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FIRAZYR 30 mg SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE

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Rita Isabel Calero Garcia

General medicine 2 years exp.

Dr. Rita Isabel Calero Garcia is a physician with extensive experience in emergency medical care, general medicine, and healthcare assistance in various clinical and out-of-hospital settings.

She currently works as a physician at the Canary Islands Emergency Service (Servicio de Urgencias Canario – SUC), where she is responsible for the assessment and care of patients in medical emergency situations, performing the initial diagnosis, patient stabilization, and coordination with hospital services when necessary.

She has also developed her professional activity within the Primary Care Management Service, providing consultations in general medicine. In this setting she is responsible for patient follow-up, management of acute and chronic conditions, as well as health promotion and disease prevention.

She has also worked as a physician in a mobile ICU unit, providing medical assistance in out-of-hospital emergencies, treating critical patients and participating in medicalized patient transport.

In addition, she has collaborated with the Red Cross, participating in healthcare support units, providing medical assistance at events and supporting emergency interventions.

Furthermore, she has provided medical services in the private sector with Salvaser, conducting clinical assessments of patients and providing healthcare services within private medical services.
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This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use FIRAZYR 30 mg SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

Show original

Contents of the leaflet

  1. Introduction
  2. What is Firazyr and what is it used for
  3. What you need to know before you use Firazyr
  4. How to use Firazyr
  5. Possible side effects
  6. Storage of Firazyr
  7. Package Contents and Additional Information

Introduction

Package Leaflet: Information for the User

Firazyr 30 mg solution for injection in pre-filled syringe

Icatibant

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack and other information

  1. What is Firazyr and what is it used for
  2. What you need to know before you use Firazyr
  3. How to use Firazyr
  4. Possible side effects
  5. Storage of Firazyr
  6. Contents of the pack and other information
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1. What is Firazyr and what is it used for

Firazyr contains the active substance icatibant.

Firazyr is used to treat the symptoms of hereditary angioedema (HAE) in adults, adolescents and children aged 2 years and above.

In HAE, the levels of a substance in the blood called bradykinin increase, leading to symptoms such as swelling, pain, nausea and diarrhoea.

Firazyr blocks the action of bradykinin and therefore slows down the progression of the symptoms of an HAE attack.

2. What you need to know before you use Firazyr

Do not use Firazyr

  • If you are allergic to icatibant or any of the other ingredients of this medicine (listed in section 6).

Warnings and precautions

Consult your doctor before starting treatment with Firazyr:

  • If you have coronary heart disease (reduced blood flow to the heart).
  • If you have recently had a stroke.

The side effects related to Firazyr are similar to the symptoms of your own illness.

Consult your doctor immediately if you notice that the symptoms of the attack worsen after you have been given Firazyr.

Also:

  • You or your carer must learn the technique of administering subcutaneous injections (under the skin) before you self-administer or your carer administers Firazyr to you.
  • Immediately after self-administering Firazyr or after your carer has administered it to you while you are experiencing a laryngeal attack (obstruction of the upper airway), you should seek medical attention at a medical institution.
  • If your symptoms do not resolve after a self-administered injection of Firazyr or after an injection administered by your carer, you should consult your doctor about the administration of additional injections of Firazyr. In adult patients, up to 2 additional injections can be administered within 24 hours.

Children and adolescents

Firazyr is not recommended for use in children below 2 years of age or weighing less than 12 kg because it has not been studied in these patients.

Other medicines and Firazyr

Tell your doctor if you are taking, have recently taken or might take any other medicines.

No interactions of Firazyr with other medicines are known. If you are taking a medicine that is an angiotensin-converting enzyme inhibitor (e.g. captopril, enalapril, ramipril, quinapril, lisinopril) to lower your blood pressure or for any other reason, inform your doctor before using Firazyr.

Pregnancy and breast-feeding

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.

If you are breast-feeding, you should not breast-feed your child for 12 hours after the last administration of Firazyr.

