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SUNLENCA 464 mg INJECTABLE SOLUTION

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About the medicine

How to use SUNLENCA 464 mg INJECTABLE SOLUTION

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the Patient

Sunlenca 464 mg Solution for Injection

lenacapavir

This medicine is subject to additional monitoring, which will allow for the quick identification of new safety information. You can help by reporting any side effects you may get. The last section of section 4 will tell you how to report side effects.

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What is Sunlenca and what is it used for
  2. What you need to know before you are given Sunlenca
  3. How Sunlenca is given
  4. Possible side effects
  5. Storage of Sunlenca
  6. Contents of the pack and other information

1. What is Sunlenca and what is it used for

Sunlenca contains the active substance lenacapavir. It is an antiretroviral medicine known as a capsid inhibitor.

Sunlenca is a long-acting medicine and is used in combination with other antiretroviral medicinesto treat human immunodeficiency virus type 1 (HIV-1), the virus that causes acquired immune deficiency syndrome (AIDS).

It is used to treat HIV-1 infection in adults with limited treatment options (for example, when other antiretroviral medicines are not effective enough or are not suitable).

Treatment with Sunlenca in combination with other antiretrovirals reduces the amount of HIV in the body. This will improve the function of the immune system (the body's natural defenses) and reduce the risk of developing illnesses associated with HIV infection.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before you are given Sunlenca

Do not receive Sunlenca

  • If you are allergic to lenacapavir or any of the other ingredients of this medicine (listed in section 6).
  • If you are taking any of the following medicines:
    • rifampicin, used to treat some bacterial infections such as tuberculosis
    • carbamazepine, phenytoin, used to prevent seizures
    • St. John's Wort (Hypericum perforatum), a herbal medicine used for depression and anxiety

If you think this applies to you, do not receive Sunlenca and tell your doctor immediately.

Warnings and precautions

Talk to your doctor before using Sunlenca

  • Talk to your doctor or pharmacist if you have or have ever had severe liver disease or if tests have shown liver problems. Your doctor will carefully consider whether to treat you with Sunlenca.

While you are using Sunlenca

Once you start using Sunlenca, be aware of:

  • Signs of inflammation or infection.

If you notice any of these symptoms, tell your doctor immediately.For more information, see section 4, Possible side effects.

Regular appointments are important

It is important that you attend your scheduled appointmentsto receive the Sunlenca injection to control HIV infection and prevent your disease from getting worse. Talk to your doctor if you are considering stopping treatment. If there is a delay in giving you your injection or if you stop receiving Sunlenca, you will need to take other medicines to treat HIV infection and reduce the risk of developing viral resistance.

Children and adolescents

Do not give this medicine to children under 18 years of age. The use of Sunlenca in patients under 18 years of age has not been studied yet, so it is not known how safe and effective the medicine is in this age group.

Other medicines and Sunlenca

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. Sunlenca may interact with other medicines. This can prevent Sunlenca or other medicines from working properly or can increase the risk of side effects. In some cases, your doctor may need to adjust the dose or check your blood levels.

Medicines that must not be taken with Sunlenca:

  • rifampicin, used to treat some bacterial infections such as tuberculosis
  • carbamazepine, phenytoin, used to prevent seizures
  • St. John's Wort (Hypericum perforatum), a herbal medicine used for depression and anxiety

If you are taking any of these medicines, do not receive Sunlenca injection and tell your doctor immediately.

Tell your doctor especially if you are taking:

  • antibiotics that contain:
    • rifabutin
  • antiepileptics, used to treat epilepsy and prevent seizures (convulsions), that contain:
    • oxcarbazepine or phenobarbital
  • medicines used to treat HIV, that contain:
    • atazanavir/cobicistat, efavirenz, nevirapine, tipranavir/ritonavir or etravirine
  • medicines used to treat migraine headaches, that contain:
    • dihydroergotamine or ergotamine
  • medicines used to treat impotence and pulmonary hypertension, that contain:
    • sildenafil or tadalafil
  • medicines used to treat impotence, that contain:
    • vardenafil
  • corticosteroids (also known as “steroids”) given by mouth or by injection, used to treat allergies, inflammatory bowel diseases and other diseases that involve inflammation in the body, that contain:
    • dexamethasone or hydrocortisone/cortisone
  • medicines used to lower cholesterol, that contain:
    • lovastatin or simvastatin
  • antiarrhythmics used to treat heart problems, that contain:
    • digoxin
  • medicines used to help you sleep, that contain:
    • midazolam or triazolam
  • anticoagulants used to prevent and treat blood clots, that contain:
    • rivaroxaban, dabigatran or edoxaban

Tell your doctor if you are taking any of these medicinesor if you start taking any of these medicines during treatment with Sunlenca. Do not stop your treatment without talking to your doctor.

