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PERIACTIN 4 mg TABLETS

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About the medicine

How to use PERIACTIN 4 mg TABLETS

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Leaflet: information for the patient

Periactin 4 mg tablets

ciproheptadine hydrochloride 1.5 hydrate

Read the entire leaflet carefully before starting to take this medication, as it contains important information for you.

Follow the administration instructions for the medication contained in this leaflet or as indicated by your doctor or pharmacist.

  • Keep this leaflet, as you may need to read it again.
  • If you need advice or more information, consult your pharmacist.
  • If you experience side effects, consult your doctor or pharmacist, even if they are side effects that do not appear in this leaflet. See section 4.
  • You should consult a doctor if it worsens or does not improve.

Contents of the leaflet

  1. What is Periactin and what is it used for
  2. What you need to know before taking Periactin
  3. How to take Periactin
  4. Possible side effects

5 Conservation of Periactin

  1. Package contents and additional information

1. What is Periactin and what is it used for

Periactin contains the active ingredient ciproheptadine hydrochloride 1.5 hydrate, an antihistamine used in adults and children from 2 years of age for:

  • the symptomatic treatment of allergies (rhinitis, conjunctivitis, urticaria).
  • the complementary treatment of severe allergic reactions (anaphylactic reactions) after controlling acute symptoms.

You should consult a doctor if it worsens or does not improve.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before taking Periactin

Do not take Periactin

  • If you are allergic to ciproheptadine hydrochloride 1.5 hydrate or to any of the other components of this medication (listed in section 6).
  • If you are allergic to drugs with a similar chemical structure to ciproheptadine (piperidines, such as donepezil) or to other antihistamines.
  • If you have narrow-angle glaucoma
  • If you are having an acute asthma attack
  • If you have intestinal ulcers that lead to narrowing of the stomach, small intestine, or esophagus (peptic ulcer stenosis)
  • If you have an enlarged prostate (prostatic hypertrophy)
  • If you have an obstruction of the neck of the bladder or an obstruction of the valve that connects the stomach to the duodenum (pyloroduodenal obstruction)
  • If you are undergoing treatment with monoamine oxidase inhibitors (see section 2 "Other medications and Periactin")
  • If you are breastfeeding (see "Pregnancy and lactation")
  • Do not give this medication to a newborn or premature baby
  • If you are elderly or in poor health, as you are more prone to experiencing drowsiness and low blood pressure with this medication.

Warnings and precautions

Consult your doctor or pharmacist before starting to take this medication:

  • If you have a severe respiratory disease.
  • If you have porphyria (a rare, usually inherited disorder in which a large amount of porphyrin is eliminated in feces and urine)
  • If you have a disease in which there is an abnormal increase in thyroid gland activity (hyperthyroidism), high intraocular pressure, heart disease, or high blood pressure.
  • If you are using any medication that causes ear toxicity, as symptoms of those toxic effects, such as ringing in the ears, dizziness, or vertigo, may be masked.
  • If you have any kidney disease or disorder

Antihistamines can decrease alertness; on the other hand, they can sometimes cause excitement, especially in young children.

Rarely, prolonged treatment with antihistamines can cause changes in blood cell counts.

Treatment with antihistamines can mask the toxic effects of medications that cause ear toxicity.

Children and adolescents

This medication should not be used in newborns or premature babies (see "Do not take Periactin").

This medication is not recommended for children under 2 years of age because its efficacy and safety have not been established in this population.

Given the high sensitivity of children to antihistamines, the dose of ciproheptadine should be established with special caution in this group.

Other medications and Periactin

Tell your doctor or pharmacist if you are using, have recently used, or may need to use any other medication.

Tell your doctor if you are taking:

  • Monoamine oxidase inhibitors (MAOIs), such as moclobemide (used to treat depression) or selegiline, rasagiline (used to treat Parkinson's disease). These medications should not be taken at the same time as Periactin (see section 2 "Do not take Periactin").
  • Medications that induce sleep and medications that reduce the activity of the central nervous system (hypnotics, sedatives, tranquilizers, anxiolytics). This medication may increase their effects.
  • Selective serotonin reuptake inhibitors, such as fluoxetine, paroxetine, sertraline, citalopram, escitalopram (medications used for depression), as Periactin may cause a possible recurrence of depression and associated symptoms.

Taking Periactin with food, drinks, and alcohol

Alcohol consumption should be avoided during treatment. Alcohol increases the effects of this medication.

Interference with diagnostic tests

If you are going to have a pituitary function test, inform your doctor that you are taking this medication, as it may alter the result of the test.

