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ALLUZIENCE 200 Units/mL Injectable Solution

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About the medicine

How to use ALLUZIENCE 200 Units/mL Injectable Solution

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Leaflet: information for the patient user

Alluzience, 200 units Speywood/ml, injectable solution

Botulinum toxin type A from Clostridium botulinum– hemagglutinin complex

Read the entire leaflet carefully before starting to use this medicine, as it contains important information for you.

  • Keep this leaflet, as you may need to read it again.
  • If you have any questions, consult your doctor.
  • If you experience side effects, consult your doctor, even if they are not listed in this leaflet. See section 4.

Contents of the leaflet

  1. What is Alluzience and what is it used for
  2. What you need to know before starting to use Alluzience
  3. How to use Alluzience
  4. Possible side effects
  5. Storage of Alluzience
  6. Contents of the pack and further information

1. What is Alluzience and what is it used for

Alluzience contains a substance, botulinum toxin A, which causes muscles to relax. Alluzience acts on the connection between nerves and muscles, blocking the release of a chemical messenger called acetylcholine at the nerve endings. This phenomenon prevents muscle contraction. Muscle relaxation is temporary and gradually recovers.

Some people feel unwell when wrinkles appear on their face. Alluzience can be used in adults under 65 years of age for the temporary improvement of the appearance of moderate to severe glabellar lines (vertical expression lines between the eyebrows).

Doctor consultation

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Discuss your symptoms and treatment with a doctor online.

2. What you need to know before using Alluzience

Do not use Alluzience:

  • if you are allergic to botulinum toxin A or any of the other components of this medicine (listed in section 6).
  • if you have an infection at the sites where you plan to inject.
  • if you have severe myasthenia, Eaton-Lambert syndrome, or amyotrophic lateral sclerosis.

Warnings and precautions

Consult your doctor before starting to use this medicine:

  • if you have any neuromuscular disorder
  • if you often have difficulty swallowing (dysphagia)
  • if you often have problems with food or drink entering your airways, causing choking or coughing
  • if you have any inflammation at the proposed injection site
  • if the muscles where you will be injected are weak or show signs of atrophy
  • if you have any coagulation disorder, which means you may bleed more than normal, such as hemophilia (hereditary bleeding disorder caused by coagulation factor deficiencies)
  • if you have undergone or will undergo facial surgery or other surgery
  • if you did not experience any improvement in your glabellar lines after your last treatment with botulinum toxin

This information will help your doctor make a decision about the risks and benefits of your treatment.

Special precautions:

Very rare side effects have been reported with botulinum toxin, possibly related to the spread of the toxin effect to areas away from the injection site (e.g., muscle weakness, difficulty swallowing, or unwanted food or liquids in the airways). Seek medical attention immediately if you have difficulty swallowing, speaking, or breathing.

When using Alluzience in the muscles around the eye, your eyes may become dry, which can damage the surface of your eyes. To avoid this, you may need treatment with protective drops, ointments, or a protective cover that closes the eye. Your doctor will tell you if this is necessary.

When botulinum toxin has been used at more frequent intervals of 3 months or at higher doses to treat other conditions, the production of antibodies has been observed infrequently. The formation of neutralizing antibodies can reduce the effectiveness of treatment.

If you visit your doctor for any reason, make sure to inform them that you are being treated with Alluzience.

Children and adolescents

Alluzience is not indicated for patients under 18 years of age.

Other medicines and Alluzience

Tell your doctor if you are taking, have recently taken, or may take any other medicine. This is important because some of these medicines can increase the effect of Alluzience:

  • antibiotics to treat an infection (e.g., aminoglycosides such as gentamicin or amikacin), or
  • other muscle relaxants.

Pregnancy and breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor before using this medicine.

Alluzience should not be used during pregnancy or breastfeeding.

Driving and using machines

You may experience blurred vision or temporary muscle weakness after treatment with Alluzience. If this occurs, do not drive or use machines.

Alluzience contains sodium

This medicine contains less than 1 mmol of sodium (23 mg) per vial, which is essentially "sodium-free".

3. How to use Alluzience

Alluzience can only be administered by doctors with the necessary qualifications and experience in this treatment and who have the necessary equipment.

Your doctor will apply the injections. A vial of Alluzience should be used for a single patient and a single treatment session.

