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CUPRIPEN 250 mg CAPSULES

CUPRIPEN 250 mg CAPSULES

Ask a doctor about a prescription for CUPRIPEN 250 mg CAPSULES

5.0(39)
Doctor

Yevgen Yakovenko

General surgery11 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use CUPRIPEN 250 mg CAPSULES

Introduction

Package Leaflet: Information for the User

Cupripen250 mg hard capsules

penicillamine

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What is Cupripen and what is it used for
  2. What you need to know before you take Cupripen
  3. How to take Cupripen
  4. Possible side effects

5 Conservation of Cupripen

  1. Contents of the pack and further information

1. What is Cupripen and what is it used for

Cupripen contains the active substance penicillamine, a chelating agent that acts mainly by binding to certain metals in your body, including copper and lead, to help reduce the amounts of metals absorbed by your body. Penicillamine has the ability to form a soluble complex with cysteine.

Cupripen is indicated in adults, adolescents, and children aged 5 years or older for the treatment of:

  • Wilson's disease, a disease in which the body cannot eliminate copper properly
  • In cases of heavy metal poisoning

A kidney problem called cystinuria

2. What you need to know before you take Cupripen

Do not take Cupripen

  • if you are allergic to penicillamine or any of the other ingredients of this medicine (listed in section 6),
  • if you are allergic to penicillins,
  • if you have had any liver, kidney, or severe blood diseases when taking penicillamine,
  • if you have a disease called systemic lupus erythematosus
  • if you are taking gold salts, antimalarials, cytotoxics, oxyphenbutazone, or phenylbutazone.

Do not take Cupripen if you have any of the above conditions. If you are not sure, talk to your doctor or pharmacist before taking Cupripen, as this medicine may worsen these problems.

Warnings and precautions

Talk to your doctor or pharmacist before starting to use Cupripen if:

  • you are elderly
  • you are going to have or have had surgery.
  • you have glucose-6-phosphate dehydrogenase deficiency
  • you have liver or kidney problems
  • if you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medicine (see section "Pregnancy, breastfeeding, and fertility").

Before starting treatment, tell your doctor or pharmacist if you have any of the conditions mentioned above. Your doctor will want to monitor the effect of the medicine on you.

Special precautions for treatment with Cupripen:

Penicillamine may cause serious birth defects. You should avoid becoming pregnant while using Cupripen and for at least six months and five days after finishing treatment. See also section "Pregnancy, breastfeeding, and fertility".

Recommended follow-up tests and safety measures:

Even when Cupripen is administered at low doses, severe side effects can occur. To detect them in time, your doctor will need to perform blood tests and check-ups.

Before starting treatment with Cupripen:

You will have blood tests and urine tests. If you have any liver or kidney disease, you will have tests to check liver and kidney function.

During treatment:

You will have the following tests, at least once a week for the first two months of treatment and then every month:

  • blood tests
  • urine tests

Maintain the frequency of intakes that your doctor has indicated to avoid the appearance of poor tolerance symptoms.

In prolonged treatments, your doctor may prescribe pyridoxine (Vitamin B6).

Other medicines and Cupripen

Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.

If you are taking other medicines, penicillamine may affect their mechanism of action or cause side effects. Therefore, it may be necessary to change the dose of the medicine or suspend treatment together. If you take any of the following medicines, consult your doctor or pharmacist before taking Cupripen:

  • Aluminum or magnesium salts (medicines used to treat heartburn)
  • Digoxin (a medicine used to treat heart diseases)
  • Indomethacin (a medicine used to treat pain)
  • Isoniazid (a medicine used to treat tuberculosis)
  • Levodopa (a medicine used to treat Parkinson's disease)
  • Iron salts (medicines used to treat low iron levels or anemia)
  • Gold salts (a medicine used to treat rheumatism)
  • Phenylbutazone or oxyphenbutazone (medicines used to treat pain and inflammation)
  • Antimalarials (medicines used to treat malaria)
  • Cytotoxics (medicines used to treat cancer)

If you are unsure whether any of the medicines you are taking are included in the above list, ask your doctor or pharmacist before taking Cupripen.

Taking Cupripen with food and drinks

Take preferably on an empty stomach, 1 hour before or 2 hours after meals, as food interferes with its absorption.

The capsules should be swallowed whole with water.

Pregnancy, breastfeeding, and fertility

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medicine.

Pregnancy

The use of Cupripen is not recommended during pregnancy. Inform your doctor if you are pregnant or trying to become pregnant. Your doctor will decide if you can take Cupripen during that time.

Breastfeeding

It is not known whether Cupripen passes into breast milk. For this reason, its administration is not recommended during the breastfeeding period. Your doctor will decide if you can take Cupripen during this time.

Male fertility

Penicillamine may be genotoxic, which means it can cause genetic mutations. Therefore, you should avoid fathering a child or donating sperm while taking Cupripen and for at least three months and five days after stopping treatment.