Sunlenca is a long-acting medicine. You should know that if you decide to stop or change your treatment to another one after talking to your doctor, low levels of lenacapavir (the active substance of Sunlenca) may remain in your body for several months after your last injection. It is not expected that the presence of these low levels will affect other antiretroviral medicines you may take later to treat HIV infection. However, the presence of low levels of lenacapavir in your body may affect other medicines you take in the 9 months following your last Sunlenca injection. Ask your doctor if these medicines are safe for you after stopping treatment with Sunlenca.

Pregnancy and breast-feeding

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

As a precaution, you should avoid using Sunlenca during pregnancy unless your doctor tells you otherwise.

Women with HIV-1 infection should not breast-feed their babies, as HIV-1 can be passed to the baby through breast milk. If you are breast-feeding or think you may want to breast-feed, talk to your doctor as soon as possible.

Driving and using machines

Sunlenca is not expected to affect your ability to drive or use machines.

Sunlenca contains sodium

This medicine contains less than 1 mmol of sodium (23 mg) per injection; this is, essentially “sodium-free”.

3. How Sunlenca is given

Sunlenca is used in combination with other antiretroviral medicinesto treat HIV infection. Your doctor will tell you which other medicines you should take to treat HIV infection and when you should take them.

Treatment with Sunlenca starts with taking tablets by mouth, followed by injections given by your doctor or nurse, as described below.

Talk to your doctor before taking the tablets.The doctor will tell you when to start taking the tablets and when to schedule your appointment to receive the first injections.

Day 1 of treatment:

  • Two tablets by mouth. These can be taken with or without food.

Day 2 of treatment:

  • Two tablets by mouth. These can be taken with or without food.

Day 8 of treatment:

  • One tablet by mouth. This can be taken with or without food.

Day 15 of treatment:

  • Two injections in the abdomen (belly) given at the same time by your doctor or nurse.

Every 6 months:

  • Two injections in the abdomen given at the same time by your doctor or nurse.

If you are given more Sunlenca injection than you should

Your doctor or nurse will give you this medicine, so it is unlikely that you will be given too much. Tell your doctor or nurse if you are concerned.

If you miss a Sunlenca injection

  • It is important that you attend your scheduled appointments every 6 months to receive the Sunlenca injections. This will help control HIV infection and prevent your disease from getting worse.
  • If you think you will not be able to attend your appointment to receive the injections, call your doctor as soon as possible to discuss your treatment options.

Read the package leaflet of Sunlenca tablets if you miss a dose or vomit after taking the tablets.

If you stop treatment with Sunlenca

Do not stop treatment with Sunlenca without talking to your doctor. Continue treatment with Sunlenca injections as long as your doctor recommends. Stopping Sunlenca may seriously affect the effectiveness of future treatments for HIV.

Talk to your doctor if you want to stop treatment with Sunlenca injections.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Serious side effects: tell a doctor immediately

  • Any sign of inflammation or infection. In some patients with advanced HIV infection (AIDS) and a history of opportunistic infections (infections that occur in people with a weakened immune system), signs and symptoms of inflammation due to previous infections may occur shortly after starting HIV treatment. These symptoms are thought to be due to an improvement in the body's immune response, which enables it to fight off infections that may have been present without obvious symptoms.
  • Autoimmune disorders, where the immune system attacks the body's healthy tissues, can also occur after starting HIV treatment. Autoimmune disorders may occur many months after starting treatment. Be aware of any symptoms of infection or other symptoms, such as:
    • muscle weakness
    • weakness of the body that starts in the hands and feet and moves towards the trunk
    • palpitations, tremors or hyperactivity

If you notice any of these symptoms or any symptoms of inflammation or infection, tell your doctor immediately.

Very common side effects

(may affect more than 1 in 10 people)

  • Reactions at the Sunlenca injection site.

Symptoms may include:

  • pain and discomfort
  • a lump or hardened mass
  • inflammatory reaction such as redness, itching and swelling

Common side effects

(may affect up to 1 in 10 people)

  • Nausea

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist, even if they are not listed in this leaflet. You can also report side effects directly via the national reporting system listed in Appendix V. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Sunlenca

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the vial label and carton after {EXP}. The expiry date is the last day of the month shown.

This medicine does not require any special storage conditions. Keep the vial in the original packaging to protect it from light.

6. Container Contents and Additional Information

Sunlenca Composition

The active ingredient is lenacapavir. Each single-dose vial contains 463.5 mg of lenacapavir.

The other components are

Macrogol (E1521), water for injectable preparations.

