LEDERFOLIN 15 mg Tablets

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Discuss your symptoms and possible next steps in a quick online consultation.

Doctor
5.0(36)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

Book a video appointment
€86
This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use LEDFOLIN 15 mg TABLETS

Contents of the leaflet

  1. Introduction
  2. What Lederfolin is and what it is used for
  3. What you need to know before you take Lederfolin
  4. How to take Lederfolin
  5. Possible side effects
  6. Storage of Lederfolin
  7. Contents of the pack and further information

Introduction

Package Leaflet: Information for the User

Lederfolin 15 mg Tablets

Folinic Acid

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others, as it may harm them, even if their symptoms are the same as yours.
  • If you experience any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack:

  1. What Lederfolin is and what it is used for
  2. What you need to know before you take Lederfolin
  3. How to take Lederfolin
  4. Possible side effects
  5. Storage of Lederfolin
  6. Contents of the pack and further information

1. What Lederfolin is and what it is used for

Lederfolin belongs to a group of medicines called detoxifying agents for the treatment of tumors.

This medicine is used in:

  • Megaloblastic anemia due to folate deficiency.
  • Reducing the toxicity and counteracting the effect of folic acid antagonist medications.
Doctor consultation

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2. What you need to know before you take Lederfolin

Do not take Lederfolin:

  • If you are allergic to the active substance or to any of the other ingredients of this medicine (listed in section 6).
  • If you have or have had pernicious anemia (a disorder characterized by a decrease in the number of red blood cells and/or hemoglobin in the blood) or other megaloblastic anemias due to vitamin B12 deficiency.

Warnings and precautions:

Consult your doctor or pharmacist before starting treatment with Lederfolin.

  • Since treatment with Lederfolin may mask pernicious anemia and other megaloblastic anemias resulting from vitamin B12 deficiency.
  • If you are epileptic and are being treated with phenobarbital, phenytoin, primidone, and succinimides, as there is a risk of increased frequency of epileptic seizures.
  • If you are being treated with anticancer medications such as:
    • Methotrexate: it is essential that you strictly follow the dose of Lederfolin prescribed by your doctor, as non-compliance may cause excessive toxicity or lack of efficacy of methotrexate.
    • In case of renal insufficiency due to methotrexate, higher doses or longer use of Lederfolin may be necessary.
  • If you experience severe nausea, vomiting, or diarrhea, consult your doctor as it may be necessary to administer Lederfolin parenterally.

Taking Lederfolin with other medicines

Tell your doctor or pharmacist if you are taking or have recently taken or might take any other medicines.

Certain medicines may interact with Lederfolin; in these cases, it may be necessary to change the dose or interrupt treatment with one of them.

It is essential that you inform your doctor if you are taking or have recently taken any of the following medicines:

  • Folic acid antagonists (e.g., cotrimoxazole, trimethoprim, pyrimethamine, methotrexate). In this case, it is essential that you strictly follow the dose of Lederfolin prescribed by your doctor, as non-compliance may cause excessive toxicity or lack of efficacy of these medicines.
  • Antiepileptic medications: phenobarbital, primidone, phenytoin, and succinimides. Calcium folinate hydrate may decrease the effect of these medications and may increase the frequency of epileptic seizures.
  • Chloramphenicol (in patients with folate deficiency)
  • Fluorouracil

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor before using this medicine.

It is not known whether calcium folinate hydrate is excreted in breast milk.

Driving and using machines

There is no evidence that this medicine affects the ability to drive or use machines.

Lederfolin contains lactose and sodium

This medicine contains lactose. If your doctor has told you that you have an intolerance to certain sugars, consult with them before taking this medicine.

This medicine contains less than 1 mmol of sodium (23 mg) per tablet; this is essentially "sodium-free".

3. How to take Lederfolin

Follow exactly the administration instructions of this medicine indicated by your doctor. In case of doubt, consult your doctor or pharmacist again.

Remember to take your medicine.

Your doctor will indicate the duration of your treatment with Lederfolin. Do not stop treatment before, as you will not achieve the desired therapeutic effect.

  • For the treatment of megaloblastic anemia due to folate deficiency, the normal dose is 15 mg of folinic acid (one tablet) per day, orally, usually for 10 or 15 days.
  • For the treatment of neutralizing the effect of methotrexate or other folic acid antagonists, your doctor will indicate the dose you should take.

The tablets are scored. The score line should not be used to divide the tablet.

If you take more Lederfolin than you should:

If you have taken more Lederfolin than you should, consult your doctor or pharmacist immediately. No significant harm has been reported in patients who have received significantly higher doses of calcium folinate hydrate than recommended.

In case of overdose or accidental ingestion, consult the Toxicology Information Service, phone: 91/562.04.20.

If you forget to take Lederfolin

Do not take a double dose to make up for forgotten doses.

If you stop treatment with Lederfolin

If you have any other questions about the use of this medicine, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

If you experience any side effect, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet.

