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TACHOSIL TISSUE ADHESIVE

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Prescription review online

A doctor will review your case and decide whether a prescription is medically appropriate.

Talk to a doctor about this medicine

Talk to a doctor about this medicine

Discuss your symptoms and possible next steps in a quick online consultation.

Doctor
5.0(38)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a General Practitioner with specialized training in chronic pain. He provides online consultations for adult patients in Spain and other European countries.

Dr. Popov understands that seeking help with weight-related concerns or pain that has persisted for months can be difficult. Many patients come to him after trying different approaches without feeling truly heard. During the consultation, the doctor creates a comfortable and supportive, non-judgmental environment where the patient’s medical history can be discussed in detail, questions can be answered, and the next steps can be decided together.

Weight Management and Metabolic Health

Dr. Popov can help assess overweight, obesity, and related conditions such as hypertension, diabetes, or metabolic disorders. During the consultation, the patient’s medical history, test results, current medications, and previous treatments will be reviewed.

If you would like to learn about possible medication options or have already started treatment, the doctor can assess your situation, review the effectiveness and tolerability of the therapy, and clearly explain its benefits, potential risks, and alternatives.

Not every patient requires the same treatment. A consultation does not guarantee a prescription — it provides an objective medical assessment and a plan tailored to your individual situation.

Pain and General Medicine

You can also consult Dr. Popov regarding:

* chronic pain, migraines, neuralgia, and fibromyalgia;

* back, neck, lower back, or joint pain;

* hypertension, diabetes, and follow-up of chronic conditions;

* review of test results, medical reports, and current treatment;

* preventive medicine and a second medical opinion.

How the Consultation Works

The video consultation lasts up to 30 minutes. The doctor will listen carefully, review the information you provide, and explain the next steps in clear and understandable language.

If additional tests, an in-person consultation, or urgent medical care are required, the doctor will inform you directly.

Dr. Popov’s goal is to make sure the patient feels heard and leaves the consultation with a clear understanding of their condition and the next steps they can take.

Book a video appointment
€86
This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use TACHOSIL Adhesive Matrix

Contents of the leaflet

  1. Introduction
  2. What is TachoSil and what is it used for
  3. What you need to know before using TachoSil
  4. How to use TachoSil
  5. Possible side effects
  6. Storage of TachoSil
  7. Package Contents and Further Information

Introduction

Package Leaflet: Information for the User

TachoSil, Adhesive Matrix

Human Fibrinogen/Human Thrombin

Read the entire package leaflet carefully before starting to use the medicine

  • Keep this package leaflet, as you may need to read it again.
  • If you have any further questions, ask your doctor.
  • If you experience side effects, consult your doctor, even if they are not listed in this package leaflet.

Contents of the Package Leaflet:

  1. What is TachoSil and what is it used for
  2. What you need to know before using TachoSil
  3. How to use TachoSil
  4. Possible side effects
  5. Storage of TachoSil
  6. Package Contents and Further Information

1. What is TachoSil and what is it used for

How does TachoSil work?

The yellow side of TachoSil contains two active substances: fibrinogen and thrombin. The yellow side of TachoSil is therefore the active side. When the active side comes into contact with a fluid (e.g., blood, lymph, or saline solution), the fibrinogen and thrombin are activated and form a fibrin network. This means that TachoSil adheres to the tissue surface, the blood coagulates (local hemostasis), and the tissue is sealed. TachoSil dissolves in the body and disappears completely.

What is TachoSil used for?

TachoSil is used during surgery to stop local bleeding (hemostasis) and to seal the surfaces of internal organ tissues.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before using TachoSil

Do not use TachoSil

Warnings and Precautions

TachoSil is for local use only and should not be administered into a blood vessel. If TachoSil is accidentally administered into a blood vessel, blood clots may form.

It is possible that after administration of TachoSil, you may experience an allergic reaction. You may suffer from flushing, or a rash similar to hives, chest discomfort or tightness, wheezing, or a drop in blood pressure. You should contact your doctor immediately if any of these symptoms occur.

After abdominal surgery, if TachoSil adheres to nearby tissues, it is possible that scar tissue may develop in the operated area. Scar tissue can cause some surfaces of your intestine to stick together, which can lead to intestinal obstruction.

When medicines are manufactured from human blood or plasma, certain measures are taken to prevent the transmission of infections to other patients. These measures include careful selection of blood and plasma donors to ensure the exclusion of individuals who may be carriers of infections, as well as testing of each donation and plasma pools for signs of viruses or infections. Additionally, manufacturers of these types of products include steps in the processing of blood or plasma that can inactivate or eliminate viruses. Despite these measures, when administering a medicine prepared from human blood or plasma, it is not possible to completely exclude the risk of transmission of an infection. This also applies to unknown or newly emerging viruses, or other types of infections.