Appearance of Sunlenca and Container Contents

Sunlenca injectable solution is a clear, yellow to brown solution without visible particles. Sunlenca is presented in two glass vials containing 1.5 ml of injectable solution each. These vials are included in an administration kit that also contains 2 vial access devices (a device that will allow your doctor or nurse to extract Sunlenca from the vial), 2 disposable syringes, and 2 injection needles.

Marketing Authorization Holder

Gilead Sciences Ireland UC

Carrigtohill

County Cork, T45 DP77

Ireland

Manufacturer

Gilead Sciences Ireland UC

IDA Business & Technology Park

Carrigtohill

County Cork

Ireland

You can request more information about this medication by contacting the local representative of the marketing authorization holder:

Belgium

Gilead Sciences Belgium SRL-BV

Tel: + 32 (0) 24 01 35 50

Lithuania

Gilead Sciences Poland Sp. z o.o.

Tel.: + 48 22 262 8702

Greece

Gilead Sciences Ireland UC

Tel: + 353 (0) 1 686 1888

Luxembourg

Gilead Sciences Belgium SRL-BV

Tel: + 32 (0) 24 01 35 50

Czech Republic

Gilead Sciences s.r.o.

Tel: + 420 910 871 986

Hungary

Gilead Sciences Ireland UC

Tel.: + 353 (0) 1 686 1888

Denmark

Gilead Sciences Sweden AB

Tlf: + 46 (0) 8 5057 1849

Malta

Gilead Sciences Ireland UC

Tel: + 353 (0) 1 686 1888

Germany

Gilead Sciences GmbH

Tel: + 49 (0) 89 899890-0

Netherlands

Gilead Sciences Netherlands B.V.

Tel: + 31 (0) 20 718 36 98

Estonia

Gilead Sciences Poland Sp. z o.o.

Tel.: +48 22 262 8702

Norway

Gilead Sciences Sweden AB

Tlf: + 46 (0) 8 5057 1849

Greece

Gilead Sciences Ελλάς Μ.ΕΠΕ.

Tel: + 30 210 8930 100

Austria

Gilead Sciences GesmbH

Tel: + 43 1 260 830

Spain

Gilead Sciences, S.L.

Tel: + 34 91 378 98 30

Poland

Gilead Sciences Poland Sp. z o.o.

Tel.: + 48 22 262 8702

France

Gilead Sciences

Tel: + 33 (0) 1 46 09 41 00

Portugal

Gilead Sciences, Lda.

Tel: + 351 21 7928790

Croatia

Gilead Sciences Ireland UC

Tel: + 353 (0) 1 686 1888

Romania

Gilead Sciences (GSR) S.R.L.

Tel: + 40 31 631 18 00

Ireland

Gilead Sciences Ireland UC

Tel: + 353 (0) 214 825 999

Slovenia

Gilead Sciences Ireland UC

Tel: + 353 (0) 1 686 1888

Iceland

Gilead Sciences Sweden AB

Sími: + 46 (0) 8 5057 1849

Slovakia

Gilead Sciences Slovakia s.r.o.

Tel: + 421 232 121 210

Italy

Gilead Sciences S.r.l.

Tel: + 39 02 439201

Finland

Gilead Sciences Sweden AB

Tel: + 46 (0) 8 5057 1849

Cyprus

Gilead Sciences Ελλάς Μ.ΕΠΕ.

Tel: + 30 210 8930 100

Sweden

Gilead Sciences Sweden AB

Tel: + 46 (0) 8 5057 1849

Latvia

Gilead Sciences Poland Sp. z o.o.

Tel.: + 48 22 262 8702

United Kingdom (Northern Ireland)

Gilead Sciences Ireland UC

Tel: + 44 (0) 8000 113 700

Date of Last Revision of this Prospectus:

Detailed information on this medication is available on the European Medicines Agency website: http://www.ema.europa.eu.

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This information is intended solely for healthcare professionals:

Instructions for Use - Sunlenca 464 mg Injectable Solution

The Kit Contains

2 vials

Clear glass vial with yellow liquid and black sealed cap

2 vial access devices

Green adapter with circular base and white top with sealing ring

2 syringes

Transparent syringe with black plunger and numerical graduations marked along the cylinder

2 injection needles

Hypodermic needle with angled bevel showing sharp tip and light gray cylindrical body

All components are for single use.

Two 1.5 ml injectionsare required for a complete dose. It is necessary to use the vial access device.

Check that:

  • The vial contains a yellow to brown solution without visible particles
  • The contents are not damaged
  • The medication has not expired
  1. Prepare the vial

Vial with yellow liquid and black cap being held by a hand with a blue arrow pointing upwards

Remove the cap.

