Bg pattern

BUPIVACAINE PHYSAN 5 mg/ml INJECTABLE SOLUTION

Prescription review online

Prescription review online

A doctor will review your case and decide whether a prescription is medically appropriate.

Talk to a doctor about this medicine

Talk to a doctor about this medicine

Discuss your symptoms and possible next steps in a quick online consultation.

This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use BUPIVACAINE PHYSAN 5 mg/ml INJECTABLE SOLUTION

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

Show original

Introduction

Package Leaflet: Information for the User

Bupivacaine Physan 5 mg/ml Solution for Injection

Bupivacaine Hydrochloride

Read all of this leaflet carefully before you start using this medicine because it contains important information for you

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor, pharmacist, or nurse.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor, pharmacist, or nurse. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack:

  1. What Bupivacaine Physan 5 mg/ml is and what it is used for
  2. What you need to know before you use Bupivacaine Physan 5 mg/ml
  3. How to use Bupivacaine Physan 5 mg/ml
  4. Possible side effects
  5. Storage of Bupivacaine Physan 5 mg/ml
  6. Contents of the pack and other information

1. What Bupivacaine Physan 5 mg/ml is and what it is used for

This medicine contains bupivacaine hydrochloride, a local anesthetic (an agent that reduces or eliminates sensations, affecting a particular region) belonging to the amide subgroup.

It has been prescribed for you to provide an anesthetic effect.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you use Bupivacaine Physan 5 mg/ml

Do not use Bupivacaine Physan 5 mg/ml:

  • If you are allergic to bupivacaine hydrochloride or any of the other ingredients of this medicine (listed in section 6).
  • If you are allergic to any other local anesthetic of the same group (e.g., articaine, mepivacaine, lidocaine, or prilocaine).
  • If it is used as regional intravenous anesthesia (Bier block), as the unintended passage of bupivacaine into the bloodstream may lead to acute systemic toxicity reactions.
  • If you have any of the following conditions, epidural anesthesia should not be performed:
  • Pre-existing central nervous system disease due to infection, tumors, or other causes.
  • Spinal deformity and active disease (e.g., spondylitis, tumor, tuberculosis) or recent injury (e.g., fracture) of the spine.
  • Skin infection at the injection site or nearby.
  • Cardiovascular disease, especially heart block or hypovolemic shock.
  • Coagulation disorders or ongoing anticoagulant treatment.

Warnings and precautions

Consult your doctor before starting to use Bupivacaine Physan 5 mg/ml:

  • If you have any type of heart block
  • If you have heart rhythm disturbances
  • If you have low blood pressure
  • If you have bleeding
  • If you have any type of infection
  • If you have liver or kidney disorders.

Children

Bupivacaine should be used with caution in children from 1 to 12 years old, as they have a higher probability of systemic toxicity.

Other medicines and Bupivacaine Physan 5 mg/ml

Tell your doctor or pharmacist if you are using or have recently used or might use any other medicines, including those obtained without a prescription.

Bupivacaine should be used with caution in patients receiving treatment with agents structurally similar to amide-type local anesthetics, as an increase in systemic toxic effects may occur.

Tell your doctor if you are taking any of the following medicines, as they may alter the effects of Bupivacaine Physan 5 mg/ml:

  • Anticoagulants, such as heparin.
  • Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, to combat inflammation, pain, or fever.
  • Plasma substitutes (dextran).

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.

Pregnancy

If you are pregnant, your doctor will prescribe Bupivacaine Physan 5 mg/ml, taking into account the benefit to you and the risk to your baby.

Breastfeeding

Bupivacaine is excreted in breast milk, but at therapeutic doses of this medicine, no effects are expected in breastfed infants.

Driving and using machines

Bupivacaine Physan 5 mg/ml may temporarily affect your ability to move, attention, and coordination. Your doctor will indicate if you can drive or use machines.

Bupivacaine Physan 5 mg/ml contains sodium

This medicine contains 31.5 mg of sodium (a major component of table/cooking salt) per 10 ml ampoule. This is equivalent to 1.58% of the maximum daily sodium intake recommended for an adult.

3. How to use Bupivacaine Physan 5 mg/ml

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

This medicine should only be administered under the supervision of a doctor with experience in the use of this type of medicine.

This medicine is administered by injection through infiltration, subcutaneously, intramuscularly, epidurally, intra-articularly, perineurally, periosteally, and retrobulbarly.

The dose, rate of administration, and duration of treatment will vary depending on the anesthetic procedure, the area to be anesthetized, and the patient's weight, clinical situation, and response.

If you are given more Bupivacaine Physan 5 mg/ml than you should

As with other local anesthetics, due to excessive dosing, rapid absorption, or accidental injection into blood vessels, symptoms of intoxication may occur, which can manifest:

  • On the central nervous system:

Characterized by tingling, numbness of the tongue, slight fainting, ringing in the ears, blurred vision, and muscle tremors. Then, convulsions and loss of consciousness may appear, followed by breathing problems.

