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TIXTAR 550 MG FILM-COATED TABLETS

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About the medicine

How to use TIXTAR 550 MG FILM-COATED TABLETS

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

TIXTAR 550 mg film-coated tablets

rifaximin

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What is TIXTAR and what is it used for
  2. What you need to know before you take TIXTAR
  3. How to take TIXTAR
  4. Possible side effects
  5. Storage of TIXTAR
  6. Contents of the pack and other information

1. What is TIXTAR and what is it used for

TIXTAR contains the active substance rifaximin. Rifaximin is an antibiotic that eliminates bacteria that can cause a disease called hepatic encephalopathy (symptoms include agitation, confusion, muscle problems, difficulty speaking, and in some cases, coma).

Informative text on the correct use of antibiotics and the importance of following medical instructions

TIXTAR is used in adults with liver disease to reduce the recurrence of episodes of overt hepatic encephalopathy.

TIXTAR may be used alone or, more commonly, in combination with medications that contain lactulose (a laxative).

Doctor consultation

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2. What you need to know before you take TIXTAR

Do not take TIXTAR:

  • if you are allergic to:

-rifaximin

-similar antibiotics (such as rifampicin or rifabutin)

-any of the other components of this medicine (listed in section 6)

  • if you have an intestinal obstruction

Warnings and precautions

Consult your doctor or pharmacist before starting to take TIXTAR.

If you have ever developed a severe skin rash or skin peeling, blisters, and/or sores in the mouth after taking rifaximin.

Be careful with rifaximin:

Severe skin reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis, have been reported in association with rifaximin treatment. Stop using rifaximin and seek immediate medical attention if you notice any of the symptoms related to these severe skin reactions described in section 4.

While taking TIXTAR, your urine may turn reddish. This is normal.

Treatment with any antibiotic, including rifaximin, can cause severe diarrhea. This can happen several months after you have finished taking the medicine. If you have severe diarrhea during or after using TIXTAR, you should stop taking TIXTAR and contact your doctor immediately.

If your liver problems are severe, your doctor should keep you under close observation.

TIXTAR contains sodium

This medicine contains less than 1 mmol of sodium (23 mg) per tablet; it is essentially "sodium-free".

Children and adolescents

TIXTAR is not recommended for children and adolescents under 18 years of age. This medicine has not been studied in children and adolescents.

Other medicines and TIXTAR

Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.

Tell your doctor if you are taking any of the following medicines:

  • antibiotics (medicines to treat infections)
  • warfarin (medicine to prevent blood clotting)
  • antiepileptics (medicines to treat epilepsy)
  • antiarrhythmics (medicines to treat abnormal heart rhythm)
  • cyclosporin (immunosuppressant)
  • oral contraceptives

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

It is not known if TIXTAR can harm the fetus. Therefore, TIXTAR should not be used if you are pregnant.

It is not known if rifaximin can pass into breast milk. Therefore, TIXTAR should not be used if you are breastfeeding.

Driving and using machines

TIXTAR normally does not affect your ability to drive and use machines, but it can cause dizziness in some patients. If you feel dizzy, do not drive or operate machinery.

3. How to take TIXTAR

Follow exactly the administration instructions of this medicine given by your doctor. In case of doubt, consult your doctor or pharmacist again.

The recommended dose is 1 tablet twice a day taken with a glass of water.

Continue taking TIXTAR until your doctor tells you to stop.

If you take more TIXTAR than you should

If you have taken more tablets than you should, even if you do not notice any problems, consult your doctor, pharmacist, or call the Toxicology Information Service, phone 91-562 04 20, indicating the medicine and the amount taken.

If you forget to take TIXTAR

Take the next dose at the usual time. Do not take a double dose to make up for forgotten doses.

If you stop taking TIXTAR

Do not stop taking TIXTAR without consulting your doctor first, because the symptoms may come back.

If you have any other questions about the use of this medicine, ask your doctor or pharmacist.

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4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Stop using TIXTAR and seek immediate medical attention if you notice any of the following symptoms:

Uncommon(may affect up to 1 in 100 people)

  • If you have bleeding from swollen blood vessels in the throat (esophageal varices).
  • If you have severe diarrhea during or after using this medicine. This can be due to an intestinal infection.

Frequency not known(cannot be estimated from the available data)

  • Reddish, non-raised, target-like or circular patches on the trunk, often with central blisters, skin peeling, mouth ulcers, and ulcers on the genitals and eyes. These severe skin reactions can be preceded by fever and flu-like symptoms.
  • If you suffer an allergic reaction, hypersensitivity, or angioedema. The symptoms include:
    • swelling of the face, tongue, or throat
    • difficulty swallowing
    • hives and difficulty swallowing.
  • If you have any unexpected or unusual bleeding or bruising. This can be due to a decrease in platelets in the blood, which increases the risk of bleeding.

