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CUPRIPEN 250 mg Capsules

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Prescription review online

A doctor will review your case and decide whether a prescription is medically appropriate.

Talk to a doctor about this medicine

Talk to a doctor about this medicine

Discuss your symptoms and possible next steps in a quick online consultation.

Doctor
5.0(38)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a General Practitioner with specialized training in chronic pain. He provides online consultations for adult patients in Spain and other European countries.

Dr. Popov understands that seeking help with weight-related concerns or pain that has persisted for months can be difficult. Many patients come to him after trying different approaches without feeling truly heard. During the consultation, the doctor creates a comfortable and supportive, non-judgmental environment where the patient’s medical history can be discussed in detail, questions can be answered, and the next steps can be decided together.

Weight Management and Metabolic Health

Dr. Popov can help assess overweight, obesity, and related conditions such as hypertension, diabetes, or metabolic disorders. During the consultation, the patient’s medical history, test results, current medications, and previous treatments will be reviewed.

If you would like to learn about possible medication options or have already started treatment, the doctor can assess your situation, review the effectiveness and tolerability of the therapy, and clearly explain its benefits, potential risks, and alternatives.

Not every patient requires the same treatment. A consultation does not guarantee a prescription — it provides an objective medical assessment and a plan tailored to your individual situation.

Pain and General Medicine

You can also consult Dr. Popov regarding:

* chronic pain, migraines, neuralgia, and fibromyalgia;

* back, neck, lower back, or joint pain;

* hypertension, diabetes, and follow-up of chronic conditions;

* review of test results, medical reports, and current treatment;

* preventive medicine and a second medical opinion.

How the Consultation Works

The video consultation lasts up to 30 minutes. The doctor will listen carefully, review the information you provide, and explain the next steps in clear and understandable language.

If additional tests, an in-person consultation, or urgent medical care are required, the doctor will inform you directly.

Dr. Popov’s goal is to make sure the patient feels heard and leaves the consultation with a clear understanding of their condition and the next steps they can take.

Book a video appointment
€86
This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use CUPRIPEN 250 mg CAPSULES

Contents of the leaflet

  1. Introduction
  2. What is Cupripen and what is it used for
  3. What you need to know before you take Cupripen
  4. How to take Cupripen
  5. Possible side effects
  6. Conservation of Cupripen
  7. Contents of the pack and further information

Introduction

Package Leaflet: Information for the User

Cupripen250 mg hard capsules

penicillamine

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What is Cupripen and what is it used for
  2. What you need to know before you take Cupripen
  3. How to take Cupripen
  4. Possible side effects

5 Conservation of Cupripen

  1. Contents of the pack and further information

1. What is Cupripen and what is it used for

Cupripen contains the active substance penicillamine, a chelating agent that acts mainly by binding to certain metals in your body, including copper and lead, to help reduce the amounts of metals absorbed by your body. Penicillamine has the ability to form a soluble complex with cysteine.

Cupripen is indicated in adults, adolescents, and children aged 5 years or older for the treatment of:

  • Wilson's disease, a disease in which the body cannot eliminate copper properly
  • In cases of heavy metal poisoning

A kidney problem called cystinuria

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you take Cupripen

Do not take Cupripen

  • if you are allergic to penicillamine or any of the other ingredients of this medicine (listed in section 6),
  • if you are allergic to penicillins,
  • if you have had any liver, kidney, or severe blood diseases when taking penicillamine,
  • if you have a disease called systemic lupus erythematosus
  • if you are taking gold salts, antimalarials, cytotoxics, oxyphenbutazone, or phenylbutazone.

Do not take Cupripen if you have any of the above conditions. If you are not sure, talk to your doctor or pharmacist before taking Cupripen, as this medicine may worsen these problems.

Warnings and precautions

Talk to your doctor or pharmacist before starting to use Cupripen if:

  • you are elderly
  • you are going to have or have had surgery.
  • you have glucose-6-phosphate dehydrogenase deficiency
  • you have liver or kidney problems
  • if you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medicine (see section "Pregnancy, breastfeeding, and fertility").

Before starting treatment, tell your doctor or pharmacist if you have any of the conditions mentioned above. Your doctor will want to monitor the effect of the medicine on you.

Special precautions for treatment with Cupripen:

Penicillamine may cause serious birth defects. You should avoid becoming pregnant while using Cupripen and for at least six months and five days after finishing treatment. See also section "Pregnancy, breastfeeding, and fertility".

