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About the medicine

How to use ROYEN 500 mg HARD CAPSULE

Contents of the leaflet

  1. Introduction
  2. What is ROYEN 500 mg and what is it used for
  3. Before taking ROYEN 500 mg
  4. How to take ROYEN 500 mg
  5. Possible side effects
  6. Storage of ROYEN 500 mg
  7. Further information

Introduction

Package Leaflet: Information for the User

ROYEN 500 mg Hard Capsule

Calcium Acetate

Read all of this leaflet carefully before you start taking this medicine.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you. Do not pass it on to others, as it may harm them, even if their symptoms are the same as yours.
  • If you experience any of the side effects mentioned in this leaflet, or if you notice any other unusual effects not mentioned here, inform your doctor or pharmacist.

Contents of the Package Leaflet:

  1. What is ROYEN 500 mg and what is it used for
  2. Before taking ROYEN 500 mg
  3. How to take ROYEN 500 mg
  4. Possible side effects
  5. Storage of ROYEN 500 mg
  6. Further information

1. What is ROYEN 500 mg and what is it used for

ROYEN 500 mg is presented in the form of hard capsules for oral administration in containers containing 60 and 120 hard capsules.

Calcium acetate is a drug that belongs to the group of medicines called chelating agents. It combines with dietary phosphate and forms insoluble phosphates that are eliminated with the feces, which helps control blood phosphate levels.

ROYEN 500 mg hard capsule is indicated in:

  • Control of hyperphosphatemia (high blood phosphate levels) in patients with advanced renal failure.
Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. Before taking ROYEN 500 mg

Do not take ROYEN:

  • If you are allergic to calcium acetate or any of the other components of ROYEN 500 mg.
  • If you suffer from hypercalcemia (high blood calcium levels) or hypercalciuria (excessive elimination of calcium in the urine).

Be cautious with ROYEN:

  • At the start of treatment, as excessive dosing of ROYEN may cause an increase in blood calcium levels. Your doctor should determine your blood calcium levels twice a week. Phosphorus levels in the blood should also be determined periodically.
  • If you are being treated with digitalis, as increased calcium levels in the blood may cause cardiac arrhythmias.
  • Do not take other calcium supplements with ROYEN, as this may cause an overdose and a serious increase in blood calcium levels. For the same reason, it is essential to control your daily intake of calcium-rich foods, such as dairy products and similar items.

If you are on dialysis, reducing the concentration of calcium in the dialysate may reduce the incidence and severity of ROYEN-induced hypercalcemia.

Consult your doctor if any of the above circumstances have occurred to you.

Use of other medicines:

Inform your doctor or pharmacist if you are using, or have recently used, any other medicines, including those obtained without a prescription.

Inform your doctor if you are taking any of the following medicines, as they may interact with calcium acetate, and it may be necessary to adjust the dose or interrupt one of the treatments:

  • Tetracyclines (a specific group of antibiotics).
  • Zinc: zinc levels should be monitored, as ROYEN decreases intestinal zinc absorption.
  • Antacids or other preparations containing high concentrations of calcium, which may contribute to increased blood calcium levels.

Pregnancy:

Consult your doctor or pharmacist before using any medicine.

It is unknown whether ROYEN can cause fetal harm when administered to pregnant women or affect reproductive capacity.

ROYEN should only be administered to pregnant or breastfeeding women in cases of strict necessity.

Driving and using machines:

ROYEN has no influence on the ability to drive and use machines.

3. How to take ROYEN 500 mg

Follow your doctor's instructions for taking ROYEN 500 mg exactly. Consult your doctor or pharmacist if you have any doubts.

ROYEN is taken orally. Swallow the capsules with a glass of water.

The normal dose is 3 to 5 capsules with each meal (breakfast, lunch, and dinner), according to medical criteria.

Start treatment with ROYEN at a low dose. Do not increase the dose without previously determining blood calcium levels.

The dose of ROYEN should be adjusted based on the calculation of daily calcium intake. The recommended initial dose of ROYEN for a patient on dialysis is 2 capsules at breakfast, lunch, and dinner. This dose may be gradually increased to achieve serum phosphate levels below 6 mg/dl, while controlling the increase in blood calcium levels.

Your doctor will indicate the duration of your treatment with ROYEN. Do not stop treatment before this, as it may cause a sudden increase in blood phosphate levels. Similarly, do not use it for longer than indicated by your doctor.

If you think the effect of ROYEN is too strong or too weak, inform your doctor or pharmacist.

If you take more ROYEN than you should:

If you have taken more ROYEN than you should, consult your doctor or pharmacist immediately, indicating the medicine and the amount ingested.

The most frequent symptom in case of overdose is an increase in blood calcium levels. If the increase is mild, it can be easily controlled by reducing the dose of ROYEN or temporarily interrupting treatment. In case of severe hypercalcemia, hemodialysis should be performed, and treatment should be temporarily interrupted until your doctor indicates otherwise.

In case of overdose or accidental ingestion, consult the Toxicology Information Service. Telephone 91 562 04 20.

If you forget to take ROYEN:

Do not take a double dose to make up for forgotten doses.

