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PRODERMA 100 mg HARD CAPSULES

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About the medicine

How to use PRODERMA 100 mg HARD CAPSULES

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Package Leaflet: Information for the User

Proderma 100 mg Hard Capsules

Doxycycline

Read the entire package leaflet carefully before starting to take the medicine, as it contains important information for you.

  • Keep this package leaflet, as you may need to read it again.
  • If you have any questions, consult your doctor or pharmacist.
  • This medicine has been prescribed to you only, and you should not give it to others, even if they have the same symptoms as you, as it may harm them.
  • If you experience side effects, consult your doctor or pharmacist, even if they are not listed in this package leaflet.

Contents of the Package Leaflet

  1. What Proderma 100 mg Hard Capsules are and what they are used for
  2. What you need to know before taking Proderma 100 mg Hard Capsules
  3. How to take Proderma 100 mg Hard Capsules
  4. Possible side effects
  5. Storage of Proderma 100 mg Hard Capsules
  6. Package Contents and Additional Information

1. What Proderma 100 mg Hard Capsules are and what they are used for

Doxycycline belongs to a group of medicines called tetracyclines, which are broad-spectrum antibiotics, active against multiple microorganisms.

Text on a white background explaining the use of antibiotics and precautions regarding their administration and disposal

Doxycycline is primarily indicated for infections of the skin and soft tissues, respiratory tract infections, and genitourinary infections, such as:

  • Atypical pneumonia
  • Psittacosis (disease transmitted to humans by certain birds, characterized by pneumonia, fever, and cough)
  • Typhus and other infections caused by microorganisms called rickettsias
  • Sexually transmitted diseases
  • Brucellosis (Malta fever)
  • Cholera
  • Early stages of Lyme disease (disease transmitted by ticks)
  • Fever transmitted by lice and ticks
  • Malaria
  • Severe acne vulgaris
Doctor consultation

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2. What you need to know before taking Proderma 100 mg Hard Capsules

Do not take Proderma 100 mg Hard Capsules

If you are allergic to doxycycline, tetracyclines, or any of the other components of Proderma 100 mg (listed in section 6).

Warnings and Precautions

Consult your doctor or pharmacist before starting to take Proderma 100 mg.

Children

Proderma 100 mg should not be administered during the dentition period (second half of pregnancy, lactation, and children under 8 years), as it may cause permanent tooth discoloration and delay bone development.

General

  • There have been reports of bulging fontanelles (unossified skull space) in children and increased intracranial pressure (increased cerebrospinal fluid pressure in the brain) in both children and adults (see section 4. Possible Side Effects).
  • If you experience diarrhea while receiving treatment with doxycycline, consult your doctor.
  • If you take this medicine while lying down or without sufficient water, ulcers may appear in the digestive system, so it is essential to follow the administration instructions (see section 3. How to Take Proderma 100 mg Hard Capsules and section 4. Possible Side Effects).
  • If you have liver or kidney disease, consult your doctor.
  • In prolonged treatments, your doctor will perform renal and hepatic function tests.
  • If you have systemic lupus erythematosus, you should avoid using this medicine.
  • In case of direct sun exposure, skin redness may occur; if this happens, consult your doctor.
  • If you have myasthenia gravis (a form of muscular weakness), consult your doctor before taking this medicine.
  • If you need to undergo any urine tests, inform the healthcare staff that you are being treated with this medicine, as doxycycline may interfere with the results.

Use of Proderma 100 mg Hard Capsules with Other Medicines

Tell your doctor or pharmacist if you are taking or have recently taken other medicines, including those obtained without a prescription.

Like all medicines, Proderma 100 mg may interact with some medicines, such as:

  • Aluminum, calcium, and magnesium antacids, which reduce the absorption of Proderma 100 mg.
  • Antibiotics, which may reduce the effectiveness of Proderma 100 mg.
  • Methoxyflurane, which, together with tetracyclines and Proderma 100 mg, may cause kidney toxicity, which can be severe.
  • Anticoagulants (such as warfarin), as Proderma 100 mg may alter the effect of these anticoagulants; consult your doctor.
  • Medicines for the treatment of epilepsy, such as carbamazepine and phenytoin.
  • Oral contraceptives and barbiturates, as Proderma 100 mg may reduce their effectiveness.
  • Chronic alcohol consumption may reduce the effectiveness of Proderma 100 mg.