Recommended follow-up tests and safety measures:

Even when Cupripen is administered at low doses, severe side effects can occur. To detect them in time, your doctor will need to perform blood tests and check-ups.

Before starting treatment with Cupripen:

You will have blood tests and urine tests. If you have any liver or kidney disease, you will have tests to check liver and kidney function.

During treatment:

You will have the following tests, at least once a week for the first two months of treatment and then every month:

  • blood tests
  • urine tests

Maintain the frequency of intakes that your doctor has indicated to avoid the appearance of poor tolerance symptoms.

In prolonged treatments, your doctor may prescribe pyridoxine (Vitamin B6).

Other medicines and Cupripen

Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.

If you are taking other medicines, penicillamine may affect their mechanism of action or cause side effects. Therefore, it may be necessary to change the dose of the medicine or suspend treatment together. If you take any of the following medicines, consult your doctor or pharmacist before taking Cupripen:

  • Aluminum or magnesium salts (medicines used to treat heartburn)
  • Digoxin (a medicine used to treat heart diseases)
  • Indomethacin (a medicine used to treat pain)
  • Isoniazid (a medicine used to treat tuberculosis)
  • Levodopa (a medicine used to treat Parkinson's disease)
  • Iron salts (medicines used to treat low iron levels or anemia)
  • Gold salts (a medicine used to treat rheumatism)
  • Phenylbutazone or oxyphenbutazone (medicines used to treat pain and inflammation)
  • Antimalarials (medicines used to treat malaria)
  • Cytotoxics (medicines used to treat cancer)

If you are unsure whether any of the medicines you are taking are included in the above list, ask your doctor or pharmacist before taking Cupripen.

Taking Cupripen with food and drinks

Take preferably on an empty stomach, 1 hour before or 2 hours after meals, as food interferes with its absorption.

The capsules should be swallowed whole with water.

Pregnancy, breastfeeding, and fertility

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medicine.

Pregnancy

The use of Cupripen is not recommended during pregnancy. Inform your doctor if you are pregnant or trying to become pregnant. Your doctor will decide if you can take Cupripen during that time.

Breastfeeding

It is not known whether Cupripen passes into breast milk. For this reason, its administration is not recommended during the breastfeeding period. Your doctor will decide if you can take Cupripen during this time.

Male fertility

Penicillamine may be genotoxic, which means it can cause genetic mutations. Therefore, you should avoid fathering a child or donating sperm while taking Cupripen and for at least three months and five days after stopping treatment.

Driving and using machines

Cupripen is unlikely to affect your ability to drive or use tools or machines.

3. How to take Cupripen

Follow exactly the administration instructions of this medicine indicated by your doctor. In case of doubt, consult your doctor or pharmacist again.

Method of administration

Cupripen is for oral use.

The capsules should be swallowed whole, with a glass of water, on an empty stomach, at least 1 hour before or 2 hours after meals.

Dose

Your doctor will establish the suitable dose for you and make the necessary adjustments, as the dosage must be individualized.

Wilson's disease

Adults

Your doctor will indicate how many capsules you should take per day. The usual dose is 6 to 8 capsules per day. Once you feel better, your doctor may reduce the dose to 3 to 4 capsules per day. It is not recommended to take 8 capsules per day for more than 12 months.

Use in elderly patients

Your doctor will indicate how many capsules you should take and how often during the day. The dose will depend on your weight. The usual dose is 20 mg of penicillamine per day per kilogram of weight. Your doctor will adjust the dose to the minimum necessary to control your disease.

Use in adolescents (12 to < 18 years)

Your doctor will indicate how many capsules you should take per day. The usual dose is 3 to 4 capsules per day.

Use in children (5 to < 12 years)

Your doctor will indicate how many capsules the child should take and how often during the day. The dose will depend on the child's weight. The usual dose is 20 mg of penicillamine per day per kilogram of weight, divided into two or three doses taken 1 hour before meals.

Patients with renal insufficiency

In patients with renal impairment, special precautions should be taken to control side effects.

Heavy metal poisoning

Adults (including elderly patients)

Your doctor will indicate how many capsules you should take per day. The dose is 4 to 6 capsules per day until your doctor indicates that the amount of heavy metals in your urine is normal. If treatment is prolonged, the dose should not exceed 40 mg per day per kilogram of weight.

Use in children and adolescents (5 to < 18 years)

Your doctor will indicate how many capsules you should take per day. The dose will depend on the child's weight. The usual dose is 20 to 25 mg per day per kilogram of weight. If necessary, a dose of 100 mg of penicillamine per day per kilogram of weight may be administered, up to a maximum dose of 1,050 mg of penicillamine per day per kilogram of weight.

