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UVADEX 20 micrograms/ml SOLUTION FOR MODIFICATION OF BLOOD FRACTIONS

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5.0(16)

Sergey Ilyasov

PsychiatryNeurology7 years of experience

Dr Sergey Ilyasov is an experienced neurologist and qualified psychiatrist who provides online consultations for adults and adolescents. Combining deep neurological expertise with a modern psychiatric approach, he ensures comprehensive diagnostics and effective treatment for a wide range of conditions affecting both physical and mental health.

Dr. Ilyasov helps patients in the following cases:

  • Chronic headaches (migraine, tension-type headache), back pain, neuropathic pain, dizziness, numbness in limbs, coordination disorders.
  • Anxiety disorders (panic attacks, generalized anxiety disorder), depression (including atypical and treatment-resistant forms), sleep disturbances (insomnia, hypersomnia, nightmares), stress, burnout.
  • Chronic pain syndromes and psychosomatic symptoms (e.g., irritable bowel syndrome related to stress, vegetative-vascular dystonia).
  • Behavioral disorders and concentration difficulties in adolescents (including ADHD, autism spectrum disorders), nervous tics.
  • Memory impairments, phobias, obsessive-compulsive disorder (OCD), emotional swings, and support for post-traumatic stress disorder (PTSD).

Thanks to his dual specialization in neurology and psychiatry, Dr Sergey Ilyasov offers integrated and evidence-based care for complex conditions requiring a multidisciplinary approach. His consultations focus on accurate diagnosis, development of an individualized treatment plan (including pharmacotherapy and psychotherapeutic methods), and long-term support adapted to each patient's unique needs.

Book an online consultation with Dr. Sergey Ilyasov to receive qualified assistance and improve your well-being today.

Book a video appointment
€106
This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use UVADEX 20 micrograms/ml SOLUTION FOR BLOOD COMPONENT MODIFICATION

Contents of the leaflet

  1. Introduction
  2. What UVADEX is and what it is used for
  3. The name of this medicine is UVADEX 20 micrograms/ml solution for modification of blood fractions.
  4. What you need to know before you use UVADEX
  5. A
  6. How to use UVADEX
  7. Possible side effects
  8. Storage of UVADEX
  9. Contents of the pack and further information

Introduction

Package Leaflet: Information for the User

UVADEX

20 MICROGRAMS/ML SOLUTION FOR MODIFICATION OF BLOOD FRACTIONS

(methoxsalen)

Read all of this leaflet carefully before you start using this medicine, because it contains important information for you.Keep this leaflet, you may need to read it again.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • If you experience any side effects, talk to your doctor, even if they are not listed in this leaflet. See section 4.

Contents of the pack:

  1. What UVADEX is and what it is used for
  2. What you need to know before you use UVADEX
  3. How to use UVADEX
  4. Possible side effects
  5. Storage of UVADEX
  6. Contents of the pack and further information

1. What UVADEX is and what it is used for

Doctor consultation

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Discuss your symptoms and treatment with a doctor online.

The name of this medicine is UVADEX 20 micrograms/ml solution for modification of blood fractions.

Methoxsalen is a product that alters the body's response to light that is activated when exposed to UV radiation.

Cutaneous T-cell lymphoma (CTCL) is a blood disorder that causes abnormal growths that affect the skin. UVADEX is used in combination with the THERAKOS CELLEX photopheresis system to relieve the skin symptoms of cutaneous T-cell lymphoma (CTCL) when other treatments have not been effective.

The THERAKOS CELLEX photopheresis system provides the necessary UV light to activate methoxsalen, which then destroys the diseased white blood cells.

2. What you need to know before you use UVADEX

Do not use UVADEX:

  • If you have had an allergic reaction to methoxsalen, to another psoralen compound, or to any of the other ingredients.
  • If you have any disease that involves sensitivity to light, such as porphyria, systemic lupus erythematosus, or albinism (a disease in which skin pigmentation is reduced).
  • If you have had your spleen removed.
  • If you have a blood coagulation disorder or a high white blood cell count (above 25,000/mm3).
  • If you are pregnant or breastfeeding.
  • If you are sexually active and do not use contraceptive precautions. If you are sexually active, you must use contraceptive precautions during and after treatment, as methoxsalen may harm a child conceived during or after treatment.
  • If you have a disease that makes you unable to tolerate the removal of large amounts of blood, such as heart disease or severe anemia.
  • If you have had the lens of either eye removed.
Medicine questions

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A

Talk to your doctor before you start using UVADEX

  • If you suffer from EPILEPSY and are being treated with phenytoin (this may make UVADEX treatment ineffective).
  • If you have SKIN CANCER (melanoma, basal cell carcinoma, or squamous cell carcinoma).
  • If you have LIVER or KIDNEY problems.
  • If you are taking tolbutamide for DIABETES (may increase photosensitivity).
  • If you have recently been in the sun before treatment.
  • If you are taking any other medicine that causes sensitivity to light, including some antibiotics (e.g., ciprofloxacin, doxycycline, and nalidixic acid), some diuretics, some medicines used to treat diabetes (e.g., chlorpropamide), some medicines used to treat mental health problems (e.g., trifluoperazine and haloperidol), and some medicines used to treat skin conditions (e.g., isotretinoin).
  • If there is any possibility that you may become PREGNANT (see previous section).