The measures taken are considered effective for enveloped viruses such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), and hepatitis C virus (HCV), as well as for the non-enveloped hepatitis A virus (HAV). These measures may have a limited effect on non-enveloped viruses such as parvovirus B19. Infection with parvovirus B19 can be severe in pregnant women (fetal infection) and in individuals with weakened immune systems or those suffering from certain types of anemia (such as sickle cell anemia or hemolytic anemia).

Traceability

In order to improve the traceability of biological medicines, the name and batch number of the administered medicine should be clearly recorded.

Using TachoSil with other medicines

Tell your doctor if you are using, have recently used, or might use other medicines.

3. How to use TachoSil

The doctor treating you will apply TachoSil during the procedure. The amount of TachoSil used depends on the size of the wound. The doctor will place TachoSil on the internal organ to stop bleeding or to seal the tissue. Then, TachoSil will dissolve and disappear.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

TachoSil is made from components that contain proteins. The active substances are made from human blood. All medicines based on human blood can cause allergic reactions in rare cases. In isolated cases, these allergic reactions can lead to anaphylactic shock.

Such allergic reactions can occur especially if TachoSil is used repeatedly or if you are allergic to one of the components of the medicine.

A clinical trial has shown that some patients produce antibodies against the components of TachoSil, although no adverse effects resulting from the development of antibodies have been reported.

In some patients, scar tissue may develop after surgery and the use of TachoSil. Intestinal obstruction and pain may also occur after abdominal surgery. The frequency of these events is not known (cannot be estimated from the available data). Your surgeon will ensure that the operating area is cleaned when applying TachoSil to reduce this risk.

Reporting side effects

If you experience side effects, consult your doctor, even if they are not listed in this package leaflet. You can also report them directly through the national reporting system listed in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of TachoSil

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date stated on the packaging after "EXP". The expiry date is the last day of the month indicated.

Do not store above 25°C.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. Package Contents and Further Information

Composition of TachoSil

  • The active substances are human fibrinogen (5.5 mg per cm2) and human thrombin (2.0 IU per cm2).
  • The other components are equine collagen, human albumin, riboflavin (E101), sodium chloride, sodium citrate (E331), and L-arginine hydrochloride.

Appearance and Package Contents

TachoSil is a collagen matrix coated on the yellow side with human fibrinogen and human thrombin.

The product is available in different sizes and is packaged in packs of 5 units:

Package of 1 matrix, 9.5 cm x 4.8 cm

Package of 2 matrices, 4.8 cm x 4.8 cm

Package of 1 matrix, 3 cm x 2.5 cm

Package of 5 matrices, 3 cm x 2.5 cm

Package of 1 pre-rolled matrix, 4.8 cm x 4.8 cm

Not all pack sizes may be marketed.

Marketing Authorization Holder and Manufacturer

Takeda Austria GmbH

St. Peter Strasse, 25

A-4020 Linz, Austria

Date of last revision of this package leaflet:{month YYYY}

Other sources of information

Detailed information on this medicine is available on the European Medicines Agency website: http://www.ema.europa.eu.

The package leaflet for this medicine can be found on the European Medicines Agency website in all EU/EEA languages.

-------------------------------------------------------------------------------------------------------------------------------

This information is intended only for healthcare professionals:

INSTRUCTIONS FOR USE

Read the following before opening the packaging:

TachoSil is presented in sterile packaging and it is therefore important:

  • to use only intact packaging that has not been opened (it is not possible to re-sterilize).
  • that a person in non-sterile conditions opens the outer aluminum covering
  • that a person in sterile conditions opens the inner sterile packaging
  • to use TachoSil shortly after opening the outer aluminum covering.
  • to use TachoSil immediately after opening the inner sterile packaging.

Instructions

Use TachoSil only in sterile conditions.

Determine the size of TachoSil needed. The size of the adhesive matrix depends on the size of the wound. Note that the matrix should completely cover the wound, leaving a gap of 1 or 2 cm between the edges of the wound and the edges of the sponge. If two or more matrices are needed, they should overlap. For smaller wounds, such as in minimally invasive surgery, the use of smaller sizes (4.8 x 4.8 cm or 3 x 2.5 cm) or pre-rolled TachoSil (4.8 cm x 4.8 cm) is recommended. TachoSil can be cut to the appropriate size and shaped to fit the wound.