  • On the cardiovascular system:

Low blood pressure (hypotension), decreased heart rate, arrhythmia, and cardiac arrest.

If toxic effects occur, the first measure is to stop the administration of the local anesthetic. The subsequent treatment consists of stopping the convulsions and ensuring adequate breathing with oxygen, if necessary by assisted breathing. If convulsions occur, they can be treated with 100-150 mg of thiopental i.v. or 5-10 mg of diazepam i.v. If hypotension exists, a vasopressor should be administered intravenously, for example, 5-10 mg of ephedrine. If cardiac arrest occurs, cardiopulmonary resuscitation should be applied immediately, and 0.1-0.2 mg of adrenaline should be administered as soon as possible intravenously or intracardially. If cardiac arrest appears, prolonged resuscitation efforts should be applied.

In case of overdose or accidental administration, consult your doctor or pharmacist immediately or call the Toxicology Information Service. Tel. 91 5620420, indicating the medicine and the amount administered.

4. Possible side effects

Like all medicines, Bupivacaine Physan 5 mg/ml can cause side effects, although not everybody gets them.

The side effects you may experience can be classified by frequency as:

  • Very common (may affect more than 1 in 10 people): decrease in blood pressure and nausea.
  • Common (may affect up to 1 in 10 people): tingling, dizziness, decreased heart rate, increased blood pressure, vomiting, urinary retention.
  • Uncommon (may affect up to 1 in 100 people): convulsions, tingling around the mouth, numbness of the tongue, increased hearing sensitivity, visual disturbances, loss of consciousness, tremors, mild headache, ringing in the ears, difficulty speaking correctly.
  • Rare (may affect up to 1 in 1,000 people): allergic reactions, anaphylactic shock, nervous system disorders, double vision, cardiac arrest, arrhythmias, and breathing difficulties.

Reporting of side effects

If you experience any side effects, talk to your doctor, even if it is possible side effects not listed in this leaflet. You can also report side effects directly through the Spanish Medicines and Health Products Agency's website www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Bupivacaine Physan 5 mg/ml

Keep this medicine out of the sight and reach of children.

Do not store above 25°C. Do not freeze.

Do not use this medicine after the expiry date stated on the ampoule and carton. The expiry date is the last day of the month stated.

The solutions do not contain preservatives and should be used immediately after opening. Any remaining solution should be discarded.

Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. Contents of the pack and other information

Composition of Bupivacaine Physan 2.5 mg/ml

  • The active ingredient is bupivacaine hydrochloride. One ml contains 2.5 mg of bupivacaine hydrochloride. Each 10 ml ampoule contains 25 mg of bupivacaine hydrochloride.
  • The other ingredients are: sodium chloride, sodium hydroxide (E-524) and/or hydrochloric acid (for pH adjustment) and water for injections.

Appearance and packaging

Bupivacaine Physan 2.5 mg/ml is packaged in glass ampoules.

This medicine is presented in clinical packs containing 50 ampoules or 100 ampoules of 10 ml glass.

Not all pack sizes may be marketed.

Marketing authorization holder

LAPHYSAN S.A.U.

Anabel Segura, 11 Edificio A, Planta 4, Puerta D,

28108 Alcobendas

MADRID. SPAIN

Manufacturer

LABORATORIOS BASI – INDUSTRIA FARMACÉUTICA, S.A.

Parque Industrial Manuel Lourenço Ferreira,

Nº 8, Nº 15 y Nº 16

3450-232 Mortágua - Portugal

This information is intended only for healthcare professionals

The solutions should be used immediately after opening. Any remaining solution should be discarded.

Precautions should be taken to prevent acute toxicity reactions, avoiding intravascular injection. Aspiration before and during administration is recommended. Accidental intravascular injection can be detected by a temporary increase in heart rate. The maximum dose should be administered very slowly, at a rate of 25-50 mg/min, or in dose increments, maintaining constant verbal contact with the patient. If symptoms of toxicity appear, administration should be stopped immediately.

Regional or local anesthesia procedures, except for those of a trivial nature, should always be performed by properly trained professionals and in areas with immediate access to resuscitation equipment and medicines. When performing major blocks, an intravascular catheter should be inserted beforehand at the injection site of the local anesthetic. Doctors should receive adequate training according to the procedure they will perform and be familiar with the diagnosis and treatment of side effects, systemic toxicity, and other complications.

In any case, and considering that the dosage should be calculated based on several factors, we recommend consulting the information provided in the Technical Sheet before using this medicine.

Incompatibilities

Bupivacaine has limited solubility at a pH above 6.5. This should be taken into account in case alkaline solutions (e.g., carbonates) need to be added, as precipitation may occur.

Last revision of the leaflet: October 2020

Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.es/

Online doctors for BUPIVACAINE PHYSAN 5 mg/ml INJECTABLE SOLUTION

Discuss questions about BUPIVACAINE PHYSAN 5 mg/ml INJECTABLE SOLUTION, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

5.0 (180)
Doctor

Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

Camera Book a video appointment
€50
0.0 (17)
Doctor

Daniel Cichi

Family medicine 24 years exp.

