Addison's disease
Addison's disease (primary adrenal insufficiency) is a rare condition where small glands above your kidneys (adrenal glands) do not work properly. It can often be managed with treatment.
If these symptoms are severe, persistent or worsening, seek medical advice promptly.
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Medicines commonly prescribed for Addison's disease
For informational purposes only. Always consult a doctor before using any medicine.
Dosage form: INJECTABLE, 373 mgActive substance: hydrocortisoneManufacturer: Cheplapharm Arzneimittel GmbhPrescription requiredDosage form: INJECTABLE, 75 mgActive substance: hydrocortisoneManufacturer: Cheplapharm Arzneimittel GmbhPrescription requiredDosage form: CAPSULE, 0.5 mgActive substance: hydrocortisoneManufacturer: Diurnal Europe B.V.Prescription required
Addison's disease (primary adrenal insufficiency) is a rare condition where small glands above your kidneys (adrenal glands) do not work properly. It can often be managed with treatment.
Symptoms of Addison's disease
Many of the symptoms of Addison’s disease are the same as the symptoms of other conditions.
Symptoms of Addison’s disease include:
- extreme tiredness (fatigue)
- areas of skin that are darker than surrounding skin – this may be harder to see on brown or black skin
- loss of appetite, weight loss, tummy pain, feeling or being sick and cravings for salty foods
- feeling dizzy or light-headed when standing up
- joint pain, muscle weakness and muscle cramps
- headache
- a slightly raised temperature
- feeling thirsty and needing to pee a lot
- difficulty concentrating
- anxiety and depression
Addison’s disease most commonly affects adults between the ages of 30 and 50, but it can sometimes affect children.
See a GP if:
- you think you might have Addison’s disease
Tests for Addison's disease
If a GP thinks you or your child might have Addison’s disease, they’ll refer you to a specialist.
This is usually a hormone specialist (endocrinologist), although children are often referred to a doctor who specialises in the treatment of children (paediatrician).
The specialist will ask about your symptoms and you may have:
- a test to see how well your adrenal glands are working by checking samples of your blood before and after having an injection of a medicine called Synacthen
- blood tests to check your hormone levels and how well your thyroid gland is working
Treatments for Addison's disease
There’s currently no cure for Addison’s disease, but there are medicines that can help manage the condition.
If you have Addison’s disease, your adrenal glands are not producing enough hormones, including types of hormones called steroids.
The main treatment is steroid medicine to replace the missing hormones your body needs.
Medicines you may be given include:
- hydrocortisone
- prednisolone
- fludrocortisone
You’ll usually need to take your medicine every day for the rest of your life. It’s important you always have enough to avoid running out.
At certain times you may need to take extra medicine, such as when you’re unwell, about to have surgery, or during stressful periods like when taking exams. Your specialist will be able to advise you about this.
If you’re taking steroids, you should carry a steroid emergency card with you at all times. This tells healthcare professionals you have Addison’s disease and you take steroid medicine that should not be stopped suddenly.
You can also get jewellery and wristbands with details of your condition and the medicine you take engraved or printed on them.
Complications of Addison's disease
Adrenal crisis is the most serious complication of Addison’s disease.
During adrenal crisis your symptoms get worse very quickly. This can be triggered by things like an infection, an accident or injury, or surgery.
It can cause problems such as:
- severe dehydration
- low blood pressure (hypotension)
- seizures (fits)
- loss of consciousness
- stroke
- your heart suddenly stopping (cardiac arrest)
Adrenal crisis is a medical emergency and can usually be treated with an injection of steroid medicine.
You should be given an emergency kit so you can give the injection yourself if needed.
Your specialist may also give you or your carer training in what to do if you have adrenal crisis.
Call 112 if:
You have Addison's disease and the symptoms suddenly get worse or you:
- have a fast heart rate
- feel very dizzy or light-headed (particularly when standing up after sitting or lying down)
- have severe tummy pain or pain in the side
- have muscle weakness, pain or spasms
- have a headache that does not go away
- feel sick (nausea) or vomit
- feel very drowsy, irritable or confused
- have a seizure (fit)
- lose consciousness
These could be signs of adrenal crisis.
It’s important to call 112 even if you’ve given yourself an emergency steroid injection.
How Addison’s disease affects your life
Addison’s disease is a serious condition that can be challenging to live with.
You’ll need to remember to take your steroid medicine every day and there may be times when your symptoms get worse or you need emergency treatment.
But with treatment, you can have a good quality of life with a normal life expectancy.
You’ll have appointments with your specialist to discuss things like:
- your symptoms
- how well your medicine is working
- how confident you feel about managing your condition
Addison’s disease and pregnancy
It’s very important Addison’s disease is well managed during pregnancy otherwise it can cause serious problems, including an increased risk of miscarriage.
If you’re planning a pregnancy, your specialist can tell you what you need to do to manage your condition and keep healthy during pregnancy.
Causes of Addison’s disease
The most common cause of Addison’s disease is the immune system mistakenly attacking and damaging the adrenal glands.
This means the adrenal glands are unable to produce hormones that your body needs.
Other causes of Addison’s disease include:
- your adrenal glands being bigger than usual at birth (congenital adrenal hyperplasia)
- infections, such as tuberculosis, meningitis, flu, cytomegalovirus and HIV, which can damage your adrenal glands
- surgery to remove your adrenal glands
Recording information about you and your condition
This helps scientists look for better ways to prevent and treat this condition. You can opt out of the register at any time.
Online doctors for Addison's disease
Discuss your symptoms and possible next steps for Addison's disease with a doctor online.