Driving and using machines

Do not drive or use machines if you feel tired or dizzy as a result of the HAE attack or after using Firazyr.

Firazyr contains a small amount of sodium

This medicine contains less than 23 milligrams (1 mmol) of sodium per syringe, and is therefore essentially ‘sodium-free’.

Medicine questions

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3. How to use Firazyr

Follow the instructions for administration of this medicine exactly as told by your doctor. If you are not sure, ask your doctor again.

If you have never been administered Firazyr before, the first dose must always be injected by medical or nursing staff. Your doctor will discharge you when they consider it safe for you to go home. After discussing with your doctor or nurse and learning the technique for subcutaneous injections (under the skin), you or your carer can administer Firazyr to you if you have an HAE attack. It is important to inject Firazyr subcutaneously (under the skin) as soon as you notice an angioedema attack. The healthcare staff will teach you and your carer how to inject Firazyr safely, following the instructions in the leaflet.

When and how often should you use Firazyr?

Your doctor has determined the exact dose of Firazyr and will tell you how often to use it.

Adults

  • The recommended dose of Firazyr is one injection (3 ml, 30 mg) administered subcutaneously (under the skin) as soon as you notice the angioedema attack (e.g. with increased skin swelling, especially on the face and neck, or increased abdominal pain).
  • If you do not notice an improvement in symptoms after 6 hours, you should seek medical advice about the administration of additional injections of Firazyr. In adults, up to 2 additional injections can be administered within 24 hours.
  • You should not receive more than 3 injections in a 24-hour period and if you need more than 8 injections in a month, you should seek medical advice.

Children and adolescents from 2 to 17 years

  • The recommended dose of Firazyr is an injection of 1 ml up to a maximum of 3 ml based on body weight, administered subcutaneously (under the skin) as soon as symptoms of an angioedema attack appear (e.g. increased skin swelling, especially on the face and neck, or increased abdominal pain).
  • Refer to the section on instructions for use to see the dose you should inject.
  • If you are unsure about the dose to inject, consult your doctor, pharmacist or nurse.
  • If your symptoms worsen or do not improve, you should seek medical advice immediately.

How should Firazyr be administered?

Firazyr is administered by subcutaneous injection (under the skin). Each syringe should only be used once.

Firazyr is injected with a short needle into the fatty tissue under the skin of the abdomen (tummy).

If you have any other questions about the use of this medicine, ask your doctor or pharmacist.

The following step-by-step instructions are intended for:

  • self-administration (adults)
  • administration by a carer or healthcare professional for adults, adolescents or children over 2 years (weighing at least 12 kg).

The instructions include the following main steps:

  1. General information

2a) Preparation of the syringe for children and adolescents (2-17 years) weighing 65 kg or less

2b) Preparation of the syringe and needle for injection (all patients)

  1. Preparation of the injection site
  2. Injection of the solution
  3. Disposal of the injection materials

Step-by-step instructions for injection

  1. General information
  • Clean the work surface (area) before you start the process.
  • Wash your hands with water and soap
  • Open the tray by removing the seal
  • Remove the pre-filled syringe from the tray
  • Unscrew and remove the cap from the end of the pre-filled syringe
  • Leave the pre-filled syringe once the cap has been unscrewed

2a) Preparation of the syringe for children and adolescents (2-17 years) weighing 65 kg or less:

Important information for healthcare professionals and carers:

When the dose is less than 30 mg (3 ml), the following equipment is needed to extract the correct dose (see information below):

  1. Firazyr pre-filled syringe (with icatibant solution)
  2. Connector (adapter)
  3. 3 ml graduated syringe

Syringe with plunger and graduated cylinder, separate needle and connection detail, simplified linear diagram

The required injection volume in ml should be prepared in an empty 3 ml graduated syringe (see table below).