Glass vial with yellow liquid and a needle inserted into the cap held by a gloved hand

Clean the vial seal with an alcohol swab.

  1. Prepare the vial access device

Yellow vial with liquid held by a hand and a green adapter in a vertical position with an arrow indicating downward direction

Push down.

Green adapter with slots and a hand rotating a blue cylinder over it with blue arrows indicating rotation

Turn to remove.

  1. Attach and fill the syringe

Syringe with a green safety device showing how to connect and disconnect the needle protector with blue arrows

  • Attach the syringe and inject 1.5 ml of air into the vial.
  • Turn upside down and withdraw all the contents.
  1. Prepare an injection site on the patient's abdomen

Human silhouette showing the abdomen with dark circles indicating possible injection sites

Possible injection sites (at a minimum of 5 cm from the navel)

  1. Attach the needle and syringe

Hand holding yellow syringe with medication turning the blue plunger clockwise

Attach the injection needle and fill 1.5 ml.

  1. Inject the dose

Hand injecting medication with syringe into the skin, blue arrow indicating direction of needle insertion and yellow liquid in the plunger

Inject 1.5 ml of Sunlenca subcutaneously

  1. Administer the second injection

Blue circle with curved arrows indicating a rotational movement in a clockwise direction within a white square

Repeat the steps for the 2nd injection in a new injection site.

Online doctors for SUNLENCA 464 mg INJECTABLE SOLUTION

Discuss questions about SUNLENCA 464 mg INJECTABLE SOLUTION, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Doctor

Daniel Cichi

Family medicine 24 years exp.

Dr Daniel Cichi is a family medicine doctor with over 20 years of clinical experience. He provides online consultations for adults, supporting patients with acute symptoms, chronic conditions, and everyday health concerns that require timely medical guidance.

His background includes work in emergency care, ambulance services, and family medicine, which allows him to assess symptoms quickly, identify warning signs, and help patients choose the safest next steps – whether that means home care, treatment adjustment, or in-person evaluation.

Patients commonly consult Dr Daniel Cichi for:

  • acute symptoms: fever, infections, flu-like illness, cough, sore throat, shortness of breath;
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  • medical advice while travelling or living abroad;
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Dr Cichi’s consultations are structured and practical. He focuses on clear explanations, risk assessment, and actionable recommendations, helping patients understand their symptoms and make informed decisions about their health.
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Doctor

Lina Travkina

Family medicine 13 years exp.

Dr. Lina Travkina is a licensed family and preventive medicine doctor based in Italy. She provides online consultations for adults and children, supporting patients across all stages of care – from acute symptom management to long-term health monitoring and prevention.

Areas of medical care include:

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Dr. Travkina combines evidence-based medicine with an attentive, personalised approach. Her consultations focus not only on treatment, but also on prevention, recovery, and long-term wellbeing.

If during the consultation it becomes clear that your case requires in-person assessment or specialised care outside of her scope, the session will be terminated and the payment fully refunded.

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Alina Tsurkan

Family medicine 13 years exp.

Dr. Alina Tsurkan is a licensed family medicine physician based in Portugal, offering online consultations for adults and children. She provides professional primary care, with a focus on prevention, accurate diagnosis, and long-term management of acute and chronic conditions.

Dr. Tsurkan supports patients with a wide range of health issues, including:

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Dr. Tsurkan’s approach is evidence-based and holistic. She works closely with each patient to develop an individualised care plan that addresses both symptoms and root causes. Her goal is to empower patients to take control of their health and maintain well-being through lifestyle adjustments, routine check-ups, and early intervention.

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Doctor

Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

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Experience and qualifications:

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If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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Frequently Asked Questions

Is a prescription required for SUNLENCA 464 mg INJECTABLE SOLUTION?
SUNLENCA 464 mg INJECTABLE SOLUTION requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in SUNLENCA 464 mg INJECTABLE SOLUTION?
The active ingredient in SUNLENCA 464 mg INJECTABLE SOLUTION is lenacapavir. This information helps identify medicines with the same composition but different brand names.
Who manufactures SUNLENCA 464 mg INJECTABLE SOLUTION?
SUNLENCA 464 mg INJECTABLE SOLUTION is manufactured by Gilead Sciences Ireland Unlimited Company. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of SUNLENCA 464 mg INJECTABLE SOLUTION online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether SUNLENCA 464 mg INJECTABLE SOLUTION is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to SUNLENCA 464 mg INJECTABLE SOLUTION?
Other medicines with the same active substance (lenacapavir) include SUNLENCA 300 mg FILM-COATED TABLETS, CELSENTRI 150 mg FILM-COATED TABLETS, CELSENTRI 300 MG FILM-COATED TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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