Driving and using machines

Cupripen is unlikely to affect your ability to drive or use tools or machines.

3. How to take Cupripen

Follow exactly the administration instructions of this medicine indicated by your doctor. In case of doubt, consult your doctor or pharmacist again.

Method of administration

Cupripen is for oral use.

The capsules should be swallowed whole, with a glass of water, on an empty stomach, at least 1 hour before or 2 hours after meals.

Dose

Your doctor will establish the suitable dose for you and make the necessary adjustments, as the dosage must be individualized.

Wilson's disease

Adults

Your doctor will indicate how many capsules you should take per day. The usual dose is 6 to 8 capsules per day. Once you feel better, your doctor may reduce the dose to 3 to 4 capsules per day. It is not recommended to take 8 capsules per day for more than 12 months.

Use in elderly patients

Your doctor will indicate how many capsules you should take and how often during the day. The dose will depend on your weight. The usual dose is 20 mg of penicillamine per day per kilogram of weight. Your doctor will adjust the dose to the minimum necessary to control your disease.

Use in adolescents (12 to < 18 years)

Your doctor will indicate how many capsules you should take per day. The usual dose is 3 to 4 capsules per day.

Use in children (5 to < 12 years)

Your doctor will indicate how many capsules the child should take and how often during the day. The dose will depend on the child's weight. The usual dose is 20 mg of penicillamine per day per kilogram of weight, divided into two or three doses taken 1 hour before meals.

Patients with renal insufficiency

In patients with renal impairment, special precautions should be taken to control side effects.

Heavy metal poisoning

Adults (including elderly patients)

Your doctor will indicate how many capsules you should take per day. The dose is 4 to 6 capsules per day until your doctor indicates that the amount of heavy metals in your urine is normal. If treatment is prolonged, the dose should not exceed 40 mg per day per kilogram of weight.

Use in children and adolescents (5 to < 18 years)

Your doctor will indicate how many capsules you should take per day. The dose will depend on the child's weight. The usual dose is 20 to 25 mg per day per kilogram of weight. If necessary, a dose of 100 mg of penicillamine per day per kilogram of weight may be administered, up to a maximum dose of 1,050 mg of penicillamine per day per kilogram of weight.

Cystinuria

The dose must be adjusted individually, taking into account the amount of cystine excreted in the urine.

Adults

If you are taking Cupripen to dissolve cystine stones, the dose is 4 to 12 capsules per day, divided into several doses. If you are taking Cupripen to prevent the formation of cystine stones, the dose will be 2 to 4 capsules per day before bedtime; in this case, you should drink at least 3 liters of fluids per day.

Use in elderly patients

Your doctor will determine the suitable dose for you, which should be the minimum necessary to keep cystine levels below 200 mg per liter of urine.

Use in children and adolescents (5 to < 18 years)

The dose will depend on the child's weight. The usual dose is 20 to 30 mg per day per kilogram of weight, in two or three divided doses taken 1 hour before meals. Your doctor may change the dose depending on the results of the child's urine tests.

Patients with renal insufficiency

In patients with renal impairment at the start of treatment, lower initial doses should be administered. Maintenance doses should be reviewed at least every 4 weeks.

If you take more Cupripen than you should

If you take more Cupripen than you should, consult your doctor immediately.

If you forget to take Cupripen

Do not take a double dose to make up for forgotten doses.

If you stop taking Cupripen

Do not stop or change treatment without talking to your doctor, even if you feel better. If you have forgotten to take several doses, consult your doctor to indicate the dosage schedule to follow until you reach your maintenance dose.

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or call the Toxicology Information Service, phone: 91 562 04 20.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

The frequency and severity of side effects will depend on the dose and frequency of administration. It is important that your doctor performs periodic checks, as serious side effects can occur even with the lowest doses. Your doctor will perform tests to control abnormalities that occur in the blood and changes in the kidneys and liver.

Common (may affect up to 1 in 10 people)

  • nausea, loss of taste, bad taste, loss of appetite, and vomiting.
  • skin rashes
  • redness of the skin (erythema)
  • itching
  • proteins in your urine (detected with a urine test)

Uncommon (may affect up to 1 in 100 people)

  • ringing in the ears
  • vision loss
  • muscle weakness, joint pain (arthralgia)
  • excessive elimination of proteins in the urine (nephrotic syndrome)
  • inflammatory kidney disease (membranous glomerulonephritis)

Rare (may affect up to 1 in 1,000 people)

  • diarrhea
  • decrease in the number of blood cells (anemia, leukopenia, thrombocytopenia)
  • mouth ulcers
  • hair loss
  • inflammation of the lung tissue (pneumonitis)
  • bronchiolitis
  • yellowish discoloration of the nails (yellow nail syndrome)
  • inflammatory disease that causes muscle weakness (polymyositis)
  • breast enlargement

Not known (cannot be estimated from the available data)

  • pseudoxanthoma elasticum (a disease of the connective tissue)
  • perforating elastosis (a skin disease)
  • systemic lupus erythematosus (an allergic condition that causes joint pain, skin rashes, and fever)
  • myasthenia gravis (a disease that causes muscle weakness)

Reporting of side effects

If you experience any side effects, talk to your doctor, even if it is possible side effects not listed in this leaflet. You can also report them directly through the Spanish Medicines and Healthcare Products Agency (AEMPS) website (http://www.aemps.gob.es/). By reporting side effects, you can help provide more information on the safety of this medicine.