In case of doubt, consult your doctor or pharmacist.

Taking Proderma 100 mg Hard Capsules with Food and Drinks

  • During treatment with doxycycline, alcohol consumption should be avoided.
  • Proderma 100 mg should be taken with food or water to avoid esophageal irritation (see section 3. How to Take Proderma 100 mg Hard Capsules and section 4. Possible Side Effects).

Pregnancy and Breastfeeding

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medicine.

Breastfeeding

You should avoid taking this medicine during breastfeeding.

Driving and Using Machines

There is no evidence that Proderma 100 mg alters the ability to drive or use machines.

Proderma 100 mg Hard Capsules contain Saccharose. If your doctor has told you that you have an intolerance to certain sugars, consult with them before taking this medicine.

3. How to Take Proderma 100 mg Hard Capsules

Follow your doctor's instructions for taking Proderma 100 mg exactly. If in doubt, consult your doctor or pharmacist again.

Remember to take your medicine.

Consult your doctor or pharmacist if you think the effect of doxycycline is not what you expected, either because it is too strong and causes unwanted side effects or because it is too weak and insufficient for treating the infection.

IMPORTANT:

This medicine should be taken during a meal, accompanied by a large glass of water.

It is essential that, after taking the medicine, you wait at least one hour before lying down or going to bed to sleep.

The above recommendations aim to prevent digestive problems, especially stomach ulcers.

Your doctor will indicate the duration of treatment with Proderma 100 mg. Do not stop treatment early, even if you have started to improve.

Adults:the usual dose of doxycycline is 200 mg on the first day of treatment, taken in one or two doses, followed by a maintenance dose of 100 mg/day. For the treatment of more severe infections, 200 mg/day should be administered throughout the treatment period. In general, treatment should continue until at least 24 to 48 hours after the disappearance of symptoms and fever.

Children over 8 years old:children over 8 years old who weigh 45 kg or less, the usual dose is 4 mg/kg body weight on the first day of treatment, administered in a single dose or in two equal doses every 12 hours. In severe infections: 4 mg/kg body weight every 24 hours, maintaining the same dose throughout treatment. Treatment should continue for 24 to 48 hours after symptoms have disappeared.

If you take more Proderma 100 mg Hard Capsules than you should

If you have taken more Proderma 100 mg Hard Capsules than you should, consult your doctor or pharmacist immediately.

In case of overdose or accidental ingestion, consult the Toxicology Information Service. Phone: (91) 562 04 20.

If you forget to take Proderma 100 mg Hard Capsules

If you forget to take a dose, take the next one when it is due. Do not take a double dose to make up for the forgotten dose.

Medicine questions

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4. Possible Side Effects

Like all medicines, Proderma 100 mg Hard Capsules can cause side effects, although not everyone gets them.

After taking Proderma 100 mg, the following side effects have been detected:

Blood and Lymphatic System Disorders:blood disorders after tetracycline administration are very rare. However, cases of hemolytic anemia (consequence of increased red blood cell destruction), thrombocytopenia (decreased platelet count), neutropenia (decreased neutrophil count), and eosinophilia (increased eosinophil count) have been reported.

Nervous System Disorders:infrequently, intracranial hypertension occurs, characterized by headache, nausea, vomiting, dizziness, tinnitus, and visual disturbances. These symptoms resolve after withdrawal of the drug. Bulging fontanelles in children have also been reported.

Gastrointestinal Disorders:digestive alterations, such as esophageal ulcers (see section 3. How to Take Proderma 100 mg Hard Capsules), nausea, stomach pain, diarrhea, loss of appetite, tongue inflammation, intestinal inflammation, and anogenital candidiasis (infection by a microscopic fungus), may occur.

Permanent tooth discoloration may also occur if doxycycline is used during dental development (second half of pregnancy, lactation, and children under 8 years).

Liver Disorders:treatment with high doses may cause hepatitis and liver function disorders.

