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KREON 25,000 U HARD GASTRO-RESISTANT CAPSULES

This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use KREON 25,000 U HARD GASTRO-RESISTANT CAPSULES

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

Kreon 25,000 U Enteric-Coated Capsules

pancreatin (lipase, amylase, protease)

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor, pharmacist, or nurse.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours.
  • If you get any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the Package Leaflet:

  1. What is Kreon and what is it used for
  2. What you need to know before you take Kreon
  3. How to take Kreon
  4. Possible side effects
  5. Storage of Kreon
  6. Contents of the pack and further information

1. What is Kreon and what is it used for

Kreon belongs to a group of medicines known as pancreatic enzymes.

Thanks to its activity on fats, carbohydrates, and proteins, pancreatic enzymes facilitate digestion and promote the absorption of food by people whose bodies are not able to produce these enzymes in sufficient quantities.

The pancreatin (lipase, amylase, protease) contained in this preparation is extracted from pig pancreas.

Kreon is used for the treatment of pancreatic exocrine insufficiency.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you take Kreon

Do not take Kreon:

  • if you are allergic to pancreatin (lipase, amylase, protease) or any of the other components of this medicine (listed in section 6).

Warnings and precautions:

Consult your doctor, pharmacist, or nurse before taking Kreon.

Be particularly careful with Kreon:

  • if you experience symptoms of an allergy.
  • if you have a rare intestinal disorder called "fibrosing colonopathy", where the intestine narrows, which has been described in patients with cystic fibrosis taking high doses of pancreatic enzymes.

However, if you have cystic fibrosis and take more than 10,000 units of lipase per kilogram of body weight per day and experience unusual abdominal symptoms or changes in abdominal symptoms, inform your doctor.

Traceability

In order to improve the traceability of biological medicinal products, the name and batch number of the administered medicinal product must be clearly recorded.

Other medicines and Kreon

Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including those obtained without a prescription.

Taking Kreon with food, drinks, and alcohol

This medicine is taken during or immediately after meals. If necessary, the contents of the capsules can be mixed with soft or liquid foods. In this case, the mixture should be taken immediately to avoid damaging the enzymes.

Pregnancy, Breast-feeding, and Fertility

If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

There are no data in pregnant or breast-feeding women, but animal studies do not show absorption or systemic exposure of pancreatic enzymes. Precautions should be taken when prescribing this medication to pregnant or breast-feeding women.

In case it is necessary to use Kreon during pregnancy or breast-feeding, it should be administered in doses that are sufficient to achieve an adequate nutritional status.

Driving and Using Machines

Given the characteristics of this medicine, it is unlikely that its administration will affect the ability to drive and operate hazardous machinery.

Kreon contains sodium

This medicine contains less than 23 mg of sodium (1 mmol) per dose unit; it is essentially "sodium-free".

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

3. How to Take Kreon

Follow exactly the administration instructions of this medicine given by your doctor or pharmacist. In case of doubt, consult your doctor or pharmacist again.

Dosing inPediatric and Adult Patients with Cystic Fibrosis

The initial dose is established according to weight and age. The initial dose should be 1,000 units of lipase/kg/meal in children under 4 years and 500 units of lipase/kg/meal in children over 4 years.

The doctor will decide the maintenance dose based on symptom control.

The administered dose should not exceed 10,000 units of lipase/kg body weight and day or 4,000 units of lipase/g of fat ingested.

Dosing in OtherConditions Associated with Pancreatic Exocrine Insufficiency

The dose should be adjusted individually according to symptoms and dietary fat content. The necessary dose per meal varies between approximately 25,000 to 80,000 Ph. Eur. units of lipase and half the individual dose in the case of light meals.

The capsules should be swallowed whole, without chewing or crushing, with sufficient liquid during or after main meals.

When there is difficulty swallowing the capsules, they can be opened and the contents mixed with a small amount of slightly acidic food or acidic liquids. Slightly acidic foods could be, for example, apple sauce or yogurt. Acidic liquids could be apple, orange, or pineapple juice.

Mixing with foods or liquids that are not acidic, crushing, or chewing the capsules can cause irritation in the mouth or change the way Kreon works in the body.

Do not retain Kreon capsules or their contents in the mouth.

This mixture should be taken immediately to avoid damaging the coating of the granules.

Do not store the mixture.

Drink plenty of fluids (2-3 liters) while taking this medicine to maintain adequate hydration.

If you take more Kreon than you should

In case of overdose or accidental ingestion, it is advisable to stop treatment and drink plenty of water.

Consult your doctor, pharmacist, or nurse immediately or call the Toxicology Information Service, phone 91.562.04.20, indicating the medicine and the amount ingested.

If you forget to take Kreon

If you forget to take this medicine, wait until the next meal and take the usual number of capsules. Do not take a double dose to make up for forgotten doses.

If you stop taking Kreon

Your doctor will indicate the duration of your treatment with Kreon. Do not stop it without consulting him first.

4. Possible Side Effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

The following side effects were detected during studies in patients taking Kreon. These side effects may occur with this medicine:

Very common (may affect more than 1 in 10 people): abdominal pain.

