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ICATIBANT EXELTIS 30 mg Injectable Solution in Pre-filled Syringe

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About the medicine

How to use ICATIBANT EXELTIS 30 mg Injectable Solution in Pre-filled Syringe

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

Show original

Contents of the leaflet

  1. Introduction
  2. What is Icatibant Exeltis and what is it used for
  3. What you need to know before you use Icatibant Exeltis
  4. How to use Icatibant Exeltis
  5. Possible side effects
  6. Storing Icatibant Exeltis
  7. Package Contents and Additional Information

Introduction

Package Leaflet: Information for the User

Icatibant Exeltis 30 mg solution for injection in pre-filled syringe EFG

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What is Icatibant Exeltis and what is it used for
  2. What you need to know before you use Icatibant Exeltis
  3. How to use Icatibant Exeltis
  4. Possible side effects
  5. Storing Icatibant Exeltis
  6. Contents of the pack and other information

1. What is Icatibant Exeltis and what is it used for

Icatibant Exeltis contains the active substance icatibant.

This medicine is used to treat the symptoms of hereditary angioedema (HAE) in adults, adolescents and children aged 2 years and above.

In HAE, the levels of a substance in the blood called bradykinin increase, leading to symptoms such as swelling, pain, nausea and diarrhoea.

This medicine blocks the action of bradykinin and therefore reduces the progression of the symptoms of an HAE attack.

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2. What you need to know before you use Icatibant Exeltis

Do not use Icatibant Exeltis

  • if you are allergic to icatibant or any of the other ingredients of this medicine (listed in section 6).

Warnings and precautions

Talk to your doctor before you start using this medicine:

  • If you have coronary heart disease (reduced blood flow to the heart).
  • If you have recently had a stroke.

The side effects related to this medicine are similar to the symptoms of your own illness. Consult your doctor immediately if you notice that the symptoms of the attack worsen after you have been given this medicine.

Also:

  • You or your carer must learn the technique for subcutaneous injections (under the skin) before you self-administer or your carer administers this medicine to you.
  • Immediately after self-administering this medicine or after your carer has administered it to you while you are experiencing a laryngeal attack (obstruction of the upper airway), you must seek medical attention at a medical centre.
  • If your symptoms do not resolve after a self-administered injection of this medicine or after an injection administered by your carer, you should consult your doctor about the administration of additional injections of this medicine. In adult patients, up to 2 additional injections can be administered within 24 hours.

Children and adolescents

This medicine is not recommended for use in children under 2 years of age or weighing less than 12 kg because it has not been studied in these patients.

Other medicines and Icatibant Exeltis

Tell your doctor if you are taking, have recently taken or might take any other medicines.

No interactions of this medicine with other medicines are known. If you are taking any medicine that is an angiotensin-converting enzyme inhibitor (e.g. captopril, enalapril, ramipril, quinapril, lisinopril) to lower your blood pressure or for any other reason, inform your doctor before using this medicine.

Pregnancy and breast-feeding

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before using this medicine.

If you are breast-feeding, you should not breast-feed your child during the 12 hours following the last administration of this medicine.

Driving and using machines

Do not drive or use machines if you feel tired or dizzy as a result of the HAE attack or after using this medicine.

Icatibant Exeltis contains sodium

This medicine contains less than 23 mg of sodium (1 mmol) per syringe; this is essentially “sodium-free”.

3. How to use Icatibant Exeltis

Follow the instructions for administration of this medicine exactly as told by your doctor. If you are not sure, consult your doctor again.

If you have never been administered this medicine before, the first dose must always be injected by medical or nursing staff. Your doctor will discharge you when they consider it safe for you to go home. After discussing with your doctor or nurse and after learning the technique for subcutaneous injections (under the skin), you or your carer can administer this medicine to you if you have an HAE attack. It is important to inject this medicine subcutaneously (under the skin) as soon as you notice an angioedema attack. The healthcare staff will teach you and your carer how to inject this medicine safely, following the instructions in the package leaflet.

When and how often should you use Icatibant Exeltis?

Your doctor has determined the exact dose of this medicine and will tell you how often you should use it.

Adults

  • The recommended dose of this medicine is one injection (3 ml, 30 mg) administered subcutaneously (under the skin) as soon as you notice the angioedema attack (e.g. with increased skin swelling, especially on the face and neck, or increased abdominal pain).
  • If you do not notice an improvement in symptoms after 6 hours, you should seek medical advice about the administration of additional injections of this medicine. In adults, up to 2 additional injections can be administered within 24 hours.
  • You should not receive more than 3 injections in a 24-hour period and if you need more than 8 injections in a month, you should seek medical advice.

Children and adolescents from 2 to 17 years

  • The recommended dose of this medicine is an injection of 1 ml up to a maximum of 3 ml based on body weight, administered subcutaneously (under the skin) as soon as symptoms of an angioedema attack appear (e.g. increased skin swelling, especially on the face and neck, or increased abdominal pain).
  • See the instructions for use section to see the dose you should inject.
  • If you are not sure about the dose you should inject, consult your doctor, pharmacist or nurse.
  • If your symptoms worsen or do not improve, you should seek medical advice immediately.

