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PERIACTIN 4 mg TABLETS

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About the medicine

How to use PERIACTIN 4 mg TABLETS

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Leaflet: information for the patient

Periactin 4 mg tablets

ciproheptadine hydrochloride 1.5 hydrate

Read the entire leaflet carefully before starting to take this medication, as it contains important information for you.

Follow the administration instructions for the medication contained in this leaflet or as indicated by your doctor or pharmacist.

  • Keep this leaflet, as you may need to read it again.
  • If you need advice or more information, consult your pharmacist.
  • If you experience side effects, consult your doctor or pharmacist, even if they are side effects that do not appear in this leaflet. See section 4.
  • You should consult a doctor if it worsens or does not improve.

Contents of the leaflet

  1. What is Periactin and what is it used for
  2. What you need to know before taking Periactin
  3. How to take Periactin
  4. Possible side effects

5 Conservation of Periactin

  1. Package contents and additional information

1. What is Periactin and what is it used for

Periactin contains the active ingredient ciproheptadine hydrochloride 1.5 hydrate, an antihistamine used in adults and children from 2 years of age for:

  • the symptomatic treatment of allergies (rhinitis, conjunctivitis, urticaria).
  • the complementary treatment of severe allergic reactions (anaphylactic reactions) after controlling acute symptoms.

You should consult a doctor if it worsens or does not improve.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before taking Periactin

Do not take Periactin

  • If you are allergic to ciproheptadine hydrochloride 1.5 hydrate or to any of the other components of this medication (listed in section 6).
  • If you are allergic to drugs with a similar chemical structure to ciproheptadine (piperidines, such as donepezil) or to other antihistamines.
  • If you have narrow-angle glaucoma
  • If you are having an acute asthma attack
  • If you have intestinal ulcers that lead to narrowing of the stomach, small intestine, or esophagus (peptic ulcer stenosis)
  • If you have an enlarged prostate (prostatic hypertrophy)
  • If you have an obstruction of the neck of the bladder or an obstruction of the valve that connects the stomach to the duodenum (pyloroduodenal obstruction)
  • If you are undergoing treatment with monoamine oxidase inhibitors (see section 2 "Other medications and Periactin")
  • If you are breastfeeding (see "Pregnancy and lactation")
  • Do not give this medication to a newborn or premature baby
  • If you are elderly or in poor health, as you are more prone to experiencing drowsiness and low blood pressure with this medication.

Warnings and precautions

Consult your doctor or pharmacist before starting to take this medication:

  • If you have a severe respiratory disease.
  • If you have porphyria (a rare, usually inherited disorder in which a large amount of porphyrin is eliminated in feces and urine)
  • If you have a disease in which there is an abnormal increase in thyroid gland activity (hyperthyroidism), high intraocular pressure, heart disease, or high blood pressure.
  • If you are using any medication that causes ear toxicity, as symptoms of those toxic effects, such as ringing in the ears, dizziness, or vertigo, may be masked.
  • If you have any kidney disease or disorder

Antihistamines can decrease alertness; on the other hand, they can sometimes cause excitement, especially in young children.

Rarely, prolonged treatment with antihistamines can cause changes in blood cell counts.

Treatment with antihistamines can mask the toxic effects of medications that cause ear toxicity.

Children and adolescents

This medication should not be used in newborns or premature babies (see "Do not take Periactin").

This medication is not recommended for children under 2 years of age because its efficacy and safety have not been established in this population.

Given the high sensitivity of children to antihistamines, the dose of ciproheptadine should be established with special caution in this group.

Other medications and Periactin

Tell your doctor or pharmacist if you are using, have recently used, or may need to use any other medication.

Tell your doctor if you are taking:

  • Monoamine oxidase inhibitors (MAOIs), such as moclobemide (used to treat depression) or selegiline, rasagiline (used to treat Parkinson's disease). These medications should not be taken at the same time as Periactin (see section 2 "Do not take Periactin").
  • Medications that induce sleep and medications that reduce the activity of the central nervous system (hypnotics, sedatives, tranquilizers, anxiolytics). This medication may increase their effects.
  • Selective serotonin reuptake inhibitors, such as fluoxetine, paroxetine, sertraline, citalopram, escitalopram (medications used for depression), as Periactin may cause a possible recurrence of depression and associated symptoms.

Taking Periactin with food, drinks, and alcohol

Alcohol consumption should be avoided during treatment. Alcohol increases the effects of this medication.

Interference with diagnostic tests

If you are going to have a pituitary function test, inform your doctor that you are taking this medication, as it may alter the result of the test.

If you are going to have a test to determine tricyclic antidepressants in blood or urine, inform your doctor that you are taking this medication, as it may alter the result of the test.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medication.

