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BENEXOL B1-B6-B12 FILM-COATED TABLETS

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About the medicine

How to use BENEXOL B1-B6-B12 FILM-COATED TABLETS

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Leaflet: information for the user

Benexol B1-B6-B12 film-coated tablets

Read the entire leaflet carefully before starting to take this medication,as it contains important information for you.

Follow the administration instructions for the medication contained in this leaflet or as indicated by your doctor or pharmacist exactly.

  • Keep this leaflet, as you may need to read it again.
  • If you need advice or more information, consult your pharmacist.
  • If you experience side effects, consult your doctor or pharmacist, even if they are side effects not listed in this leaflet. See section 4.
  • You should consult a doctor if it worsens or does not improve after 7 days.

Contents of the leaflet

  1. What Benexol B1-B6-B12 tablets are and what they are used for.
  2. What you need to know before taking Benexol B1-B6-B12 tablets.
  3. How to take Benexol B1-B6-B12 tablets.
  4. Possible side effects.
  5. Storage of Benexol B1-B6-B12 tablets.
  6. Package contents and additional information.

1. What Benexol B1-B6-B12 tablets are and what they are used for.

It is an association of the water-soluble vitamins of the B complex: thiamine (vitamin B1), pyridoxine (vitamin B6), and cyanocobalamin (vitamin B12) for oral administration.

Vitamins are essential nutrients that intervene in numerous human metabolic processes.

It is indicated in: Prevention and treatment of deficiency states of vitamins B1, B6, and B12 due to increased needs, reduced consumption, or reduced absorption, which could manifest as cases of back pain, during convalescence, or insufficient diets.

Benexol B1-B6-B12 is indicated for adults and adolescents over 14 years of age.

Doctor consultation

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Discuss your symptoms and treatment with a doctor online.

2. What you need to know before taking Benexol B1-B6-B12 tablets.

Do not takeBenexol B1-B6-B12 tablets:

  • if you are allergic to the active ingredients, to cobalamins (e.g., hydroxocobalamin), to cobalt, or to any of the other components of the medication (listed in section 6).
  • if you are being treated with levodopa (a medication used in Parkinson's disease).
  • it should not be administered to patients with Leber's disease (hereditary optic nerve atrophy) or with tobacco amblyopia (decreased visual acuity that can occur in people who abuse tobacco), as they may worsen.

Due to the doses it contains, do not take this medication:

  • if you have kidney or liver disease.
  • if you are pregnant or breastfeeding.
  • children under 14 years of age.

Warnings and precautions

Consult your doctor, pharmacist, or nurse before starting to take Benexol B1-B6-B12 tablets.

  • Do not take a higher dose than recommended or for a longer period than recommended. When high doses of pyridoxine (vitamin B6) are administered continuously, adverse effects of a neurological type (headache, tingling sensation, etc.) may occur.
  • If you suffer from a blood disease, such as anemia, your doctor should check its cause before taking vitamin B12.
  • If you have a predisposition to suffer from gout, you should be cautious because it could be produced due to the content of vitamin B12.
  • If you have conditions such as uremia (accumulation of urea in the blood), infections, iron or folic acid deficiency, or are being treated with medications that have a suppressive effect on the bone marrow (e.g., chloramphenicol), the effect of vitamin B12 may decrease.
  • Cases of dependence and withdrawal have been reported when taking doses of 200 mg of pyridoxine for a month.
  • You should be cautious with the sun or avoid exposure to it, as pyridoxine can produce photosensitivity, with the appearance of a skin rash.
  • If you have previously suffered from an allergy to vitamin B1 on skin contact (contact dermatitis) for professional reasons, you may suffer a relapse when taking this medication.
  • Interference with analytical tests: If you are going to undergo any diagnostic test (including blood tests, urine tests, skin tests that use allergens, etc.), inform your doctor that you are taking this medication, as it may alter the results. In some determinations of urobilinogen, theophylline, uric acid, or antibodies against the intrinsic factor (FI), false results may occur.

Children

This medication is contraindicated in children under 14 years of age.

Taking Benexol B1-B6-B12 tablets with other medications

Inform your doctor or pharmacist if you are using, have recently used, or may need to use any other medication.

Benexol B1-B6-B12 may interact with the following medications:

