FOLINATO 10 mg /Ml Injectable Solution

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Doctor
5.0(36)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

Book a video appointment
€86
This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use FOLINATE CALCIUM HIKMA 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION

Contents of the leaflet

  1. Introduction
  2. What is Calcium Folinate Hikma and what is it used for
  3. What you need to know before you use Calcium Folinate Hikma
  4. How to use Calcium Folinate Hikma
  5. Possible side effects
  6. Storage of Calcium Folinate Hikma
  7. Contents of the pack and other information

Introduction

Package Leaflet: Information for the User

Calcium Folinate Hikma 10 mg/ml Solution for Injection/Infusion

Folinic Acid

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.

If you have any further questions, ask your doctor, pharmacist, or nurse.

  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.
  • If you get any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the Package Leaflet

  1. What is Calcium Folinate Hikma and what is it used for
  2. What you need to know before you use Calcium Folinate Hikma
  3. How to use Calcium Folinate Hikma
  4. Possible side effects
  5. Storage of Calcium Folinate Hikma
  6. Contents of the pack and other information

1. What is Calcium Folinate Hikma and what is it used for

Calcium Folinate Hikma contains calcium folinate, which belongs to a group of medicines called detoxifying agents. It is the calcium salt of folinic acid, which is related to folic acid vitamin.

Calcium Folinate Hikma is used to:

  • reduce the harmful effects and to treat overdose of certain cancer medicines, such as methotrexate and other folic acid antagonists. This process is known as "calcium folinate rescue".
  • treat cancer in combination with 5-fluorouracil (a cancer medicine). 5-fluorouracil works better when given with Calcium Folinate Hikma.
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2. What you need to know before you use Calcium Folinate Hikma

Calcium Folinate Hikma must not be administered intrathecally (in the spine).

Do not use Calcium Folinate Hikma:

  • if you are allergic to calcium folinate or any of the other ingredients of this medicine (listed in section 6).
  • if you have a type of anemia caused by having very low vitamin B12.

Warnings and Precautions

Consult your doctor, pharmacist, or nurse before starting treatment with Calcium Folinate Hikma.

If you are receiving treatment with calcium folinate and fluorouracil at the same time, be particularly careful if:

  • you have had radiotherapy
  • you have stomach or intestine problems

Special care is also needed if you are over 65 years old and are going to receive treatment with calcium folinate and fluorouracil at the same time.

Using Calcium Folinate Hikma with other medicines

Tell your doctor if you are using, have recently used, or might use any other medicines.

Special care is needed if you are taking/using other medicines as they may interact with Calcium Folinate Hikma, for example:

  • folic acid antagonists (see section 1) - the effectiveness of these medicines will be reduced by calcium folinate;
  • fluorouracil (cancer medicine) - the effectiveness and side effects of this medicine will be increased with calcium folinate;
  • medicines used to treat epilepsy (phenobarbital, phenytoin, primidone, or succinimides) - the effectiveness of these medicines may be reduced with calcium folinate. Your doctor may monitor the blood levels of these medicines and change the dose to prevent an increase in seizures (epilepsy).

Pregnancy and Breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.

It is unlikely that your doctor will ask you to take/use a folic acid antagonist or fluorouracil during pregnancy or breastfeeding. However, if you have taken/used a folic acid antagonist while pregnant or breastfeeding, this medicine (calcium folinate) may be used to reduce side effects.

Calcium Folinate Hikma contains sodium

This medicine contains less than 23 mg (1 mmol) of sodium per vial, and is therefore essentially "sodium-free".

3. How to use Calcium Folinate Hikma

This medicine can be administered by injection (using a syringe) into the muscle. Alternatively, it can also be administered by injection or infusion (drip) into a vein. If administered by infusion, Calcium Folinate Hikma must be diluted first.

Your doctor will decide the correct dose of Calcium Folinate Hikma for you and how often you should receive it. The decision will depend on the medical condition being treated.

If you use more Calcium Folinate Hikma than you should

This medicine is administered in a hospital, under the supervision of a doctor.