If you stop taking ROYEN:

Consult your doctor to indicate the dosage to follow until you reach your maintenance dose.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, ROYEN can cause side effects, although not everyone gets them.

Rare (less than 1 in 1,000 but more than 1 in 10,000 treated subjects):

  • Nausea, vomiting, diarrhea, constipation, abdominal pain.
  • Asthenia, fatigue.
  • Mild increase in blood calcium levels.
  • Severe increase in blood calcium levels that can cause confusion, delirium, stupor, and coma.

Very rare (less than 1 in 10,000 treated subjects, including isolated reports):

  • Itching that may be due to allergic reactions.

If you think any of the side effects you are experiencing is serious, or if you notice any side effects not mentioned in this leaflet, inform your doctor or pharmacist.

5. Storage of ROYEN 500 mg

Do not store above 25°C.

Keep out of the reach and sight of children.

Do not use ROYEN after the expiration date stated on the container. The expiration date is the last day of the month indicated.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of containers and unused medicines. This will help protect the environment.

6. Further information

Composition of ROYEN:

The active ingredient of this medicine is calcium acetate.

Each capsule contains 500 mg of calcium acetate (equivalent to 127 mg of calcium).

The other ingredients are: magnesium stearate and talc. The capsule is also composed of gelatin, titanium dioxide, and indigo carmine.

Appearance of the product and container contents:

ROYEN 500 mg hard capsule is presented in the form of capsules for oral administration in containers containing 60 and 120 capsules.

Marketing authorization holder and manufacturer:

LABORATORIOS RUBIÓ, S.A.

C/ Industria, 29

Polígono Industrial Comte de Sert

08755 Castellbisbal, Barcelona – Spain

This leaflet was approved in

June 2012

Online doctors for ROYEN 500 mg HARD CAPSULE

Discuss questions about ROYEN 500 mg HARD CAPSULE, including use, safety considerations and whether a prescription is appropriate, subject to medical assessment and local regulations.

Doctor
5.0(6)

Jorge Correa Bellido

General medicine7 years of experience
Licence no. 464626297

Dr. Jorge Correa Bellido is a Spanish physician who offers online consultations in Spanish and English. He graduated from the University of La Laguna and has a solid background in clinical practice and international research.

Throughout his career, he has participated in various medical and academic projects, including a research fellowship in Spain, where he contributed to evidence-based studies in the field of family medicine. This experience allowed him to broaden his global perspective on healthcare and comprehensive patient care.

Dr. Correa Bellido has worked with several healthcare providers in Spain, focusing particularly on patient-centered care and public health initiatives aimed at communities with limited access to healthcare services.

In addition, he actively participates in international medical conferences and workshops, which allows him to stay up to date with the latest medical advances and collaborate with healthcare professionals from different countries.

Dr. Correa Bellido provides comprehensive care for a wide variety of medical conditions, including:

  • respiratory infections
  • gastrointestinal disorders
  • cardiovascular problems
  • endocrine and metabolic diseases
  • musculoskeletal and dermatological conditions
  • as well as mental health conditions such as anxiety and depression.

He also treats infectious and allergic diseases, general health concerns, and provides guidance on prevention and healthy lifestyle habits.

His services include virtual consultations, diagnosis and management of acute and chronic diseases, prescription renewals, and personalized medical advice.

With a patient-centered approach and a strong commitment to continuous learning, Dr. Correa Bellido provides accessible and high-quality healthcare to patients both in Spain and around the world.

Book a video appointment
€86
Doctor

Chikeluo Okeke

General medicine4 years of experience

Dr Chikeluo Okeke is an internal medicine doctor with extensive international clinical experience. Originally from Nigeria, he has worked across multiple European healthcare systems and currently practises in Sweden. This professional path has given him a strong understanding of different medical approaches and the ability to work effectively with patients from diverse cultural and linguistic backgrounds.

Dr Okeke focuses on general internal medicine and adult primary care, combining clinical accuracy with careful attention to lifestyle, personal context, and everyday health concerns. His consultations are particularly well suited for people who seek medical advice online, live abroad, or need clear guidance without unnecessary complexity.

He provides online consultations covering symptom assessment, prevention, and long-term management of chronic conditions, helping patients understand what is happening and decide on appropriate next steps.

Common reasons for consultation:

  • General internal medicine concerns and initial health assessment.
  • Acute symptoms such as fever, cough, infections, pain, or weakness.
  • Chronic conditions and treatment adjustment.
  • Blood pressure issues, fatigue, metabolic concerns.
  • Preventive consultations and routine check-ups.
  • Interpretation of laboratory results and medical reports.
  • Medical advice for patients receiving care online.

Dr Okeke is known for his clear communication, calm approach, and cultural awareness. He listens carefully, explains medical decisions in a structured way, and supports patients in making informed choices about their health.

Online consultations with Dr Chikeluo Okeke offer reliable internal medicine care without geographic limitations, focused on medical relevance, clarity, and patient comfort.