If you are going to have a test to determine tricyclic antidepressants in blood or urine, inform your doctor that you are taking this medication, as it may alter the result of the test.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medication.

Ciproheptadine should be used during pregnancy only if strictly necessary and under close medical supervision.

If you take this medication during the last three months of pregnancy, your baby may experience side effects.

This medication is contraindicated in breastfeeding mothers (see "Do not take Periactin"). It is unknown whether ciproheptadine passes into breast milk. Due to the possibility of serious side effects in infants, your doctor will decide with you whether to interrupt breastfeeding or treatment.

Driving and using machines

This medication may cause drowsiness, which could affect your ability to drive and/or operate machinery. Patients should avoid operating hazardous machinery, including automobiles, until they know how they tolerate the medication.

This medication contains lactose

If your doctor has told you that you have an intolerance to certain sugars, consult with them before taking this medication.

3. How to take Periactin

Follow the administration instructions for the medication contained in this leaflet or as indicated by your doctor or pharmacist. In case of doubt, ask your doctor or pharmacist.

Adults

The recommended initial dose is 4 mg (1 tablet) three times a day; afterwards, the dose should be adjusted according to the patient's response. The recommended maintenance dose is 12 mg to 16 mg per day, divided into 3 doses. The dose should not exceed 32 mg per day, divided into 3 doses.

Use in children

Children from 2 to 6 years:The recommended dose is 2 mg (half a tablet) two or three times a day, according to the patient's response. The total dose should not exceed 12 mg per day, divided into 3 doses.

Children from 7 to 14 years:The recommended dose is 4 mg (1 tablet) two or three times a day, according to the patient's response. The total dose should not exceed 16 mg per day, divided into 3 doses.

Adolescents from 15 years:The recommended initial dose is 4 mg (1 tablet) three times a day; afterwards, the dose should be adjusted according to the patient's response. The recommended maintenance dose is 12 mg to 16 mg per day, divided into 3 doses. The dose should not exceed 32 mg per day, divided into 3 doses.

The tablet can be divided into equal doses.

If you take more Periactin than you should

If you take more Periactin than recommended, you may experience hallucinations, decreased or stimulated central nervous system function, convulsions, respiratory and cardiac arrest, and death, especially in children.

Gastrointestinal symptoms and other symptoms such as dry mouth, flushing, and pupil dilation may also appear.

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately, or call the Toxicology Information Service, phone 91-562 04 20, indicating the medication and the amount ingested.

If you forget to take Periactin

Do not take a double dose to make up for forgotten doses.

If you have any other questions about the use of this medication, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medications, this medication can cause side effects, although not everyone experiences them.

The frequently occurring side effects are drowsiness and tendency to sleep. Many patients who experience drowsiness at the start of treatment recover normality after 3 or 4 days of treatment.

During the period of use of ciproheptadine, the following adverse reactions have been reported, whose frequency could not be established with accuracy:

  • hemolytic anemia, decreased white blood cells, decreased granulocytes, decreased platelets
  • allergic edema (swelling of the face, lips, mouth, tongue, or throat), anaphylactic shock (severe allergic reaction)
  • increased appetite, decreased appetite
  • agitation, confusion, feeling of being disconnected from oneself, thoughts, feelings, and surroundings, euphoria, hallucinations, insomnia, irritability, nervousness, restlessness
  • sedation, drowsiness, dizziness, coordination disorders, tremors, numbness, tingling, or burning sensation (paresthesia), nerve inflammation, convulsions, syncope, headache)
  • inner ear inflammation (labyrinthitis), blurred vision, double vision, vertigo, ringing in the ears (tinnitus)
  • palpitations, tachycardia (rapid heartbeat), extrasystoles (premature heartbeats)
  • low blood pressure
  • dry nose, dry throat, thickening of bronchial secretions, chest tightness, wheezing (respiratory sounds), sneezing, nasal congestion
  • dry mouth, stomach discomfort, nausea, vomiting, diarrhea, constipation
  • jaundice (yellowish color of skin and mucous membranes), increased transaminases in blood
  • allergic dermatitis, excessive sweating, urticaria, increased skin sensitivity to sunlight and ultraviolet light (photosensitivity)
  • frequent urination, difficult urination, urinary retention
  • early menstruation
  • fatigue, chills, tiredness
  • weight gain

Reporting side effects

If you experience any type of side effect, consult your doctor or pharmacist, even if it is a possible side effect that does not appear in this leaflet. You can also report them directly through the Spanish Medication Surveillance System for Human Use: www.notificaram.es. By reporting side effects, you can contribute to providing more information on the safety of this medication.

5. Conservation of Periactin

Keep this medication out of sight and reach of children.

