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LIDBREE 42 mg/mL INTRAUTERINE GEL

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About the medicine

How to use LIDBREE 42 mg/mL INTRAUTERINE GEL

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

PACKAGE LEAFLET

Package Leaflet: Information for the patient

Lidbree 42 mg/ml intrauterine gel

lidocaine

Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
    1. If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
    • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What is Lidbree and what is it used for
  2. What you need to know before you use Lidbree
  3. How to use Lidbree
  4. Possible side effects

5 Conservation of Lidbree

  1. Contents of the pack and further information

1. What is Lidbree and what is it used for

Lidbree is an anesthetic gel used to prevent pain from gynecological procedures, such as the placement of contraceptive devices in the uterus and biopsy sampling for laboratory evaluation in gynecological examinations, in adults and adolescents from 15 years of age. It contains the active ingredient lidocaine, a local anesthetic of the amide type (which numbs the parts of the body to which it is applied).

How does Lidbree work?

After applying the gel, it takes 2 to 5 minutes before the genital area (mucosa) is numb. It has been shown that the gel reduces pain during gynecological procedures and up to at least 30 minutes after the procedure. After 1 hour, the analgesic effect disappears.

Doctor consultation

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2. What you need to know before you use Lidbree

Do not use Lidbree

If you are allergic to lidocaine or any of the other components of this medicine (listed in section 6).

Warnings and precautions

Exclusive use by endocervical and intrauterine route. After using the gel for the placement of an intrauterine contraceptive (intrauterine device, IUD), in cases of difficult insertion, bleeding and/or exceptional pain may occur. In these cases, a physical examination and an ultrasound should be performed immediately to rule out a perforation of the uterus (matrix) or cervix (cervix). The average is 1 perforation per 1,000 IUD insertion procedures.

Inform the healthcare professional who will administer Lidbree to you:

  • if you have a heart rhythm disorder (partial or complete cardiac conduction block) as local anesthetics may affect it;
  • if you are being treated for a heart rhythm disorder (with potassium channel blockers or class III antiarrhythmics (e.g., amiodarone)) because cardiac effects may increase;
  • if you have a condition called acute porphyria (a family condition related to one of the proteins in the blood). Lidocaine may cause porphyria attacks and should only be prescribed in patients with acute porphyria in urgent or necessary cases;
  • if you have a poor general state of health.

Children and adolescents

This medicine should not be administered to children under 15 years of age due to the risk of side effects caused by high concentrations of lidocaine in the blood.

Other medicines and Lidbree

Tell your doctor or pharmacist if you are using, have recently used, or may need to use any other medicine that contains lidocaine or medicines to treat irregular heart rhythm (antiarrhythmics, such as mexiletine or class III antiarrhythmics like amiodarone), as their effects on the heart will be added to those of lidocaine.

Pregnancy, breastfeeding, and fertility

Based on long-term experience, it is unknown whether lidocaine produces adverse effects in the newborn.

Lidocaine can be secreted in breast milk, but in such small amounts that there is generally no risk of affecting the newborn. Therefore, breastfeeding can continue in case of treatment with Lidbree.

The effect of lidocaine on fertility is unknown.

Driving and using machines

Lidbree has a negligible influence on the ability to drive and use machines.

Lidbree contains macrogolglycerol ricinoleate (polyoxyethylated castor oil) and butylhydroxytoluene

Macrogolglycerol ricinoleate may cause severe allergic reactions.

This medicine may cause local skin reactions (such as contact dermatitis) or eye and mucous membrane irritation because it contains butylhydroxytoluene (E321).

3. How to use Lidbree

Your doctor or nurse will apply the anesthetic gel step by step, starting from the entrance of the uterus.

Use inadolescents

Adolescents with low weight, below 30 kg body weight, should receive a reduced dose.

If you use more Lidbree than you should

With the recommended doses, the following effects are not expected to occur; however, inform your doctor or nurse immediately if you experience numbness of the lips or tongue, dizziness, ringing in the ear (tinnitus), or have difficulty speaking or seeing correctly (visual disturbances), as they may be the first symptoms of high concentrations of lidocaine in the blood. In some cases, muscle spasms or tremors (tremors) or interruptions of breathing (apnea) may occur; in that case, your doctor or nurse should quickly ensure that you are breathing correctly (respiratory support) and administer anticonvulsants.

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or call the Toxicology Information Service, phone 91 562 04 20, indicating the medicine and the amount used or ingested.

Medicine questions

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4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

The side effects experienced after using Lidbree for the insertion of intrauterine contraceptives (matrix) are similar to those that occur in the same process without the application of Lidbree.

Possible side effects are:

  • Very common(more than 1 in 10 people): nausea (feeling unwell).
  • Common(may affect up to 1 in 10 people): dizziness, headache, unpleasant sensations in the abdomen.