The recommended dose for glabellar lines is 50 units Speywood, administered as 10 units in each of the 5 injection sites on the forehead, at the top of the nose, and eyebrows.

The recommended doses in Speywood units are different from other botulinum toxin preparations.

The effect of the treatment should be noticeable a few days after the injection and can last up to 6 months.

Your doctor will decide on the appropriate interval between each treatment with Alluzience. This interval should not be less than 3 months.

Use in children and adolescents

Alluzience is not indicated for patients under 18 years of age.

If you use more Alluzience than you should

If you receive more Alluzience than necessary, other muscles different from those treated may begin to weaken. Excessive doses can cause paralysis of the respiratory muscles. This may not occur immediately. If these symptoms appear, inform your doctor as soon as possible.

In cases of overdose or accidental administration, call the Toxicology Information Service, phone 91 562 04 20 (indicating the medicine and the amount administered).

If you have any other questions about the use of this medicine, ask your doctor.

Medicine questions

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Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everyone gets them.

Very rarely (may affect up to 1 in 10,000 people), side effects have been reported with botulinum toxin in muscles other than those at the injection site. These effects include excessive muscle weakness, difficulty swallowing, coughing, and a feeling of choking when swallowing (if liquids or food enter the airways when trying to swallow, respiratory problems such as pneumonia can occur). If this happens, inform your doctor immediately.

Seek urgent medical attention if:

  • You experience difficulty breathing, swallowing, or speaking
  • Your face swells or your skin turns red, or you have a rough rash with itching. You may be suffering an allergic reaction to Alluzience.

Tell your doctor if you experience any of these side effects:

Very common (may affect more than 1 in 10 people)

  • Headache
  • Reactions at the injection site (such as pain, tingling, bruising, redness, swelling, itching, rash, irritation, discomfort, stinging), generalized weakness, fatigue, and flu-like symptoms.

Common (may affect up to 1 in 10 people)

  • Temporary facial paralysis
  • Drooping of the upper eyelid, swelling of the eyelid, drooping of the eyebrow, eye fatigue, or decreased vision, dry eye, contraction of the muscles around the eye, tearing.

Uncommon (may affect up to 1 in 100 people)

  • Eyelid twitching, vision changes, blurred or double vision
  • Ocular allergy, hypersensitivity, rash.

Frequency not known (cannot be estimated from available data)

  • Numbness
  • Muscle mass loss

Reporting side effects:

If you experience any side effects, consult your doctor, even if they are not listed in this leaflet. You can also report them directly through the Spanish Medicines Monitoring System: https://www.notificaRAM.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Alluzience

Keep this medicine out of the sight and reach of children.

Do not use Alluzience after the expiration date stated on the label.

Store Alluzience in the refrigerator (2°C - 8°C). Do not freeze. Keep the vials in the original packaging to protect them from light.

After removing the vial from the refrigerator, it is recommended to let the vial reach room temperature. Alluzience can be stored at temperatures up to a maximum of 25°C for a single period of 12 hours without opening and protected from light. Alluzience should be discarded if not used within 12 hours after removal from refrigeration.

Once opened, the product must be used immediately.

6. Contents of the pack and further information

Composition of Alluzience

The active substance is botulinum toxin type A*, 200 units Speywood/ml. One vial contains 125 units Speywood in 0.625 ml of solution.

The other components are: L-histidine, sucrose, sodium chloride, polysorbate 80, hydrochloric acid, water for injectable preparations

*Botulinum toxin type A from Clostridium botulinum(a bacterium) – hemagglutinin complex.

The units of botulinum toxin are not interchangeable from one product to another. The recommended doses in Speywood units are different from other botulinum toxin preparations.

Appearance of the product and pack contents

Alluzience is an injectable solution. It comes in a single pack of 1 or 2 vials or in a multipack containing 6 single packs, each containing 2 vials. Not all pack sizes may be marketed.

Alluzience is a clear and colorless solution.

Marketing authorization holder and manufacturer

Marketing authorization holder:

Ipsen Pharma

65 quai Georges Gorse

92100 Boulogne-Billancourt

France

Manufacturer:

Ipsen Manufacturing Ireland Limited

Blanchardstown Industrial Park

Blanchardstown

Dublin 15

Ireland

You can request more information about this medicine by contacting the local representative of the Marketing Authorization Holder:

Local representative:

Laboratorios Galderma SA

Serrano Galvache, 56.