Cystinuria

The dose must be adjusted individually, taking into account the amount of cystine excreted in the urine.

Adults

If you are taking Cupripen to dissolve cystine stones, the dose is 4 to 12 capsules per day, divided into several doses. If you are taking Cupripen to prevent the formation of cystine stones, the dose will be 2 to 4 capsules per day before bedtime; in this case, you should drink at least 3 liters of fluids per day.

Use in elderly patients

Your doctor will determine the suitable dose for you, which should be the minimum necessary to keep cystine levels below 200 mg per liter of urine.

Use in children and adolescents (5 to < 18 years)

The dose will depend on the child's weight. The usual dose is 20 to 30 mg per day per kilogram of weight, in two or three divided doses taken 1 hour before meals. Your doctor may change the dose depending on the results of the child's urine tests.

Patients with renal insufficiency

In patients with renal impairment at the start of treatment, lower initial doses should be administered. Maintenance doses should be reviewed at least every 4 weeks.

If you take more Cupripen than you should

If you take more Cupripen than you should, consult your doctor immediately.

If you forget to take Cupripen

Do not take a double dose to make up for forgotten doses.

If you stop taking Cupripen

Do not stop or change treatment without talking to your doctor, even if you feel better. If you have forgotten to take several doses, consult your doctor to indicate the dosage schedule to follow until you reach your maintenance dose.

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or call the Toxicology Information Service, phone: 91 562 04 20.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

The frequency and severity of side effects will depend on the dose and frequency of administration. It is important that your doctor performs periodic checks, as serious side effects can occur even with the lowest doses. Your doctor will perform tests to control abnormalities that occur in the blood and changes in the kidneys and liver.

Common (may affect up to 1 in 10 people)

  • nausea, loss of taste, bad taste, loss of appetite, and vomiting.
  • skin rashes
  • redness of the skin (erythema)
  • itching
  • proteins in your urine (detected with a urine test)

Uncommon (may affect up to 1 in 100 people)

  • ringing in the ears
  • vision loss
  • muscle weakness, joint pain (arthralgia)
  • excessive elimination of proteins in the urine (nephrotic syndrome)
  • inflammatory kidney disease (membranous glomerulonephritis)

Rare (may affect up to 1 in 1,000 people)

  • diarrhea
  • decrease in the number of blood cells (anemia, leukopenia, thrombocytopenia)
  • mouth ulcers
  • hair loss
  • inflammation of the lung tissue (pneumonitis)
  • bronchiolitis
  • yellowish discoloration of the nails (yellow nail syndrome)
  • inflammatory disease that causes muscle weakness (polymyositis)
  • breast enlargement

Not known (cannot be estimated from the available data)

  • pseudoxanthoma elasticum (a disease of the connective tissue)
  • perforating elastosis (a skin disease)
  • systemic lupus erythematosus (an allergic condition that causes joint pain, skin rashes, and fever)
  • myasthenia gravis (a disease that causes muscle weakness)

Reporting of side effects

If you experience any side effects, talk to your doctor, even if it is possible side effects not listed in this leaflet. You can also report them directly through the Spanish Medicines and Healthcare Products Agency (AEMPS) website (http://www.aemps.gob.es/). By reporting side effects, you can help provide more information on the safety of this medicine.

5. Conservation of Cupripen

Keep this medicine out of the sight and reach of children.

Store in the original packaging to protect from moisture.

Do not use this medicine after the expiry date stated on the packaging. The expiry date is the last day of the month indicated.

Medicines should not be disposed of via wastewater or household waste. Return the packaging and any unused medicine to a pharmacy. Ask your pharmacist how to dispose of the packaging and any unused medicine. This will help protect the environment.

6. Contents of the pack and further information

Composition of Cupripen 250 mg hard capsules:

  • The active substance is penicillamine. Each hard capsule of Cupripen contains 250 mg of penicillamine.
  • The other ingredients are:

Contents of the capsules: Magnesium stearate; Capsule shell: Gelatin, Titanium dioxide (E171), Quinoline yellow (E104).

Appearance and packaging of the product

Cupripen 250 mg hard capsules:

Cupripen are hard gelatin capsules, oblong, white and yellow in color.

They are available in a pack containing 30 capsules.

Marketing authorization holder and manufacturer

Laboratorios Rubió, S. A.