Skin and Subcutaneous Tissue Disorders:urticaria, maculopapular rash (spots and small elevations of the skin), exudative erythema (redness and spots on the skin), multiform eruptions (redness and swelling of the skin), photosensitivity reactions, exceptionally exfoliative dermatitis (inflammation and peeling of the skin), and rarely Stevens-Johnson syndrome.

Frequency not known: photoonycholysis (nail pigmentation).

Musculoskeletal and Connective Tissue Disorders:joint pain and muscle pain, as well as delayed growth in children, may occur.

Kidney Disorders:like all tetracyclines, doxycycline may cause increased blood urea nitrogen levels.

General Disorders:occasionally, severe hypersensitivity reactions (allergies), urticaria, angioedema (fluid retention in blood vessels), hypotension (decreased blood pressure), pericarditis (inflammation of the tissue surrounding the heart), worsening of systemic lupus erythematosus, angioneurotic edema, serum sickness (allergic reaction to serum), and, very rarely, anaphylactic shock (unusual or exaggerated allergic reaction), may occur.

Jarisch-Herxheimer reaction: characterized by fever, chills, headache, muscle pain, and rash, and usually resolves spontaneously. It occurs shortly after starting treatment with doxycycline for spirochetal infections, such as Lyme disease.

If you think any of the side effects you are experiencing is serious or if you notice any side effect not mentioned in this package leaflet, inform your doctor or pharmacist.

Reporting Side Effects

If you experience any side effects, consult your doctor or pharmacist, even if they are not listed in this package leaflet. You can also report them directly through the Spanish Medicines and Healthcare Products Agency's website: www.notificaRAM.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Proderma 100 mg Hard Capsules

Keep out of sight and reach of children.

No special storage conditions are required.

Do not use this medicine after the expiration date stated on the carton after CAD. The expiration date is the last day of the month indicated.

Medicines should not be disposed of via wastewater or household waste. Place the empty packaging and any unused medicines in the pharmacy's SIGRE collection point. If in doubt, ask your pharmacist how to dispose of the packaging and unused medicines. This will help protect the environment.

6. Package Contents and Additional Information

Composition of Proderma 100 mg Hard Capsules

  • The active ingredient is doxycycline. Each capsule contains 100 mg of doxycycline (as hyclate).
  • The other ingredients are: saccharose, cornstarch, crospovidone, polyaminomethacrylate (Eudragit E100), talc, gelatin, carmine indigo (E132), erythrosine (E127), and titanium dioxide (E171).

Appearance of the Product and Package Contents

Proderma 100 mg is available in packs of 42 capsules.

Other presentations:

Proderma 50 mg Hard Capsules

Proderma 200 mg Hard Capsules

Marketing Authorization Holder

INDUSTRIAL FARMACÉUTICA CANTABRIA, S.A.

Carretera de Cazoña-Adarzo, s/n.

39011, Santander

Spain

Manufacturer

INDUSTRIAL FARMACÉUTICA CANTABRIA, S.A.

C/ Pirita, 9 28850 Torrejón de Ardoz (Madrid)

Spain

or

TOLL MANUFACTURING SERVICES, S.L.

Aragoneses 2,

28108 Alcobendas (Madrid)

Spain

This package leaflet was approved in June 2022.

Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Healthcare Products (AEMPS) http://www.aemps.gob.es/

Online doctors for PRODERMA 100 mg HARD CAPSULES

Discuss questions about PRODERMA 100 mg HARD CAPSULES, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Doctor

Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

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Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
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Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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Anna Biriukova

General medicine 6 years exp.

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

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Endocrinology – Diabetes, thyroid, metabolism:
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Gastroenterology – Digestive health:
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  • Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
  • Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).
General internal medicine and preventive care:
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Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.
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Dmytro Horobets

Family medicine 7 years exp.

Dr. Dmytro Horobets is a licensed family medicine physician in Poland, specialising in endocrinology, diabetology, obesity management, gastroenterology, pediatrics, general surgery, and pain medicine. He offers online consultations for adults and children, providing personalised medical support for a wide range of acute and chronic health concerns.

