FOLINATO 50 mg Injectable

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Doctor
5.0(36)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

Book a video appointment
€86
This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use FOLINATE CALCIUM ALTAN 50 mg POWDER FOR INJECTABLE SOLUTION

Contents of the leaflet

  1. Introduction
  2. P
  3. What is Calcium Folinate Altan 50 mg powder for injectable solution EFG and what is it used for
  4. What you need to know before starting to use Calcium Folinate Altan 50 mg powder for injectable solution EFG
  5. How to use Calcium Folinate Altan 50 mg powder for injectable solution EFG
  6. Possible side effects
  7. Storage of Calcium Folinate Altan 50 mg powder for injectable solution EFG
  8. Package contents and additional information

Introduction

P

Calcium Folinate Altan 50 mg powder for injectable solution EFG

folinic acid

Read the entire leaflet carefully before starting to use this medication, as it contains important information for you.

  • Keep this leaflet, as you may need to read it again.
  • If you have any questions, ask your doctor or pharmacist.
  • This medication has been prescribed to you only, and you should not give it to others, even if they have the same symptoms as you, as it may harm them.
  • If you experience side effects, consult your doctor or pharmacist, even if they are not listed in this leaflet. See section 4.

Contents of the leaflet:

  1. What is Calcium Folinate Altan 50 mg powder for injectable solution EFG and what is it used for
  2. Before using Calcium Folinate Altan 50 mg powder for injectable solution EFG
  3. How to use Calcium Folinate Altan 50 mg powder for injectable solution EFG
  4. Possible side effects
  5. Storage of Calcium Folinate Altan 50 mg powder for injectable solution EFG
  1. Package contents and additional information
Doctor consultation

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1. What is Calcium Folinate Altan 50 mg powder for injectable solution EFG and what is it used for

Calcium Folinate Altan 50 mg contains calcium folinate, which belongs to the group of medications called detoxifying agents. It is the calcium salt of folinic acid and is related to folic acid vitamin.

Calcium Folinate Altan is indicated for:

  • reducing the harmful effects and treating overdose of certain types of cancer medications, such as methotrexate and other folic acid antagonists. This is known as "Calcium Folinate Rescue".
  • treating cancer in combination with 5-fluorouracil (a cancer medication). 5-fluorouracil works better when administered with calcium folinate.

Calcium Folinate Altan is presented in the form of powder for injectable solution, which can be administered intramuscularly or intravenously.

2. What you need to know before starting to use Calcium Folinate Altan 50 mg powder for injectable solution EFG

Calcium Folinate Altan should not be injected intrathecally (into the spine).

Do not use Calcium Folinate Altan 50 mg powder for injectable solution EFG:

  • If you are allergic to calcium folinate or any of the other components of this medication (listed in section 6).
  • If you have or have had pernicious anemia or other megaloblastic anemias due to vitamin B12 deficiency.

Warnings and precautions

Consult your doctor, pharmacist, or nurse before using Calcium Folinate Altan.

  • Calcium folinate should only be administered by intramuscular or intravenous injection.
  • Treatment with calcium folinate may mask pernicious anemia and other megaloblastic anemias resulting from vitamin B12 deficiency.
  • If you are epileptic and are being treated with phenobarbital, phenytoin, primidone, and succinimides, as there is a risk of increased frequency of seizures.
  • If you are being treated with antitumor medications such as:
  • 5-Fluorouracil:
      • The combined treatment may increase the toxicity of 5-fluorouracil.
      • Particularly in the case of elderly or debilitated patients, a dose reduction may be necessary.
      • If you experience diarrhea, as this may be a symptom of gastrointestinal toxicity.
      • During treatment, your doctor should monitor your blood calcium levels.
    • Methotrexate:
      • In case of renal failure due to methotrexate, higher doses or longer use of calcium folinate may be necessary.

Using other medications and Calcium Folinate Altan:

Tell your doctor or pharmacist if you are using, have recently used, or may need to use any other medication.

Certain medications may interact with calcium folinate; in these cases, it may be necessary to change the dose or interrupt treatment with one of them.

It is essential that you inform your doctor if you are taking or have recently taken any of the following medications:

  • Folic acid antagonists (e.g., cotrimoxazole, pyrimethamine), as their efficacy may be reduced when administered with calcium folinate.
  • Antiepileptic medications: phenobarbital, primidone, phenytoin, and succinimides. Calcium folinate may reduce the effect of these medications and increase the frequency of epileptic seizures.
  • 5-Fluorouracil, as the combined administration of calcium folinate with 5-fluorouracil has been shown to increase the efficacy and toxicity of 5-fluorouracil.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medication.

It is unlikely that your doctor will ask you to use a folic acid antagonist or fluorouracil while pregnant or breastfeeding. However, if you have used a folic acid antagonist during pregnancy or breastfeeding, this medication (calcium folinate) may be used to reduce its side effects.

Driving and using machines:

There is no evidence that Calcium Folinate Altan affects the ability to drive vehicles or use machines.

Calcium Folinate Altan 50 mg powder for injectable solution EFG contains sodium

This medication contains less than 1 mmol of sodium (23 mg) per vial, i.e., it is essentially "sodium-free".

