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BENERVA 100 mg/ml INJECTABLE SOLUTION

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Doctor

Rita Isabel Calero Garcia

General medicine 2 years exp.

Dr. Rita Isabel Calero Garcia is a physician with extensive experience in emergency medical care, general medicine, and healthcare assistance in various clinical and out-of-hospital settings.

She currently works as a physician at the Canary Islands Emergency Service (Servicio de Urgencias Canario – SUC), where she is responsible for the assessment and care of patients in medical emergency situations, performing the initial diagnosis, patient stabilization, and coordination with hospital services when necessary.

She has also developed her professional activity within the Primary Care Management Service, providing consultations in general medicine. In this setting she is responsible for patient follow-up, management of acute and chronic conditions, as well as health promotion and disease prevention.

She has also worked as a physician in a mobile ICU unit, providing medical assistance in out-of-hospital emergencies, treating critical patients and participating in medicalized patient transport.

In addition, she has collaborated with the Red Cross, participating in healthcare support units, providing medical assistance at events and supporting emergency interventions.

Furthermore, she has provided medical services in the private sector with Salvaser, conducting clinical assessments of patients and providing healthcare services within private medical services.

This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use BENERVA 100 mg/ml INJECTABLE SOLUTION

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Patient Information Leaflet

BENERVA 100 mg/ml injectable solution

Thiamine hydrochloride

Read this leaflet carefully before starting to use this medicine, as it contains important information for you.

  • Keep this leaflet, as you may need to read it again.
  • If you have any questions, ask your doctor or pharmacist.
  • This medicine has been prescribed to you only, and you should not give it to others, even if they have the same symptoms as you, as it may harm them.
  • If you experience side effects, consult your doctor or pharmacist, even if they are not listed in this leaflet. See section 4.

Contents of the leaflet

  1. What Benerva injectable solution is and what it is used for
  2. What you need to know before using Benerva injectable solution
  3. How to use Benerva injectable solution
  4. Possible side effects
  5. Storage of Benerva injectable solution
  6. Package contents and additional information

1. What Benerva injectable solution is and what it is used for

Benerva contains thiamine (vitamin B1), a water-soluble vitamin that plays a role in many human metabolic processes, mainly carbohydrate metabolism.

It is indicated in adults for:

Prevention and treatment of vitamin B1 deficiency due to increased requirements, reduced intake, or reduced absorption.

Situations often accompanied by vitamin B1 deficiency and requiring supplementation include:

  • Regular excessive alcohol consumption.
  • Prolonged infection.
  • Intestinal diseases, such as celiac disease or persistent diarrhea.
  • High carbohydrate intake.
  • Poor nutritional status.

Treatment of beriberi (characterized by intense fatigue and slow movement, affecting mainly the nervous and cardiovascular systems), Wernicke's disease (affecting the nervous system), and Korsakoff's syndrome (caused by excessive alcohol consumption, with effects on the brain).

Doctor consultation

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2. What you need to know before using Benerva injectable solution

Do not use Benerva

  • if you are allergic to thiamine (vitamin B1) or any of the other components of this medicine (listed in section 6).

Warnings and precautions

Consult your doctor or pharmacist before starting to use Benerva injectable solution.

The risk of hypersensitivity reactions increases with repeated intravenous or intramuscular administration of thiamine. Therefore, when possible, oral administration is recommended. In this case, another medicine with the active ingredient administered orally would be preferable.

Administer intravenously only by a healthcare professional. The administration of the product and the handling of needles must be done with caution.

If you have previously suffered from an allergy to vitamin B1 on skin contact (contact dermatitis) for professional reasons, for example, you may experience a relapse when treated with this medicine.

Interference with laboratory tests: If you are going to undergo any diagnostic test (including blood, urine, etc.), inform your doctor that you are being treated with this medicine, as it may alter the results. In some determinations of uric acid, urobilinogen, or theophylline, false results may occur.

Children

Do not use this medicine in children, as there is no data available for them.

Other medicines and Benerva injectable solution

Inform your doctor or pharmacist if you are taking/using, have recently taken/used, or may need to take/use any other medicine.

Benerva injectable solution may interact with the following medicines:

  • 5-Fluorouracil and capecitabine (for certain types of cancer)
  • Tegafur (for certain types of cancer).

Pregnancy, breastfeeding, and fertility

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor before using this medicine.

It is not recommended to use Benerva injectable solution if you are pregnant or breastfeeding.

