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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use PRODERMA 50 mg HARD CAPSULES

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

Proderma 50 mg Hard Capsules

Doxycycline

Read the entire package leaflet carefully before starting to take the medicine, as it contains important information for you.

  • Keep this package leaflet, as you may need to read it again.
  • If you have any doubts, consult your doctor or pharmacist.
  • This medicine has been prescribed to you only, and you should not give it to others, even if they have the same symptoms as you, as it may harm them.
  • If you experience side effects, consult your doctor or pharmacist, even if they are not listed in this package leaflet.

Contents of the Package Leaflet

  1. What Proderma 50 mg Hard Capsules are and what they are used for
  2. What you need to know before taking Proderma 50 mg Hard Capsules
  3. How to take Proderma 50 mg Hard Capsules
  4. Possible side effects
  5. Storage of Proderma 50 mg Hard Capsules
  6. Package Contents and Additional Information

1. What Proderma 50 mg Hard Capsules are and what they are used for

Doxycycline belongs to a group of medicines called tetracyclines, which are broad-spectrum antibiotics, active against multiple microorganisms.

Informative text about the use of antibiotics and precautions regarding their administration and disposal Doxycycline is primarily indicated for infections of the skin and soft tissues, respiratory tract infections, and genitourinary infections, such as:

  • Atypical pneumonia.
  • Psittacosis (disease transmitted to humans by certain birds, characterized by pneumonia, fever, and cough).
  • Typhus and other infections caused by microorganisms called rickettsias.
  • Sexually transmitted diseases.
  • Brucellosis (Malta fever).
  • Cholera.
  • Early stages of Lyme disease (disease transmitted by ticks).
  • Fever transmitted by lice and ticks.
  • Malaria.
  • Severe acne vulgaris.
Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before taking Proderma 50 mg Hard Capsules

Do not take Proderma 50 mg Hard Capsules

If you are allergic to doxycycline, tetracyclines, or any of the other components of Proderma 50 mg (listed in section 6).

Warnings and Precautions

Consult your doctor or pharmacist before starting to take Proderma 50 mg.

Children

Proderma 50 mg should not be administered during the dentition period (second half of pregnancy, lactation, and children under 8 years), as it may cause permanent tooth discoloration and delay bone development.

General

  • Bulging of the fontanelles (unossified space in the skull) has been reported in children, and intracranial hypertension (increased pressure of the cerebrospinal fluid in the brain) has been reported in both children and adults (see section 4. Possible side effects).
  • If you experience diarrhea while receiving treatment with doxycycline, consult your doctor.
  • If you take this medicine while lying down or without sufficient water, ulcers may appear in the digestive system; therefore, it is essential to follow the administration instructions (see section 3. How to take Proderma 50 mg Hard Capsules and section 4. Possible side effects).
  • If you have liver or kidney disease, consult your doctor.
  • In prolonged treatments, the doctor will perform renal and hepatic function tests.
  • If you have systemic lupus erythematosus, you should avoid using this medicine.
  • In case of direct sun exposure, skin redness may occur; if this happens, consult your doctor.
  • If you suffer from myasthenia gravis (a form of muscle weakness), consult your doctor before taking this medicine.
  • If you are going to have a urine test, inform the healthcare staff that you are being treated with this medicine, as doxycycline may interfere with the results.

Use of Proderma 50 mg Hard Capsules with other medicines

Inform your doctor or pharmacist if you are taking or have recently taken other medicines, including those purchased without a prescription.

Like all medicines, Proderma 50 mg can interact with some medicines, such as:

  • Antacids containing aluminum, calcium, and magnesium, as they decrease the absorption of Proderma 50 mg.
  • Antibiotics, as they may decrease the efficacy of Proderma 50 mg.
  • Methoxyflurane, as it may cause kidney toxicity when used with tetracyclines and Proderma 50 mg, which can be severe.
  • Anticoagulants (such as warfarin), as Proderma 50 mg may alter the effect of these anticoagulants; therefore, consult your doctor.
  • Medicines for the treatment of epilepsy, such as carbamazepine and phenytoin.
  • Oral contraceptives and barbiturates, as Proderma 50 mg may decrease their efficacy.
  • Chronic alcohol consumption may decrease the efficacy of Proderma 50 mg.