The following side effects are described according to their frequency of occurrence in patients treated:

Rare(at least 1 in 10,000 but less than 1 in 1,000 patients):

  • Seizures and/or syncope
  • Increased frequency of seizures in epileptic patients
  • Insomnia, agitation, and depression after high doses

Very rare(at least 1 in 10,000 patients):

  • Anaphylactoid reactions
  • Anaphylactic reactions
  • Anaphylactic shock

Frequency not known(cannot be estimated from available data):

  • Allergic reactions
  • Urticaria
  • Fever

There have been reports of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), some of which were fatal, in patients treated with calcium folinate hydrate in combination with other agents whose association with these disorders is known. It cannot be excluded that calcium folinate hydrate may have contributed to these cases of SJS/TEN.

Stevens-Johnson syndrome is a widespread rash with blisters and peeling of the skin, particularly around the mouth, nose, eyes, and genitals.

Toxic epidermal necrolysis is a widespread rash with blisters and peeling of the skin, particularly around the mouth, nose, eyes, and genitals, causing widespread skin peeling (more than 30% of the body surface).

Reporting of side effects

If you experience any side effects, talk to your doctor, pharmacist, or nurse, even if it is possible that the side effects are not listed in this leaflet. You can also report side effects directly through the Spanish Medicines and Healthcare Products Agency (AEMPS) website: www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Lederfolin

Keep this medicine out of the sight and reach of children.

Do not store above 30°C.

Do not use this medicine after the expiry date which is stated on the packaging after "EXP". The expiry date is the last day of the month stated.

Medicines should not be disposed of via wastewater or household waste. Return any unused medicine to your pharmacist. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. Contents of the pack and further information

Composition of Lederfolin

  • The active substance is folinic acid (in the form of calcium folinate hydrate). Each tablet contains 15 mg of folinic acid.
  • The other ingredients are: lactose, microcrystalline cellulose, sodium starch glycolate, corn starch pregelatinized, and magnesium stearate.

Appearance of the product and pack contents

White, circular, scored tablets; available in PVC/Aluminum blister packs containing 10 tablets.

Marketing authorization holder

Pfizer, S.L.

Avda. de Europa, 20-B

Parque Empresarial La Moraleja

28108 Alcobendas (Madrid)

Pfizer Logo

Manufacturer

FARMASIERRA MANUFACTURING S.L.

Ctra. Irún, km.26, 200.

San Sebastián de los Reyes (Madrid) 28700 Spain

Date of last revision of this leaflet:July 2023

Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Healthcare Products (AEMPS) http://www.aemps.es/

Online doctors for LEDFOLIN 15 mg TABLETS

Discuss questions about LEDFOLIN 15 mg TABLETS, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

Doctor
5.0(36)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

Book a video appointment
€86
Doctor
5.0(12)

Yevgen Yakovenko

Family medicine12 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

Book a video appointment
€72
Doctor
5.0(3)

Lina Travkina

Family medicine13 years of experience

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
  • Medical advice and follow-up consultations.
  • Test interpretation and diagnostic guidance.
  • Structured support for undiagnosed complaints.
  • Second opinion on diagnoses and treatment plans.
  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
  • Post-operative recovery support and pain management.
  • Preconception counselling and postpartum support.
  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

Book a video appointment
€75
Doctor
5.0(19)

Nuno Tavares Lopes

Family medicineGeneral medicine18 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies
  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management
  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses
  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment
  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance
  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis
  • Pain management: acute and chronic pain, post-surgical care
  • Public health: prevention, health screenings, long-term monitoring
  • Sick leave (Baixa médica) connected to Segurança Social in Portugal
  • IMT medical certificates for driving licence exchange
Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.

Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

Book a video appointment
€70

Get LEDFOLIN 15 mg TABLETS Prescription Online

1

Fill in a 2-min form

Tell us your symptoms, history, and what medicine you're requesting.

2

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3

Doctor reviews your case

Usually within 30 minutes. They may ask follow-up questions via chat.

4

Collect from any pharmacy

Electronic prescription sent to your email — valid across Spain.

Frequently Asked Questions

Is a prescription required for LEDFOLIN 15 mg TABLETS?

LEDFOLIN 15 mg TABLETS requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

What is the active substance in LEDFOLIN 15 mg TABLETS?

The active ingredient in LEDFOLIN 15 mg TABLETS is calcium folinate. This information helps identify medicines with the same composition but different brand names.

How much does LEDFOLIN 15 mg TABLETS cost in pharmacies?

The average pharmacy price for LEDFOLIN 15 mg TABLETS is around 8.99 EUR. Prices may vary depending on the manufacturer and dosage form.

Who manufactures LEDFOLIN 15 mg TABLETS?

LEDFOLIN 15 mg TABLETS is manufactured by Pfizer S.L.. Pharmacy brands and packaging may differ depending on the distributor.

Which doctors can assess the use of LEDFOLIN 15 mg TABLETS online?

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether LEDFOLIN 15 mg TABLETS is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

How to buy LEDFOLIN 15 mg TABLETS in Spain?

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy LEDFOLIN 15 mg TABLETS in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

What are the alternatives to LEDFOLIN 15 mg TABLETS?

Other medicines with the same active substance (calcium folinate) include FOLINATE CALCIUM ALTAN 350 mg POWDER FOR INJECTABLE SOLUTION, FOLINATE CALCIUM ALTAN 50 mg POWDER FOR INJECTABLE SOLUTION, FOLINATE CALCIUM HIKMA 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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