Dr Daniel Cichi is a family medicine doctor with over 20 years of clinical experience. He provides online consultations for adults, supporting patients with acute symptoms, chronic conditions, and everyday health concerns that require timely medical guidance. His background includes work in emergency care, ambulance services, and family medicine, which allows him to assess symptoms quickly, identify warning signs, and help patients choose the safest next steps – whether that means home care, treatment adjustment, or in-person evaluation. Patients commonly consult Dr Daniel Cichi for: 

  • acute symptoms: fever, infections, flu-like illness, cough, sore throat, shortness of breath;
  • chest discomfort, palpitations, dizziness, fatigue, and blood pressure concerns;
  • digestive problems: abdominal pain, nausea, diarrhoea, constipation, reflux;
  • sexually transmitted infections, erectile dysfunction;
  • muscle, joint, and back pain, minor injuries, post-traumatic symptoms;
  • chronic conditions: hypertension, diabetes, high cholesterol, thyroid disorders, weight loss, hair loss;
  • review and interpretation of lab tests, imaging reports, and medical documents;
  • medication review and treatment adjustment;
  • medical advice while travelling or living abroad;
  • second opinions and guidance on whether in-person care is needed.

Dr Cichi’s consultations are structured and practical. He focuses on clear explanations, risk assessment, and actionable recommendations, helping patients understand their symptoms and make informed decisions about their health.

Camera Book a video appointment
€55
0.0 (0)
Doctor

Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
Camera Book a video appointment
€58
0.0 (0)
Doctor

Pedro Alvarez Guerrero

Psychiatry 8 years exp.

Dr. Alvarez Guerrero graduated in Medicine from the San Pablo CEU University in Madrid. He subsequently completed his specialization in Psychiatry in the Department of Psychiatry at Hospital Sant Joan de Deu in Manresa (Barcelona), where over the course of four years he acquired solid training in the bio-psycho-social model, developing his expertise across the different areas of mental health.

During his residency, he undertook training placements at Hospital Clínic de Barcelona, where he trained for several months in the psychiatric consultation-liaison unit. He also completed another placement at Hospital de Cruces in Bilbao, in the first-episode psychosis unit.

Throughout his professional career, Dr. Alvarez Guerrero has sought to complement his medical training with psychotherapeutic tools that allow him to address mental health disorders from a comprehensive perspective. For this reason, he specialized in Brief Strategic Psychotherapy through the Spanish Society of Psychosomatic Medicine and Psychotherapy, an approach focused on targeted and effective interventions.

With the aim of deepening his knowledge and promoting the rational use of treatments, he also completed a Master’s Degree in Psychopharmacology at the University of Valencia, which has enabled him to rigorously integrate the most up-to-date scientific evidence into the clinical management of psychopharmacological treatments.

He has also shown a particular interest in the field of legal psychiatry, completing an Official Master’s Degree in Legal, Forensic and Criminological Psychopathology at the Universitat Internacional de Catalunya. This training has allowed him to acquire the necessary competencies for the preparation of psychiatric expert reports in judicial and medico-legal contexts, thereby broadening the scope of his professional activity.

Camera Book a video appointment
€130
5.0 (5)
Doctor

Tomasz Grzelewski

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques. For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance. Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults. In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions. Patients commonly seek his care for: 

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
  • urticaria, atopic dermatitis and skin reactions
  • recurrent infections in children
  • sports-related health questions
  • general family medicine concerns

Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.

Camera Book a video appointment
€80

Frequently Asked Questions

Is a prescription required for BUPIVACAINE PHYSAN 5 mg/ml INJECTABLE SOLUTION?
BUPIVACAINE PHYSAN 5 mg/ml INJECTABLE SOLUTION requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in BUPIVACAINE PHYSAN 5 mg/ml INJECTABLE SOLUTION?
The active ingredient in BUPIVACAINE PHYSAN 5 mg/ml INJECTABLE SOLUTION is bupivacaine. This information helps identify medicines with the same composition but different brand names.
Who manufactures BUPIVACAINE PHYSAN 5 mg/ml INJECTABLE SOLUTION?
BUPIVACAINE PHYSAN 5 mg/ml INJECTABLE SOLUTION is manufactured by Laphysan S.A.U.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of BUPIVACAINE PHYSAN 5 mg/ml INJECTABLE SOLUTION online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether BUPIVACAINE PHYSAN 5 mg/ml INJECTABLE SOLUTION is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to BUPIVACAINE PHYSAN 5 mg/ml INJECTABLE SOLUTION?
Other medicines with the same active substance (bupivacaine) include BUPIVACAINE AUROVITAS 2.5 mg/ml INJECTABLE SOLUTION, BUPIVACAINE AUROVITAS 5 mg/ml INJECTABLE SOLUTION, BUPIVACAINE B. BRAUN 5 mg/ml INJECTABLE SOLUTION. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
bg-pattern-dark

Stay informed about Oladoctor

News about new services, product updates and useful information for patients.

Follow us on social media