In case of doubt, consult your doctor or pharmacist.

Taking Proderma 50 mg Hard Capsules with food and drinks

  • During treatment with doxycycline, alcohol consumption should be avoided.
  • Proderma 50 mg should be administered with food or water to avoid esophageal irritation (see section 3. How to take Proderma 50 mg Hard Capsules and section 4. Possible side effects).

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medicine.

Breastfeeding

You should avoid taking this medicine during breastfeeding.

Driving and using machines

There is no evidence that Proderma 50 mg alters the ability to drive or use machines.

Proderma 50 mg Hard Capsules containsucrose.If your doctor has told you that you have an intolerance to certain sugars, consult with them before taking this medicine.

3. How to take Proderma 50 mg Hard Capsules

Follow the administration instructions for Proderma 50 mg exactly as indicated by your doctor. In case of doubt, consult your doctor or pharmacist again.

Remember to take your medicine.

Consult your doctor or pharmacist if you think the effect of doxycycline is not what you expected, either because it is too strong and causes unwanted side effects or because it is too weak and insufficient for the treatment of the infection.

IMPORTANT:

This medicine should be taken during a meal, accompanied by a large glass of water.

It is essential that, after taking the medicine, you wait at least one hour before lying down or going to bed to sleep.

The above recommendations aim to prevent the appearance of digestive problems, especially stomach ulcers.

Your doctor will indicate the duration of treatment with Proderma 50 mg. Do not stop treatment prematurely, even if you have started to improve.

Adults:the usual dose of doxycycline is 200 mg in one or two doses on the first day of treatment, followed by a maintenance dose of 100 mg/day. For the treatment of more severe infections, 200 mg/day should be administered throughout the treatment period. In general, treatment should continue until at least 24 to 48 hours after the disappearance of symptoms and fever.

Children over 8 years old:children over 8 years old who weigh 45 kg or less, the usual dose is 4 mg/kg of body weight on the first day of treatment, administered in a single dose or in two equal doses every 12 hours. In severe infections: 4 mg/kg of body weight every 24 hours, maintaining the same dose throughout treatment. Treatment should continue for 24 to 48 hours after the symptoms have disappeared.

If you take more Proderma 50 mg Hard Capsules than you should

If you have taken more Proderma 50 mg Hard Capsules than you should, consult your doctor or pharmacist immediately.

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or call the Toxicology Information Service. Phone: (91) 562 04 20, indicating the medicine and the amount ingested.

If you forget to take Proderma 50 mg Hard Capsules

If you forget to take a dose, take the next one when it is due. Do not take a double dose to make up for the forgotten dose.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, Proderma 50 mg can cause side effects, although not everyone gets them.

The following side effects have been detected after taking Proderma 50 mg:

Blood and lymphatic system disorders:blood disorders after tetracycline administration are very rare. However, cases of hemolytic anemia (consequence of excessive red blood cell destruction), thrombocytopenia (decrease in platelet count), neutropenia (decrease in neutrophil count), and eosinophilia (increase in eosinophil count) have been reported.

Nervous system disorders:infrequently, intracranial hypertension characterized by headache, nausea, vomiting, dizziness, tinnitus, and visual disturbances occurs. These symptoms resolve after withdrawal of the drug. Bulging of the fontanelles in children has also been reported.

Gastrointestinal disorders:digestive alterations such as esophageal ulcers (see section 3. How to take Proderma 50 mg Hard Capsules), nausea, stomach pain, diarrhea, loss of appetite, tongue inflammation, intestinal inflammation, and anogenital candidiasis (infection by a microscopic fungus) may occur.

Permanent tooth discoloration may also occur if doxycycline is used during dental development (second half of pregnancy, lactation, and children under 8 years).

Liver disorders:treatment with high doses may cause hepatitis and liver function disorders.