28033 Madrid - Spain

Phone: 902 02 75 95

Date of last revision of this leaflet:November 2022

Other sources of information

Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es/.

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This information is intended only for healthcare professionals:

Posology and method of administration:

See section 3 of the Patient Information Leaflet.

Special precautions for disposal and other handling

Instructions for use, handling, and disposal must be strictly followed.

RECOMMENDATIONS FOR THE DISPOSAL OF CONTAMINATED MATERIALS

Immediately after patient treatment, any unused Alluzience (in the vial or syringe) should be inactivated with a diluted sodium hypochlorite solution (bleach) (1% available chlorine).

Any spilled Alluzience should be cleaned with an absorbent cloth soaked in a diluted sodium hypochlorite solution.

Used vials, syringes, and materials should not be emptied and should be disposed of in appropriate containers and eliminated according to local requirements.

RECOMMENDATIONS IN CASE OF ACCIDENT DURING HANDLING OF BOTULINUM TOXIN

  • Any remaining product should be cleaned with a dry absorbent material.
  • Contaminated surfaces should be cleaned with an absorbent material soaked in a sodium hypochlorite solution (bleach) and then dried.
  • If a vial is broken, proceed as indicated above, carefully collecting the glass fragments and cleaning the product, avoiding cuts with the broken glass.
  • If the product comes into contact with the skin, wash the affected area with a sodium hypochlorite solution (bleach) and rinse with plenty of water.
  • If the product comes into contact with the eyes, rinse carefully with plenty of water or an eye cleaning solution.
  • If the product comes into contact with a wound, cut, or broken skin, rinse carefully with plenty of water and take appropriate medical measures according to the injected dose.

These instructions for use, handling, and disposal must be strictly followed.

Online doctors for ALLUZIENCE 200 Units/mL Injectable Solution

Discuss questions about ALLUZIENCE 200 Units/mL Injectable Solution, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Doctor

Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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€58
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Doctor

Chikeluo Okeke

General medicine 4 years exp.

Dr Chikeluo Okeke is an internal medicine doctor with extensive international clinical experience. Originally from Nigeria, he has worked across multiple European healthcare systems and currently practises in Sweden. This professional path has given him a strong understanding of different medical approaches and the ability to work effectively with patients from diverse cultural and linguistic backgrounds.

Dr Okeke focuses on general internal medicine and adult primary care, combining clinical accuracy with careful attention to lifestyle, personal context, and everyday health concerns. His consultations are particularly well suited for people who seek medical advice online, live abroad, or need clear guidance without unnecessary complexity.

He provides online consultations covering symptom assessment, prevention, and long-term management of chronic conditions, helping patients understand what is happening and decide on appropriate next steps.

Common reasons for consultation:

  • General internal medicine concerns and initial health assessment.
  • Acute symptoms such as fever, cough, infections, pain, or weakness.
  • Chronic conditions and treatment adjustment.
  • Blood pressure issues, fatigue, metabolic concerns.
  • Preventive consultations and routine check-ups.
  • Interpretation of laboratory results and medical reports.
  • Medical advice for patients receiving care online.

Dr Okeke is known for his clear communication, calm approach, and cultural awareness. He listens carefully, explains medical decisions in a structured way, and supports patients in making informed choices about their health.

Online consultations with Dr Chikeluo Okeke offer reliable internal medicine care without geographic limitations, focused on medical relevance, clarity, and patient comfort.

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Doctor

Andrei Popov

General medicine 7 years exp.

Dr. Andrei Popov is a family physician with specialized training in the management of chronic pain. He provides video consultations for adults in Spain and across Europe: whether you have been living with pain for months that no one has been able to properly explain, or you need to resolve a health issue without waiting weeks for an appointment.

His approach is clear: to listen, organize your case, and provide you with a practical roadmap based on evidence-based medicine and adapted to your medical history and personal needs.