Reporting of side effects

If you experience any side effects, talk to your doctor, pharmacist, or nurse, even if it is possible side effects not listed in this leaflet. You can also report side effects directly through the Spanish Pharmacovigilance System for Human Use Medicines: https://www.notificaram.es By reporting side effects, you can help provide more information on the safety of this medicine.

5. Conservation of Lidbree

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date (month-year) that appears on the carton and on the syringe. The expiry date is the last day of the month indicated.

This medicine does not require special storage conditions.

Medicines should not be disposed of via wastewater or household waste. Place the packaging and medicines you no longer need in the SIGRE collection point at the pharmacy. If in doubt, ask your pharmacist how to dispose of the packaging and medicines you no longer need. This will help protect the environment.

6. Contents of the pack and further information

Composition of Lidbree

  • The active ingredient is lidocaine. Each ml of intrauterine gel contains 42 mg of lidocaine.
  • The other components are:
  • Macrogolglycerol ricinoleate (polyoxyethylated castor oil)
  • Poloxamer (contains butylhydroxytoluene (E 321))
  • Sodium ascorbate (E 301)
  • Hydrochloric acid for pH adjustment
  • Sodium hydroxide for pH adjustment
  • Water for injectable preparations

Appearance of the product and contents of the pack

The product is a sterile, transparent or almost transparent, slightly brownish-yellow viscous liquid intrauterine gel at room temperature, containing 42 mg/ml of lidocaine. The formulation shows a reversible temperature-dependent gelification, it is a gel at body temperature (thermogelification). Lidbree 42 mg/ml intrauterine gel is presented in a 10 ml pre-filled sterile syringe (cycloolefin copolymer) with a bromobutyl rubber tip cap and a plunger rod, packaged in a blister pack with the plunger rod. The syringe is graduated in ml. A sterile applicator (polypropylene) with a Luer lock adapter compatible with the pre-filled syringe is provided in a separate bag within the carton. 8.5 ml of gel can be extracted from the applicator.

Pack size: 1 x 10 ml intrauterine gel in pre-filled syringe.

Symbols on the Lidbree applicator label

Mathematical formula that calculates volume with body weight in kilograms and initial dose in milligrams

Hand placing a cotton swab soaked with liquid over the injection site on the skin, gently pressing with the fingers

Circle with a white box and black lines indicating a prohibition of stacking or pressing the product

Circular symbol with a thick diagonal line over the number two indicating prohibition or do not use

Stylized CE symbols in black on a white background indicating European conformity with safety regulations

Catalog number

Batch code

Do not use if the packaging is damaged

Do not reuse

CE marking

Black silhouette of industrial building with smoking chimneys on a white background

Stylized hourglass with an inverted trapezoid shape showing the passage of time

Sterile packaging with the letters “STERILE R” printed in black on a white background and a black rectangular border

Open book with a letter

Manufacturer

Expiry date

Sterilized by irradiation

Consult the instructions for use

Marketing authorization holder and manufacturer

Marketing authorization holder

Gedeon Richter Plc.

Gyömroi út 19-21.

Budapest H-1103

Hungary

Manufacturers:

Recipharm Karlskoga AB

Björkbornsvägen 5

SE-691 33 Karlskoga

Sweden

Gedeon Richter Plc.

Gyömroi út 19-21.

Budapest H-1103

Hungary

You can request more information about this medicine by contacting the local representative of the marketing authorization holder:

Gedeon Richter Ibérica, S.A.

Sabino Arana, 28 - 4º 2ª

08028 Barcelona

Spain

This medicine is authorized in the Member States of the European Economic Area under the following names:

Austria, Belgium, Bulgaria, Cyprus, Czech Republic, Germany, Denmark, Estonia, Greece, Spain, Finland, France, Croatia, Hungary, Ireland, Iceland, Italy, Luxembourg, Latvia, Lithuania, Malta, Norway, Poland, Portugal, United Kingdom, Romania, Sweden, Slovenia, Slovakia: Lidbree

Date of the last revision of thisleaflet:June2020

Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) (http://www.aemps.gob.es/)

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This information is intended only for healthcare professionals:

Exclusive use by endocervical and intrauterine route.

After using Lidbree, in cases of difficult insertion and/or exceptional pain or bleeding during or after insertion, a physical examination and an ultrasound should be performed immediately to rule out a perforation of the uterus (matrix) or cervix (cervix), as with effective topical anesthesia, the patient may not react with pain in case of perforation.

Thermogelifying formulation:Lidbree is a local anesthetic, viscous liquid, thermogelifying, without preservatives. The formulation forms a gel when the temperature increases to body temperature, adhering to the mucous tissue of the cervical canal and uterus (minimizing losses that would occur with a liquid formulation).

Method of application and dosage

Lidbree should be administered in a liquid state. If a gel forms, place it in the refrigerator until it becomes liquid again. The visible air bubble in the syringe moves when the syringe is tilted.

