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About the medicine

How to use BRILIQUE 60 mg FILM-COATED TABLETS

Contents of the leaflet

  1. Introduction
  2. What is Brilique and what is it used for
  3. What you need to know before you take Brilique
  4. How to take Brilique
  5. Possible side effects
  6. Storing Brilique
  7. Package Contents and Additional Information

Introduction

Package Leaflet: Information for the User

Brilique 60mg film-coated tablets

ticagrelor

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What is Brilique and what is it used for
  2. What you need to know before you take Brilique
  3. How to take Brilique
  4. Possible side effects
  5. Storing Brilique
  6. Package contents and further information

1. What is Brilique and what is it used for

What is Brilique

Brilique contains the active substance ticagrelor. It belongs to a group of medicines called antiplatelet agents.

What Brilique is used for

Brilique in combination with acetylsalicylic acid (another antiplatelet agent) should only be used in adults. You have been prescribed this medicine because you have had:

  • a heart attack, more than a year ago.

This medicine reduces the risk of you having another heart attack, a stroke or of dying from a heart or blood vessel disease.

How Brilique works

Brilique works on cells called ‘platelets’ (also called thrombocytes). These very small blood cells help stop bleeding by clumping together to block small holes in blood vessels that are cut or damaged.

However, platelets can also form clots inside damaged blood vessels in the heart and brain. This can be very dangerous because:

  • the clot can completely block the blood flow; this can cause a heart attack (myocardial infarction) or a stroke, or
  • the clot can partially block the blood vessels going to the heart; this reduces blood flow to the heart and can cause intermittent chest pain (called ‘unstable angina’).

Brilique helps prevent platelets from clumping together. This reduces the chance of a blood clot forming that could block blood flow.

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2. What you need to know before you take Brilique

Do not take Brilique if:

  • You are allergic to ticagrelor or any of the other ingredients of this medicine (listed in section 6).
  • You have any current bleeding.
  • You have had a stroke caused by bleeding in the brain.
  • You have severe liver disease.
  • You are taking any of the following medicines:
  • ketoconazole (used to treat fungal infections)
  • clarithromycin (used to treat bacterial infections)
  • nefazodone (an antidepressant)
  • ritonavir and atazanavir (used to treat HIV and AIDS)

Do not take Brilique if any of the above applies to you. If you are unsure, consult your doctor or pharmacist before taking this medicine.

Warnings and precautions

Consult your doctor or pharmacist before taking Brilique if:

  • You have a higher risk of bleeding due to:
  • a recent serious injury
  • a recent surgery (including dental procedures, ask your dentist about this)
  • a condition that affects blood clotting
  • a recent stomach or intestine bleeding (such as stomach ulcer or colon polyps)
  • You need to have surgery (including dental procedures) at any time while taking Brilique. This is because it increases the risk of bleeding. Your doctor may want to stop your treatment with this medicine 5 days before surgery.
  • Your heart rate is abnormally slow (usually less than 60 beats per minute) and you do not have a device that regulates your heart (pacemaker).
  • You have asthma or other lung problems or breathing difficulties.
  • You develop irregular breathing patterns, such as speeding up, slowing down, or brief pauses in breathing. Your doctor will decide if you need any further evaluation.
  • You have had any liver problems or have had a disease that may have affected your liver.
  • You have had a blood test showing that the level of uric acid is higher than normal.

If any of the above applies to you (or if you are unsure), consult your doctor or pharmacist before taking this medicine.

If you are taking Brilique and heparin:

  • Your doctor may require a blood sample for diagnostic tests if they suspect the presence of a rare platelet disorder caused by heparin. It is important that you inform your doctor that you are taking Brilique and heparin, as Brilique may affect the diagnostic test.

Children and adolescents

Brilique is not recommended for children and adolescents under 18 years of age.

Using Brilique with other medicines

Tell your doctor or pharmacist if you are using, have recently used or might use any other medicines. This is because Brilique may affect the way some medicines work and some medicines may affect Brilique.