Pain: how he can help

  • Chronic pain (more than 3 months
  • Migraine and recurrent or high-intensity headaches
  •  Neck, lower back, back and joint pain
  •  Post-traumatic pain after injuries or surgeries
  •  Pain of neurological origin: neuralgia, neuropathic pain, fibromyalgia

General medicine

  • Frequent respiratory infections (cold, flu, persistent cough)
  • Hypertension, diabetes and metabolic disorders
  • Review of laboratory tests and MRI/CT reports (explained in clear language)
  • Preventive medicine and health monitoring
  • Second opinions and treatment adjustments (when clinically appropriate)

What the consultation is like
 Each session lasts up to 30 minutes. We review symptoms, medical history, medications and any tests you provide, and you finish the consultation with a clear treatment plan, defined next steps, and criteria to understand when follow-up may be needed. If warning signs are detected, he will clearly advise whether you need in-person care or urgent medical attention.

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€80
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Doctor

Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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€50
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Doctor

Joao Silva

General medicine 6 years exp.

Dr. João Silva is a physician with training and experience in the field of General and Family Medicine, dedicated to providing healthcare focused on the well-being and quality of life of his patients. Throughout his professional career, he has developed broad clinical competencies, striving to maintain a medical practice based on scientific evidence and continuous knowledge updates.

Between 2013 and 2019, he completed the Integrated Master's Degree in Medicine at the Abel Salazar Institute of Biomedical Sciences in Porto, where he acquired a solid academic and clinical education.

Subsequently, between January 2021 and December 2021, he completed the General Internship at the Entre Douro e Vouga Hospital Center in Santa Maria da Feira, where he had the opportunity to work in different hospital settings and deepen his competencies in several areas of medicine.

From January 2022 until March 2026, he works as a Resident Physician in General and Family Medicine at USF Salvador Machado in Oliveira de Azeméis, developing clinical activities in primary healthcare, follow-up of chronic patients, and health promotion in the community.

Complementing his medical training, Dr. João Silva also completed a Postgraduate Degree in Continuing and Palliative Care at CESPU, strengthening his preparation in the comprehensive approach to patient care, especially in situations requiring prolonged care and multidisciplinary support.

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€55
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Doctor

Bulat Garipov

General medicine 15 years exp.

Dr. Bulat Garipov is a radiologist with more than 15 years of experience, specializing in magnetic resonance imaging (MRI). Throughout his professional career, he has worked in leading diagnostic imaging centers, both in on-site practice and teleradiology, which has allowed him to develop a broad and versatile approach to radiology.

Over the years, he has gained solid experience in interpreting MRI studies in various areas, including:

  •  Neuroimaging
  •  Musculoskeletal system (MSK)
  •  Angiography
  •  Abdomen and pelvis
  •  Soft tissues

Additionally, Dr. Garipov is open to new collaboration opportunities in radiology and teleradiology projects. He offers his expertise in MRI, providing both first and second readings of studies, as well as advanced image interpretation, ensuring accurate and high-quality diagnostics.

You could consult Dr. Bulat Garipov in cases where accurate interpretation of MRI studies or a second expert opinion is required. His expertise is especially valuable in cases of suspected neurological conditions, back and joint pain, vascular disorders, as well as in the diagnosis of abdominal and pelvic diseases. The doctor also provides support in complex or unclear clinical situations, including the review of previously performed studies, which helps improve diagnostic accuracy and determine the optimal treatment strategy. A teleradiology format is available, allowing you to receive a professional opinion remotely.

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€60

Frequently Asked Questions

Is a prescription required for ALLUZIENCE 200 Units/mL Injectable Solution?
ALLUZIENCE 200 Units/mL Injectable Solution requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in ALLUZIENCE 200 Units/mL Injectable Solution?
The active ingredient in ALLUZIENCE 200 Units/mL Injectable Solution is botulinum toxin. This information helps identify medicines with the same composition but different brand names.
Who manufactures ALLUZIENCE 200 Units/mL Injectable Solution?
ALLUZIENCE 200 Units/mL Injectable Solution is manufactured by Ipsen Pharma. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of ALLUZIENCE 200 Units/mL Injectable Solution online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether ALLUZIENCE 200 Units/mL Injectable Solution is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to ALLUZIENCE 200 Units/mL Injectable Solution?
Other medicines with the same active substance (botulinum toxin) include AZZALURE 125 units SPEYWOOD powder for injectable solution, BOCOUTURE 100 units powder for injectable solution, BOCOUTURE 50 units powder for injectable solution. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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