BRILIQUE 90 mg Orally Disintegrating Tablets
Prescription review online
A doctor will review your case and decide whether a prescription is medically appropriate.
Talk to a doctor about this medicine
Discuss your symptoms and possible next steps in a quick online consultation.
How to use BRILIQUE 90 mg ORALLY DISINTEGRATING TABLETS
Contents of the leaflet
- Introduction
- What is Brilique and what is it used for
- What you need to know before you take Brilique
- How to take Brilique
- Possible side effects
- Storing Brilique
- Packaging Contents and Additional Information
Introduction
Package Leaflet: Information for the User
Brilique 90mg orodispersible tablets
ticagrelor
Read all of this leaflet carefully before you start taking this medicine, because it contains important information for you.
- Keep this leaflet, you may need to read it again.
- If you have any further questions, ask your doctor or pharmacist.
- This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
- If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.
Contents of the pack
- What is Brilique and what is it used for
- What you need to know before you take Brilique
- How to take Brilique
- Possible side effects
- Storing Brilique
- Contents of the pack and other information
1. What is Brilique and what is it used for
What is Brilique
Brilique contains the active substance ticagrelor. It belongs to a group of medicines called antiplatelet agents.
What Brilique is used for
Brilique, in combination with acetylsalicylic acid (another antiplatelet agent), should only be used in adults. You have been prescribed this medicine because you have had:
- a heart attack, or
- unstable angina (chest pain or angina that is not well controlled).
This medicine reduces the risk of you having another heart attack, a stroke or of dying from a heart or blood vessel-related illness.
How Brilique works
Brilique works on cells called ‘platelets’ (also called thrombocytes). These very small blood cells help stop bleeding by clumping together to block tiny holes in blood vessels that are cut or damaged.
However, platelets can also form clots inside damaged blood vessels in the heart and brain. This can be very dangerous because:
- the clot can completely block the blood flow; this can cause a heart attack (myocardial infarction) or a stroke, or
- the clot can partially block the blood vessels that supply the heart; this reduces blood flow to the heart and can cause intermittent chest pain (called ‘unstable angina’).
Brilique helps prevent platelets from clumping together. This reduces the chance of a blood clot forming that could block blood flow.
Not sure if this medicine is right for you?
Discuss your symptoms and treatment with a doctor online.
2. What you need to know before you take Brilique
Do not take Brilique if:
- You are allergic to ticagrelor or any of the other ingredients of this medicine (listed in section 6).
- You have any current bleeding.
- You have had a stroke caused by bleeding in the brain.
- You have severe liver disease.
- You are taking any of the following medicines:
- ketoconazole (used to treat fungal infections)
- clarithromycin (used to treat bacterial infections)
- nefazodone (an antidepressant)
- ritonavir and atazanavir (used to treat HIV and AIDS)
Do not take Brilique if any of the above applies to you. If you are unsure, consult your doctor or pharmacist before taking this medicine.
Warnings and precautions
Consult your doctor or pharmacist before taking Brilique if:
- You have a higher risk of bleeding due to:
- a recent serious injury
- a recent surgery (including dental procedures, ask your dentist about this)
- a condition that affects blood clotting
- a recent stomach or intestine bleeding (such as stomach ulcer or colon ‘polyps’)
- You are due to have surgery (including dental procedures) at any time while taking Brilique. This is because it increases the risk of bleeding. Your doctor may want to stop your treatment with this medicine 5 days before surgery.
- Your heart rate is abnormally slow (usually less than 60 beats per minute) and you do not have a device that regulates your heart (pacemaker).
- You have asthma or other lung problems or breathing difficulties.
- You develop irregular breathing patterns, such as speeding up, slowing down or brief pauses in breathing. Your doctor will decide if you need any further evaluation.
- You have had any liver problems or have had a disease that may have affected your liver.
- You have had a blood test that shows you have a higher than normal level of uric acid.
If any of the above applies to you (or if you are unsure), consult your doctor or pharmacist before taking this medicine.
If you are taking Brilique and heparin:
- Your doctor may need a blood sample for diagnostic tests if they suspect the presence of a rare platelet disorder caused by heparin. It is important that you inform your doctor that you are taking Brilique and heparin, as Brilique may affect the diagnostic test.
Children and adolescents
Brilique is not recommended for children and adolescents under 18 years of age.
Using Brilique with other medicines
Tell your doctor or pharmacist if you are using, have recently used or might use any other medicines. This is because Brilique may affect the way some medicines work and some medicines may affect Brilique.
