Urgencias Canario – SUC), where she is responsible for the assessment and care of patients in medical emergency situations, performing the initial diagnosis, patient stabilization, and coordination with hospital services when necessary.

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Throughout his career, he has participated in various medical and academic projects, including a research fellowship in Spain, where he contributed to evidence-based studies in the field of family medicine. This experience allowed him to broaden his global perspective on healthcare and comprehensive patient care.

Dr. Correa Bellido has worked with several healthcare providers in Spain, focusing particularly on patient-centered care and public health initiatives aimed at communities with limited access to healthcare services.

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Dr. Correa Bellido provides comprehensive care for a wide variety of medical conditions, including:

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He also treats infectious and allergic diseases, general health concerns, and provides guidance on prevention and healthy lifestyle habits.

His services include virtual consultations, diagnosis and management of acute and chronic diseases, prescription renewals, and personalized medical advice.

With a patient-centered approach and a strong commitment to continuous learning, Dr. Correa Bellido provides accessible and high-quality healthcare to patients both in Spain and around the world.

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She has conducted research on the genetic background of stroke and is skilled in communicating with patients from diverse cultural backgrounds. Her approach combines clinical expertise with empathy and clear communication.
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  • acute respiratory symptoms (cough, sore throat, runny nose, fever)
  • viral illnesses such as colds and seasonal infections
  • gastrointestinal complaints (nausea, diarrhoea, abdominal pain, gastroenteritis)
  • sudden changes in how a child or adult feels
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  • renewal of prescriptions when clinically appropriate

Dr. Shalko works specifically with urgent and short-term problems, providing practical recommendations and helping patients determine the safest next step. She explains symptoms clearly, guides patients through decision-making and offers straightforward medical advice for everyday acute issues.She does not provide long-term management of chronic conditions, ongoing follow-up or comprehensive care plans for complex long-term illnesses. Her consultations are designed for acute symptoms, sudden concerns and situations where timely medical input is important.With clinical experience in both paediatrics and general medicine, Dr. Shalko confidently supports adults and children. Her communication style is clear, simple and reassuring, helping patients feel informed and supported throughout the consultation.

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Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

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  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
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  • questions about test results and treatment plans
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Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

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He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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Dr Okeke is known for his clear communication, calm approach, and cultural awareness. He listens carefully, explains medical decisions in a structured way, and supports patients in making informed choices about their health.

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Throughout her education and professional career, Dr. Trafimchuk has gained extensive experience in managing diseases of the skin, hair, and nails, as well as in the diagnosis, treatment, and prevention of sexually transmitted infections (STIs). Her clinical approach is based on evidence-based medicine, combined with personalized care tailored to each patient’s needs.

In her daily practice, she treats a wide range of dermatological conditions, including chronic inflammatory dermatoses such as acne, rosacea, atopic dermatitis, psoriasis, and eczema. She also has experience in treating pigmentation disorders, including melasma, post-inflammatory hyperpigmentation, and dyschromia.

She has developed a particular interest in trichology, treating various types of alopecia, chronic hair loss, and scalp disorders. In addition, she has experience in managing infectious dermatoses of fungal, viral, and bacterial origin, as well as in evaluating benign and suspicious skin lesions, with referral to specialized care when necessary.

With a strong interest in a comprehensive approach to skin health, she also treats scars, post-procedural skin changes, and conditions related to hormonal factors and aging, including those associated with pregnancy, menopause, and age-related skin changes.

Thanks to her experience and continuous professional development, Dr. Trafimchuk provides high-quality medical care that is professional, confidential, and aligned with modern dermatology standards.

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Cristina Andrada Brazo

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As a licensed physician fully integrated with the Spanish electronic prescription system, Dr. Andrada can issue legally valid e-prescriptions following a medical assessment during an online consultation. Whether you need help with an acute illness, prescription renewal, neurological symptoms, or travel-related healthcare, she offers convenient, patient-centered medical care without the need to visit a clinic.

Dr. Andrada combines extensive emergency medicine experience with advanced expertise in neurology, epilepsy, sleep medicine, and headache disorders. Her international clinical background includes several years working in Switzerland, where she collaborated with multidisciplinary teams in emergency departments and neurology services. This experience strengthened her commitment to evidence-based medicine, compassionate communication, and high-quality patient care.

She graduated in Medicine from the University of Seville and completed her residency in Clinical Neurophysiology at Hospital Virgen de la Salud and the National Hospital for Paraplegics in Toledo. She currently works as a Clinical Neurophysiology Specialist at Hospital San Pedro in Logroño.

To further expand her expertise, Dr. Andrada completed several postgraduate qualifications, including Master's degrees in Sleep Physiology and Medicine, Medical Professionalism and Clinical Practice, Epilepsy, and Clinical Management.

Patients appreciate her thorough consultations, practical treatment recommendations, and empathetic approach. She speaks Spanish, French, and Portuguese, allowing her to communicate comfortably with patients from different backgrounds.

Conditions Dr. Cristina Andrada Treats Online

Dr. Andrada provides online consultations for a wide range of common medical conditions, including:

  • Fever, flu, COVID-19 symptoms, sore throat and respiratory infections
  • Sinusitis, bronchitis, cough and seasonal allergies
  • Urinary tract infections (UTIs)
  • Migraine and tension headaches
  • Dizziness and vertigo
  • Epilepsy and seizure follow-up
  • Sleep disorders, including insomnia and circadian rhythm disturbances
  • Heartburn, gastritis, diarrhea and constipation
  • Back pain, muscle injuries and joint pain
  • Minor skin infections and allergic reactions
  • Fatigue and general medical assessment
  • Prescription renewals for appropriate chronic treatments
  • Follow-up consultations after surgery or previous medical treatment
  • Travel medicine advice and preventive healthcare
  • Interpretation of laboratory results and medical reports

If your condition requires urgent in-person assessment or emergency care, Dr. Andrada will advise you on the most appropriate next steps.

Book an Online Consultation

Book a secure online consultation with Dr. Cristina Andrada Brazo through Oladoctor and receive professional medical advice from an experienced Spanish physician without leaving home. Online appointments are available for adults throughout Spain, with fast access to medical care and electronic prescriptions whenever clinically indicated.

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Frequently Asked Questions

CAFERGOT 1 mg/100 mg TABLETS requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

The active ingredient in CAFERGOT 1 mg/100 mg TABLETS is ergotamine, combinations excl. psycholeptics. This information helps identify medicines with the same composition but different brand names.

CAFERGOT 1 mg/100 mg TABLETS is manufactured by Amdipharm Limited. Pharmacy brands and packaging may differ depending on the distributor.

Doctors such as Psychiatrists, Neurologists, General medicine doctors, Pain medicine doctors, Anaesthesiologists may assess whether CAFERGOT 1 mg/100 mg TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

The prescription is issued by a doctor after assessing your health. In Spain, CAFERGOT 1 mg/100 mg TABLETS is then dispensed in pharmacies with that prescription. An online consultation does not guarantee that a prescription will be issued: the decision always rests with the doctor.

To request an assessment, you can use Oladoctor:

Other medicines with the same active substance (ergotamine, combinations excl. psycholeptics) include HEMICRANEAL 400 MG/100 MG /2 MG SUPPOSITORIES, HEMICRANEAL TABLETS, AIMOVIG 140 mg SOLUTION FOR INJECTION IN A PRE-FILLED PEN. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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