  1. Carefully clean the wound surface before placing TachoSil on it. Profuse bleeding (uninterrupted) should be surgically intervened.
  1. Open the inner sterile packaging and remove the matrix. Moisten the flat surface of the TachoSil matrix with a saline solution beforehand and place it in the wound immediately after (if the wound is completely moistened by blood and other fluids, it will not be necessary to moisten the matrix before application). Pre-rolled TachoSil should not be moistened beforehand before passing it through the trocar or port.
  1. Clean the instruments, surgical gloves, and adjacent tissues, if necessary. TachoSil may adhere to instruments, surgical gloves, or adjacent tissues that are covered in blood. It is important to note that not thoroughly cleaning the adjacent tissues can cause adhesions.
  1. If a trocar is used to access the wound, the inside of the trocar should be dry. It is recommended to remove the top part of the trocar before passing the pre-rolled TachoSil through the trocar.
  1. Place the active yellow side of TachoSil on the wound. Hold TachoSil in place by applying gentle pressure for a period of 3 to 5 minutes. Use a moistened glove or a damp compress to keep TachoSil in place. In minimally invasive surgery, the pre-rolled matrix can be unrolled with the instrument at the application site. Once unrolled, TachoSil should be moistened at the application site with a damp compress and held in place by applying gentle pressure for a period of 3 to 5 minutes.
  1. After the specified time (3 to 5 minutes), slowly release the pressure. To ensure that TachoSil does not adhere to the glove or damp compress and thus does not separate from the wound, you can hold it by one end, for example, with the help of forceps. It is not necessary to remove any residual component, as the entire matrix dissolves (is reabsorbed).

Traceability

In order to improve the traceability of biological medicines, the name and batch number of the administered medicine should be clearly recorded.

Online doctors for TACHOSIL Adhesive Matrix

Discuss questions about TACHOSIL Adhesive Matrix, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

Doctor
5.0(38)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a General Practitioner with specialized training in chronic pain. He provides online consultations for adult patients in Spain and other European countries.

Dr. Popov understands that seeking help with weight-related concerns or pain that has persisted for months can be difficult. Many patients come to him after trying different approaches without feeling truly heard. During the consultation, the doctor creates a comfortable and supportive, non-judgmental environment where the patient’s medical history can be discussed in detail, questions can be answered, and the next steps can be decided together.

Weight Management and Metabolic Health

Dr. Popov can help assess overweight, obesity, and related conditions such as hypertension, diabetes, or metabolic disorders. During the consultation, the patient’s medical history, test results, current medications, and previous treatments will be reviewed.

If you would like to learn about possible medication options or have already started treatment, the doctor can assess your situation, review the effectiveness and tolerability of the therapy, and clearly explain its benefits, potential risks, and alternatives.

Not every patient requires the same treatment. A consultation does not guarantee a prescription — it provides an objective medical assessment and a plan tailored to your individual situation.

Pain and General Medicine

You can also consult Dr. Popov regarding:

* chronic pain, migraines, neuralgia, and fibromyalgia;

* back, neck, lower back, or joint pain;

* hypertension, diabetes, and follow-up of chronic conditions;

* review of test results, medical reports, and current treatment;

* preventive medicine and a second medical opinion.

How the Consultation Works

The video consultation lasts up to 30 minutes. The doctor will listen carefully, review the information you provide, and explain the next steps in clear and understandable language.

If additional tests, an in-person consultation, or urgent medical care are required, the doctor will inform you directly.

Dr. Popov’s goal is to make sure the patient feels heard and leaves the consultation with a clear understanding of their condition and the next steps they can take.

Book a video appointment
€86
Doctor
5.0(12)

Yevgen Yakovenko

General medicine12 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

Book a video appointment
€72
Doctor
5.0(3)

Lina Travkina

General medicine13 years of experience

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.

  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.

  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.

  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.

  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.

  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.

  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.

  • Medical advice and follow-up consultations.

  • Test interpretation and diagnostic guidance.

  • Structured support for undiagnosed complaints.

  • Second opinion on diagnoses and treatment plans.

  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.

  • Post-operative recovery support and pain management.

  • Preconception counselling and postpartum support.

  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

Book a video appointment
€75
Doctor
5.0(20)

Nuno Tavares Lopes

General medicine18 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies

  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management

  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses

  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment

  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance

  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis

  • Pain management: acute and chronic pain, post-surgical care

  • Public health: prevention, health screenings, long-term monitoring

  • Sick leave (Baixa médica) connected to Segurança Social in Portugal

  • IMT medical certificates for driving licence exchange

Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

Book a video appointment
€70
Doctor
0.0(0)

Hocine Lokchiri

General medicine21 years of experience

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
Book a video appointment
€64

Get TACHOSIL Adhesive Matrix Prescription Online

1

Fill in a 2-min form

Tell us your symptoms, history, and what medicine you're requesting.

2

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Choose a specialist or we'll match you with the next available doctor.

3

Doctor reviews your case

Usually within 30 minutes. They may ask follow-up questions via chat.

4

Collect from any pharmacy

Electronic prescription sent to your email — valid across Spain.

Frequently Asked Questions

TACHOSIL Adhesive Matrix requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

The active ingredient in TACHOSIL Adhesive Matrix is combinations. This information helps identify medicines with the same composition but different brand names.

TACHOSIL Adhesive Matrix is manufactured by Corza Medical Gmbh. Pharmacy brands and packaging may differ depending on the distributor.

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether TACHOSIL Adhesive Matrix is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy TACHOSIL Adhesive Matrix in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

Other medicines with the same active substance (combinations) include ARTISS Tissue Adhesive Solution, Ultracold, EVICEL Tissue Adhesive Solution, TACHOSIL Adhesive Matrix. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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