  • Levodopa (medication for Parkinson's disease): may decrease its effect.
    • Phenobarbital, phenytoin (medications for epilepsy).
    • Amiodarone (for the heart).
    • Altretamine (for cancer treatment).
    • Neuromuscular blocking medications (used in anesthesia for surgery).
    • 5-Fluorouracil (for some types of cancer).
  • The following medications may interfere with pyridoxine (vitamin B6) and may reduce its levels, including: tuberculosis antibiotics (isoniazid, cycloserine, ethionamide, pyrazinamide), penicillamine (for rheumatic diseases), hydralazine (for hypertension), immunosuppressants such as corticosteroids (anti-inflammatory medications), and alcohol.
  • Several medications may decrease the absorption of cyanocobalamin (vitamin B12) or reduce its effect, such as: ascorbic acid (vitamin C) in high doses, aminoglycoside antibiotics such as neomycin, colchicine (for gout treatment), H2 antagonists (medications against acidity or stomach ulcers, such as ranitidine, cimetidine, etc.), aminosalicylic acid (for intestinal diseases), proton pump inhibitors such as omeprazol (for stomach ulcers), epilepsy medications, metformin (for diabetes), sustained-release potassium preparations, or cobalt radiation. The need for vitamin B12 may be increased in patients receiving these medications.
    • Chloramphenicol: may delay or interrupt the response to red blood cell formation to vitamin B12. Close monitoring of the blood count should be performed if this combination cannot be avoided.
  • Oral contraceptives may reduce the levels of both vitamin B6 and vitamin B12.

Taking Benexol B1-B6-B12 tablets with food and drinks

Excessive alcohol consumption decreases the absorption of vitamins.

Pregnancy, breastfeeding, and fertility

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medication.

This product is contraindicated in pregnant or breastfeeding women.

This product is not recommended for women of childbearing age who do not use an effective contraceptive method.

Driving and using machines

The influence of Benexol tablets on the ability to drive and use machines is nil or insignificant. This medication may cause drowsiness in a few patients, who should not drive and/or use machines during treatment.

Benexol contains sodium

This medication contains less than 1 mmol of sodium (23 mg) per tablet; it is essentially "sodium-free".

3. How to take Benexol B1-B6-B12 tablets.

Follow the administration instructions for the medication contained in this leaflet or as indicated by your doctor or pharmacist exactly. In case of doubt, ask your doctor or pharmacist.

The recommended dose is:

Adults and adolescents over 14 years of age.

It is recommended to take 1 tablet per day.

Oral route.

It is recommended to take Benexol B1-B6-B12 tablets without chewing with the help of a little water.

In general, treatment should not exceed two weeks, although your doctor may recommend administration for more than 15 days.

If symptoms do not improve after 7 days of treatment, you should consult your doctor.

Patient with hepatic or renal insufficiency.

These patients should not take Benexol B1-B6-B12 tablets.

Use in children

This medication is contraindicated in children under 14 years of age.

If you take more Benexol B1-B6-B12 tablets than you should.

No cases of overdose have been reported.

If you take more than the recommended dose in the leaflet or as indicated by your doctor, due to the content of pyridoxine, you may experience nervous disorders such as alterations or reduction of sensitivity, tingling, numbness in feet and hands, unsteady gait, etc.; in case of overdose, you may experience symptoms such as gastrointestinal disorders (diarrhea, nausea, and vomiting) and headache. You may also experience photosensitivity with skin lesions, drowsiness, difficulty breathing, among other effects, depending on the dose, increased serum concentrations of AST (SGOT) (a transaminase) and decreased serum concentrations of folic acid. In rare cases, a severe allergic reaction (anaphylactic shock) may occur.

In children, the accidental ingestion of very high doses of vitamin B6 can also produce deep sedation, weakness, and difficulty breathing.

The effects are generally reversible when treatment is discontinued.

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or go to a medical center, or call the Toxicological Information Service, phone: 91 562 04 20, indicating the medication and the amount ingested.

If you forget to take Benexol B1-B6-B12 tablets.

Do not take a double dose to make up for the forgotten doses.

If you have any other doubts about the use of this medication, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects.

Like all medications, this medication can cause side effects, although not everyone experiences them.

The assessment of side effects that may occur is based on the following frequencies: very common (may affect more than 1 in 10 people), common (may affect up to 1 in 10 people), uncommon (may affect up to 1 in 100 people), rare (may affect up to 1 in 1,000 people), and very rare (may affect up to 1 in 10,000 people).

Uncommonly, the following may appear: nausea, vomiting, headache, drowsiness, paresthesias (tingling sensation in arms and legs) or sensory alterations (alterations in touch) and skin rash. Allergic reactions (hypersensitivity reactions) to vitamins B1, B6, and B12 have also been described.

Other side effects that have been reported, with an unknown frequency, are: gastrointestinal disorders, diarrhea, loss of appetite, photosensitivity with skin lesions such as blisters; very occasionally, a decrease in platelet count (thrombocytopenia); dizziness, restlessness, insomnia; disorder with reduced sensitivity and tingling, unsteady gait, numbness of feet or hands, which generally decrease when treatment is discontinued; a pyridoxine withdrawal syndrome more likely with higher doses, memory impairment with high doses; changes in urine color, swelling, and eye irritation; occasionally, anaphylactic reaction with rash, itching, swelling, difficulty breathing, etc.; some cases of affection with nodules and pus on the face and neck.

Reporting side effects

If you experience any type of side effect, consult your doctor or pharmacist, even if it is a possible side effect not listed in this leaflet. You can also report them directly through the Spanish Medication Surveillance System for Human Use: www.notificaram.es. By reporting side effects, you can contribute to providing more information on the safety of this medication.