How should you administer Icatibant Exeltis?

This medicine is administered by subcutaneous injection (under the skin). Each syringe should only be used once.

This medicine is injected with a short needle into the fatty tissue under the skin of the abdomen (belly). If you have any other questions about the use of this medicine, ask your doctor or pharmacist.

The following step-by-step instructions are for:

  • self-administration (adults)
  • administration by a carer or healthcare professional for adults, adolescents or children over 2 years (weighing at least 12 kg).

The instructions include the following main steps:

  1. General information

2a) Preparation of the syringe for children and adolescents (2-17 years) weighing 65 kg or less

2b) Preparation of the syringe and needle for injection (all patients)

  1. Preparation of the injection site
  2. Injection of the solution
  3. Disposal of the injection materials

Step-by-step instructions for injection

  1. General information
  • Clean the work surface (area) before you start the process.
  • Wash your hands with water and soap
  • Open the tray by removing the seal
  • Remove the pre-filled syringe from the tray
  • Unscrew and remove the cap from the end of the pre-filled syringe
  • Leave the pre-filled syringe once the cap has been unscrewed

2a) Preparation of the syringe for children and adolescents (2-17 years) weighing 65 kg or less:

Important information for healthcare professionals and carers:

When the dose is less than 30 mg (3 ml), the following equipment is needed to extract the correct dose (see information below):

  1. Pre-filled syringe of Firazyr (with icatibant solution)
  2. Connector (adapter)
  3. 3 ml graduated syringe

Pre-filled syringe with medication showing retracted piston and graduated scale with separate needle protector

The required injection volume in ml should be prepared in an empty 3 ml graduated syringe (see table below).

Table 1: Dosage schedule for children and adolescents

Body weight

Injection volume

12 kg to 25 kg

1.0 ml

26 kg to 40 kg

1.5 ml

41 kg to 50 kg

2.0 ml

51 kg to 65 kg

2.5 ml

Patients weighing more than 65kgwill use the entire contents of the pre-filled syringe (3 ml).

If you are not sure about the volume of solution to extract, consult your doctor, pharmacist or nurse

  1. Remove the caps from each end of the connector.

Avoid touching the ends of the connector and the tips of the syringes to prevent contamination

  1. Screw the connector onto the pre-filled syringe.
  1. Attach the graduated syringe to the other end of the connector, making sure that both connections fit securely.

Pre-filled syringe with transparent medication and retracted plunger showing arrow indicating direction of injection

Transfer the icatibant solution to the graduated syringe:

  1. To start the transfer of the icatibant solution, push the plunger of the pre-filled syringe (on the left end of the image below).

Transparent pre-filled syringe with two circular plungers and measurement marks, arrows indicate direction of movement

  1. If the icatibant solution does not start to transfer to the graduated syringe, gently pull the plunger of the graduated syringe until the icatibant solution starts to flow into the graduated syringe (see image below).

Transparent syringe with black plunger and sealing rings, tip with protector and arrow indicating direction of plunger

  1. Continue pushing the plunger of the pre-filled syringe until the required injection volume (dose) is transferred to the graduated syringe. See Table 1 for dosing information.

If there is airin the graduated syringe:

  • Turn the connected syringes so that the pre-filled syringe is on top (see image below)
  • Push the plunger of the graduated syringe to transfer the air back to the pre-filled syringe (this step may need to be repeated several times).
  • Extract the required volume of icatibant solution.
  1. Remove the pre-filled syringe and connector from the graduated syringe.
  1. Dispose of the pre-filled syringe and connector in the sharps container.

2b) Preparation of the syringe and needle for injection: All patients (adults, adolescents and children)

Hands holding pre-filled injection device with connected needle and removed protector, arrow indicating rotation

  • Remove the needle cap from the blister pack
  • Twist the needle cap to break the seal (the needle should remain inside the cap).

Hand holding syringe with needle being inserted into vial stopper, arrow indicates direction

  • Hold the syringe firmly. Carefully connect the needle to the pre-filled syringe with the colourless solution.
  • Screw the pre-filled syringe onto the needle, still fixed in the cap
  • Pull the syringe to remove the needle from the cap. Do not pull the plunger.
  • The syringe is now ready to administer the injection
  1. Preparation of the injection site

Hand pinching skin with thumb and index finger forming a skin fold for injection

  • Choose the injection site. The injection site should be a fold of the abdomen, approximately 5-10 cm (2-4 inches) below the navel, to one side or the other. The area should be at least 5 cm (2 inches) away from any scar. Do not choose an area with bruises, inflammation or pain.
  • Clean the injection site by rubbing it with an alcohol swab and let it dry.
  1. Injection of the solution

Hand holding syringe with needle pointing upwards on transparent base, arrow indicating direction of push

  • Hold the syringe between two fingers, with your thumb on the end of the plunger
  • Check that there is no air in the syringe by pressing the plunger until the first drop appears at the tip of the needle

Hand holding syringe injecting into thigh skin at an angle, with other hand holding and guiding the process