This medicine is not recommended for women of childbearing age who do not use an effective contraceptive method.

Driving and using machines

The influence of this medicine on the ability to drive and use machines is negligible.

Benerva injectable solution contains sodium

This medicine contains less than 1 mmol of sodium (23 mg) per ml of injectable solution; it is essentially "sodium-free".

3. How to use Benerva injectable solution

Follow exactly the administration instructions of this medicine indicated by your doctor.

In case of doubt, consult your doctor again.

Intramuscularly, or by slow intravenous injection or short-duration perfusion.

The contents of the ampoule should not be mixed with any other parenteral product or injection fluid. The injection should be administered by a qualified healthcare professional.

The recommended dose is:

  • Adults:

50 mg (half an ampoule) of vitamin B1 should be administered daily by intramuscular injection for several days when absorption is significantly affected and also for the treatment of Wernicke-Korsakoff syndrome and beriberi.

For the initial treatment of vitamin B1 deficiency or severe hypovitaminosis B1, the initial daily dose may be 100 mg or up to 200 mg by parenteral route, for example, intramuscularly or by slow intravenous injection or even by short-duration perfusion, to achieve an adequate blood concentration of vitamin B1 as quickly as possible.

For Wernicke-Korsakoff syndrome due to alcohol abuse, the usual dose is 100 mg by intravenous injection followed by 50-100 mg by intramuscular injection daily until the patient consumes a balanced diet.

For emergency treatment, 100 mg (or 200 mg if necessary, or up to 1000 mg in the first 12 hours if necessary) by slow intravenous injection daily for three days.

Intramuscular administration can be used if intravenous administration is not possible. Treatment can be continued with 100 mg of thiamine orally.

If you use more Benerva injectable solution than you should

Rapid intravenous administration and multiple and/or high doses increase the likelihood of adverse reactions, such as anaphylactoid reactions and injection site reactions.

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or go to a medical center, or call the Toxicology Information Service, Telephone 91 562 04 20, indicating the medicine and the amount ingested.

If you forget to use Benerva

Do not use a double dose to make up for forgotten doses.

If you have any other questions about the use of this medicine, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

As these reactions are reported voluntarily, it is not possible to estimate their frequency.

The following have been reported:

Injection site reactions: frequently (may affect up to 1 in 10 people), pain at the injection site after rapid intravenous injection; this reaction can be avoided by slow administration.

Allergic or anaphylactic reactions, hypersensitivity reactions with their respective clinical and laboratory manifestations, including asthmatic syndrome, mild to moderate skin and/or respiratory tract reactions, gastrointestinal tract and/or cardiovascular system reactions, have been reported after intravenous, intramuscular, or subcutaneous injection of thiamine. Symptoms that may include rash, itching, urticaria, angioedema, and cardio-respiratory difficulty, as well as severe reactions including anaphylactic shock, have been communicated.

If an allergic reaction occurs, treatment should be discontinued and a healthcare professional consulted.

Contact dermatitis in predisposed patients.

Reporting of side effects

If you experience any side effects, consult your doctor or pharmacist, even if they are not listed in this leaflet. You can also report them directly through the Spanish Medicines and Health Products Agency's website www.notificaRAM.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Benerva injectable solution

Keep this medicine out of the sight and reach of children.

Do not store above 25°C.

Do not use this medicine after the expiry date stated on the label and carton after EXP. The expiry date is the last day of the month indicated.

Do not use this medicine if you notice visible particles, the solution is not transparent, or the container is damaged.

Medicines should not be disposed of via wastewater or household waste. Place the containers and medicines you no longer need in the pharmacy's SIGRE point. Ask your pharmacist how to dispose of the containers and medicines you no longer need. This will help protect the environment.

6. Package contents and additional information

Composition of Benerva injectable solution

  • The active ingredient is thiamine hydrochloride (Vitamin B1).

Each 1 ml ampoule contains 100 mg of thiamine hydrochloride.

  • The other ingredients (excipients) are: glycerol, phenol, sodium phosphate, sodium hydrogen carbonate, and water for injectable preparations.

Appearance and package contents

Injectable solution, transparent, colorless or slightly yellowish, contained in 1 ml glass ampoules.

6 and 10 ampoules of 1 ml.