Tell your doctor or pharmacist if you are taking any of the following medicines:

  • Rosuvastatin (a medicine to treat high cholesterol)
  • more than 40 mg daily of simvastatin or lovastatin (medicines used to treat high cholesterol levels)
  • rifampicin (an antibiotic)
  • phenytoin, carbamazepine, and phenobarbital (used to control epilepsy seizures)
  • digoxin (used to treat heart failure)
  • cyclosporin (used to reduce the body's immune response)
  • quinidine and diltiazem (used to treat irregular heart rhythms)
  • beta-blockers and verapamil (used to treat high blood pressure)
  • morphine and other opioids (used to treat acute pain)

In particular, tell your doctor or pharmacist if you are taking any of the following medicines that increase the risk of bleeding:

  • ‘oral anticoagulants’, often referred to as ‘blood thinners’, including warfarin.
  • Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) frequently taken as painkillers, such as ibuprofen and naproxen.
  • Selective Serotonin Reuptake Inhibitors (SSRIs) taken as antidepressants, such as paroxetine, sertraline, and citalopram.
  • other medicines such as ketoconazole (used to treat fungal infections), clarithromycin (used to treat bacterial infections), nefazodone (an antidepressant), ritonavir and atazanavir (used to treat HIV and AIDS), cisapride (used to treat stomach acidity), and ergot alkaloids (used to treat migraines and headaches).

Tell your doctor that, because you are taking Brilique, you may have a higher risk of bleeding if your doctor gives you fibrinolytics, often referred to as ‘clot dissolvers’, such as streptokinase or alteplase.

Pregnancy and breastfeeding

Brilique is not recommended during pregnancy or if you are planning to become pregnant. Women should use appropriate contraceptive methods to prevent pregnancy while taking this medicine.

Consult your doctor before taking this medicine if you are breastfeeding. Your doctor will explain the benefits and risks of taking Brilique during this period.

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, consult your doctor or pharmacist before taking this medicine.

Driving and using machines

Brilique is unlikely to affect your ability to drive or use machines. If you feel dizzy or confused while taking this medicine, be careful while driving or using machines.

Sodium content

This medicine contains less than 1 mmol of sodium (23 mg) per dose, which is essentially ‘sodium-free’.

3. How to take Brilique

Always take this medicine exactly as your doctor has told you. If you are unsure, consult your doctor or pharmacist.

How much to take

  • The usual dose is one 60 mg tablet twice a day. Keep taking Brilique for as long as your doctor recommends.
  • Take this medicine at the same time every day (for example, one tablet in the morning and one in the evening).

Taking Brilique with other medicines for blood clotting

Your doctor will also usually prescribe acetylsalicylic acid. This is a substance found in many medicines used to prevent blood clotting. Your doctor will tell you how much to take (usually between 75-150 mg daily).

How to take Brilique

  • You can take this medicine with or without food.
  • You can check when you last took a Brilique tablet by looking at the blister pack. A sun symbol (for morning) and a moon symbol (for evening) will appear. This will tell you if you have taken your dose.

If you have difficulty swallowing the tablet

If you have difficulty swallowing the tablet, you can crush it and mix it with water as follows:

  • Crush the tablet into a fine powder
  • Pour the powder into half a glass of water
  • Stir and drink immediately
  • To make sure you get all the medicine, rinse the empty glass with another half glass of water and drink it

If you are in hospital, this tablet may be given to you mixed with a little water through a tube in your nose (nasogastric tube).

If you take more Brilique than you should

If you take more Brilique than you should, consult your doctor or go to hospital immediately. Take the medicine pack with you. You may have a higher risk of bleeding.

If you forget to take Brilique

  • If you forget to take a dose, just take your next dose at the usual time.
  • Do not take a double dose (two doses at the same time) to make up for forgotten doses.

If you stop taking Brilique

Do not stop taking Brilique without consulting your doctor. Take this medicine regularly and for as long as your doctor recommends. If you stop taking Brilique, you may increase the risk of having another heart attack or stroke or of dying from a heart or blood vessel disease.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

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4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. The following side effects may occur with Brilique:

Brilique affects blood clotting, so most side effects are related to bleeding. Bleeding can occur anywhere in the body. Some level of bleeding is common (such as bruising and nosebleeds). Serious bleeding is rare but can be life-threatening.

Tell your doctor immediately if you notice any of the following - you may need urgent medical treatment:

  • Bleeding in the brain or inside the skull is an uncommon side effect and can cause signs of a stroke such as:
  • sudden numbness or weakness of the arms, legs, or face, especially if it affects only one side of the body
  • sudden confusion, difficulty speaking or understanding others
  • sudden difficulty walking or loss of balance or coordination
  • sudden feeling of dizziness or severe headache of unknown cause
  • Signs of bleeding such as:
  • severe or uncontrolled bleeding
  • unexpected or prolonged bleeding
  • pink, red, or brown urine
  • vomiting blood or vomit that looks like “coffee grounds”
  • black or red stools (like tar)
  • coughing or vomiting blood
  • Fainting (syncope)
  • temporary loss of consciousness due to a sudden drop in blood flow to the brain (common)
  • Signs of a blood clotting problem called Thrombotic Thrombocytopenic Purpura (TTP) such as:
  • fever and purple spots (called purpura) on the skin and in the mouth, with or without yellowing of the skin or eyes (jaundice), extreme tiredness, or confusion.