C/ Industria, 29

Polígono Industrial Comte de Sert

08755 Castellbisbal – Barcelona

Spain

Date of last revision of this leaflet:10/2023.

Detailed information on this medicine is available on the website of the Spanish Medicines and Healthcare Products Agency (AEMPS) (http://www.aemps.gob.es/).

Online doctors for CUPRIPEN 250 mg CAPSULES

Discuss questions about CUPRIPEN 250 mg CAPSULES, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

Doctor
5.0(38)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a General Practitioner with specialized training in chronic pain. He provides online consultations for adult patients in Spain and other European countries.

Dr. Popov understands that seeking help with weight-related concerns or pain that has persisted for months can be difficult. Many patients come to him after trying different approaches without feeling truly heard. During the consultation, the doctor creates a comfortable and supportive, non-judgmental environment where the patient’s medical history can be discussed in detail, questions can be answered, and the next steps can be decided together.

Weight Management and Metabolic Health

Dr. Popov can help assess overweight, obesity, and related conditions such as hypertension, diabetes, or metabolic disorders. During the consultation, the patient’s medical history, test results, current medications, and previous treatments will be reviewed.

If you would like to learn about possible medication options or have already started treatment, the doctor can assess your situation, review the effectiveness and tolerability of the therapy, and clearly explain its benefits, potential risks, and alternatives.

Not every patient requires the same treatment. A consultation does not guarantee a prescription — it provides an objective medical assessment and a plan tailored to your individual situation.

Pain and General Medicine

You can also consult Dr. Popov regarding:

* chronic pain, migraines, neuralgia, and fibromyalgia;

* back, neck, lower back, or joint pain;

* hypertension, diabetes, and follow-up of chronic conditions;

* review of test results, medical reports, and current treatment;

* preventive medicine and a second medical opinion.

How the Consultation Works

The video consultation lasts up to 30 minutes. The doctor will listen carefully, review the information you provide, and explain the next steps in clear and understandable language.

If additional tests, an in-person consultation, or urgent medical care are required, the doctor will inform you directly.

Dr. Popov’s goal is to make sure the patient feels heard and leaves the consultation with a clear understanding of their condition and the next steps they can take.

Book a video appointment
€86
Doctor
5.0(12)

Yevgen Yakovenko

General medicine12 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

Book a video appointment
€72
Doctor
5.0(3)

Lina Travkina

General medicine13 years of experience

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.

  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.

  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.

  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.

  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.

  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.

  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.

  • Medical advice and follow-up consultations.

  • Test interpretation and diagnostic guidance.

  • Structured support for undiagnosed complaints.

  • Second opinion on diagnoses and treatment plans.

  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.

  • Post-operative recovery support and pain management.

  • Preconception counselling and postpartum support.

  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

Book a video appointment
€75
Doctor
5.0(21)

Nuno Tavares Lopes

General medicine18 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies

  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management

  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses

  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment

  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance

  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis

  • Pain management: acute and chronic pain, post-surgical care

  • Public health: prevention, health screenings, long-term monitoring

  • Sick leave (Baixa médica) connected to Segurança Social in Portugal

  • IMT medical certificates for driving licence exchange

Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

Book a video appointment
€70

Get CUPRIPEN 250 mg CAPSULES Prescription Online

1

Fill in a 2-min form

Tell us your symptoms, history, and what medicine you're requesting.

2

Pick a doctor or let us assign

Choose a specialist or we'll match you with the next available doctor.

3

Doctor reviews your case

Usually within 30 minutes. They may ask follow-up questions via chat.

4

Collect from any pharmacy

Electronic prescription sent to your email — valid across Spain.

Frequently Asked Questions

CUPRIPEN 250 mg CAPSULES requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

The active ingredient in CUPRIPEN 250 mg CAPSULES is penicillamine. This information helps identify medicines with the same composition but different brand names.

The average pharmacy price for CUPRIPEN 250 mg CAPSULES is around 24.91 EUR. Prices may vary depending on the manufacturer and dosage form.

CUPRIPEN 250 mg CAPSULES is manufactured by Laboratorios Rubio S.A.. Pharmacy brands and packaging may differ depending on the distributor.

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether CUPRIPEN 250 mg CAPSULES is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy CUPRIPEN 250 mg CAPSULES in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

Other medicines with the same active substance (penicillamine) include CUPRIPEN 50 mg TABLETS, ACECLOFENAC CINFA 100 mg FILM-COATED TABLETS, ACECLOFENAC KERN PHARMA 100 MG FILM-COATED TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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