Common (may affect up to 1 in 10 people): nausea, vomiting, constipation, abdominal bloating, diarrhea.

These may be due to the disease for which you are taking Kreon. During the studies, the number of patients taking Kreon who had stomach pain or diarrhea was similar or lower than those not taking Kreon.

Uncommon (may affect up to 1 in 100 people): skin rash.

Frequency not known (cannot be estimated from the available data): itching, hives.

Kreon may cause other severe allergic reactions (hypersensitivity) that include breathing problems or swelling of the lips.

Intestinal strictures and colonopathy (fibrosing colonopathy) have been reported in patients with cystic fibrosis taking high doses of pancreatic enzyme preparations.

If you experience side effects, talk to your doctor, pharmacist, or nurse, even if it is a possible side effect not listed in this leaflet.

Reporting of side effects

If you experience any side effects, talk to your doctor, pharmacist, or nurse, even if it is a possible side effect not listed in this leaflet. You can also report them directly through the Spanish Medicines and Health Products Agency (AEMPS) website: https://www.notificaram.es.

By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Kreon

Keep this medicine out of the sight and reach of children.

Do not store above 25°C.

Once opened, do not store above 25°C and use within 6 months. Keep the container tightly closed.

Do not use this medicine after the expiry date which is stated on the carton after CAD or EXP. The expiry date is the last day of the month shown.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help protect the environment.

6. Contents of the Pack and Further Information

Composition of Kreon

  • The active substance is pancreatin (lipase, amylase, protease). Each capsule contains 300 mg of pancreatin, equivalent to 25,000 Ph. Eur. units of lipase, 18,000 Ph. Eur. units of amylase, and 1,000 Ph. Eur. units of protease.
  • The other ingredients are macrogol 4000, hypromellose phthalate, cetyl alcohol, triethyl citrate, and dimeticone. The capsule ingredients are: gelatin, red and yellow iron oxide (E-172), and sodium lauryl sulfate.

Appearance of the Product and Contents of the Pack

Kreon 25,000 is presented in the form of hard gelatin capsules with an orange opaque head and a transparent body in plastic containers. Each container contains 50 or 100 capsules.

Marketing Authorization Holder and Manufacturer

Marketing Authorization Holder

Viatris Healthcare Limited

Damastown Industrial Park

Mulhuddart, Dublin 15

Dublin

Ireland

Manufacturer

Abbott Laboratories GmbH

Justus von Liebig Strasse 33

31535 Neustadt (Germany)

You can obtain further information on this medicine by contacting the local representative of the Marketing Authorization Holder:

Viatris Pharmaceuticals, S.L.

C/ General Aranaz, 86

28027 Madrid

Spain

Date of the last revision of this leaflet: July 2021

Detailed information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es/

Online doctors for KREON 25,000 U HARD GASTRO-RESISTANT CAPSULES

Discuss questions about KREON 25,000 U HARD GASTRO-RESISTANT CAPSULES, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

5.0 (1204)
Doctor

Andrei Popov

General medicine 7 years exp.

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

0.0 (0)
Doctor

Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
0.0 (0)
Doctor

Joao Silva

General medicine 6 years exp.

Dr. João Silva is a physician with training and experience in the field of General and Family Medicine, dedicated to providing healthcare focused on the well-being and quality of life of his patients. Throughout his professional career, he has developed broad clinical competencies, striving to maintain a medical practice based on scientific evidence and continuous knowledge updates.

Between 2013 and 2019, he completed the Integrated Master's Degree in Medicine at the Abel Salazar Institute of Biomedical Sciences in Porto, where he acquired a solid academic and clinical education.

Subsequently, between January 2021 and December 2021, he completed the General Internship at the Entre Douro e Vouga Hospital Center in Santa Maria da Feira, where he had the opportunity to work in different hospital settings and deepen his competencies in several areas of medicine.

From January 2022 until March 2026, he works as a Resident Physician in General and Family Medicine at USF Salvador Machado in Oliveira de Azeméis, developing clinical activities in primary healthcare, follow-up of chronic patients, and health promotion in the community.

Complementing his medical training, Dr. João Silva also completed a Postgraduate Degree in Continuing and Palliative Care at CESPU, strengthening his preparation in the comprehensive approach to patient care, especially in situations requiring prolonged care and multidisciplinary support.

5.0 (53)
Doctor

Anna Biriukova

General medicine 6 years exp.

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

  • High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
  • Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
  • Leg swelling, chronic fatigue, reduced exercise tolerance.
  • EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
  • Post-COVID-19 cardiac monitoring and care.
Endocrinology – Diabetes, thyroid, metabolism:
  • Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
  • Individual treatment plans including oral medications and insulin therapy.
  • GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
  • Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
  • Metabolic syndrome – obesity, lipid disorders, insulin resistance.
Gastroenterology – Digestive health:
  • Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
  • Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
  • Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).
General internal medicine and preventive care:
  • Respiratory infections – cough, colds, bronchitis.
  • Lab test analysis, therapy adjustments, medication management.
  • Adult vaccinations – planning, contraindications assessment.
  • Cancer prevention – screening strategies and risk assessment.
  • Holistic approach – symptom relief, complication prevention, and quality of life improvement.
Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.
0.0 (15)
Doctor

Antonio Cayatte

General medicine 44 years exp.