5. Conservation of Cupripen

Keep this medicine out of the sight and reach of children.

Store in the original packaging to protect from moisture.

Do not use this medicine after the expiry date stated on the packaging. The expiry date is the last day of the month indicated.

Medicines should not be disposed of via wastewater or household waste. Return the packaging and any unused medicine to a pharmacy. Ask your pharmacist how to dispose of the packaging and any unused medicine. This will help protect the environment.

6. Contents of the pack and further information

Composition of Cupripen 250 mg hard capsules:

  • The active substance is penicillamine. Each hard capsule of Cupripen contains 250 mg of penicillamine.
  • The other ingredients are:

Contents of the capsules: Magnesium stearate; Capsule shell: Gelatin, Titanium dioxide (E171), Quinoline yellow (E104).

Appearance and packaging of the product

Cupripen 250 mg hard capsules:

Cupripen are hard gelatin capsules, oblong, white and yellow in color.

They are available in a pack containing 30 capsules.

Marketing authorization holder and manufacturer

Laboratorios Rubió, S. A.

C/ Industria, 29

Polígono Industrial Comte de Sert

08755 Castellbisbal – Barcelona

Spain

Date of last revision of this leaflet:10/2023.

Detailed information on this medicine is available on the website of the Spanish Medicines and Healthcare Products Agency (AEMPS) (http://www.aemps.gob.es/).

About the medicine

How much does CUPRIPEN 250 mg CAPSULES cost in Spain ( 2025)?

The average price of CUPRIPEN 250 mg CAPSULES in December, 2025 is around 24.91 EUR. Prices may vary depending on the region, pharmacy, and whether a prescription is required. Always check with a local pharmacy or online source for the most accurate information.

Alternatives to CUPRIPEN 250 mg CAPSULES in other countries

The best alternatives with the same active ingredient and therapeutic effect.

Alternative to CUPRIPEN 250 mg CAPSULES in Польша

Dosage form: Таблетки, 250 мг
Active substance: пеницилламина
Prescription required

Alternative to CUPRIPEN 250 mg CAPSULES in Украина

Dosage form: таблетки, по 250 мг
Active substance: пеницилламина

Online doctors for CUPRIPEN 250 mg CAPSULES

Discuss dosage, side effects, interactions, contraindications, and prescription renewal for CUPRIPEN 250 mg CAPSULES – subject to medical assessment and local rules.

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Andrei Popov

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Dr. Andrei Popov is a licensed pain management specialist and general practitioner based in Spain. He provides expert online care for adults dealing with both chronic and acute pain, as well as a wide range of everyday health concerns.

He specialises in diagnosing and treating pain conditions that affect quality of life, including:

  • Chronic pain lasting more than 3 months.
  • Migraines and recurring headaches.
  • Neck, back, lower back, and joint pain.
  • Post-traumatic pain following injury or surgery.
  • Nerve-related pain, fibromyalgia, and neuralgia.
In addition to pain management, Dr. Popov helps patients with:
  • Respiratory infections (colds, bronchitis, pneumonia).
  • High blood pressure and metabolic conditions such as diabetes.
  • Preventive care and routine health check-ups.

Online consultations last up to 30 minutes and include a detailed symptom review, personalised treatment planning, and medical follow-up when needed.

Dr. Popov’s approach is rooted in evidence-based medicine, combined with individualised care tailored to each patient’s history, lifestyle, and clinical needs.

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Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance.

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In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions.

Patients commonly seek his care for:

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  • sports-related health questions
  • general family medicine concerns
Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.
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With a patient-focused and evidence-based approach, Dr. Ben Ami supports individuals at all stages of life — offering clear medical guidance, timely interventions, and continuity of care.

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You can consult Dr. Ben Harbi for:

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Dr. Ben Harbi offers reliable, accessible medical support through online consultations, helping patients make informed decisions about their health with a clear, structured, and compassionate approach.

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  • assessment of sudden or unclear symptoms
  • ongoing care for chronic conditions
  • follow-up after hospital discharge
  • interpretation of test results
  • medical support while abroad
Dr Cayatte earned his degree from the University of Lisbon and taught internal medicine at Boston University School of Medicine. He holds active medical registrations in both Portugal and the UK and is a Fellow of the American Heart Association.

Consultations are available in English and Portuguese. Patients value his clarity, professionalism, and balanced approach to evidence-based care.

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