  • Other presentations

Benerva 300 mg film-coated tablets

Marketing authorization holder and manufacturer

Marketing authorization holder

TEOFARMA Srl

Via F.lli Cervi, 8

27010 Valle Salimbene (PV) – Italy

Manufacturer

CENEXI SAS

Rue Marcel et Jacques Gaucher, 52 - Fontenay Sous Bois

F-94120 – France

Date of last revision of this leaflet:April 2018.

Detailed information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es/

Online doctors for BENERVA 100 mg/ml INJECTABLE SOLUTION

Discuss questions about BENERVA 100 mg/ml INJECTABLE SOLUTION, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Doctor

Rita Isabel Calero Garcia

General medicine 2 years exp.

Dr. Rita Isabel Calero Garcia is a physician with extensive experience in emergency medical care, general medicine, and healthcare assistance in various clinical and out-of-hospital settings.

She currently works as a physician at the Canary Islands Emergency Service (Servicio de Urgencias Canario – SUC), where she is responsible for the assessment and care of patients in medical emergency situations, performing the initial diagnosis, patient stabilization, and coordination with hospital services when necessary.

She has also developed her professional activity within the Primary Care Management Service, providing consultations in general medicine. In this setting she is responsible for patient follow-up, management of acute and chronic conditions, as well as health promotion and disease prevention.

She has also worked as a physician in a mobile ICU unit, providing medical assistance in out-of-hospital emergencies, treating critical patients and participating in medicalized patient transport.

In addition, she has collaborated with the Red Cross, participating in healthcare support units, providing medical assistance at events and supporting emergency interventions.

Furthermore, she has provided medical services in the private sector with Salvaser, conducting clinical assessments of patients and providing healthcare services within private medical services.

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Doctor

Joao Silva

General medicine 6 years exp.

Dr. João Silva is a physician with training and experience in the field of General and Family Medicine, dedicated to providing healthcare focused on the well-being and quality of life of his patients. Throughout his professional career, he has developed broad clinical competencies, striving to maintain a medical practice based on scientific evidence and continuous knowledge updates.

Between 2013 and 2019, he completed the Integrated Master's Degree in Medicine at the Abel Salazar Institute of Biomedical Sciences in Porto, where he acquired a solid academic and clinical education.

Subsequently, between January 2021 and December 2021, he completed the General Internship at the Entre Douro e Vouga Hospital Center in Santa Maria da Feira, where he had the opportunity to work in different hospital settings and deepen his competencies in several areas of medicine.

From January 2022 until March 2026, he works as a Resident Physician in General and Family Medicine at USF Salvador Machado in Oliveira de Azeméis, developing clinical activities in primary healthcare, follow-up of chronic patients, and health promotion in the community.

Complementing his medical training, Dr. João Silva also completed a Postgraduate Degree in Continuing and Palliative Care at CESPU, strengthening his preparation in the comprehensive approach to patient care, especially in situations requiring prolonged care and multidisciplinary support.

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Chikeluo Okeke

General medicine 4 years exp.

Dr Chikeluo Okeke is an internal medicine doctor with extensive international clinical experience. Originally from Nigeria, he has worked across multiple European healthcare systems and currently practises in Sweden. This professional path has given him a strong understanding of different medical approaches and the ability to work effectively with patients from diverse cultural and linguistic backgrounds.

Dr Okeke focuses on general internal medicine and adult primary care, combining clinical accuracy with careful attention to lifestyle, personal context, and everyday health concerns. His consultations are particularly well suited for people who seek medical advice online, live abroad, or need clear guidance without unnecessary complexity.

He provides online consultations covering symptom assessment, prevention, and long-term management of chronic conditions, helping patients understand what is happening and decide on appropriate next steps.

Common reasons for consultation:

  • General internal medicine concerns and initial health assessment.
  • Acute symptoms such as fever, cough, infections, pain, or weakness.
  • Chronic conditions and treatment adjustment.
  • Blood pressure issues, fatigue, metabolic concerns.
  • Preventive consultations and routine check-ups.
  • Interpretation of laboratory results and medical reports.
  • Medical advice for patients receiving care online.

Dr Okeke is known for his clear communication, calm approach, and cultural awareness. He listens carefully, explains medical decisions in a structured way, and supports patients in making informed choices about their health.

Online consultations with Dr Chikeluo Okeke offer reliable internal medicine care without geographic limitations, focused on medical relevance, clarity, and patient comfort.

5.0 (194)
Doctor

Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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Doctor

Daniel Cichi

Family medicine 24 years exp.