Tell your doctor if you notice any of the following:

  • Difficulty breathing - this is very common.It may be due to heart disease or another cause, or it may be a side effect of Brilique. Breathlessness related to Brilique is usually mild and is characterized by a sudden, unexpected need for air that usually occurs at rest and may appear in the first weeks of treatment and in many cases may disappear. If you think your breathlessness has worsened or is lasting longer, tell your doctor. They will decide if you need treatment or further investigations.

Other possible side effects

Very common (may affect more than 1 in 10 people)

  • High level of uric acid in the blood (as seen in blood tests)
  • Bleeding caused by blood disorders

Common (may affect up to 1 in 10 people)

  • Bruising
  • Headache
  • Feeling dizzy or as if everything is spinning
  • Diarrhea or indigestion
  • Feeling sick (nausea)
  • Constipation
  • Rash
  • Itching
  • Severe pain and swelling in the joints - these are signs of gout
  • Feeling dizzy or faint, or blurred vision - these are signs of low blood pressure
  • Nosebleeds
  • Bleeding more than usual after surgery or cuts (for example, when shaving) and injuries
  • Bleeding from the stomach lining (stomach ulcer)
  • Bleeding gums

Uncommon (may affect up to 1 in 100 people)

  • Allergic reaction - a skin rash, itching, or swelling of the face or lips may be signs of an allergic reaction
  • Confusion
  • Vision problems caused by bleeding in the eye
  • Heavier or more prolonged vaginal bleeding, or bleeding at times other than your usual menstrual period
  • Bleeding into the joints and muscles that causes painful swelling
  • Bleeding in the ear
  • Internal bleeding, which can cause dizziness or fainting

Frequency not known (cannot be estimated from the available data)

  • Abnormally slow heart rate (usually below 60 beats per minute)

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storing Brilique

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the blister and on the carton after EXP/CAD. The expiry date refers to the last day of the month shown.

This medicine does not require any special storage conditions.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help protect the environment.

6. Package Contents and Additional Information

Composition ofBrilique

  • The active substance is ticagrelor. Each film-coated tablet contains 60 mg of ticagrelor.
  • The other ingredients are:

Tablet core:mannitol (E421), calcium hydrogen phosphate dihydrate, sodium carboxymethyl starch type A, hydroxypropylcellulose (E463), magnesium stearate (E470b).

Tablet film coating:hypromellose (E464), titanium dioxide (E171), macrogol 400, black iron oxide (E172), red iron oxide (E172).

Appearance and Package Contents

Film-coated tablet (tablet): The tablets are round, biconvex, pink, film-coated, and marked with a "60" over a "T" on one side.

Brilique is available in:

  • standard blisters (with sun/moon symbols) in packs of 60 and 180 tablets
  • calendar blisters (with sun/moon symbols) in packs of 14, 56, and 168 tablets

Not all pack sizes may be marketed.

Marketing Authorisation Holder and Manufacturer

Marketing Authorisation Holder:

AstraZeneca AB

SE-152 57 Södertälje

Sweden

Manufacturer:

AstraZeneca AB

Gärtunavägen

SE-151 85 Södertälje

Sweden

For further information about this medicinal product, please contact the local representative of the Marketing Authorisation Holder:

Belgium/Belgique/Belgien

AstraZeneca S.A./N.V.

Tel: +32 2 370 48 11

Lithuania

UAB AstraZeneca Lietuva

Tel: +370 5 2660550

Text in Bulgarian language with the name of a company AstraZeneca Bulgaria EOOD and a phone number

Luxembourg/Luxemburg

NV AstraZeneca SA

Tél/Tel: +32 2 370 48 11

Czech Republic

AstraZeneca Czech Republic s.r.o

Tel: +420 222 807 111

Hungary

AstraZeneca kft

Tel.: +36 1 883 6500

Denmark

AstraZeneca A/S

Tlf: +45 43 66 64 62

Malta

Associated Drug Co. Ltd

Tel: +356 2277 8000

Germany

AstraZeneca GmbH

Tel: +49 40 809034100

Netherlands

AstraZeneca BV

Tel: +31 85 808 9900

Estonia

AstraZeneca

Tel: +372 6549 600

Norway

AstraZeneca AS

Tlf: +47 21 00 64 00

Greece

AstraZeneca A.E.