Tell your doctor or pharmacist if you are taking any of the following medicines:
- Rosuvastatin (a medicine used to treat high cholesterol)
- more than 40 mg daily of simvastatin or lovastatin (medicines used to treat high cholesterol levels)
- rifampicin (an antibiotic)
- phenytoin, carbamazepine and phenobarbital (used to control epilepsy)
- digoxin (used to treat heart failure)
- ciclosporin (used to reduce the body’s immune response)
- quinidine and diltiazem (used to treat irregular heart rhythms)
- beta-blockers and verapamil (used to treat high blood pressure)
- morphine and other opioids (used to treat acute pain)
In particular, tell your doctor or pharmacist if you are taking any of the following medicines that increase the risk of bleeding:
- ‘oral anticoagulants’, often referred to as ‘blood thinners’, including warfarin.
- Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) frequently taken as painkillers, such as ibuprofen and naproxen.
- Selective Serotonin Reuptake Inhibitors (SSRIs) taken as antidepressants, such as paroxetine, sertraline and citalopram.
- other medicines such as ketoconazole (used to treat fungal infections), clarithromycin (used to treat bacterial infections), nefazodone (an antidepressant), ritonavir and atazanavir (used to treat HIV and AIDS), cisapride (used to treat stomach acidity), ergot alkaloids (used to treat migraines and headaches).
Tell your doctor that, because you are taking Brilique, you may have a higher risk of bleeding if your doctor gives you fibrinolytics, often referred to as ‘clot dissolvers’, such as streptokinase or alteplase.
Pregnancy and breast-feeding
Brilique should not be used if you are pregnant or can become pregnant. Women should use appropriate contraceptive methods to prevent pregnancy while taking this medicine.
Consult your doctor before taking this medicine if you are breast-feeding. Your doctor will explain the benefits and risks of taking Brilique during this time.
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Driving and using machines
Brilique is unlikely to affect your ability to drive or use machines. If you feel dizzy or confused while taking this medicine, be careful while driving or using machines.
Sodium content
This medicine contains less than 1 mmol of sodium (23 mg) per dose, which is essentially ‘sodium-free’.
3. How to take Brilique
Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
How much to take
- The initial dose is two tablets at the same time (a loading dose of 180 mg). This dose will usually be given to you in hospital.
- After this initial dose, the usual dose is one 90 mg tablet twice a day for 12 months, unless your doctor tells you otherwise.
- Take this medicine at the same time every day (for example, one tablet in the morning and one in the evening).
Taking Brilique with other medicines for blood clotting
Your doctor will also usually prescribe acetylsalicylic acid for you. This is a substance found in many medicines used to prevent blood clotting. Your doctor will tell you how much to take (usually between 75-150 mg daily).
How to take Brilique
Do not open the blister until you are ready to take your medicine.
- To remove the tablet, open the blister pack – do not push the tablet through the blister because the tablet may break.
- Place the tablet on your tongue and let it dissolve.
- You can then swallow it with or without water.
- You can take this medicine with or without food.
If you are in hospital, this tablet may be given to you mixed with a little water and through a tube in your nose (nasogastric tube).
If you take more Brilique than you should
If you take more Brilique than you should, contact your doctor or go to hospital immediately. Take the medicine pack with you. You may have a higher risk of bleeding.
If you forget to take Brilique
- If you forget to take a dose, just take your next dose at the usual time.
- Do not take a double dose (two doses at the same time) to make up for a forgotten dose.
If you stop taking Brilique
Do not stop taking Brilique without consulting your doctor. Take this medicine regularly and for as long as your doctor tells you. If you stop taking Brilique, you may increase your risk of having another heart attack or a stroke or of dying from a heart or blood vessel-related illness.
If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Started taking the medicine and have questions?
Discuss your symptoms and treatment with a doctor online.
4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them. The following side effects may occur with Brilique:
Brilique affects blood clotting, so most side effects are related to bleeding. Bleeding can occur anywhere in the body. Some level of bleeding is common (such as bruising and nosebleeds). Serious bleeding is rare but can be life-threatening.
