Background pattern

Anticude

About the medicineAbout the medication

Introduction

Package Insert: Information for the User

ANTICUDE 25mg/2ml ampoules

Edrofonium Bromide

Read this package insert carefully before starting to use this medication, as it contains important information for you.

  • Keep this package insert, as you may need to read it again.
    If you have any questions, consult your doctor or pharmacist.
  • This medication has been prescribed to you alone, and you should not give it to others even if they have the same symptoms as you, as it may harm them.
  • If you experience any adverse effects, consult your doctor or pharmacist, even if they are not listed in this package insert. See section 4.

1. What Anticude is and for what it is used

2. What you need to know before starting to use Anticude

3. How to use Anticude

4. Possible adverse effects

5. Storage of Anticude

6. Contents of the package and additional information

1. What is Anticude and what is it used for

Anticude is a medication used as an antidote for curarizing agents, including synthetic ones, in prolonged apnea and in any syndrome that involves atonia of the striated or smooth muscle.

It is also used for the diagnosis and treatment of myasthenia gravis and to facilitate differential diagnosis of arrhythmias caused by digitalis intoxication.

2. What you need to know before starting to use Anticude

Do not use Anticude

If you are allergic (hypersensitive) to Edrofonium bromide or to any of the other components of Anticude.

Be especially careful with Anticude

In hyperadrenergic states.

Use of other medications

Inform your doctor or pharmacist if you are using or have recently used other medications, including those obtained without a prescription.

No interactions of Anticude with other medications have been described.

Anticude is incompatible with the use of any sympathomimetic or anticholinergic.

Pregnancy and breastfeeding

Consult your doctor or pharmacist before using any medication.

Important information about some of the components of Anticude

This medication contains Sodium bisulfite (E-222) so it may produce severe allergic reactions and bronchospasm (sudden sensation of choking) because it contains 0.8mg per ampoule.

This medication contains less than 23mg (1mmol) of sodium per ampoule, so it is considered essentially "sodium-free".

3. How to use Anticude

Follow exactly the administration instructions for Anticude as indicated by your doctor. Consult your doctor or pharmacist if you have any doubts.

Although the average dose as an antidote for myorelaxants is 1 to 3 ampoules, it varies according to the clinician's criteria, the patient's idiosyncrasy, and the type of curarizing agent employed whose action is of interest to antagonize.

Anticude is administered exclusively by intravenous route.

If you use more Anticude than you should

Consult your doctor, pharmacist immediately, or call the Toxicological Information Service, phone 91 562 04 20, indicating the medication and the amount used.

If you forgot to use Anticude

Do not use a double dose to compensate for the missed doses.

If you have any other questions about the use of this product, ask your doctor or pharmacist.

4. Possible Adverse Effects

Like all medications, Anticude may produce adverse effects, although not all people will experience them.

No known adverse effects are known, and it is exempt from the secondary effects inherent to most cholinesterase inhibitors, such as hypotension, salivation, etc., which should be avoided in the recently operated.

No clinical intoxication cases have been described due to effects of Edrofonio. However, if this incidence occurs, antagonistic action drugs, that is, sympathomimetics or anticholinergics, should be administered.

If you consider that any of the adverse effects you are experiencing is severe or if you notice any adverse effect not mentioned in this prospectus, inform your doctor or pharmacist.

5. Conservation of Anticude

No requires special conditions for conservation.

Keep out of reach and sight of children.

Do not use Anticude after the expiration date that appears on the packaging after CAD. The expiration date is the last day of the month indicated.

Do not use Anticude ampoules if you observe visible signs of deterioration.

Dispose of the packaging and medications you do not need at the SIGRE collection point of the pharmacy. In case of doubt, ask your pharmacist how to dispose of the packaging and medications you do not need. In this way, you will help protect the environment.

6. Contents of the packaging and additional information

Composition of Anticude

  • The active principle is Edrofonio bromide. Each ampule of 2mL contains 25mg of Edrofonio bromide.
  • The other components are: Sodium chloride, Sodium bisulfite, and Water for injection c.s.

Appearance of the product and contents of the packaging

Box with 2 ampules of 2mL.

Holder of the marketing authorization:

MANA PHARMA, S.L.

Carr. Fuencarral 22

Alcobendas 28108

(Madrid) Spain

Telephone: 910 68 44 50

Responsible for manufacturing:

B. BRAUN MEDICAL, S.A.

Ronda de los Olivares

Polígono Industrial Los Olivares

Parcela 11

23009, Jaén, Spain

Telephone:+34 953 24 98 80

Fax: +34 953 28 13 51

Date of the last review of this leaflet11/2023

The detailed and updated information of this medicine is available on the website of the Spanish Agency for Medicines and Medical Devices (AEMPS) http://www.aemps.es/

Country of registration
Active substance
Prescription required
Yes
Manufacturer
Composition
Bisulfito sodico (0,8 mg mg), Cloruro de sodio (18,0 mg mg)
This information is for reference only and does not constitute medical advice. Always consult a licensed doctor before taking any medication. Oladoctor is not responsible for medical decisions based on this content.