Dr Daniel Cichi is a family medicine doctor with over 20 years of clinical experience. He provides online consultations for adults, supporting patients with acute symptoms, chronic conditions, and everyday health concerns that require timely medical guidance. His background includes work in emergency care, ambulance services, and family medicine, which allows him to assess symptoms quickly, identify warning signs, and help patients choose the safest next steps – whether that means home care, treatment adjustment, or in-person evaluation. Patients commonly consult Dr Daniel Cichi for: 

  • acute symptoms: fever, infections, flu-like illness, cough, sore throat, shortness of breath;
  • chest discomfort, palpitations, dizziness, fatigue, and blood pressure concerns;
  • digestive problems: abdominal pain, nausea, diarrhoea, constipation, reflux;
  • sexually transmitted infections, erectile dysfunction;
  • muscle, joint, and back pain, minor injuries, post-traumatic symptoms;
  • chronic conditions: hypertension, diabetes, high cholesterol, thyroid disorders, weight loss, hair loss;
  • review and interpretation of lab tests, imaging reports, and medical documents;
  • medication review and treatment adjustment;
  • medical advice while travelling or living abroad;
  • second opinions and guidance on whether in-person care is needed.

Dr Cichi’s consultations are structured and practical. He focuses on clear explanations, risk assessment, and actionable recommendations, helping patients understand their symptoms and make informed decisions about their health.

5.0 (71)
Doctor

Lina Travkina

Family medicine 13 years exp.

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.
  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.
  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.
  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.
  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.
  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.
  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.
  • Medical advice and follow-up consultations.
  • Test interpretation and diagnostic guidance.
  • Structured support for undiagnosed complaints.
  • Second opinion on diagnoses and treatment plans.
  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.
  • Post-operative recovery support and pain management.
  • Preconception counselling and postpartum support.
  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

5.0 (52)
Doctor

Anna Biriukova

General medicine 6 years exp.

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

  • High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
  • Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
  • Leg swelling, chronic fatigue, reduced exercise tolerance.
  • EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
  • Post-COVID-19 cardiac monitoring and care.
Endocrinology – Diabetes, thyroid, metabolism:
  • Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
  • Individual treatment plans including oral medications and insulin therapy.
  • GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
  • Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
  • Metabolic syndrome – obesity, lipid disorders, insulin resistance.
Gastroenterology – Digestive health:
  • Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
  • Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
  • Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).
General internal medicine and preventive care:
  • Respiratory infections – cough, colds, bronchitis.
  • Lab test analysis, therapy adjustments, medication management.
  • Adult vaccinations – planning, contraindications assessment.
  • Cancer prevention – screening strategies and risk assessment.
  • Holistic approach – symptom relief, complication prevention, and quality of life improvement.
Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.

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Frequently Asked Questions

Is a prescription required for BENERVA 100 mg/ml INJECTABLE SOLUTION?

BENERVA 100 mg/ml INJECTABLE SOLUTION requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

What is the active substance in BENERVA 100 mg/ml INJECTABLE SOLUTION?

The active ingredient in BENERVA 100 mg/ml INJECTABLE SOLUTION is thiamine (vit B1). This information helps identify medicines with the same composition but different brand names.

How much does BENERVA 100 mg/ml INJECTABLE SOLUTION cost in pharmacies?

The average pharmacy price for BENERVA 100 mg/ml INJECTABLE SOLUTION is around 6.35 EUR. Prices may vary depending on the manufacturer and dosage form.

Who manufactures BENERVA 100 mg/ml INJECTABLE SOLUTION?

BENERVA 100 mg/ml INJECTABLE SOLUTION is manufactured by Teofarma S.R.L.. Pharmacy brands and packaging may differ depending on the distributor.

Which doctors can assess the use of BENERVA 100 mg/ml INJECTABLE SOLUTION online?

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether BENERVA 100 mg/ml INJECTABLE SOLUTION is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

How to buy BENERVA 100 mg/ml INJECTABLE SOLUTION in Spain?

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy BENERVA 100 mg/ml INJECTABLE SOLUTION in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

What are the alternatives to BENERVA 100 mg/ml INJECTABLE SOLUTION?

Other medicines with the same active substance (thiamine (vit B1)) include BENERVA 300 mg FILM-COATED TABLETS, MELGAMA 300 MG FILM-COATED TABLETS, SURMENALIT 200 mg FILM-COATED TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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