  • Hold the syringe with the needle pointing towards the skin at an angle of 45 to 90 degrees
  • Holding the syringe in one hand, with the other hand gently take a fold of skin between your thumb and fingers, at the previously cleaned site
  • Hold the skin fold, bring the syringe close and quickly insert the needle into the fold
  • Slowly press the plunger with a firm pulse, until all the fluid has been injected into the skin and no liquid remains in the syringe
  • Press slowly, so that the process takes approximately 30 seconds
  • Release the skin fold and gently remove the needle
  1. Disposal of the injection materials

Hand holding syringe disposing of needle in white sharps container

  • Dispose of the syringe, needle and needle cap in the sharps container for disposal of sharp objects.
Medicine questions

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4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. Almost all patients who receive this medicine will experience a reaction at the injection site (such as skin irritation, swelling, pain, itching, redness of the skin and a burning sensation). These effects are usually mild and disappear without the need for any additional treatment.

Very common (may affect more than 1 in 10 people):

Additional reactions at the injection site (feeling of pressure, bruising, decreased sensitivity and/or numbness, increased skin rash with itching and heat).

Common (may affect up to 1 in 10 people): Nausea

Headache

Dizziness

Fever

Itching

Rash

Redness of the skin

Abnormal liver function tests

Frequency not known (cannot be estimated from the available data): Hives (urticaria)

Tell your doctor immediately if you notice that the symptoms of the attack worsen after you have received this medicine.

If you experience side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet.

Reporting of side effects

If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Spanish Medicines Monitoring System for Human Use: https://www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storing Icatibant Exeltis

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the carton after “EXP”. The expiry date refers to the last day of that month.

Do not store above 30°C. Do not freeze.

Do not use this medicine if you notice that the syringe or needle packaging is damaged or if you notice visible signs of deterioration; for example, if the solution is cloudy, if it contains floating particles or if the colour of the solution has changed.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

6. Package Contents and Additional Information

Composition of Icatibant Exeltis

The active ingredient is icatibant. Each pre-filled syringe contains 30 milligrams of icatibant (as acetate). The other components are sodium chloride, glacial acetic acid, sodium hydroxide, and water for injectable preparations.

Appearance of Icatibant Exeltis and Package Contents

Icatibant Exeltis is presented as a clear and colorless injectable solution in a 3 ml pre-filled glass syringe.

The package contains a sterile subcutaneous needle.

This medication is available in a single-unit package of one pre-filled syringe with one needle or in a multi-unit package of three pre-filled syringes with three needles.

Only some package sizes may be marketed.

Marketing Authorization Holder and Manufacturer

Marketing Authorization Holder

Exeltis Healthcare S.L.

Miralcampo Avenue, 7.

Miralcampo Industrial Estate.

19200 Azuqueca de Henares. Guadalajara.

Spain.

Manufacturer

Universal Farma, S.L.

Miralcampo Industrial Estate.

El Tejido Street, 2.

19200 Azuqueca de Henares. Guadalajara.

Spain.

This medication is authorized in the member states of the European Economic Area under the following names:

Netherlands:

Icatibant Xiromed 30 mg solution for injection, in pre-filled syringe.

Germany:

Icatibant AXiromed 30 mg injection solution in a pre-filled syringe.

Iceland:

Icatibant Medical Valley 30 mg solution for injection, in pre-filled syringe.

Poland:

Icatibant Medical Valley.

Sweden:

Icatibant Medical Valley 30 mg injectable solution, in pre-filled syringe.

Denmark:

Icatibant Medical Valley.

Norway:

Icatibant Medical Valley.

Spain:

Icatibanto Exeltis 30 mg injectable solution in pre-filled syringe EFG.

Date of the last revision of this prospectus: June 2024.

Detailed information about this medication is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es/.

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Frequently Asked Questions

Is a prescription required for ICATIBANT EXELTIS 30 mg Injectable Solution in Pre-filled Syringe?
ICATIBANT EXELTIS 30 mg Injectable Solution in Pre-filled Syringe requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in ICATIBANT EXELTIS 30 mg Injectable Solution in Pre-filled Syringe?
The active ingredient in ICATIBANT EXELTIS 30 mg Injectable Solution in Pre-filled Syringe is icatibant. This information helps identify medicines with the same composition but different brand names.
Who manufactures ICATIBANT EXELTIS 30 mg Injectable Solution in Pre-filled Syringe?
ICATIBANT EXELTIS 30 mg Injectable Solution in Pre-filled Syringe is manufactured by Exeltis Healthcare S.L.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of ICATIBANT EXELTIS 30 mg Injectable Solution in Pre-filled Syringe online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether ICATIBANT EXELTIS 30 mg Injectable Solution in Pre-filled Syringe is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to ICATIBANT EXELTIS 30 mg Injectable Solution in Pre-filled Syringe?
Other medicines with the same active substance (icatibant) include FIRAZYR 30 mg SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE, ICATIBANT ACCORD 30 mg Injectable Solution in Pre-filled Syringe, ICATIBANTO AGUETTANT 30 mg Injectable Solution in Pre-filled Syringe EFG. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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