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GASTROFRENAL 100 mg HARD CAPSULES

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Doctor

Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
This page is for general information. Consult a doctor for personal advice. Call emergency services if symptoms are severe.
About the medicine

How to use GASTROFRENAL 100 mg HARD CAPSULES

Translated with AI

This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

Show original

Introduction

Leaflet: information for the user

GASTROFRENAL 100 mg hard capsules

Sodium cromoglicate

Read this leaflet carefully before starting to take this medicine, as it contains important information for you.

  • Keep this leaflet, as you may need to read it again.
  • If you have any questions, ask your doctor or pharmacist.
  • This medicine has been prescribed to you only, and you should not give it to others, even if they have the same symptoms as you, as it may harm them.
  • If you experience side effects, consult your doctor or pharmacist, even if they are not listed in this leaflet. See section 4.

Contents of the leaflet

  1. What Gastrofrenal 100 mg hard capsules are and what they are used for.
  2. What you need to know before taking Gastrofrenal 100 mg hard capsules.
  3. How to take Gastrofrenal 100 mg hard capsules.
  4. Possible side effects.
  5. Storage of Gastrofrenal 100 mg hard capsules.
  6. Package contents and additional information.

1. What Gastrofrenal 100 mg hard capsules are and what they are used for

Gastrofrenal is indicated in food allergies and in the treatment of symptoms associated with the release of mast cell mediators (mastocytosis and mast cell activation syndromes) in adults, adolescents, and children with a weight of 40 kg or more.

Doctor consultation

Not sure if this medicine is right for you?

Discuss your symptoms and treatment with a doctor online.

2. What you need to know before taking Gastrofrenal 100 mg hard capsules

Do not take Gastrofrenal 100 mg hard capsules:

  • If you are allergic to sodium cromoglicate or any of the other components of this medicine (listed in section 6).

Warnings and precautions

Consult your doctor or pharmacist before starting to take this medicine.

In the treatment of food allergies, any reintroduction of an allergenic food into the diet should only be done under strict medical supervision.

If you are taking oral corticosteroid medications, consult your doctor before taking this medicine, as you may need to adjust the dose of your medication.

Children and adolescents

Treatment of mastocytosis with cromoglicate in children should only be done in cases where the doctor considers it necessary, such as when severe symptoms require intensive treatment.

Elderly patients (over 65 years)

The presence of other concomitant diseases should be taken into account. In case of renal or hepatic impairment, your doctor may adjust the dose of this medicine.

If you experience an allergic reaction, you should permanently discontinue treatment.

If you experience any other adverse reaction, discontinue treatment and consult your doctor. Your doctor will indicate how to resume treatment with Gastrofrenal.

Patients with renal or hepatic impairment

If you have renal or hepatic impairment, consult your doctor to adjust the dose of the medicine.

Taking Gastrofrenal 100 mg hard capsules with other medicines

Tell your doctor or pharmacist if you are taking, have recently taken, or may take any other medicines.

Although no interactions with other medicines have been described, it is still recommended to space out the administration of cromoglicate and other medicines.

Taking Gastrofrenal 100 mg hard capsules with food, drinks, and alcohol

This medicine should be taken on an empty stomach. You can eat food 30 minutes after taking the medicine or 2 hours before taking it.

Pregnancy, breastfeeding, and fertility

If you are pregnant or breastfeeding, think you may be pregnant, or plan to become pregnant, consult your doctor or pharmacist before using this medicine.

There are no data on the treatment with this medicine in pregnant women, so it should be avoided during pregnancy unless your doctor considers it strictly necessary. Women who wish to become pregnant should consult their doctor.

There are no data on the excretion of sodium cromoglicate in breast milk. Breastfeeding women should consult their doctor before taking this medicine.

Driving and using machines

This medicine is unlikely to affect your ability to drive and use machines.

3. How to take Gastrofrenal 100 mg hard capsules

Treatment with this medicine can only be initiated and supervised by an experienced doctor in the management of these diseases.

Your doctor will indicate the recommended dose for you, as a guideline:

  1. Treatment of food allergies

-Initial dose:

Adults:

2 capsules of 100 mg (200 mg) 4 times a day, before meals.

Adolescents and children with weight ≥ 40 kg:

10 to 15 mg/kg body weight per day, divided into 4 doses, before meals.

If satisfactory control is not achieved after 2 or 3 weeks, the dosage may be increased to 1500 mg/day in adults and up to 20 mg/kg/day in children, always divided into 4 doses.

-Maintenance dose:

Once a therapeutic response is achieved, the dose should be reduced to the minimum necessary to keep the patient symptom-free.