Table 1: Dosage schedule for children and adolescents

Body weight

Injection volume

12 kg to 25 kg

1.0 ml

26 kg to 40 kg

1.5 ml

41 kg to 50 kg

2.0 ml

51 kg to 65 kg

2.5 ml

Patients weighing more than 65 kgwill use the entire contents of the pre-filled syringe (3 ml).

If you are unsure about the volume of solution to extract, consult your doctor, pharmacist or nurse

  1. Remove the caps from each end of the connector.

Avoid touching the ends of the connector and the tips of the syringes to prevent contamination

  1. Screw the connector onto the pre-filled syringe.
  1. Attach the graduated syringe to the other end of the connector, making sure that both connections fit securely.

Pre-filled transparent syringe with plunger and removable needle protector showing separate parts

Transfer the icatibant solution to the graduated syringe:

  1. To start the transfer of the icatibant solution, push the plunger of the pre-filled syringe (on the left end of the image below).

Transparent syringe with black plunger and graduated scale showing arrows indicating direction of movement

  1. If the icatibant solution does not start to transfer to the graduated syringe, pull the plunger of the graduated syringe slightly until the icatibant solution starts to flow into the graduated syringe (see image below).

Transparent syringe with plunger and needle showing graduated measurement marks, arrow indicates direction of plunger

  1. Continue pushing the plunger of the pre-filled syringe until the required injection volume (dose) has been transferred to the graduated syringe. Refer to Table 1 for dosing information.

If there is air in the graduated syringe:

  • Turn the connected syringes so that the pre-filled syringe is on top (see image below).

Pre-filled transparent syringe with plunger and graduated scale showing dose and direction of extraction

  • Push the plunger of the graduated syringe to transfer the air back to the pre-filled syringe (this step may need to be repeated several times).
  • Extract the required volume of icatibant solution.
  1. Remove the pre-filled syringe and connector from the graduated syringe.
  1. Dispose of the pre-filled syringe and connector in the sharps container or puncture-proof container.

2b) Preparation of the syringe and needle for injection: All patients (adults, adolescents and children)

Hands holding a device applicator with a needle and a grey button for injection

  • Remove the needle cap from the blister pack
  • Remove the seal from the needle cap (the needle should remain inside the cap)

Hands holding syringe with needle inserted and arrow indicating direction of injection

  • Hold the syringe firmly. Carefully attach the needle to the pre-filled syringe with the colourless solution.
  • Screw the pre-filled syringe onto the needle, still fixed in the cap
  • Pull the syringe to remove the needle from the cap. Do not pull the plunger.
  • The syringe is now ready to administer the injection
  1. Preparation of the injection site

Hand holding a pre-filled syringe applying pressure on the skin of the arm within a red circle

  • Choose the injection site. The injection site should be a fold of the abdomen, approximately 5-10 cm (2-4 inches) below the navel, to one side or the other. The area should be at least 5 cm (2 inches) away from any scar. Do not choose an area with bruises, inflammation or pain.
  • Clean the injection site by rubbing it with an alcohol swab and let it dry.
  1. Injection of the solution

Hand holding syringe with needle pointing upwards and arrow indicating direction of injection in the skin

  • Hold the syringe between two fingers, with your thumb on the end of the plunger
  • Check that there is no air in the syringe by pressing the plunger until the first drop appears at the tip of the needle

Hand holding syringe with needle inserted in arm skin, subcutaneous injection technique with visible angle

  • Hold the syringe with the needle pointing towards the skin at an angle of 45 to 90 degrees
  • Holding the syringe in one hand, with the other hand gently take a fold of skin between your thumb and fingers, at the previously cleaned site
  • Hold the skin fold, bring the syringe close and quickly insert the needle into the fold
  • Slowly press the plunger with a firm pulse, until all the fluid has been injected into the skin and no liquid remains in the syringe
  • Press slowly, so that the process takes approximately 30 seconds
  • Release the skin fold and gently remove the needle
  1. Disposal of the injection materials

Needle inserted into a vial stopper with a syringe connected and an arrow indicating the direction of insertion

  • Throw away the syringe, needle and its cap in the sharps container or puncture-proof container.