Children

The use of UVADEX is not indicated in children, as there is not enough experience in this age group.

Other medicines and UVADEX

Make sure your doctor knows what other medicines you are taking, including any that you may have bought for yourself, such as paracetamol.

Using UVADEX with food and drink

No studies have been conducted to evaluate the effect of food and drink. As UVADEX is administered as part of a hospital procedure, your specialist doctor will decide whether you can eat or drink during the procedure.

Pregnancy, breastfeeding, and fertility

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor before taking this medicine. You should not be given UVADEX if you are pregnant or breastfeeding.

If you are a sexually active woman of childbearing age, during treatment with UVADEX, you must use adequate contraceptive methods because the active ingredient - methoxsalen - may be harmful to a child conceived during treatment with UVADEX.

Driving and using machines

You should not drive or operate machinery immediately after treatment.

UVADEX contains small amounts of ethanol

This medicine contains 217 mg of ethanol (alcohol) per 5.6 ml dose, which corresponds to 3.1 mg/kg per 5.6 ml dose. The amount of a 5.6 ml dose of this medicine is equivalent to less than 6 ml of beer or 3 ml of wine.

The small amount of alcohol in this medicine will not have noticeable effects.

UVADEX contains small amounts of sodium

This medicine contains less than 1 mmol of sodium (23 mg) per dose unit; it is essentially "sodium-free".

3. How to use UVADEX

This medicine is always administered by a specialist doctor who can explain exactly what is happening. Your doctor will decide how many treatment sessions you need. Most patients receive treatment on two consecutive days once a month for six months. After four months, this frequency may be increased to two consecutive days twice a month if your doctor thinks it is necessary.

Method of administration

This medicine is administered as follows:

A professional with specific training in the use of photopheresis will insert a needle into your arm to remove blood into a specially designed instrument (the THERAKOS CELLEX photopheresis system) and separate it into red blood cells, white blood cells, and plasma. The red blood cells and most of the plasma are returned to your circulation during the procedure. The white blood cells and the remaining plasma are mixed with a calculated dose of UVADEX, exposed to UV light in the instrument, and then returned to you.

Duration of treatment

The procedure lasts between three and four hours from the time the needle is inserted until all blood components are returned to you.

You should not receive more than 20 photopheresis sessions in 6 months.

During treatment and for 24 hours after, you must wear special wrap-around sunglasses that prevent UVA rays from passing through to avoid damaging your eyes and causing cataracts.

After treatment

After receiving treatment, you should avoid sunlight for at least 24 hours because it could damage your skin, causing burns or premature aging in the long term. If you need to go outside, you must cover your skin, use a high sun protection factor, and wear sunglasses (see above).

If you use more UVADEX than you should

This is very unlikely. However, if you are given too much, you may need to stay in a dark room for 24 hours or more as part of your treatment.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

The following side effects have been reported:

Common (may affect up to 1 in 10 people):

  • Low blood pressure.
  • Nausea (feeling sick) and vomiting.
  • Infections.
  • Transient fever (may appear 6-8 hours after treatment).
  • Venositis (as a result of repeated insertion of the needle into the veins).
  • Altered taste.

Uncommon:

  • Photosensitivity.

Frequency not known (frequency cannot be estimated from the available data):

  • Allergic reaction.

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist, even if they are not listed in this leaflet. You can also report side effects directly through the Spanish Medicines and Health Products Agency (AEMPS) website: www.notificaRAM.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of UVADEX

UVADEX will be stored in the hospital pharmacy. Do not store above 25°C.

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the carton after EXP. The expiry date is the last day of the month shown.

6. Contents of the pack and further information

Composition of UVADEX

  • The active ingredient is methoxsalen.
  • Each 10 ml vial contains 200 micrograms (µg) of methoxsalen. Each milliliter contains 20 micrograms of methoxsalen.
  • The other ingredients are ethanol 95%, propylene glycol, glacial acetic acid, sodium acetate trihydrate, sodium chloride, sodium hydroxide, and water for injection.

Appearance and pack contents

Clear, colorless solution.

10 ml amber glass vial with rubber stopper.