Talk to a doctor online

Have questions about this medication or your symptoms? Connect with a licensed doctor for guidance and personalized care.

5.01 review
Doctor

Anna Moret

Dermatology18 years of experience

Dr. Anna Moret is a board-certified dermatologist and dermatovenereologist. She specialises in adult and pediatric dermatology, venereology, aesthetic skin care, and general medicine. Her consultations are evidence-based and tailored to each patient’s dermatological needs.

Dr. Moret provides expert evaluation and treatment for: • Skin conditions such as eczema, acne, rosacea, dermatitis, and psoriasis • Hair and scalp issues including hair loss, dandruff, and seborrheic dermatitis • Pediatric skin problems — from newborns to adolescents • Sexually transmitted infections (STIs) and dermatovenereology • Aesthetic concerns: skin ageing, non-invasive cosmetic treatments • Skin allergies and hypersensitivity reactions • Mole checks, lesion evaluation, and skin cancer screening • Skincare advice and personalised cosmeceutical routines

Combining dermatology with general medical knowledge, Dr. Moret offers comprehensive care that addresses both skin health and underlying conditions. She also holds certification from the Canadian Board of Aesthetic Medicine, ensuring an internationally aligned approach to aesthetic dermatology.

CameraBook a video appointment
5.05 reviews
Doctor

Alina Tsurkan

Family medicine12 years of experience

Dr. Alina Tsurkan is a licensed family medicine physician based in Portugal, offering online consultations for adults and children. She provides professional primary care, with a focus on prevention, accurate diagnosis, and long-term management of acute and chronic conditions.

Dr. Tsurkan supports patients with a wide range of health issues, including: • Respiratory infections: cold, flu, bronchitis, pneumonia, and lingering coughs • ENT conditions: sinusitis, tonsillitis, otitis (ear infections), sore throat, allergic rhinitis • Eye conditions: allergic or infectious conjunctivitis, red eyes, irritation • Digestive issues: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), constipation, bloating, nausea • Urinary and reproductive health: urinary tract infections (UTIs), cystitis, prevention of recurrent infections • Chronic diseases: hypertension, diabetes, thyroid disorders, elevated cholesterol, weight management • Neurological complaints: headaches, migraines, sleep disturbances, fatigue, general weakness • Women’s health: menstrual irregularities, perimenopausal symptoms, preventive screening • Children’s health: fever, infections, digestive issues, follow-ups, vaccination guidance

She also provides: • IMT medical certificates for driving licence exchange in Portugal • Personalised preventive care and wellness consultations • Interpretation of test results and medical reports • Follow-up care and medication review • Support in managing multiple coexisting conditions • Remote prescription management and medical documentation

Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

CameraBook a video appointment
5.04 reviews
Doctor

Andrei Popov

General medicine6 years of experience

Dr. Andrei Popov is a licensed pain management specialist and general practitioner based in Spain. He provides expert online care for adults dealing with both chronic and acute pain, as well as a wide range of everyday health concerns.

He specialises in diagnosing and treating pain conditions that affect quality of life, including: • Chronic pain lasting more than 3 months • Migraines and recurring headaches • Neck, back, lower back, and joint pain • Post-traumatic pain following injury or surgery • Nerve-related pain, fibromyalgia, and neuralgia In addition to pain management, Dr. Popov helps patients with: • Respiratory infections (colds, bronchitis, pneumonia) • High blood pressure and metabolic conditions such as diabetes • Preventive care and routine health check-ups

Online consultations last up to 30 minutes and include a detailed symptom review, personalised treatment planning, and medical follow-up when needed.

Dr. Popov’s approach is rooted in evidence-based medicine, combined with individualised care tailored to each patient’s history, lifestyle, and clinical needs.

CameraBook a video appointment
5.03 reviews
Doctor

Yevgen Yakovenko

General surgery11 years of experience

Dr. Yevhenii Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise: • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan. • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions. • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies. • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries. • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required. • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up. • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data. • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications: • 12+ years of clinical experience in university hospitals in Germany and Spain • International education: Ukraine – Germany – Spain • Member of the German Society of Surgeons (BDC) • Certified in radiological diagnostics and robotic surgery • Active participant in international medical conferences and research

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

CameraBook a video appointment
See all doctors

Stay informed and save on care

Get health tips, platform updates, and exclusive promos for subscribers.

Follow us on social media
FacebookInstagramTikTok