4. Possible side effects

Like all medicines, Firazyr can cause side effects, although not everybody gets them. Almost all patients who receive Firazyr notice a reaction at the injection site (such as skin irritation, inflammation, pain, itching, redness of the skin and burning). These effects are usually mild and improve without the need for any additional treatment.

Very common (may affect more than 1 in 10 people) are:

Additional reactions at the injection site (feeling of pressure, bruising, decreased sensitivity and/or numbness, increased skin rash with itching and heat).

Common (may affect up to 1 in 10 people) are:

Nausea

Headache

Dizziness

Fever

Itching

Rash

Redness of the skin

Abnormal liver function tests

Frequency not known (cannot be estimated from the available data):

Hives (urticaria)

Tell your doctor immediately if you notice that the symptoms of the attack worsen after you have been given Firazyr.

If you experience side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet.

Reporting of side effects

If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Firazyr

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the carton after “EXP”. The expiry date refers to the last day of that month.

Do not store above 25°C. Do not freeze.

Do not use this medicine if you notice that the syringe or needle packaging is damaged or if you notice visible signs of deterioration, e.g. if the solution is cloudy, contains particles or has changed colour.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. Package Contents and Additional Information

Composition of Firazyr

The active ingredient is icatibant. Each pre-filled syringe contains 30 milligrams of icatibant (as acetate). The other components are sodium chloride, glacial acetic acid, sodium hydroxide, and water for injectable preparations.

Appearance of Firazyr and Package Contents

Firazyr is presented as a clear and colorless injectable solution in a 3 ml pre-filled glass syringe.

The package contains a hypodermic needle.

Firazyr is available in a single-pack unit of one pre-filled syringe with one needle or in a multi-pack unit of three pre-filled syringes with three needles.

Only some pack sizes may be marketed.

Marketing Authorization Holder

Shire Pharmaceutical Ireland Limited

Block 2 & 3 Miesian Plaza

50 – 58 Baggot Street Lower

Dublin 2

D02 Y754, Ireland

Tel: +44(0)1256 894 959 E-mail: [email protected]

Date of the Last Revision of this Leaflet:

Other Sources of Information

Detailed information on this medicinal product is available on the European Medicines Agency website: http://www.ema.europa.eu. It also provides links to other websites on rare diseases and orphan medicines.

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2

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Choose a specialist or we'll match you with the next available doctor.

3

Doctor reviews your case

Usually within 30 minutes. They may ask follow-up questions via chat.

4

Collect from any pharmacy

Electronic prescription sent to your email — valid across Spain.

Frequently Asked Questions

Is a prescription required for FIRAZYR 30 mg SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE?

FIRAZYR 30 mg SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

What is the active substance in FIRAZYR 30 mg SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE?

The active ingredient in FIRAZYR 30 mg SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE is icatibant. This information helps identify medicines with the same composition but different brand names.

Who manufactures FIRAZYR 30 mg SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE?

FIRAZYR 30 mg SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE is manufactured by Takeda Pharmaceuticals International Ag Ireland Branch. Pharmacy brands and packaging may differ depending on the distributor.

Which doctors can assess the use of FIRAZYR 30 mg SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE online?

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether FIRAZYR 30 mg SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

How to buy FIRAZYR 30 mg SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE in Spain?

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy FIRAZYR 30 mg SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

What are the alternatives to FIRAZYR 30 mg SOLUTION FOR INJECTION IN PRE-FILLED SYRINGE?

Other medicines with the same active substance (icatibant) include ICATIBANT ACCORD 30 mg Injectable Solution in Pre-filled Syringe, ICATIBANTO AGUETTANT 30 mg Injectable Solution in Pre-filled Syringe EFG, ICATIBANTO CIPLA 30 mg Injectable Solution in Pre-filled Syringe. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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