Ciproheptadine should be used during pregnancy only if strictly necessary and under close medical supervision.

If you take this medication during the last three months of pregnancy, your baby may experience side effects.

This medication is contraindicated in breastfeeding mothers (see "Do not take Periactin"). It is unknown whether ciproheptadine passes into breast milk. Due to the possibility of serious side effects in infants, your doctor will decide with you whether to interrupt breastfeeding or treatment.

Driving and using machines

This medication may cause drowsiness, which could affect your ability to drive and/or operate machinery. Patients should avoid operating hazardous machinery, including automobiles, until they know how they tolerate the medication.

This medication contains lactose

If your doctor has told you that you have an intolerance to certain sugars, consult with them before taking this medication.

3. How to take Periactin

Follow the administration instructions for the medication contained in this leaflet or as indicated by your doctor or pharmacist. In case of doubt, ask your doctor or pharmacist.

Adults

The recommended initial dose is 4 mg (1 tablet) three times a day; afterwards, the dose should be adjusted according to the patient's response. The recommended maintenance dose is 12 mg to 16 mg per day, divided into 3 doses. The dose should not exceed 32 mg per day, divided into 3 doses.

Use in children

Children from 2 to 6 years:The recommended dose is 2 mg (half a tablet) two or three times a day, according to the patient's response. The total dose should not exceed 12 mg per day, divided into 3 doses.

Children from 7 to 14 years:The recommended dose is 4 mg (1 tablet) two or three times a day, according to the patient's response. The total dose should not exceed 16 mg per day, divided into 3 doses.

Adolescents from 15 years:The recommended initial dose is 4 mg (1 tablet) three times a day; afterwards, the dose should be adjusted according to the patient's response. The recommended maintenance dose is 12 mg to 16 mg per day, divided into 3 doses. The dose should not exceed 32 mg per day, divided into 3 doses.

The tablet can be divided into equal doses.

If you take more Periactin than you should

If you take more Periactin than recommended, you may experience hallucinations, decreased or stimulated central nervous system function, convulsions, respiratory and cardiac arrest, and death, especially in children.

Gastrointestinal symptoms and other symptoms such as dry mouth, flushing, and pupil dilation may also appear.

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately, or call the Toxicology Information Service, phone 91-562 04 20, indicating the medication and the amount ingested.

If you forget to take Periactin

Do not take a double dose to make up for forgotten doses.

If you have any other questions about the use of this medication, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medications, this medication can cause side effects, although not everyone experiences them.

The frequently occurring side effects are drowsiness and tendency to sleep. Many patients who experience drowsiness at the start of treatment recover normality after 3 or 4 days of treatment.

During the period of use of ciproheptadine, the following adverse reactions have been reported, whose frequency could not be established with accuracy:

  • hemolytic anemia, decreased white blood cells, decreased granulocytes, decreased platelets
  • allergic edema (swelling of the face, lips, mouth, tongue, or throat), anaphylactic shock (severe allergic reaction)
  • increased appetite, decreased appetite
  • agitation, confusion, feeling of being disconnected from oneself, thoughts, feelings, and surroundings, euphoria, hallucinations, insomnia, irritability, nervousness, restlessness
  • sedation, drowsiness, dizziness, coordination disorders, tremors, numbness, tingling, or burning sensation (paresthesia), nerve inflammation, convulsions, syncope, headache)
  • inner ear inflammation (labyrinthitis), blurred vision, double vision, vertigo, ringing in the ears (tinnitus)
  • palpitations, tachycardia (rapid heartbeat), extrasystoles (premature heartbeats)
  • low blood pressure
  • dry nose, dry throat, thickening of bronchial secretions, chest tightness, wheezing (respiratory sounds), sneezing, nasal congestion
  • dry mouth, stomach discomfort, nausea, vomiting, diarrhea, constipation
  • jaundice (yellowish color of skin and mucous membranes), increased transaminases in blood
  • allergic dermatitis, excessive sweating, urticaria, increased skin sensitivity to sunlight and ultraviolet light (photosensitivity)
  • frequent urination, difficult urination, urinary retention
  • early menstruation
  • fatigue, chills, tiredness
  • weight gain

Reporting side effects

If you experience any type of side effect, consult your doctor or pharmacist, even if it is a possible side effect that does not appear in this leaflet. You can also report them directly through the Spanish Medication Surveillance System for Human Use: www.notificaram.es. By reporting side effects, you can contribute to providing more information on the safety of this medication.

5. Conservation of Periactin

Keep this medication out of sight and reach of children.