Marketing authorization holder and manufacturer

The marketing authorization holder is:

Therakos Europe Ltd,

College Business & Technology Park, Cruiserath, Blanchardstown, Dublin 15,

Ireland.

Manufacturer:

Penn Pharmaceuticals Limited

Unit 23, Tafarnaubach Industrial Estate

Tredegar, Gwent

United Kingdom

or

Therakos EMEA Ltd,

College Business & Technology Park,

Cruiserath Road,

Blanchardstown,

Dublin 15,

Ireland.

Date of last revision of this leaflet:June 2025.

Detailed information on this medicine is available on the website of the Spanish Medicines and Health Products Agency (AEMPS) http://www.aemps.gob.es/

Online doctors for UVADEX 20 micrograms/ml SOLUTION FOR BLOOD COMPONENT MODIFICATION

Discuss questions about UVADEX 20 micrograms/ml SOLUTION FOR BLOOD COMPONENT MODIFICATION, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

Doctor
5.0(16)

Sergey Ilyasov

PsychiatryNeurology7 years of experience

Dr Sergey Ilyasov is an experienced neurologist and qualified psychiatrist who provides online consultations for adults and adolescents. Combining deep neurological expertise with a modern psychiatric approach, he ensures comprehensive diagnostics and effective treatment for a wide range of conditions affecting both physical and mental health.

Dr. Ilyasov helps patients in the following cases:

  • Chronic headaches (migraine, tension-type headache), back pain, neuropathic pain, dizziness, numbness in limbs, coordination disorders.
  • Anxiety disorders (panic attacks, generalized anxiety disorder), depression (including atypical and treatment-resistant forms), sleep disturbances (insomnia, hypersomnia, nightmares), stress, burnout.
  • Chronic pain syndromes and psychosomatic symptoms (e.g., irritable bowel syndrome related to stress, vegetative-vascular dystonia).
  • Behavioral disorders and concentration difficulties in adolescents (including ADHD, autism spectrum disorders), nervous tics.
  • Memory impairments, phobias, obsessive-compulsive disorder (OCD), emotional swings, and support for post-traumatic stress disorder (PTSD).

Thanks to his dual specialization in neurology and psychiatry, Dr Sergey Ilyasov offers integrated and evidence-based care for complex conditions requiring a multidisciplinary approach. His consultations focus on accurate diagnosis, development of an individualized treatment plan (including pharmacotherapy and psychotherapeutic methods), and long-term support adapted to each patient's unique needs.

Book an online consultation with Dr. Sergey Ilyasov to receive qualified assistance and improve your well-being today.

Book a video appointment
€106
Doctor
5.0(11)

Anna Biriukova

Gastroenterology6 years of experience

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

  • High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
  • Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
  • Leg swelling, chronic fatigue, reduced exercise tolerance.
  • EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
  • Post-COVID-19 cardiac monitoring and care.
Endocrinology – Diabetes, thyroid, metabolism:
  • Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
  • Individual treatment plans including oral medications and insulin therapy.
  • GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
  • Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
  • Metabolic syndrome – obesity, lipid disorders, insulin resistance.
Gastroenterology – Digestive health:
  • Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
  • Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
  • Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).
General internal medicine and preventive care:
  • Respiratory infections – cough, colds, bronchitis.
  • Lab test analysis, therapy adjustments, medication management.
  • Adult vaccinations – planning, contraindications assessment.
  • Cancer prevention – screening strategies and risk assessment.
  • Holistic approach – symptom relief, complication prevention, and quality of life improvement.
Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.
Book a video appointment
€66
Doctor
5.0(38)

Andrei Popov

General medicinePain medicine7 years of experience

Dr. Andrei Popov is a General Practitioner with specialized training in chronic pain. He provides online consultations for adult patients in Spain and other European countries.

Dr. Popov understands that seeking help with weight-related concerns or pain that has persisted for months can be difficult. Many patients come to him after trying different approaches without feeling truly heard. During the consultation, the doctor creates a comfortable and supportive, non-judgmental environment where the patient’s medical history can be discussed in detail, questions can be answered, and the next steps can be decided together.

Weight Management and Metabolic Health

Dr. Popov can help assess overweight, obesity, and related conditions such as hypertension, diabetes, or metabolic disorders. During the consultation, the patient’s medical history, test results, current medications, and previous treatments will be reviewed.

If you would like to learn about possible medication options or have already started treatment, the doctor can assess your situation, review the effectiveness and tolerability of the therapy, and clearly explain its benefits, potential risks, and alternatives.

Not every patient requires the same treatment. A consultation does not guarantee a prescription — it provides an objective medical assessment and a plan tailored to your individual situation.