Skin and subcutaneous tissue disorders:urticaria, maculopapular rash (spots and small elevations of the skin), exudative erythema (redness and spots on the skin), multiform eruptions (redness and swelling of the skin), photosensitivity reactions, exceptionally exfoliative dermatitis (inflammation and peeling of the skin), and rarely Stevens-Johnson syndrome.

Frequency not known: photoonycholysis (nail pigmentation).

Musculoskeletal and connective tissue disorders:joint pain and muscle pain may occur, as well as delayed growth in children.

Kidney disorders:like all tetracyclines, doxycycline may cause elevated blood urea nitrogen levels.

General disorders:occasionally, severe hypersensitivity reactions (allergies) may occur, exceptionally including urticaria, angioedema (fluid retention in the vessels), hypotension (decreased blood pressure), pericarditis (inflammation of the tissue surrounding the heart), worsening of systemic lupus erythematosus, angioedema, serum sickness (allergic reaction to serum), and very rarely anaphylactic shock (unusual or exaggerated allergic reaction).

Jarisch-Herxheimer reaction: characterized by fever, chills, headache, muscle pain, and skin rash, which usually resolves spontaneously. It occurs shortly after starting treatment with doxycycline for spirochetal infections, such as Lyme disease.

If you think any of the side effects you are experiencing is serious or if you notice any side effect not mentioned in this package leaflet, inform your doctor or pharmacist.

Reporting side effects

If you experience any side effects, consult your doctor or pharmacist, even if they are not listed in this package leaflet. You can also report them directly through the Spanish Medicines and Health Products Agency's website: www.notificaRAM.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Proderma 50 mg Hard Capsules

Keep out of sight and reach of children.

No special storage conditions are required.

Do not use this medicine after the expiration date stated on the carton after EXP. The expiration date is the last day of the month indicated.

Medicines should not be disposed of via wastewater or household waste. Place the packaging and any unused medicines in the pharmacy's SIGRE collection point. If in doubt, ask your pharmacist how to dispose of the packaging and any unused medicines. This will help protect the environment.

6. Package Contents and Additional Information

Composition of Proderma 50 mg Hard Capsules

  • The active ingredient is doxycycline. Each capsule contains 50 mg of doxycycline (as hyclate).
  • The other ingredients (excipients) are: sucrose, cornstarch, crospovidone, polyaminomethacrylate (Eudragit E100), talc, gelatin, carmine indigo (E132), quinoline yellow (E104), and titanium dioxide (E171).

Appearance of the product and package contents

Proderma 50 mg is available in packs of 30 capsules.

Other presentations:

Proderma 100 mg Hard Capsules

Proderma 200 mg Hard Capsules

Marketing Authorization Holder

INDUSTRIAL FARMACÉUTICA CANTABRIA, S.A.

Carretera de Cazoña-Adarzo, s/n.

39011, Santander

Spain

Manufacturer

INDUSTRIAL FARMACÉUTICA CANTABRIA, S.A.

C/ Pirita, 9 28850 Torrejón de Ardoz (Madrid)

Spain

or

TOLL MANUFACTURING SERVICES, S.L.

Aragoneses, 2

28108 Alcobendas (Madrid)

Spain

This package leaflet was approved in June 2022.

Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es/

Online doctors for PRODERMA 50 mg HARD CAPSULES

Discuss questions about PRODERMA 50 mg HARD CAPSULES, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

5.0 (100)
Doctor

Tarek Agami

General medicine 11 years exp.

Dr. Tarek Agami is a general practitioner registered in both Portugal and Israel, with broad experience in family and preventive medicine. He offers online consultations for adults and children, providing personalised support for primary care needs, chronic disease management, and everyday health concerns.

Dr. Agami received clinical training and worked in leading medical institutions in Israel (Kaplan Medical Center, Barzilai Medical Center, Wolfson Medical Center) and Portugal (European Healthcare City, Viscura Internacional, Hospital Dr. José Maria Grande, Hospital Vila Franca de Xira). His approach combines international medical standards with individualised attention to each patient.