Τηλ: +30 2 106871500

Austria

AstraZeneca Österreich GmbH

Tel: +43 1 711 31 0

Spain

AstraZeneca Farmacéutica Spain, S.A.

Tel: +34 91 301 91 00

Poland

AstraZeneca Pharma Poland Sp. z o.o.

Tel.: +48 22 245 73 00

France

AstraZeneca

Tél: +33 1 41 29 40 00

Portugal

AstraZeneca Produtos Farmacêuticos, Lda.

Tel: +351 21 434 61 00

Croatia

AstraZeneca d.o.o.

Tel: +385 1 4628 000

Romania

AstraZeneca Pharma SRL

Tel: +40 21 317 60 41

Ireland

AstraZeneca Pharmaceuticals (Ireland) DAC

Tel: +353 1609 7100

Slovenia

AstraZeneca UK Limited

Tel: +386 1 51 35 600

Iceland

Vistor hf

Sími: +354 535 7000

Slovak Republic

AstraZeneca AB o.z.

Tel: +421 2 5737 7777

Italy

AstraZeneca S.p.A.

Tel: +39 02 00704500

Finland

AstraZeneca Oy

Puh/Tel: +358 10 23 010

Cyprus

Αλκήτωρ Φαρμακευτική Λτδ

Τηλ: +357 22490305

Sweden

AstraZeneca AB

Tel: +46 8 553 26 000

Latvia

SIA AstraZeneca Latvija

Tel: +371 67377 100

United Kingdom(Northern Ireland)

AstraZeneca UK Ltd

Tel: +44 1582 836 836

Date of Last Revision of thisLeaflet:

Other Sources of Information

Detailed information on this medicinal product is available on the European Medicines Agency website http://www.ema.europa.eu.

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Dr. Anastasiia Shalko is a general practitioner with a background in both paediatrics and general medicine. She graduated from Bogomolets National Medical University in Kyiv and completed her paediatric internship at the P.L. Shupyk National Medical Academy of Postgraduate Education. After working as a paediatrician in Kyiv, she relocated to Spain, where she has been practising general medicine since 2015, providing care for both adults and children.Her work focuses on urgent, short-term medical concerns – situations where patients need quick guidance, symptom assessment and clear next steps. She helps people understand whether their symptoms require in-person evaluation, home management or a change in treatment. Common reasons for booking an online consultation include:

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  • viral illnesses such as colds and seasonal infections
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Dr. Shalko works specifically with urgent and short-term problems, providing practical recommendations and helping patients determine the safest next step. She explains symptoms clearly, guides patients through decision-making and offers straightforward medical advice for everyday acute issues.She does not provide long-term management of chronic conditions, ongoing follow-up or comprehensive care plans for complex long-term illnesses. Her consultations are designed for acute symptoms, sudden concerns and situations where timely medical input is important.With clinical experience in both paediatrics and general medicine, Dr. Shalko confidently supports adults and children. Her communication style is clear, simple and reassuring, helping patients feel informed and supported throughout the consultation.

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  • headache, dizziness, migraine symptoms
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Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

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Dr. Lizaveta Trafimchuk Takhvaniuk graduated in Medicine and subsequently specialized in Dermatology and Venereology. She has more than 10 years of clinical experience and is licensed to practice in Spain, where she focuses on the comprehensive diagnosis and treatment of dermatological conditions.

Throughout her education and professional career, Dr. Trafimchuk has gained extensive experience in managing diseases of the skin, hair, and nails, as well as in the diagnosis, treatment, and prevention of sexually transmitted infections (STIs). Her clinical approach is based on evidence-based medicine, combined with personalized care tailored to each patient’s needs.

In her daily practice, she treats a wide range of dermatological conditions, including chronic inflammatory dermatoses such as acne, rosacea, atopic dermatitis, psoriasis, and eczema. She also has experience in treating pigmentation disorders, including melasma, post-inflammatory hyperpigmentation, and dyschromia.

She has developed a particular interest in trichology, treating various types of alopecia, chronic hair loss, and scalp disorders. In addition, she has experience in managing infectious dermatoses of fungal, viral, and bacterial origin, as well as in evaluating benign and suspicious skin lesions, with referral to specialized care when necessary.

With a strong interest in a comprehensive approach to skin health, she also treats scars, post-procedural skin changes, and conditions related to hormonal factors and aging, including those associated with pregnancy, menopause, and age-related skin changes.