Medicine questions

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3. How to use Calcium Folinate Altan 50 mg powder for injectable solution EFG

Follow your doctor's instructions for administering this medication exactly. If in doubt, consult your doctor or pharmacist.

Remember to have your medication administered to you.

Your doctor will indicate the duration of your treatment with Calcium Folinate Altan. Do not stop treatment before completing it, as you will not achieve the desired therapeutic effect.

Since this medication increases the toxicity of 5-fluorouracil, treatment with the combination of both should be supervised by an experienced doctor in the use of anticancer medications.

Calcium Folinate Altan should only be administered intravenously and intramuscularly. In the case of intravenous administration, no more than 160 mg of calcium folinate should be injected per minute due to the calcium content of the solution.

For intravenous perfusion, calcium folinate can be diluted with 0.9% sodium chloride solution or 5% glucose solution before use.

If you use more Calcium Folinate Altan 50 mg powder for injectable solution EFG than you should:

If you have been administered more Calcium Folinate Altan than you should, consult your doctor or pharmacist immediately. No significant harm has been reported in patients who have received significantly higher doses of calcium folinate than recommended.

If an overdose of the combination of 5-fluorouracil and calcium folinate occurs, the overdose instructions for 5-fluorouracil should be followed.

In case of overdose or accidental ingestion, consult the Toxicology Information Service. Phone 91 562 04 20.

If you forget to use Calcium Folinate Altan 50 mg powder for injectable solution EFG:

Do not use a double dose to make up for forgotten doses.

If you have any other questions about using this medication, ask your doctor or pharmacist.

4. Possible side effects

Like all medications, this medication can cause side effects, although not everyone experiences them.

The following side effects may occur:

Uncommon side effects: may affect up to 1 in 100 people

Fever

Rare side effects: may affect up to 1 in 1,000 people

Insomnia, agitation, and depression after high doses.

Increased frequency of seizures in epileptics.

Gastrointestinal disorders after high doses.

Very rare side effects: may affect up to 1 in 10,000 people

Allergic reactions, including anaphylactoid reactions and urticaria.

Combination therapy with 5-fluorouracil:

Generally, the safety profile depends on the applied 5-fluorouracil regimen due to the increased toxicity induced by 5-fluorouracil.

  • Monthly regimen:

Very common (may affect more than 1 in 10 people)

  • vomiting and nausea
  • mucosal toxicity

No increase in other 5-fluorouracil-induced toxicities (e.g., neurotoxicity).

  • Weekly regimen:

Very common (may affect more than 1 in 10 people)

  • diarrhea with higher degrees of toxicity and dehydration, resulting in hospital admission for treatment and even death.

Reporting side effects

If you experience any side effects, consult your doctor or pharmacist, even if they are not listed in this leaflet. You can also report them directly through the Spanish Medication Surveillance System for Human Use: https://www.notificaram.es.

By reporting side effects, you can contribute to providing more information on the safety of this medication.

5. Storage of Calcium Folinate Altan 50 mg powder for injectable solution EFG

Keep this medication out of sight and reach of children.

Store below 25°C. Store in the original package to protect from light.

After dilution, chemical and physical stability has been demonstrated for 8 hours at 25°C.

Do not use this medication after the expiration date shown on the package after EXP. The expiration date is the last day of the month indicated.

Do not use this medication if you observe particles in suspension after reconstitution or if you observe discoloration.

Medications should not be disposed of through wastewater or household waste. Ask your pharmacist how to dispose of medication packages that you no longer need. This will help protect the environment.

6. Package contents and additional information

Composition of Calcium Folinate Altan 50 mg powder for injectable solution EFG:

  • The active ingredient is folinic acid 50mg (in the form of calcium folinate)
  • The other ingredients are: sodium chloride.

Appearance of the product and package contents:

Each package contains 1 vial of lyophilized powder.

Other presentations: 25 vials.

Not all package sizes may be marketed.

Marketing authorization holder:

Altan Pharmaceuticals, S.A.

C/ Cólquide, Nº 6. Portal 2, 1ª planta, oficina F

Edificio Prisma

28230 - Las Rozas (Madrid)

Spain

Manufacturer:

Altan Pharmaceuticals, S.A.

Avda. de la Constitución, 198-199, Polígono Industrial Monte Boyal

45950 Casarrubios del Monte (Toledo)

Spain

This medication is authorized in the Member States of the European Economic Area under the following names:

France: Folinate de Calcium Altan 50 mg powder for injectable solution

Folinate de Calcium Altan 350 mg powder for injectable solution

Date of the last revision of this leaflet:October 2020

Detailed and updated information on this medication is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.es/

This information is intended only for healthcare professionals:

For intravenous and intramuscular administration only.In the case of intravenous administration, no more than 160 mg of calcium folinate should be injected per minute due to the calcium content of the solution.

For intravenous perfusion, calcium folinate can be diluted with 0.9% sodium chloride solution or 5% glucose solution before use.

Before administration, calcium folinate should be visually inspected. The injectable solution or perfusion should be a clear, yellowish solution. If it appears turbid or particles are observed, the solution should be discarded. The calcium folinate solution for injection or perfusion is intended for single use.