Prepare the sterile applicator included in the packaging by following the indicated steps and apply the medicine:

  1. Check the appearance of the syringe while tilting it. The air bubble will move when tilting the syringe when the product is in a liquid state, ready to use. If the air bubble does not move, it is because a gel has formed; in that case, you should place the syringe in the refrigerator until it becomes liquid again.
  2. Connect the plunger rod and the applicator to the syringe, ensuring they are well engaged.

Hypodermic needle with bevel and removable transparent protector showing the plunger and metal cylinder

  1. Remove the air bubble and fill the applicator with gel by carefully pushing the syringe plunger.
  2. Use the centimeter scale on the applicator to measure the amount of Lidbree.

Once the applicator is in place, 8.5 ml of gel can be administered from the syringe. One ml contains 42 mg of lidocaine. Apply the gel step by step (1 to 3) as illustrated in the figure.

Schematic uterus with a vertically inserted syringe showing indicator numbers and arrows pointing to internal structures

Cervical procedures

  1. Using the sterile applicator, apply 2 to 3 ml of the gel in a thick layer on the exocervix.
  2. Using the applicator, administer 3 ml into the cervical canal 5 minutes before the start of the procedure.

Intrauterine procedures

  1. Using the sterile applicator, apply 1 to 2 ml of the gel on the anterior lip of the exocervix.
  2. Using the applicator, administer 2 to 3 ml into the cervical canal. Wait 2 minutes for the effect to begin in the internal canal.
  3. Then, insert the applicator into the uterine cavity and introduce 3 to 5 ml of the gel, 5 minutes before the procedure. The applicator is marked with a centimeter scale. A smaller volume can be administered, e.g., in nulliparous patients, if the patient experiences discomfort before finishing administering the entire volume.

A single intrauterine dose should not exceed 10 ml. Discard the unused contents.

Pediatric population from 15 years of age.

In adolescents with low weight, body weight below 30 kg, the dose should be reduced proportionally; the single dose should not exceed the recommended maximum parenteral dose (6 mg/kg of lidocaine hydrochloride, which corresponds to 5.2 mg/kg of lidocaine base in Lidbree, i.e., 1.2 ml per 10 kg of body weight). In adolescents with a body weight of 30 kg, the maximum dose of Lidbree is 3.6 ml in total.

Duration of the effect

It has been shown that the gel reduces pain during gynecological procedures and up to at least 30 minutes after the procedure. After 1 hour, the analgesic effect has disappeared.

Online doctors for LIDBREE 42 mg/mL INTRAUTERINE GEL

Discuss questions about LIDBREE 42 mg/mL INTRAUTERINE GEL, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

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Dr Daria Portnova is a psychiatrist and psychotherapist with over 30 years of clinical experience. She works with adults and adolescents aged 14 and over, providing online psychiatric and psychotherapeutic consultations. In her practice, Dr Portnova supports patients facing the onset of mental health conditions, chronic psychiatric disorders, psychotic symptoms, trauma-related states, and complex emotional crises. Her work is structured and safety-focused, with an emphasis on stabilisation, accurate diagnosis, and long-term improvement in quality of life. Patients consult Dr Daria Portnova for the following concerns: 

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General medicine 6 years exp.

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

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Family medicine 7 years exp.

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Cardiology 18 years exp.

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Maria Martelli

Anaesthesiology 12 years exp.

Dr Maria Martelli is a medical doctor specialising in anaesthesiology and pain medicine. She provides online consultations for adults, focusing on the assessment and management of acute, chronic, and complex pain conditions, as well as supportive care in serious illness. She graduated from the Medical University of Silesia in Katowice and completed her specialisation in Anaesthesiology and Intensive Care. Alongside hospital work, she has extensive experience in home and inpatient hospice care, supporting patients with severe pain and advanced disease. Since 2021, she has been a certified specialist and continues to work in anaesthesiology, intensive care, and pain treatment. Patients consult her for: 

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Frequently Asked Questions

Is a prescription required for LIDBREE 42 mg/mL INTRAUTERINE GEL?
LIDBREE 42 mg/mL INTRAUTERINE GEL requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in LIDBREE 42 mg/mL INTRAUTERINE GEL?
The active ingredient in LIDBREE 42 mg/mL INTRAUTERINE GEL is lidocaine. This information helps identify medicines with the same composition but different brand names.
Who manufactures LIDBREE 42 mg/mL INTRAUTERINE GEL?
LIDBREE 42 mg/mL INTRAUTERINE GEL is manufactured by Gedeon Richter Plc.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of LIDBREE 42 mg/mL INTRAUTERINE GEL online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether LIDBREE 42 mg/mL INTRAUTERINE GEL is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to LIDBREE 42 mg/mL INTRAUTERINE GEL?
Other medicines with the same active substance (lidocaine) include ACTILOGIC 700 MG MEDICATED ADHESIVE DRESSING, DYNEXAN 20 mg/g BUCAL GEL, INSTILLIDO 20 mg/ml GEL. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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