It is unlikely that you will be given too much or too little, but talk to your doctor or nurse if you have any questions.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Very rare: may affect up to 1 in 10,000 people

  • severe allergic reaction - you may feel a sudden itchy rash (urticaria), swelling of hands, feet, ankles, face, lips, mouth, or throat (which may cause difficulty in swallowing or breathing) and you may feel weak. This is a serious side effect. You may need medical attention.

Uncommon: may affect up to 1 in 100 people

  • fever

Rare: may affect up to 1 in 1,000 people

  • an increase in seizures (epilepsy) in patients with epilepsy
  • depression
  • agitation
  • gastrointestinal disorders
  • difficulty sleeping (insomnia)

Combination therapy with 5-fluorouracil:

If you receive calcium folinate in combination with a cancer medicine that contains fluoropyrimidines, you are more likely to have the following side effects of the other medicine:

Very common: may affect more than 1 in 10 people

  • nausea
  • vomiting
  • severe diarrhea
  • dehydration that may be due to diarrhea
  • inflammation of the intestinal and oral mucosa (life-threatening situations have occurred)
  • reduction in the number of blood cells (including life-threatening situations)

Common: may affect up to 1 in 10 people

  • redness and swelling of the palms of the hands and soles of the feet, which can cause skin peeling (hand-foot syndrome)

Frequency not known: cannot be estimated from the available data

  • high levels of ammonia in the blood

Reporting of side effects

If you experience any side effects, talk to your doctor, pharmacist, or nurse, even if it is possible side effects not listed in this leaflet. You can also report side effects directly through the Spanish Pharmacovigilance System for Human Use Medicines: https://www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Calcium Folinate Hikma

Keep in the refrigerator (2°C – 8°C).

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the label and carton after EXP. The expiry date is the last day of the month stated.

Store the vials in the outer packaging to protect them from light.

Unopened vials: 18 months.

After opening: 28 days at room temperature or at 2-8°C.

After dilution: the chemical and physical stability during use after dilution between 0.5 mg/ml and 4 mg/ml in 0.9% sodium chloride or 5% glucose has been demonstrated for 28 days at both room temperature and 2-8°C.

From a microbiological point of view, the product should be used immediately.

If not used immediately, the in-use storage times and conditions are the responsibility of the user and normally should not be longer than 24 hours at 2 to 8°C, unless the dilution has been carried out in a controlled and validated aseptic environment.

6. Contents of the pack and other information

Composition of Calcium Folinate Hikma

  • The active substance is calcium folinate. Each ml contains 10 mg of folinic acid as calcium folinate.
  • Each 5, 10, 30, and 50 ml of solution contains 50, 100, 300, and 500 mg of folinic acid, respectively (as calcium folinate).
  • The other ingredients are sodium chloride, hydrochloric acid, sodium hydroxide, and water for injection.

Appearance and packaging of the product

Calcium Folinate Hikma is a clear, pale yellow solution, which comes in glass containers called vials.

It is available in packs containing:

1 or 5 vials of 10 ml with 5 ml of calcium folinate

1 or 5 vials of 10 ml with 10 ml of calcium folinate

1 or 5 vials of 50 ml with 30 ml of calcium folinate

1 or 5 vials of 50 ml with 50 ml of calcium folinate

Marketing Authorisation Holder and Manufacturer

Marketing Authorisation Holder

Hikma Farmacêutica (Portugal) S.A.

Estrada do Rio da Mó, nº8, 8A e 8B, Fervença

2705-906 Terrugem SNT

Portugal

Manufacturer

Hikma Italia S.p.A

Viale Certosa, 10

27100 - Pavia

Italy

You can ask for more information about this medicine from the local representative of the Marketing Authorisation Holder:

Hikma España, S.L.U.

Calle Anabel Segura nº11, Edificio A, planta 1ª, oficina 2

28108 - Alcobendas, Madrid

Spain

This medicine is authorised in the Member States of the European Economic Area under the following names:

Germany Calciumfolinat Hikma 10 mg/ml Injektions-/Infusionslösung

Spain Folinato Cálcico Hikma 10 mg/ml Solución inyectable y para perfusión

France Folinate de Calcium Hikma 10 mg/ml solution injectable/pour perfusion

United Kingdom Calcium Folinate 10 mg/ml Solution for injection/infusion

Date of last revision of this leaflet: February 2024

------------------------------------------------------------------------------------------------------------------

This information is intended only for healthcare professionals:

In addition to the information included in section 3, practical information on the preparation/handling of this product is available here.