Main areas of consultation:

  • Diagnosis and treatment of acute and chronic conditions (high blood pressure, diabetes, respiratory infections, cardiovascular symptoms)
  • Evaluation of symptoms and guidance on further diagnostic testing
  • Preventive check-ups and regular health monitoring
  • Medical support during travel or after relocation
  • Treatment adjustments and lifestyle recommendations based on your personal history
Dr. Agami provides medical support for patients using GLP-1 medications (such as Ozempic or Mounjaro) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Portugal and Israel.

Dr. Agami is committed to evidence-based, patient-centred care, ensuring that each person receives trusted medical support tailored to their health goals.

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Nuno Tavares Lopes

Family medicine 18 years exp.

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies
  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management
  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses
  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment
  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance
  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis
  • Pain management: acute and chronic pain, post-surgical care
  • Public health: prevention, health screenings, long-term monitoring
  • Sick leave (Baixa médica) connected to Segurança Social in Portugal
  • IMT medical certificates for driving licence exchange
Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.

Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

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Rita Isabel Calero Garcia

General medicine 2 years exp.

Dr. Rita Isabel Calero Garcia is a physician with extensive experience in emergency medical care, general medicine, and healthcare assistance in various clinical and out-of-hospital settings.

She currently works as a physician at the Canary Islands Emergency Service (Servicio de Urgencias Canario – SUC), where she is responsible for the assessment and care of patients in medical emergency situations, performing the initial diagnosis, patient stabilization, and coordination with hospital services when necessary.

She has also developed her professional activity within the Primary Care Management Service, providing consultations in general medicine. In this setting she is responsible for patient follow-up, management of acute and chronic conditions, as well as health promotion and disease prevention.

She has also worked as a physician in a mobile ICU unit, providing medical assistance in out-of-hospital emergencies, treating critical patients and participating in medicalized patient transport.

In addition, she has collaborated with the Red Cross, participating in healthcare support units, providing medical assistance at events and supporting emergency interventions.

Furthermore, she has provided medical services in the private sector with Salvaser, conducting clinical assessments of patients and providing healthcare services within private medical services.

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Jorge Correa Bellido

General medicine 7 years exp.

Dr. Jorge Correa Bellido is a Spanish physician who offers online consultations in Spanish and English. He graduated from the University of La Laguna and has a solid background in clinical practice and international research.

Throughout his career, he has participated in various medical and academic projects, including a research fellowship in Spain, where he contributed to evidence-based studies in the field of family medicine. This experience allowed him to broaden his global perspective on healthcare and comprehensive patient care.

Dr. Correa Bellido has worked with several healthcare providers in Spain, focusing particularly on patient-centered care and public health initiatives aimed at communities with limited access to healthcare services.

In addition, he actively participates in international medical conferences and workshops, which allows him to stay up to date with the latest medical advances and collaborate with healthcare professionals from different countries.

Dr. Correa Bellido provides comprehensive care for a wide variety of medical conditions, including:

  • respiratory infections
  • gastrointestinal disorders
  • cardiovascular problems
  • endocrine and metabolic diseases
  • musculoskeletal and dermatological conditions
  • as well as mental health conditions such as anxiety and depression.

He also treats infectious and allergic diseases, general health concerns, and provides guidance on prevention and healthy lifestyle habits.

His services include virtual consultations, diagnosis and management of acute and chronic diseases, prescription renewals, and personalized medical advice.

With a patient-centered approach and a strong commitment to continuous learning, Dr. Correa Bellido provides accessible and high-quality healthcare to patients both in Spain and around the world.

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Andrei Popov

General medicine 7 years exp.

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

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Anastasiia Shalko

Family medicine 13 years exp.