  1. Symptoms associated with the release of mast cell mediators (mastocytosis and mast cell activation syndromes)

Treatment should be individualized and adapted to each patient. Your doctor will indicate the dose and how to take this medicine. However, the usual dose is as follows:

-Initial dose:

Adults:

For the first 2 days of treatment, only 200 mg per day will be administered, at night. If tolerance is good, during days 3 and 4 of treatment, the dose can be increased to 400 mg, divided into 2 doses (200 mg at night and 200 mg in the morning). If tolerance is good, treatment will continue with the usual dose of 200 mg, 4 times a day.

Adolescents and children with weight ≥ 40 kg:

During the first days of treatment, the same instructions given for adults should be followed.

The most suitable regimen would be: for the first 2 days, administer only 100 mg per day, at night. If tolerance is good, during days 3 and 4 of treatment, the dose can be increased to 200 mg, divided into 2 doses (100 mg at night and 100 mg in the morning). If tolerance is good, treatment will continue with the usual dose calculated based on weight (10 to 15 mg/kg/day) always divided into 4 daily doses.

-Maintenance dose:

Adults:

200 mg (2 capsules of 100 mg) 4 times a day, before meals.

Adolescents and children with weight ≥ 40 kg:

10 to 15 mg/kg body weight per day, divided into 4 doses.

If satisfactory control of symptoms is not achieved after 2 or 3 weeks, your doctor may increase the dose to 1500 mg per day in adults and up to 20 mg/kg/day in children, always divided into 4 doses.

Method of administration

This medicine is taken orally.

You should take the capsules with a glass of water and on an empty stomach. Take the medicine 30 minutes before eating or 2 hours after eating.

If you experience adverse reactions or do not observe improvement in the symptoms of the disease, you should consult your doctor, as a dose adjustment may be necessary.

If you take more Gastrofrenal 100 mg hard capsules than you should

In case of overdose or accidental ingestion, consult your doctor or pharmacist immediately or call the Toxicology Information Service, telephone (91) 5620420, indicating the medicine and the amount ingested.

If you forget to take Gastrofrenal 100 mg hard capsules

Do not take a double dose to make up for forgotten doses.

If you have any other questions about the use of this medicine, ask your doctor or pharmacist.

Medicine questions

Started taking the medicine and have questions?

Discuss your symptoms and treatment with a doctor online.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everyone gets them.

Although this medicine is generally well tolerated, serious allergic reactions have been described in some cases, especially when used by inhalation. If you experience symptoms of anaphylaxis (swelling of the face, tongue, eyes, difficulty breathing), stop taking the medicine immediately.

The following adverse reactions have been reported with an unknown frequency (cannot be estimated from the available data):

  • headache, anxiety, irritability, mood changes, sleep disorders.
  • upper abdominal pain, nausea, abdominal cramps, constipation, diarrhea, dyspepsia.
  • rash, itching.
  • muscle pain, joint pain, and moderate fatigue.

Reporting side effects

If you experience any side effects, consult your doctor or pharmacist, even if they are not listed in this leaflet. You can also report them directly through the Spanish Pharmacovigilance System for Human Use www.notificaRAM.es.

By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Gastrofrenal 100 mg hard capsules

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiration date stated on the packaging after "EXP". The expiration date is the last day of the month indicated.

Medicines should not be disposed of via wastewater or household waste. Dispose of the packaging and any unused medicine in the pharmacy's Sigre collection point. If in doubt, ask your pharmacist how to dispose of the packaging and any unused medicine. This will help protect the environment.

6. Package contents and additional information

Composition of Angileptol mint flavor

Each tablet contains:

  • The active ingredients:

Chlorhexidine dihydrochloride, 5 mg

Benzocaine, 4 mg

Enoxolone, 3 mg

  • The other ingredients (excipients) are: sorbitol (E420), potassium acesulfame (E950), magnesium stearate, and mint flavor

Appearance of the product and package contents

Angileptol are sucking tablets, white, round, and with the Greek letter σ on one face.

They are available in packages containing 15 and 30 sucking tablets.

Other presentations

Angileptol Mint-eucalyptus flavor

Angileptol Honey-lemon flavor

Marketing authorization holder

Alfasigma Spain S.L.

C/ Aribau 195, 4th floor

08021 Barcelona, Spain

Manufacturer

Pharmaloop, S.L.

Polígono Industrial Azque C/Bolivia, 15

28806 Alcalá de Henares (Madrid), Spain

or

Alfasigma, S.p.A.

Via Pontina, Km 30,400

00071 Pomezia (Rome), Italy

Date of the last revision of this leaflet:September 2021

Other sources of information

Detailed information about this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.gob.es

Online doctors for GASTROFRENAL 100 mg HARD CAPSULES

Discuss questions about GASTROFRENAL 100 mg HARD CAPSULES, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

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Doctor

Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
0.0 (11)
Doctor

Rita Isabel Calero Garcia

General medicine 2 years exp.

Dr. Rita Isabel Calero Garcia is a physician with extensive experience in emergency medical care, general medicine, and healthcare assistance in various clinical and out-of-hospital settings.