Other side effects that may occur:

Common(may affect up to 1 in 10 people)

  • Depressed mood
  • Dizziness
  • Headache
  • Breathing difficulties
  • Feeling sick or vomiting
  • Stomach pain or bloating
  • Diarrhea
  • Fluid accumulation in the abdominal cavity (ascites)
  • Skin rash or itching
  • Muscle cramps
  • Joint pain
  • Swelling of the ankles, feet, or fingers

Uncommon(may affect up to 1 in 100 people)

  • Fungal infections (such as candidiasis)
  • Urinary tract infections (such as cystitis)
  • Anemia (decrease in red blood cells that can make the skin pale and cause weakness or breathing difficulties)
  • Loss of appetite
  • Hyperkalemia (high potassium levels in the blood)
  • Confusion
  • Anxiety
  • Feeling of numbness
  • Sleep disturbances
  • Feeling of instability
  • Memory loss or poor memory
  • Decreased concentration
  • Decreased sense of touch
  • Seizures (epileptic fits)
  • Hot flushes
  • Fluid around the lungs (pleural effusion)
  • Abdominal pain
  • Dry mouth
  • Muscle pain
  • Need to urinate more frequently than usual
  • Difficulty or pain when urinating
  • Fever
  • Edema (swelling due to fluid accumulation in the body)
  • Falls

Rare(may affect up to 1 in 1,000 people)

  • Chest infections, including pneumonia
  • Cellulitis (inflammation of the tissue under the skin)
  • Infections of the upper respiratory tract (nose, mouth, throat)
  • Rhinitis (inflammation inside the nose)
  • Dehydration (loss of body water)
  • Changes in blood pressure
  • Chronic respiratory problems (such as chronic bronchitis)
  • Constipation
  • Back pain
  • Protein in the urine
  • Feeling of weakness
  • Bruising
  • Pain after surgery

Frequency not known(cannot be estimated from the available data)

  • Fainting or feeling of fainting
  • Skin irritation, eczema (dry, red, and itchy skin)
  • Decrease in platelets (seen in blood tests)
  • Changes in liver function (seen in blood tests)
  • Changes in blood clotting (International Normalized Ratio, seen in blood tests).

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist, even if it is possible side effects not listed in this leaflet. You can also report side effects directly through the Spanish Medicines Agency's website: www.notificaRAM.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of TIXTAR

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the carton and blister after EXP. The expiry date is the last day of the month shown.

TIXTAR does not require any special storage conditions.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help protect the environment.

6. Contents of the pack and other information

Composition of TIXTAR

The active substance is rifaximin. Each tablet contains 550 mg of rifaximin.

The other ingredients are:

  • Core of the tablet: sodium carboxymethyl starch type A (potato), glycerol distearate, anhydrous colloidal silica, talc, microcrystalline cellulose.
  • Tablet coating (opadry oy-s-34907): hypromellose, titanium dioxide (E171), disodium edetate, propylene glycol, iron oxide red (E172)

Appearance of the product and pack contents

Film-coated tablets, oval, convex, and pink, with "RX" engraved on one side.

TIXTAR is available in packs of 14, 28, 42, 56, and 98 tablets.

Not all pack sizes may be marketed.

Marketing authorization holder and manufacturer

Marketing authorization holder:

Alfasigma S.p.A.

Via Ragazzi del ’99, n. 5

40133 Bologna, ITALY

Manufacturer:

Alfasigma, S.p.A.

Via Enrico Fermi, 1

65020 Alanno, Pescara, ITALY

Alfasigma, S.p.A.

Via Pontina Km 30,400

00071 Pomezia, Rome, ITALY

Local representative:

Alfasigma España, S.L.

C/ Aribau 195, 4º

08021 Barcelona, SPAIN

This medicine is authorized in the Member States of the European Economic Area under the following names:

TIXTAR: Italy, Spain

Date of last revision of this leaflet: May 2024

Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS)http://www.aemps.gob.es/

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Doctor

Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

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Dmytro Horobets

Family medicine 7 years exp.

Dr. Dmytro Horobets is a licensed family medicine physician in Poland, specialising in endocrinology, diabetology, obesity management, gastroenterology, pediatrics, general surgery, and pain medicine. He offers online consultations for adults and children, providing personalised medical support for a wide range of acute and chronic health concerns.

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Alexander Nazarchuk

Allergology 7 years exp.

Dr. Alexander Nazarchuk is a physician specialising in allergology and internal medicine. He provides online consultations for adults, following the principles of evidence-based medicine — no outdated treatments or unnecessary tests, with clear explanations and a personalised approach. He helps patients with a wide range of allergic and therapeutic conditions, from common day-to-day complaints to complex cases involving allergies, gastrointestinal issues, cardiovascular concerns, respiratory symptoms, and more.

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Tomasz Grzelewski

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques. For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance. Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults. In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions. Patients commonly seek his care for: 

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Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.

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Frequently Asked Questions

Is a prescription required for TIXTAR 550 MG FILM-COATED TABLETS?

TIXTAR 550 MG FILM-COATED TABLETS requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

What is the active substance in TIXTAR 550 MG FILM-COATED TABLETS?

The active ingredient in TIXTAR 550 MG FILM-COATED TABLETS is rifaximin. This information helps identify medicines with the same composition but different brand names.

Who manufactures TIXTAR 550 MG FILM-COATED TABLETS?

TIXTAR 550 MG FILM-COATED TABLETS is manufactured by Alfasigma S.P.A.. Pharmacy brands and packaging may differ depending on the distributor.

Which doctors can assess the use of TIXTAR 550 MG FILM-COATED TABLETS online?

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether TIXTAR 550 MG FILM-COATED TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

How to buy TIXTAR 550 MG FILM-COATED TABLETS in Spain?

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy TIXTAR 550 MG FILM-COATED TABLETS in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

What are the alternatives to TIXTAR 550 MG FILM-COATED TABLETS?

Other medicines with the same active substance (rifaximin) include SPIRAXIN 200 mg FILM-COATED TABLETS, TIXTELLER 550 MG FILM-COATED TABLETS, DIFICLIR 200 mg FILM-COATED TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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