Areas of expertise:

  • Endocrinology: diabetes type 1 and type 2, prediabetes, thyroid disorders, metabolic syndrome, hormonal imbalance.
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  • Gastroenterology: acid reflux (GERD), gastritis, irritable bowel syndrome (IBS), liver and biliary conditions.
  • Pediatric care: infections, respiratory symptoms, digestive issues, growth and development monitoring.
  • General surgery support: pre- and post-surgical consultations, wound care, rehabilitation.
  • Pain management: chronic and acute pain, back pain, joint pain, post-traumatic pain syndromes.
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  • Preventive medicine: regular check-ups, health screenings, long-term management of chronic conditions.

Dr. Horobets combines evidence-based medicine with a patient-centred approach. He carefully evaluates each patient’s medical history and symptoms, offering clear explanations and structured treatment plans adapted to individual needs.

Whether you need help managing diabetes, tackling weight-related health issues, interpreting lab results, or receiving general family medicine support, Dr. Horobets provides professional online care tailored to your specific health goals.

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Svetlana Kolomeeva

Cardiology 18 years exp.

Dr. Svetlana Kolomeeva is a general practitioner and internal medicine doctor providing online consultations for adults. She helps patients manage acute symptoms, chronic conditions, and preventive care. Her clinical focus includes cardiovascular health, hypertension control, and managing symptoms like fatigue, weakness, sleep issues, and overall low energy.

Patients commonly seek her help for:

  • High blood pressure, headaches, dizziness, swelling, palpitations.
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  • Respiratory symptoms: colds, flu, sore throat, cough, fever.
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  • Chronic conditions: diabetes, thyroid disorders.
  • Interpretation of lab tests and medical reports, therapy adjustment.
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  • Long-term follow-up and dynamic health monitoring.

Dr Kolomeeva combines clinical expertise with personalised care. She clearly explains diagnoses, guides patients through symptoms and treatment options, and provides actionable plans. Her consultations are designed not only to address current complaints but also to stabilise chronic conditions and prevent future complications. She supports patients through every stage of care – from first symptoms to ongoing health management.

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Doctor

Alexander Nazarchuk

Allergology 7 years exp.

Dr. Alexander Nazarchuk is a physician specialising in allergology and internal medicine. He provides online consultations for adults, following the principles of evidence-based medicine — no outdated treatments or unnecessary tests, with clear explanations and a personalised approach. He helps patients with a wide range of allergic and therapeutic conditions, from common day-to-day complaints to complex cases involving allergies, gastrointestinal issues, cardiovascular concerns, respiratory symptoms, and more.

You can consult Dr. Nazarchuk for:

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  • Abdominal pain, bloating, changes in bowel habits, nausea, heartburn.
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During consultations, Dr. Nazarchuk takes a thorough, structured approach — analysing symptoms, identifying potential causes, and helping patients make informed decisions. Whether treatment, further investigation, or monitoring is needed, he explains each step clearly so you understand your health and how best to manage it.

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Frequently Asked Questions

Is a prescription required for PRODERMA 100 mg HARD CAPSULES?
PRODERMA 100 mg HARD CAPSULES requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in PRODERMA 100 mg HARD CAPSULES?
The active ingredient in PRODERMA 100 mg HARD CAPSULES is doxycycline. This information helps identify medicines with the same composition but different brand names.
How much does PRODERMA 100 mg HARD CAPSULES cost in pharmacies?
The average pharmacy price for PRODERMA 100 mg HARD CAPSULES is around 7.21 EUR. Prices may vary depending on the manufacturer and dosage form.
Who manufactures PRODERMA 100 mg HARD CAPSULES?
PRODERMA 100 mg HARD CAPSULES is manufactured by Industrial Farmaceutica Cantabria S.A.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of PRODERMA 100 mg HARD CAPSULES online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether PRODERMA 100 mg HARD CAPSULES is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to PRODERMA 100 mg HARD CAPSULES?
Other medicines with the same active substance (doxycycline) include DOSIL 100 mg HARD CAPSULES, DOXICICLINA NORMON 100 mg FILM-COATED TABLETS, DOXICLAT 100 mg FILM-COATED TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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