Tell your doctor immediately if you notice any of the following - you may need urgent medical treatment:
- Bleeding in the brain or inside the skull is an uncommon side effect, and can cause signs of a stroke such as:
- sudden numbness or weakness of the arms, legs or face, especially if it affects only one side of the body
- sudden confusion, difficulty speaking or understanding others
- sudden difficulty walking or loss of balance or coordination
- sudden feeling of dizziness or a sudden severe headache of unknown cause
- Signs of bleeding such as:
- severe or uncontrollable bleeding
- unexpected or prolonged bleeding
- urine that is pink, red or brown
- vomiting blood or vomit that looks like “coffee grounds”
- black or red stools (like tar)
- coughing or vomiting blood
- Fainting (syncope)
- temporary loss of consciousness due to a sudden drop in blood flow to the brain (common)
- Signs of a blood clotting problem called Thrombotic Thrombocytopenic Purpura (TTP) such as:
- fever and purple spots on the skin and in the mouth, with or without yellowing of the skin or eyes (jaundice), unexplained extreme tiredness or confusion.
Tell your doctor if you notice any of the following:
- Difficulty breathing - this is very common.It may be due to your heart condition or another cause, or it may be a side effect of Brilique. The breathing difficulty related to Brilique is usually mild and is characterised by a sudden, unexpected need for air that usually occurs at rest and may disappear in many cases. If you think your breathing difficulty has worsened or lasts for a long time, tell your doctor. They will decide if you need any treatment or further investigations.
Other possible side effects
Very common (may affect more than 1 in 10 people)
- High level of uric acid in the blood (as seen in blood tests)
- Bleeding caused by blood disorders
Common (may affect up to 1 in 10 people)
- Bruising
- Headache
- Feeling dizzy or as if everything is spinning
- Diarrhoea or indigestion
- Feeling sick (nausea)
- Constipation
- Rash
- Itching
- Severe pain and swelling in the joints – these are signs of gout
- Feeling dizzy or faint, or blurred vision – these are signs of low blood pressure
- Nosebleeds
- Bleeding that is more severe than normal after surgery or cuts (for example, when shaving) and injuries
- Bleeding from the stomach lining (stomach ulcer)
- Bleeding from the gums
Uncommon (may affect up to 1 in 100 people)
- Allergic reaction – a skin rash, itching or swelling of the face or swelling of the lips/tongue may be signs of an allergic reaction
- Confusion
- Vision problems caused by bleeding in the eye
- Heavier or more frequent vaginal bleeding, or bleeding between periods
- Bleeding into the joints and muscles that causes painful swelling
- Bleeding in the ear
- Internal bleeding, this can cause dizziness or fainting
Frequency not known (cannot be estimated from the available data)
- Abnormally slow heart rate (usually below 60 beats per minute)
Reporting of side effects
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.
5. Storing Brilique
Keep this medicine out of the sight and reach of children.
Do not use this medicine after the expiry date which is stated on the blister and on the carton after EXP/CAD. The expiry date refers to the last day of the month shown.
This medicine does not require any special storage conditions.
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help protect the environment.
6. Packaging Contents and Additional Information
Composition ofBrilique
- The active ingredient is ticagrelor. Each buccal dispersible tablet contains 90 mg of ticagrelor.
- The other ingredients are:
mannitol (E421), microcrystalline cellulose (E460), crospovidone (E1202), xylitol (E967), anhydrous calcium hydrogen phosphate (E341), sodium stearyl fumarate, hydroxypropylcellulose (E463), anhydrous colloidal silica.
Appearance and Packaging of the Product
The buccal dispersible tablets are round, flat, with beveled edges, white to pale pink in color, marked with a "90" above a "TI" on one side.
Brilique is available in:
- unit dose blisters in packs of 10 x 1, 56 x 1, and 60 x 1 buccal dispersible tablets
Not all pack sizes may be marketed.