Dr Antonio Cayatte is a physician in General and Acute Medicine with over 30 years of experience across clinical care, medical research, and education. He offers online consultations for adults with a wide range of symptoms, both acute and chronic. His clinical background includes: 

  • assessment of sudden or unclear symptoms
  • ongoing care for chronic conditions
  • follow-up after hospital discharge
  • interpretation of test results
  • medical support while abroad

Dr Cayatte earned his degree from the University of Lisbon and taught internal medicine at Boston University School of Medicine. He holds active medical registrations in both Portugal and the UK and is a Fellow of the American Heart Association. Consultations are available in English and Portuguese. Patients value his clarity, professionalism, and balanced approach to evidence-based care.

Dr. Antonio Cayatte provides comprehensive care for a broad spectrum of common health concerns, including:

  • Respiratory & ENT: acute bronchitis, concerns related to pneumonia, sinusitis, tonsillitis, ear infections, sore throat conditions, and allergic rhinitis
  • Eye Health: allergic and infectious conjunctivitis, as well as red or irritated eyes
  • Digestive & Urinary: gastroesophageal reflux disease (GERD), gastritis, urinary tract infections, and cystitis
  • Chronic Conditions: hypertension, elevated cholesterol, and structured weight management planning
0.0 (0)
Doctor

Sviatoslav Chekhun

Oncology 13 years exp.

Dr. Sviatoslav Chekhun is a medical oncologist with international clinical and research experience, specializing in modern medical oncology and a personalized approach to cancer treatment.

Currently (since 2025), he works as a Medical Oncologist at Institut Català d’Oncologia (Girona, Spain). Previously, he completed his residency in Medical Oncology and was involved in clinical research at Hospital Universitari Germans Trias i Pujol.

Dr. Chekhun has a strong academic and scientific background. He served as a lecturer in Internal Medicine at O.O. Bohomolets National Medical University and conducted research in experimental oncology at the R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology.

Earlier in his career, he worked as a medical oncologist at the Kyiv City Clinical Oncological Center and contributed to regulatory evaluation of medicinal products at the State Expert Center of the Ministry of Health of Ukraine.

When to consult Dr. Chekhun:

  •  for diagnosis or clarification of a cancer diagnosis
  •  to obtain a second opinion on an existing treatment plan 
  •  when you need a personalized treatment strategy 
  •  for interpretation of test results, CT, MRI, PET-CT, and biopsies 
  •  when choosing between treatment options (chemotherapy, targeted therapy, immunotherapy) 
  •  in case of doubts about treatment strategy or disease progression 

Consultation format

Dr. Chekhun provides online consultations, where you can receive:

  •  expert second opinion 
  •  detailed case review 
  •  recommendations based on current international treatment guidelines 
  •  personalized treatment and follow-up plan 

Important:
Prescription and monitoring of medications must be carried out by your treating physician in an in-person (offline) setting. An online consultation does not replace a face-to-face visit but helps you make more informed decisions about your treatment.

Dr. Sviatoslav Chekhun combines clinical practice, research, and international experience, enabling him to provide patients with modern, evidence-based approaches in oncology.

Get KREON 25,000 U HARD GASTRO-RESISTANT CAPSULES Prescription Online

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Electronic prescription sent to your email — valid across Spain.

Frequently Asked Questions

Is a prescription required for KREON 25,000 U HARD GASTRO-RESISTANT CAPSULES?

KREON 25,000 U HARD GASTRO-RESISTANT CAPSULES requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

What is the active substance in KREON 25,000 U HARD GASTRO-RESISTANT CAPSULES?

The active ingredient in KREON 25,000 U HARD GASTRO-RESISTANT CAPSULES is multienzymes (lipase, protease etc.). This information helps identify medicines with the same composition but different brand names.

Who manufactures KREON 25,000 U HARD GASTRO-RESISTANT CAPSULES?

KREON 25,000 U HARD GASTRO-RESISTANT CAPSULES is manufactured by Viatris Healthcare Limited. Pharmacy brands and packaging may differ depending on the distributor.

Which doctors can assess the use of KREON 25,000 U HARD GASTRO-RESISTANT CAPSULES online?

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether KREON 25,000 U HARD GASTRO-RESISTANT CAPSULES is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

How to buy KREON 25,000 U HARD GASTRO-RESISTANT CAPSULES in Spain?

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy KREON 25,000 U HARD GASTRO-RESISTANT CAPSULES in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

What are the alternatives to KREON 25,000 U HARD GASTRO-RESISTANT CAPSULES?

Other medicines with the same active substance (multienzymes (lipase, protease etc.)) include KREON 10,000 U HARD GASTRORESISTANT CAPSULES, KREON 35,000 U HARD GASTRORESISTANT CAPSULES, KREON 5,000 U GASTRO-RESISTANT GRANULES. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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