Dr. Anastasiia Shalko is a general practitioner with a background in both paediatrics and general medicine. She graduated from Bogomolets National Medical University in Kyiv and completed her paediatric internship at the P.L. Shupyk National Medical Academy of Postgraduate Education. After working as a paediatrician in Kyiv, she relocated to Spain, where she has been practising general medicine since 2015, providing care for both adults and children.Her work focuses on urgent, short-term medical concerns – situations where patients need quick guidance, symptom assessment and clear next steps. She helps people understand whether their symptoms require in-person evaluation, home management or a change in treatment. Common reasons for booking an online consultation include:

  • acute respiratory symptoms (cough, sore throat, runny nose, fever)
  • viral illnesses such as colds and seasonal infections
  • gastrointestinal complaints (nausea, diarrhoea, abdominal pain, gastroenteritis)
  • sudden changes in how a child or adult feels
  • questions about existing treatment and whether adjustments are needed
  • renewal of prescriptions when clinically appropriate

Dr. Shalko works specifically with urgent and short-term problems, providing practical recommendations and helping patients determine the safest next step. She explains symptoms clearly, guides patients through decision-making and offers straightforward medical advice for everyday acute issues.She does not provide long-term management of chronic conditions, ongoing follow-up or comprehensive care plans for complex long-term illnesses. Her consultations are designed for acute symptoms, sudden concerns and situations where timely medical input is important.With clinical experience in both paediatrics and general medicine, Dr. Shalko confidently supports adults and children. Her communication style is clear, simple and reassuring, helping patients feel informed and supported throughout the consultation.

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Doctor

Daniel Cichi

Family medicine 24 years exp.

Dr Daniel Cichi is a family medicine doctor with over 20 years of clinical experience. He provides online consultations for adults, supporting patients with acute symptoms, chronic conditions, and everyday health concerns that require timely medical guidance. His background includes work in emergency care, ambulance services, and family medicine, which allows him to assess symptoms quickly, identify warning signs, and help patients choose the safest next steps – whether that means home care, treatment adjustment, or in-person evaluation. Patients commonly consult Dr Daniel Cichi for: 

  • acute symptoms: fever, infections, flu-like illness, cough, sore throat, shortness of breath;
  • chest discomfort, palpitations, dizziness, fatigue, and blood pressure concerns;
  • digestive problems: abdominal pain, nausea, diarrhoea, constipation, reflux;
  • sexually transmitted infections, erectile dysfunction;
  • muscle, joint, and back pain, minor injuries, post-traumatic symptoms;
  • chronic conditions: hypertension, diabetes, high cholesterol, thyroid disorders, weight loss, hair loss;
  • review and interpretation of lab tests, imaging reports, and medical documents;
  • medication review and treatment adjustment;
  • medical advice while travelling or living abroad;
  • second opinions and guidance on whether in-person care is needed.

Dr Cichi’s consultations are structured and practical. He focuses on clear explanations, risk assessment, and actionable recommendations, helping patients understand their symptoms and make informed decisions about their health.

Get PRODERMA 50 mg HARD CAPSULES Prescription Online

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Tell us your symptoms, history, and what medicine you're requesting.

2

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3

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4

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Electronic prescription sent to your email — valid across Spain.

Frequently Asked Questions

Is a prescription required for PRODERMA 50 mg HARD CAPSULES?

PRODERMA 50 mg HARD CAPSULES requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

What is the active substance in PRODERMA 50 mg HARD CAPSULES?

The active ingredient in PRODERMA 50 mg HARD CAPSULES is doxycycline. This information helps identify medicines with the same composition but different brand names.

How much does PRODERMA 50 mg HARD CAPSULES cost in pharmacies?

The average pharmacy price for PRODERMA 50 mg HARD CAPSULES is around 2.58 EUR. Prices may vary depending on the manufacturer and dosage form.

Who manufactures PRODERMA 50 mg HARD CAPSULES?

PRODERMA 50 mg HARD CAPSULES is manufactured by Industrial Farmaceutica Cantabria S.A.. Pharmacy brands and packaging may differ depending on the distributor.

Which doctors can assess the use of PRODERMA 50 mg HARD CAPSULES online?

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether PRODERMA 50 mg HARD CAPSULES is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

How to buy PRODERMA 50 mg HARD CAPSULES in Spain?

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy PRODERMA 50 mg HARD CAPSULES in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

What are the alternatives to PRODERMA 50 mg HARD CAPSULES?

Other medicines with the same active substance (doxycycline) include DOSIL 100 mg HARD CAPSULES, DOXICICLINA NORMON 100 mg FILM-COATED TABLETS, DOXICLAT 100 mg FILM-COATED TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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