5. Storage of Benexol B1-B6-B12 tablets.

Store below 25°C.

Keep this medication out of the sight and reach of children.

Do not use this medication after the expiration date shown on the packaging after CAD. The expiration date is the last day of the month indicated.

Medications should not be thrown down the drain or into the trash. Deposit the packaging and medications you no longer need in the SIGRE Point of the pharmacy. If in doubt, ask your pharmacist how to dispose of the packaging and medications you no longer need. This way, you will help protect the environment.

6. Package contents and additional information.

Composition of Benexol B1-B6-B12 film-coated tablets.

  • The active ingredients are: Thiamine hydrochloride (vitamin B1), Pyridoxine hydrochloride (vitamin B6), and Cyanocobalamin (vitamin B12). Each tablet contains 250 mg of thiamine hydrochloride, 250 mg of pyridoxine hydrochloride, and 1,000 micrograms of cyanocobalamin.
  • The other components (excipients) are: mannitol (E-421), colloidal anhydrous silica, povidone K90, magnesium stearate, pregelatinized potato starch, methacrylic acid and ethyl acrylate copolymer (1:1), sodium carmellose, macrogol 6000, talc, and glycerol triacetate.

Appearance of the product and package contents.

Benexol B1-B6-B12 is presented in the form of film-coated tablets, round and pink in color.

Contents: 30 film-coated tablets.

Marketing authorization holder and manufacturer.

Marketing authorization holder:

Bayer Hispania, S.L.

Av. Baix Llobregat, 3-5.

08970 Sant Joan Despí (Barcelona)

Manufacturer:

Delpharm Gaillard.

33 rue de l’Industrie.

74240 Gaillard (France).

ROCHE, S.P.A.

Via Morelli, 2 Segrate, Milan I 20090 Italy.

Date of the last revision of this leaflet:February 2025.

Detailed information about this medication is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es/.

Online doctors for BENEXOL B1-B6-B12 FILM-COATED TABLETS

Discuss questions about BENEXOL B1-B6-B12 FILM-COATED TABLETS, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Doctor

Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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€58
5.0 (3)
Doctor

Tomasz Grzelewski

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques.

For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance.

Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults.

In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions.

Patients commonly seek his care for:

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
  • urticaria, atopic dermatitis and skin reactions
  • recurrent infections in children
  • sports-related health questions
  • general family medicine concerns
Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.
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€80
5.0 (25)
Doctor

Lina Travkina

Family medicine 13 years exp.

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
  • Medical advice and follow-up consultations.
  • Test interpretation and diagnostic guidance.
  • Structured support for undiagnosed complaints.
  • Second opinion on diagnoses and treatment plans.
  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
  • Post-operative recovery support and pain management.
  • Preconception counselling and postpartum support.
  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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€70
5.0 (764)
Doctor

Alina Tsurkan

Family medicine 13 years exp.

Dr. Alina Tsurkan is a licensed family medicine physician based in Portugal, offering online consultations for adults and children. She provides professional primary care, with a focus on prevention, accurate diagnosis, and long-term management of acute and chronic conditions.

Dr. Tsurkan supports patients with a wide range of health issues, including:

  • Respiratory infections: cold, flu, bronchitis, pneumonia, and lingering coughs.
  • ENT conditions: sinusitis, tonsillitis, otitis (ear infections), sore throat, allergic rhinitis.
  • Eye conditions: allergic or infectious conjunctivitis, red eyes, irritation.
  • Digestive issues: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), constipation, bloating, nausea.
  • Urinary and reproductive health: urinary tract infections (UTIs), cystitis, prevention of recurrent infections.
  • Chronic diseases: hypertension, elevated cholesterol, weight management.
  • Neurological complaints: headaches, migraines, sleep disturbances, fatigue, general weakness.
  • Children’s health: fever, infections, digestive issues, follow-ups, vaccination guidance.

She also provides:

  • IMT medical certificates for driving licence exchange in Portugal.
  • Personalised preventive care and wellness consultations.
  • Interpretation of test results and medical reports.
  • Follow-up care and medication review.
  • Support in managing multiple coexisting conditions.
  • Remote prescription management and medical documentation.

Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

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€55
5.0 (140)
Doctor

Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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€50

Frequently Asked Questions

Is a prescription required for BENEXOL B1-B6-B12 FILM-COATED TABLETS?
BENEXOL B1-B6-B12 FILM-COATED TABLETS does not require a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
Who manufactures BENEXOL B1-B6-B12 FILM-COATED TABLETS?
BENEXOL B1-B6-B12 FILM-COATED TABLETS is manufactured by Bayer Hispania S.L.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of BENEXOL B1-B6-B12 FILM-COATED TABLETS online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether BENEXOL B1-B6-B12 FILM-COATED TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to BENEXOL B1-B6-B12 FILM-COATED TABLETS?
Other medicines with the same active substance () include HYDROXIL B1-B6-B12 FILM-COATED TABLETS, NEUROMADE Hard Capsules, VITAGOBENS B1 B6 B12 FILM-COATED TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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