Incompatibilities

Incompatibilities have been observed between injectable forms of calcium folinate and injectable forms of droperidol, fluorouracil, foscarnet, and methotrexate.

Droperidol

Droperidol 1.25 mg/0.5 ml with calcium folinate 5 mg/0.5 ml, immediate precipitation after direct mixing in a syringe for 5 minutes at 25°C followed by 8 minutes of centrifugation.

Droperidol 2.5 mg/0.5 ml with calcium folinate 10 mg/0.5 ml, immediate precipitation when the medicines are injected sequentially into a Y-piece without flushing one arm of the equipment between injections.

Fluorouracil

Calcium folinate must not be mixed in the same infusion as 5-fluorouracil because a precipitate may form. 50 mg/ml of fluorouracil with 20 mg/ml of calcium folinate, with or without 5% dextrose in water, have been shown to be incompatible when mixed in different amounts and stored at 4°C, 23°C, or 32°C in polyvinyl chloride containers.

Foscarnet

24 mg/ml of Foscarnet with 20 mg/ml of calcium folinate: the formation of a yellowish turbid solution has been reported.

Special precautions for disposal and other handling

Calcium Folinate Hikma is intended for single use. Disposal of unused medicine and all materials that have come into contact with it should be done in accordance with local regulations.

Before administration, calcium folinate should be visually inspected. The solution for injection or infusion should be clear and pale yellow in color. If it is cloudy in appearance or particles are observed, the solution should be discarded.

Online doctors for FOLINATE CALCIUM HIKMA 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION

Discuss questions about FOLINATE CALCIUM HIKMA 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

Doctor
5.0(36)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

Book a video appointment
€86
Doctor
5.0(12)

Yevgen Yakovenko

Family medicine12 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

Book a video appointment
€72
Doctor
5.0(3)

Lina Travkina

Family medicine13 years of experience

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
  • Medical advice and follow-up consultations.
  • Test interpretation and diagnostic guidance.
  • Structured support for undiagnosed complaints.
  • Second opinion on diagnoses and treatment plans.
  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
  • Post-operative recovery support and pain management.
  • Preconception counselling and postpartum support.
  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

Book a video appointment
€75
Doctor
5.0(19)

Nuno Tavares Lopes

Family medicineGeneral medicine18 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies
  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management
  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses
  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment
  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance
  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis
  • Pain management: acute and chronic pain, post-surgical care
  • Public health: prevention, health screenings, long-term monitoring
  • Sick leave (Baixa médica) connected to Segurança Social in Portugal
  • IMT medical certificates for driving licence exchange
Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.

Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

Book a video appointment
€70

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Frequently Asked Questions

Is a prescription required for FOLINATE CALCIUM HIKMA 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION?

FOLINATE CALCIUM HIKMA 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

What is the active substance in FOLINATE CALCIUM HIKMA 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION?

The active ingredient in FOLINATE CALCIUM HIKMA 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION is calcium folinate. This information helps identify medicines with the same composition but different brand names.

Who manufactures FOLINATE CALCIUM HIKMA 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION?

FOLINATE CALCIUM HIKMA 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION is manufactured by Hikma Farmaceutica (Portugal) S.A.. Pharmacy brands and packaging may differ depending on the distributor.

Which doctors can assess the use of FOLINATE CALCIUM HIKMA 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION online?

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether FOLINATE CALCIUM HIKMA 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

How to buy FOLINATE CALCIUM HIKMA 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION in Spain?

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy FOLINATE CALCIUM HIKMA 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

What are the alternatives to FOLINATE CALCIUM HIKMA 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION?

Other medicines with the same active substance (calcium folinate) include FOLINATE CALCIUM ALTAN 350 mg POWDER FOR INJECTABLE SOLUTION, FOLINATE CALCIUM ALTAN 50 mg POWDER FOR INJECTABLE SOLUTION, FOLINIC ACID CALCIUM KALCEKS 10 MG/ML INJECTABLE SOLUTION AND PERFUSION SOLUTION. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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