Book a video appointment
€66
Doctor
5.0(21)

Nuno Tavares Lopes

General medicine18 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies

  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management

  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses

  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment

  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance

  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis

  • Pain management: acute and chronic pain, post-surgical care

  • Public health: prevention, health screenings, long-term monitoring

  • Sick leave (Baixa médica) connected to Segurança Social in Portugal

  • IMT medical certificates for driving licence exchange

Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

Book a video appointment
€70
Doctor

Hocine Lokchiri

General medicine21 years of experience

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
Book a video appointment
€64
Doctor
4.7(11)

Anastasiia Shalko

General medicine13 years of experience
Licence no. 52891

Dr. Anastasiia Shalko is a general practitioner with a background in both paediatrics and general medicine. She graduated from Bogomolets National Medical University in Kyiv and completed her paediatric internship at the P.L. Shupyk National Medical Academy of Postgraduate Education. After working as a paediatrician in Kyiv, she relocated to Spain, where she has been practising general medicine since 2015, providing care for both adults and children.Her work focuses on urgent, short-term medical concerns – situations where patients need quick guidance, symptom assessment and clear next steps. She helps people understand whether their symptoms require in-person evaluation, home management or a change in treatment. Common reasons for booking an online consultation include:

  • acute respiratory symptoms (cough, sore throat, runny nose, fever)
  • viral illnesses such as colds and seasonal infections
  • gastrointestinal complaints (nausea, diarrhoea, abdominal pain, gastroenteritis)
  • sudden changes in how a child or adult feels
  • questions about existing treatment and whether adjustments are needed
  • renewal of prescriptions when clinically appropriate

Dr. Shalko works specifically with urgent and short-term problems, providing practical recommendations and helping patients determine the safest next step. She explains symptoms clearly, guides patients through decision-making and offers straightforward medical advice for everyday acute issues.She does not provide long-term management of chronic conditions, ongoing follow-up or comprehensive care plans for complex long-term illnesses. Her consultations are designed for acute symptoms, sudden concerns and situations where timely medical input is important.With clinical experience in both paediatrics and general medicine, Dr. Shalko confidently supports adults and children. Her communication style is clear, simple and reassuring, helping patients feel informed and supported throughout the consultation.

Book a video appointment
€56
Doctor
5.0(8)

Lizaveta Trafimchuk Takhvaniuk

DermatologyGeneral medicine10 years of experience
Licence no. 58788

Dr. Lizaveta Trafimchuk Takhvaniuk graduated in Medicine and subsequently specialized in Dermatology and Venereology. She has more than 10 years of clinical experience and is licensed to practice in Spain, where she focuses on the comprehensive diagnosis and treatment of dermatological conditions.

Throughout her education and professional career, Dr. Trafimchuk has gained extensive experience in managing diseases of the skin, hair, and nails, as well as in the diagnosis, treatment, and prevention of sexually transmitted infections (STIs). Her clinical approach is based on evidence-based medicine, combined with personalized care tailored to each patient’s needs.

In her daily practice, she treats a wide range of dermatological conditions, including chronic inflammatory dermatoses such as acne, rosacea, atopic dermatitis, psoriasis, and eczema. She also has experience in treating pigmentation disorders, including melasma, post-inflammatory hyperpigmentation, and dyschromia.

She has developed a particular interest in trichology, treating various types of alopecia, chronic hair loss, and scalp disorders. In addition, she has experience in managing infectious dermatoses of fungal, viral, and bacterial origin, as well as in evaluating benign and suspicious skin lesions, with referral to specialized care when necessary.

With a strong interest in a comprehensive approach to skin health, she also treats scars, post-procedural skin changes, and conditions related to hormonal factors and aging, including those associated with pregnancy, menopause, and age-related skin changes.

Thanks to her experience and continuous professional development, Dr. Trafimchuk provides high-quality medical care that is professional, confidential, and aligned with modern dermatology standards.

Book a video appointment
€72

Frequently Asked Questions

ROYEN 500 mg HARD CAPSULE requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

The active ingredient in ROYEN 500 mg HARD CAPSULE is calcium acetate. This information helps identify medicines with the same composition but different brand names.

The average pharmacy price for ROYEN 500 mg HARD CAPSULE is around 9.77 EUR. Prices may vary depending on the manufacturer and dosage form.

ROYEN 500 mg HARD CAPSULE is manufactured by Laboratorios Rubio S.A.. Pharmacy brands and packaging may differ depending on the distributor.

Doctors such as Family doctors, Endocrinologists, Allergists, Oncologists, General medicine doctors, Immunologists may assess whether ROYEN 500 mg HARD CAPSULE is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

The prescription is issued by a doctor after assessing your health. In Spain, ROYEN 500 mg HARD CAPSULE is then dispensed in pharmacies with that prescription. An online consultation does not guarantee that a prescription will be issued: the decision always rests with the doctor.

To request an assessment, you can use Oladoctor:

Other medicines with the same active substance (calcium acetate) include ROYEN 2.5 g ORAL SUSPENSION POWDER, SEVELAMER CARBONATE WINTHROP 800 MG FILM-COATED TABLETS, FOSQUEL 2.4 g ORAL SUSPENSION POWDER. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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