Pain and General Medicine

You can also consult Dr. Popov regarding:

* chronic pain, migraines, neuralgia, and fibromyalgia;

* back, neck, lower back, or joint pain;

* hypertension, diabetes, and follow-up of chronic conditions;

* review of test results, medical reports, and current treatment;

* preventive medicine and a second medical opinion.

How the Consultation Works

The video consultation lasts up to 30 minutes. The doctor will listen carefully, review the information you provide, and explain the next steps in clear and understandable language.

If additional tests, an in-person consultation, or urgent medical care are required, the doctor will inform you directly.

Dr. Popov’s goal is to make sure the patient feels heard and leaves the consultation with a clear understanding of their condition and the next steps they can take.

Book a video appointment
€86
Doctor
5.0(12)

Yevgen Yakovenko

General medicine12 years of experience

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

Book a video appointment
€72
Doctor
5.0(24)

Taisiia Proida

Psychiatry7 years of experience

Taisiia Proida is a general practitioner with a specialization in mental health and a cognitive behavioral therapist (CBT), a member of the European Psychiatric Association. She offers online consultations for adults aged 18 and over, combining evidence-based medicine with an individualised approach to mental health care. She specialises in consultations and ongoing support for a wide range of mental health concerns, including: 

  • Mood disorders: depression, bipolar disorder, postpartum depression.
  • Anxiety disorders: generalised anxiety, OCD, panic attacks, phobias.
  • Post-traumatic stress disorder (PTSD) and complex PTSD.
  • Attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Assessment is provided only after an initial psychiatric evaluation and during a follow-up appointment.
  • Personality disorders and emotional instability.
  • Cyclothymia and mood fluctuations.
  • Schizophrenia spectrum and related conditions.

Dr. Proida combines clinical expertise with an empathetic approach, offering structured support based on evidence-based practices. Her work integrates CBT techniques with medical management, with a focus on anxiety and depressive disorders. She works with clients from different countries and cultural backgrounds, adapting her communication style and recommendations to individual needs. With experience in international clinical trials (Pfizer, Merck), she values clarity, trust, and collaborative partnership in patient care.

Book a video appointment
€156
Doctor
5.0(3)

Lina Travkina

General medicine13 years of experience

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.Areas of medical care include:

  • Respiratory conditions: colds, flu, acute and chronic bronchitis, mild to moderate pneumonia, bronchial asthma.

  • ENT and eye conditions: sinusitis, tonsillitis, pharyngitis, otitis, infectious and allergic conjunctivitis.

  • Digestive issues: gastritis, acid reflux (GERD), IBS, dyspepsia, bloating, constipation, diarrhoea, functional bowel symptoms, intestinal infections.

  • Urological and infectious diseases: acute and recurrent cystitis, bladder and kidney infections, prevention of recurrent UTIs, asymptomatic bacteriuria.

  • Chronic conditions: hypertension, diabetes, hypercholesterolemia, metabolic syndrome, thyroid disorders, excess weight.

  • Neurological and general symptoms: headache, migraine, dizziness, fatigue, sleep disturbances, reduced concentration, anxiety, asthenia.

  • Chronic pain support: back, neck, joint, and muscle pain, tension syndromes, pain associated with osteochondrosis and chronic conditions.

Additional care areas:

  • Preventive consultations and check-up planning.

  • Medical advice and follow-up consultations.

  • Test interpretation and diagnostic guidance.

  • Structured support for undiagnosed complaints.

  • Second opinion on diagnoses and treatment plans.

  • Nutritional and lifestyle support for vitamin deficiencies, anaemia, metabolic issues.

  • Post-operative recovery support and pain management.

  • Preconception counselling and postpartum support.

  • Immunity support and strategies to reduce frequency of infections.

Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

Book a video appointment
€75

Get UVADEX 20 micrograms/ml SOLUTION FOR BLOOD COMPONENT MODIFICATION Prescription Online

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Frequently Asked Questions

UVADEX 20 micrograms/ml SOLUTION FOR BLOOD COMPONENT MODIFICATION requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

UVADEX 20 micrograms/ml SOLUTION FOR BLOOD COMPONENT MODIFICATION is manufactured by Therakos Europe Limited. Pharmacy brands and packaging may differ depending on the distributor.

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether UVADEX 20 micrograms/ml SOLUTION FOR BLOOD COMPONENT MODIFICATION is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy UVADEX 20 micrograms/ml SOLUTION FOR BLOOD COMPONENT MODIFICATION in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

Other medicines with the same active substance () include BEROMUN 1 mg POWDER FOR SOLUTION FOR INFUSION, CEPLENE 0.5 mg/0.5 ml INJECTABLE SOLUTION, COPAXONE 20 mg/ml INJECTABLE SOLUTION IN PRE-FILLED SYRINGE. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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