Incompatibilities

When using Calcium Folinate Altan, the following incompatibilities should be taken into account:

  • Calcium Folinate Altan should not be mixed with injectable forms of droperidol, fluorouracil, foscarnet, and methotrexate. When mixed with droperidol, immediate precipitation occurs. When mixed in the same perfusion with 5-fluorouracil, a precipitate may form. When mixed with foscarnet, a yellowish, turbid solution forms.

Storage after reconstitution

It is recommended that the reconstituted solution be administered immediately.

Online doctors for FOLINATE CALCIUM ALTAN 50 mg POWDER FOR INJECTABLE SOLUTION

Discuss questions about FOLINATE CALCIUM ALTAN 50 mg POWDER FOR INJECTABLE SOLUTION, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

Doctor
5.0(36)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

Book a video appointment
€86
Doctor
5.0(12)

Yevgen Yakovenko

Family medicine12 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

Book a video appointment
€72
Doctor
5.0(3)

Lina Travkina

Family medicine13 years of experience

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
  • Medical advice and follow-up consultations.
  • Test interpretation and diagnostic guidance.
  • Structured support for undiagnosed complaints.
  • Second opinion on diagnoses and treatment plans.
  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
  • Post-operative recovery support and pain management.
  • Preconception counselling and postpartum support.
  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

Book a video appointment
€75
Doctor
5.0(19)

Nuno Tavares Lopes

Family medicineGeneral medicine18 years of experience

Dr. Nuno Tavares Lopes is a licensed physician in Portugal with 17 years of experience in emergency medicine, family and general practice, and public health. He is the Director of Medical and Public Health Services at an international healthcare network and serves as an external consultant for the WHO and ECDC.

  • Emergency care: infections, fever, chest/abdominal pain, minor injuries, paediatric emergencies
  • Family medicine: hypertension, diabetes, cholesterol, chronic disease management
  • Travel medicine: pre-travel advice, vaccinations, fit-to-fly certificates, travel-related illnesses
  • Sexual and reproductive health: PrEP, STD prevention, counselling, treatment
  • Weight management and wellness: personalised weight loss programmes, lifestyle guidance
  • Skin and ENT issues: acne, eczema, allergies, rashes, sore throat, sinusitis
  • Pain management: acute and chronic pain, post-surgical care
  • Public health: prevention, health screenings, long-term monitoring
  • Sick leave (Baixa médica) connected to Segurança Social in Portugal
  • IMT medical certificates for driving licence exchange
Dr. Nuno Tavares Lopes provides medical support for patients using GLP-1 medications (Mounjaro, Wegovy, Ozempic, Rybelsus) as part of a weight loss strategy. He offers individualised treatment planning, regular follow-up, dose adjustment, and advice on combining medication with sustainable lifestyle changes. Consultations follow the medical standards accepted in Europe.

Dr. Lopes also provides interpretation of medical tests, follow-up care for complex patients, and multilingual support. Whether for urgent concerns or long-term care, he helps patients act with clarity and confidence.

Book a video appointment
€70

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Frequently Asked Questions

Is a prescription required for FOLINATE CALCIUM ALTAN 50 mg POWDER FOR INJECTABLE SOLUTION?

FOLINATE CALCIUM ALTAN 50 mg POWDER FOR INJECTABLE SOLUTION requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

What is the active substance in FOLINATE CALCIUM ALTAN 50 mg POWDER FOR INJECTABLE SOLUTION?

The active ingredient in FOLINATE CALCIUM ALTAN 50 mg POWDER FOR INJECTABLE SOLUTION is calcium folinate. This information helps identify medicines with the same composition but different brand names.

Who manufactures FOLINATE CALCIUM ALTAN 50 mg POWDER FOR INJECTABLE SOLUTION?

FOLINATE CALCIUM ALTAN 50 mg POWDER FOR INJECTABLE SOLUTION is manufactured by Altan Pharmaceuticals Sa. Pharmacy brands and packaging may differ depending on the distributor.

Which doctors can assess the use of FOLINATE CALCIUM ALTAN 50 mg POWDER FOR INJECTABLE SOLUTION online?

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether FOLINATE CALCIUM ALTAN 50 mg POWDER FOR INJECTABLE SOLUTION is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

How to buy FOLINATE CALCIUM ALTAN 50 mg POWDER FOR INJECTABLE SOLUTION in Spain?

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy FOLINATE CALCIUM ALTAN 50 mg POWDER FOR INJECTABLE SOLUTION in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

What are the alternatives to FOLINATE CALCIUM ALTAN 50 mg POWDER FOR INJECTABLE SOLUTION?

Other medicines with the same active substance (calcium folinate) include FOLINATE CALCIUM ALTAN 350 mg POWDER FOR INJECTABLE SOLUTION, FOLINATE CALCIUM HIKMA 10 mg/ml INJECTABLE SOLUTION AND PERFUSION SOLUTION, FOLINIC ACID CALCIUM KALCEKS 10 MG/ML INJECTABLE SOLUTION AND PERFUSION SOLUTION. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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