Thanks to her experience and continuous professional development, Dr. Trafimchuk provides high-quality medical care that is professional, confidential, and aligned with modern dermatology standards.

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Cristina Andrada Brazo

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Dr. Cristina Andrada Brazo is a highly experienced Spanish physician with more than 15 years of clinical practice in emergency medicine, urgent care, and clinical neurophysiology. She provides professional online medical consultations for patients across Spain, helping both residents and international visitors receive timely medical advice, diagnosis, treatment recommendations, and electronic prescriptions when clinically appropriate.

As a licensed physician fully integrated with the Spanish electronic prescription system, Dr. Andrada can issue legally valid e-prescriptions following a medical assessment during an online consultation. Whether you need help with an acute illness, prescription renewal, neurological symptoms, or travel-related healthcare, she offers convenient, patient-centered medical care without the need to visit a clinic.

Dr. Andrada combines extensive emergency medicine experience with advanced expertise in neurology, epilepsy, sleep medicine, and headache disorders. Her international clinical background includes several years working in Switzerland, where she collaborated with multidisciplinary teams in emergency departments and neurology services. This experience strengthened her commitment to evidence-based medicine, compassionate communication, and high-quality patient care.

She graduated in Medicine from the University of Seville and completed her residency in Clinical Neurophysiology at Hospital Virgen de la Salud and the National Hospital for Paraplegics in Toledo. She currently works as a Clinical Neurophysiology Specialist at Hospital San Pedro in Logroño.

To further expand her expertise, Dr. Andrada completed several postgraduate qualifications, including Master's degrees in Sleep Physiology and Medicine, Medical Professionalism and Clinical Practice, Epilepsy, and Clinical Management.

Patients appreciate her thorough consultations, practical treatment recommendations, and empathetic approach. She speaks Spanish, French, and Portuguese, allowing her to communicate comfortably with patients from different backgrounds.

Conditions Dr. Cristina Andrada Treats Online

Dr. Andrada provides online consultations for a wide range of common medical conditions, including:

  • Fever, flu, COVID-19 symptoms, sore throat and respiratory infections
  • Sinusitis, bronchitis, cough and seasonal allergies
  • Urinary tract infections (UTIs)
  • Migraine and tension headaches
  • Dizziness and vertigo
  • Epilepsy and seizure follow-up
  • Sleep disorders, including insomnia and circadian rhythm disturbances
  • Heartburn, gastritis, diarrhea and constipation
  • Back pain, muscle injuries and joint pain
  • Minor skin infections and allergic reactions
  • Fatigue and general medical assessment
  • Prescription renewals for appropriate chronic treatments
  • Follow-up consultations after surgery or previous medical treatment
  • Travel medicine advice and preventive healthcare
  • Interpretation of laboratory results and medical reports

If your condition requires urgent in-person assessment or emergency care, Dr. Andrada will advise you on the most appropriate next steps.

Book an Online Consultation

Book a secure online consultation with Dr. Cristina Andrada Brazo through Oladoctor and receive professional medical advice from an experienced Spanish physician without leaving home. Online appointments are available for adults throughout Spain, with fast access to medical care and electronic prescriptions whenever clinically indicated.

Book a video appointment
€56

Frequently Asked Questions

BRILIQUE 60 mg FILM-COATED TABLETS requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

The active ingredient in BRILIQUE 60 mg FILM-COATED TABLETS is ticagrelor. This information helps identify medicines with the same composition but different brand names.

The average pharmacy price for BRILIQUE 60 mg FILM-COATED TABLETS is around 35.41 EUR. Prices may vary depending on the manufacturer and dosage form.

BRILIQUE 60 mg FILM-COATED TABLETS is manufactured by Astrazeneca Ab. Pharmacy brands and packaging may differ depending on the distributor.

Doctors such as Family doctors, Cardiologists, Nephrologists, Hematologists, General surgeons, General medicine doctors, Phlebologists may assess whether BRILIQUE 60 mg FILM-COATED TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

The prescription is issued by a doctor after assessing your health. In Spain, BRILIQUE 60 mg FILM-COATED TABLETS is then dispensed in pharmacies with that prescription. An online consultation does not guarantee that a prescription will be issued: the decision always rests with the doctor.

To request an assessment, you can use Oladoctor:

Other medicines with the same active substance (ticagrelor) include BRILIQUE 60 mg FILM-COATED TABLETS, BRILIQUE 90 mg ORALLY DISINTEGRATING TABLETS, BRILIQUE 90 mg FILM-COATED TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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