Do not use this medication after the expiration date that appears on the packaging after CAD. The expiration date is the last day of the month indicated.

No special storage conditions are required.

Medications should not be thrown down the drain or into the trash. Ask your pharmacist how to dispose of the packaging and medications you no longer need. Deposit the packaging and medications you no longer need in the SIGRE point of the pharmacy. This way, you will help protect the environment.

6. Package contents and additional information

Composition of Angileptol mint flavor

Each tablet contains:

  • The active ingredients:

Chlorhexidine dihydrochloride, 5 mg

Benzocaine, 4 mg

Enoxolone, 3 mg

  • The other components (excipients) are: sorbitol (E420), acesulfame potassium (E950), magnesium stearate, and mint flavor

Appearance of the product and package contents

Angileptol are sucking tablets, white, round, and with the Greek letter σ on one of the faces.

They come in packages containing 15 and 30 sucking tablets.

Other presentations

Angileptol Mint-eucalyptus flavor

Angileptol Honey-lemon flavor

Marketing authorization holder

Alfasigma Spain S.L.

C/ Aribau 195, 4th floor

08021 Barcelona, Spain

Manufacturer

Pharmaloop, S.L.

Polígono Industrial Azque C/Bolivia, 15

28806 Alcalá de Henares (Madrid), Spain

or

Alfasigma, S.p.A.

Via Pontina, Km 30,400

00071 Pomezia (Rome), Italy

Date of the last revision of this leaflet:September 2021

Other sources of information

Detailed information about this medication is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es

Online doctors for PERIACTIN 4 mg TABLETS

Discuss questions about PERIACTIN 4 mg TABLETS, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

5.0 (29)
Doctor

Anna Biriukova

General medicine 6 years exp.

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

  • High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
  • Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
  • Leg swelling, chronic fatigue, reduced exercise tolerance.
  • EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
  • Post-COVID-19 cardiac monitoring and care.
Endocrinology – Diabetes, thyroid, metabolism:
  • Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
  • Individual treatment plans including oral medications and insulin therapy.
  • GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
  • Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
  • Metabolic syndrome – obesity, lipid disorders, insulin resistance.
Gastroenterology – Digestive health:
  • Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
  • Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
  • Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).
General internal medicine and preventive care:
  • Respiratory infections – cough, colds, bronchitis.
  • Lab test analysis, therapy adjustments, medication management.
  • Adult vaccinations – planning, contraindications assessment.
  • Cancer prevention – screening strategies and risk assessment.
  • Holistic approach – symptom relief, complication prevention, and quality of life improvement.
Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.
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Doctor

Dmytro Horobets

Family medicine 7 years exp.

Dr. Dmytro Horobets is a licensed family medicine physician in Poland, specialising in endocrinology, diabetology, obesity management, gastroenterology, pediatrics, general surgery, and pain medicine. He offers online consultations for adults and children, providing personalised medical support for a wide range of acute and chronic health concerns.

Areas of expertise:

  • Endocrinology: diabetes type 1 and type 2, prediabetes, thyroid disorders, metabolic syndrome, hormonal imbalance.
  • Obesity medicine: structured weight management plans, nutritional counselling, obesity-related health risks.
  • Gastroenterology: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), liver and biliary conditions.
  • Pediatric care: infections, respiratory symptoms, digestive issues, growth and development monitoring.
  • General surgery support: pre- and post-surgical consultations, wound care, rehabilitation.
  • Pain management: chronic and acute pain, back pain, joint pain, post-traumatic pain syndromes.
  • Cardiovascular health: hypertension, cholesterol control, risk assessment for heart disease.
  • Preventive medicine: regular check-ups, health screenings, long-term management of chronic conditions.

Dr. Horobets combines evidence-based medicine with a patient-centred approach. He carefully evaluates each patient’s medical history and symptoms, offering clear explanations and structured treatment plans adapted to individual needs.

Whether you need help managing diabetes, tackling weight-related health issues, interpreting lab results, or receiving general family medicine support, Dr. Horobets provides professional online care tailored to your specific health goals.

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5.0 (2)
Doctor

Svetlana Kolomeeva

Cardiology 18 years exp.

Dr. Svetlana Kolomeeva is a general practitioner and internal medicine doctor providing online consultations for adults. She helps patients manage acute symptoms, chronic conditions, and preventive care. Her clinical focus includes cardiovascular health, hypertension control, and managing symptoms like fatigue, weakness, sleep issues, and overall low energy.