Do not use this medication after the expiration date that appears on the packaging after CAD. The expiration date is the last day of the month indicated.

No special storage conditions are required.

Medications should not be thrown down the drain or into the trash. Ask your pharmacist how to dispose of the packaging and medications you no longer need. Deposit the packaging and medications you no longer need in the SIGRE point of the pharmacy. This way, you will help protect the environment.

6. Package contents and additional information

Composition of Angileptol mint flavor

Each tablet contains:

  • The active ingredients:

Chlorhexidine dihydrochloride, 5 mg

Benzocaine, 4 mg

Enoxolone, 3 mg

  • The other components (excipients) are: sorbitol (E420), acesulfame potassium (E950), magnesium stearate, and mint flavor

Appearance of the product and package contents

Angileptol are sucking tablets, white, round, and with the Greek letter σ on one of the faces.

They come in packages containing 15 and 30 sucking tablets.

Other presentations

Angileptol Mint-eucalyptus flavor

Angileptol Honey-lemon flavor

Marketing authorization holder

Alfasigma Spain S.L.

C/ Aribau 195, 4th floor

08021 Barcelona, Spain

Manufacturer

Pharmaloop, S.L.

Polígono Industrial Azque C/Bolivia, 15

28806 Alcalá de Henares (Madrid), Spain

or

Alfasigma, S.p.A.

Via Pontina, Km 30,400

00071 Pomezia (Rome), Italy

Date of the last revision of this leaflet:September 2021

Other sources of information

Detailed information about this medication is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es

Online doctors for PERIACTIN 4 mg TABLETS

Discuss questions about PERIACTIN 4 mg TABLETS, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Doctor

Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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€58
5.0 (3)
Doctor

Tomasz Grzelewski

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques.

For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance.

Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults.

In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions.

Patients commonly seek his care for:

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
  • urticaria, atopic dermatitis and skin reactions
  • recurrent infections in children
  • sports-related health questions
  • general family medicine concerns
Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.
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€80
5.0 (25)
Doctor

Lina Travkina

Family medicine 13 years exp.

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
  • Medical advice and follow-up consultations.
  • Test interpretation and diagnostic guidance.
  • Structured support for undiagnosed complaints.
  • Second opinion on diagnoses and treatment plans.
  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
  • Post-operative recovery support and pain management.
  • Preconception counselling and postpartum support.
  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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€70
5.0 (764)
Doctor

Alina Tsurkan

Family medicine 13 years exp.

Dr. Alina Tsurkan is a licensed family medicine physician based in Portugal, offering online consultations for adults and children. She provides professional primary care, with a focus on prevention, accurate diagnosis, and long-term management of acute and chronic conditions.

Dr. Tsurkan supports patients with a wide range of health issues, including:

  • Respiratory infections: cold, flu, bronchitis, pneumonia, and lingering coughs.
  • ENT conditions: sinusitis, tonsillitis, otitis (ear infections), sore throat, allergic rhinitis.
  • Eye conditions: allergic or infectious conjunctivitis, red eyes, irritation.
  • Digestive issues: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), constipation, bloating, nausea.
  • Urinary and reproductive health: urinary tract infections (UTIs), cystitis, prevention of recurrent infections.
  • Chronic diseases: hypertension, elevated cholesterol, weight management.
  • Neurological complaints: headaches, migraines, sleep disturbances, fatigue, general weakness.
  • Children’s health: fever, infections, digestive issues, follow-ups, vaccination guidance.

She also provides:

  • IMT medical certificates for driving licence exchange in Portugal.
  • Personalised preventive care and wellness consultations.
  • Interpretation of test results and medical reports.
  • Follow-up care and medication review.
  • Support in managing multiple coexisting conditions.
  • Remote prescription management and medical documentation.

Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

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€55
5.0 (140)
Doctor

Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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€50

Frequently Asked Questions

Is a prescription required for PERIACTIN 4 mg TABLETS?
PERIACTIN 4 mg TABLETS does not require a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in PERIACTIN 4 mg TABLETS?
The active ingredient in PERIACTIN 4 mg TABLETS is cyproheptadine. This information helps identify medicines with the same composition but different brand names.
Who manufactures PERIACTIN 4 mg TABLETS?
PERIACTIN 4 mg TABLETS is manufactured by Alfasigma Espana S.L.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of PERIACTIN 4 mg TABLETS online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether PERIACTIN 4 mg TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to PERIACTIN 4 mg TABLETS?
Other medicines with the same active substance (cyproheptadine) include ABISAX 20 mg TABLETS, ABRILIA 20 mg TABLETS, AERIUS 0.5 mg/ml ORAL SOLUTION. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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