Marketing Authorization Holder and Manufacturer
Marketing Authorization Holder:
AstraZeneca AB
SE-152 57 Södertälje
Sweden
Manufacturer:
AstraZeneca AB
Gärtunavägen
SE-151 85 Södertälje
Sweden
For further information about this medicinal product, please contact the local representative of the Marketing Authorization Holder:
Belgium/Belgique/Belgien AstraZeneca S.A./N.V. Tel: +32 2 370 48 11 | Lithuania UAB AstraZeneca Lietuva Tel: +370 5 2660550 |
| Luxembourg/Luxemburg NV AstraZeneca SA Tél/Tel: +32 2 370 48 11 |
Czech Republic AstraZeneca Czech Republic s.r.o Tel: +420 222 807 111 | Hungary AstraZeneca kft Tel.: +36 1 883 6500 |
Denmark AstraZeneca A/S Tlf: +45 43 66 64 62 | Malta Associated Drug Co. Ltd Tel: +356 2277 8000 |
Germany AstraZeneca GmbH Tel: +49 40 809034100 | Netherlands AstraZeneca BV Tel: +31 85 808 9900 |
Estonia AstraZeneca Tel: +372 6549 600 | Norway AstraZeneca AS Tlf: +47 21 00 64 00 |
Greece AstraZeneca A.E. Τηλ: +30 2 106871500 | Austria AstraZeneca Österreich GmbH Tel: +43 1 711 31 0 |
Spain AstraZeneca Farmacéutica Spain, S.A. Tel: +34 91 301 91 00 | Poland AstraZeneca Pharma Poland Sp. z o.o. Tel.: +48 22 245 73 00 |
France AstraZeneca Tél: +33 1 41 29 40 00 | Portugal AstraZeneca Produtos Farmacêuticos, Lda. Tel: +351 21 434 61 00 |
Croatia AstraZeneca d.o.o. Tel: +385 1 4628 000 | Romania AstraZeneca Pharma SRL Tel: +40 21 317 60 41 |
Ireland AstraZeneca Pharmaceuticals (Ireland) DAC Tel: +353 1609 7100 | Slovenia AstraZeneca UK Limited Tel: +386 1 51 35 600 |
Iceland Vistor hf Sími: +354 535 7000 | Slovak Republic AstraZeneca AB o.z. Tel: +421 2 5737 7777 |
Italy AstraZeneca S.p.A. Tel: +39 02 00704500 | Finland AstraZeneca Oy Puh/Tel: +358 10 23 010 |
Cyprus Αλκήτωρ Φαρµακευτικ? Λτδ Τηλ: +357 22490305 | Sweden AstraZeneca AB Tel: +46 8 553 26 000 |
Latvia SIA AstraZeneca Latvija Tel: +371 67377 100 | United Kingdom(Northern Ireland) AstraZeneca UK Ltd Tel: +44 1582 836 836 |
Date of the Last Revision of thisLeaflet:
Other Sources of Information
Detailed information on this medicinal product is available on the European Medicines Agency website http://www.ema.europa.eu.
- Country of registration
- Dosage formORALLY DISINTEGRATING TABLET/LIOTAB, 90 mg
- ATC codeB01AC24
- Active substance
- Prescription requiredYes
- Manufacturer
- CompositionMANITOL (E-421) (341,60 mg mg), XILITOL (E-967) (19,4 mg mg), FUMARATO DE ESTEARILO Y SODIO (9 mg mg)
- This information is for reference only and does not constitute medical advice. Always consult a doctor before taking any medication. Oladoctor is not responsible for medical decisions based on this content.
- Alternatives to BRILIQUE 90 mg ORALLY DISINTEGRATING TABLETSDosage form: TABLET, 60mgActive substance: ticagrelorManufacturer: Astrazeneca AbPrescription requiredDosage form: TABLET, 60 mgActive substance: ticagrelorManufacturer: Astrazeneca AbPrescription requiredDosage form: TABLET, 90 mgActive substance: ticagrelorManufacturer: Astrazeneca AbPrescription required
Online doctors for BRILIQUE 90 mg ORALLY DISINTEGRATING TABLETS
Discuss questions about BRILIQUE 90 mg ORALLY DISINTEGRATING TABLETS, including use, safety considerations and prescription review, subject to medical assessment and local regulations.
Get BRILIQUE 90 mg ORALLY DISINTEGRATING TABLETS Prescription Online
Fill in a 2-min form
Tell us your symptoms, history, and what medicine you're requesting.
Pick a doctor or let us assign
Choose a specialist or we'll match you with the next available doctor.
Doctor reviews your case
Usually within 30 minutes. They may ask follow-up questions via chat.
Collect from any pharmacy
Electronic prescription sent to your email — valid across Spain.
Frequently Asked Questions
BRILIQUE 90 mg ORALLY DISINTEGRATING TABLETS requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
The active ingredient in BRILIQUE 90 mg ORALLY DISINTEGRATING TABLETS is ticagrelor. This information helps identify medicines with the same composition but different brand names.
BRILIQUE 90 mg ORALLY DISINTEGRATING TABLETS is manufactured by Astrazeneca Ab. Pharmacy brands and packaging may differ depending on the distributor.
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether BRILIQUE 90 mg ORALLY DISINTEGRATING TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.
You can buy BRILIQUE 90 mg ORALLY DISINTEGRATING TABLETS in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.
To obtain a prescription, you can use Oladoctor:
Other medicines with the same active substance (ticagrelor) include BRILIQUE 60 mg FILM-COATED TABLETS, BRILIQUE 60 mg FILM-COATED TABLETS, BRILIQUE 90 mg FILM-COATED TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