Patients commonly seek her help for:

  • High blood pressure, headaches, dizziness, swelling, palpitations.
  • Diagnosis and management of hypertension, arrhythmias, and tachycardia.
  • Metabolic syndrome, excess weight, high cholesterol.
  • Chronic fatigue, insomnia, poor concentration, anxiety.
  • Respiratory symptoms: colds, flu, sore throat, cough, fever.
  • Digestive issues: heartburn, bloating, constipation, IBS symptoms.
  • Chronic conditions: diabetes, thyroid disorders.
  • Interpretation of lab tests and medical reports, therapy adjustment.
  • Second opinion and decision-making support.
  • Cardiovascular disease prevention and metabolic risk reduction.
  • Long-term follow-up and dynamic health monitoring.

Dr Kolomeeva combines clinical expertise with personalised care. She clearly explains diagnoses, guides patients through symptoms and treatment options, and provides actionable plans. Her consultations are designed not only to address current complaints but also to stabilise chronic conditions and prevent future complications. She supports patients through every stage of care – from first symptoms to ongoing health management.

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5.0 (2)
Doctor

Alexander Nazarchuk

Allergology 7 years exp.

Dr. Alexander Nazarchuk is a physician specialising in allergology and internal medicine. He provides online consultations for adults, following the principles of evidence-based medicine — no outdated treatments or unnecessary tests, with clear explanations and a personalised approach. He helps patients with a wide range of allergic and therapeutic conditions, from common day-to-day complaints to complex cases involving allergies, gastrointestinal issues, cardiovascular concerns, respiratory symptoms, and more.

You can consult Dr. Nazarchuk for:

  • Test interpretation and guidance on diagnostic plans.
  • Allergic rhinitis, hay fever, bronchial asthma (including severe cases).
  • Food and drug allergies, skin rashes, angioedema.
  • Atopic dermatitis, urticaria, contact allergies.
  • Allergen-specific immunotherapy (AIT) – initiation and ongoing management.
  • Abdominal pain, bloating, changes in bowel habits, nausea, heartburn.
  • High blood pressure and adjustment of baseline antihypertensive therapy.
  • Hyperlipidaemia and elevated cholesterol.
  • Cough, nasal congestion, fever, sore throat.
  • Anaemia, including iron deficiency and related conditions.
  • Other issues related to allergology and internal medicine.

During consultations, Dr. Nazarchuk takes a thorough, structured approach — analysing symptoms, identifying potential causes, and helping patients make informed decisions. Whether treatment, further investigation, or monitoring is needed, he explains each step clearly so you understand your health and how best to manage it.

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0.0 (0)
Doctor

Marta Reguero Capilla

Allergology 8 years exp.

Dr Marta Reguero Capilla is an allergist and immunologist who works with both adults and children. She specialises in the diagnosis, treatment, and ongoing management of allergic and immune-related conditions through online consultations.

In her practice, Dr Reguero Capilla helps patients understand the causes of their symptoms, review test results, and choose appropriate treatment or monitoring strategies. Her consultations are suitable both for first-time assessments and for follow-up care over time.

Patients commonly consult Dr Marta Reguero Capilla for:

  • allergic rhinitis, seasonal allergies, and perennial allergy symptoms;
  • allergic conditions in adults and children;
  • bronchial asthma and allergy-related respiratory symptoms;
  • urticaria (acute and chronic) and angioedema;
  • food allergies and reactions to foods, additives, or medications;
  • atopic dermatitis, allergic rashes, and persistent itching;
  • unexplained or recurrent allergic reactions;
  • interpretation of laboratory tests, allergy testing, and immunology results;
  • immune system concerns, frequent infections, and reduced immune response;
  • ongoing medical follow-up and treatment adjustment.
Dr Reguero Capilla works in a structured and attentive manner, explaining medical decisions clearly and helping patients make informed choices about their own health or their child’s care.

When clinically appropriate, she may provide recommendations for further tests or referrals that patients can use within Spanish medical networks, including Sanitas and DKV, in accordance with the terms and conditions of those services.

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€60

Frequently Asked Questions

Is a prescription required for PERIACTIN 4 mg TABLETS?
PERIACTIN 4 mg TABLETS does not require a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in PERIACTIN 4 mg TABLETS?
The active ingredient in PERIACTIN 4 mg TABLETS is cyproheptadine. This information helps identify medicines with the same composition but different brand names.
Who manufactures PERIACTIN 4 mg TABLETS?
PERIACTIN 4 mg TABLETS is manufactured by Alfasigma Espana S.L.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of PERIACTIN 4 mg TABLETS online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether PERIACTIN 4 mg TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to PERIACTIN 4 mg TABLETS?
Other medicines with the same active substance (cyproheptadine) include ABISAX 20 mg TABLETS, ABRILIA 20 mg TABLETS, AERIUS 0.5 mg/ml ORAL SOLUTION. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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