She currently works as a physician at the Canary Islands Emergency Service (Servicio de Urgencias Canario – SUC), where she is responsible for the assessment and care of patients in medical emergency situations, performing the initial diagnosis, patient stabilization, and coordination with hospital services when necessary.

She has also developed her professional activity within the Primary Care Management Service, providing consultations in general medicine. In this setting she is responsible for patient follow-up, management of acute and chronic conditions, as well as health promotion and disease prevention.

She has also worked as a physician in a mobile ICU unit, providing medical assistance in out-of-hospital emergencies, treating critical patients and participating in medicalized patient transport.

In addition, she has collaborated with the Red Cross, participating in healthcare support units, providing medical assistance at events and supporting emergency interventions.

Furthermore, she has provided medical services in the private sector with Salvaser, conducting clinical assessments of patients and providing healthcare services within private medical services.

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Doctor

Antonio Cayatte

General medicine 44 years exp.

Dr Antonio Cayatte is a physician in General and Acute Medicine with over 30 years of experience across clinical care, medical research, and education. He offers online consultations for adults with a wide range of symptoms, both acute and chronic. His clinical background includes: 

  • assessment of sudden or unclear symptoms
  • ongoing care for chronic conditions
  • follow-up after hospital discharge
  • interpretation of test results
  • medical support while abroad

Dr Cayatte earned his degree from the University of Lisbon and taught internal medicine at Boston University School of Medicine. He holds active medical registrations in both Portugal and the UK and is a Fellow of the American Heart Association. Consultations are available in English and Portuguese. Patients value his clarity, professionalism, and balanced approach to evidence-based care.

Dr. Antonio Cayatte provides comprehensive care for a broad spectrum of common health concerns, including:

  • Respiratory & ENT: acute bronchitis, concerns related to pneumonia, sinusitis, tonsillitis, ear infections, sore throat conditions, and allergic rhinitis
  • Eye Health: allergic and infectious conjunctivitis, as well as red or irritated eyes
  • Digestive & Urinary: gastroesophageal reflux disease (GERD), gastritis, urinary tract infections, and cystitis
  • Chronic Conditions: hypertension, elevated cholesterol, and structured weight management planning
0.0 (0)
Doctor

Joao Silva

General medicine 6 years exp.

Dr. João Silva is a physician with training and experience in the field of General and Family Medicine, dedicated to providing healthcare focused on the well-being and quality of life of his patients. Throughout his professional career, he has developed broad clinical competencies, striving to maintain a medical practice based on scientific evidence and continuous knowledge updates.

Between 2013 and 2019, he completed the Integrated Master's Degree in Medicine at the Abel Salazar Institute of Biomedical Sciences in Porto, where he acquired a solid academic and clinical education.

Subsequently, between January 2021 and December 2021, he completed the General Internship at the Entre Douro e Vouga Hospital Center in Santa Maria da Feira, where he had the opportunity to work in different hospital settings and deepen his competencies in several areas of medicine.

From January 2022 until March 2026, he works as a Resident Physician in General and Family Medicine at USF Salvador Machado in Oliveira de Azeméis, developing clinical activities in primary healthcare, follow-up of chronic patients, and health promotion in the community.

Complementing his medical training, Dr. João Silva also completed a Postgraduate Degree in Continuing and Palliative Care at CESPU, strengthening his preparation in the comprehensive approach to patient care, especially in situations requiring prolonged care and multidisciplinary support.

5.0 (54)
Doctor

Anna Biriukova

General medicine 6 years exp.

Dr Anna Biriukova is an internal medicine doctor with clinical experience in cardiology, endocrinology, and gastroenterology. She provides online consultations for adults, offering expert medical support for heart health, hormonal balance, digestive issues, and general internal medicine.

Cardiology – Diagnosis and treatment of:

  • High blood pressure, blood pressure fluctuations, and cardiovascular risk prevention.
  • Chest pain, shortness of breath, arrhythmias (tachycardia, bradycardia, palpitations).
  • Leg swelling, chronic fatigue, reduced exercise tolerance.
  • EKG interpretation, lipid profile evaluation, cardiovascular risk assessment (heart attack, stroke).
  • Post-COVID-19 cardiac monitoring and care.
Endocrinology – Diabetes, thyroid, metabolism:
  • Diagnosis and management of type 1 and type 2 diabetes, and prediabetes.
  • Individual treatment plans including oral medications and insulin therapy.
  • GLP-1 therapy– modern pharmacological treatment for weight management and diabetes control, including drug selection, monitoring, and safety follow-up.
  • Thyroid disorders – hypothyroidism, hyperthyroidism, autoimmune thyroid diseases (Hashimoto’s, Graves’ disease).
  • Metabolic syndrome – obesity, lipid disorders, insulin resistance.
Gastroenterology – Digestive health:
  • Abdominal pain, nausea, heartburn, gastroesophageal reflux (GERD).
  • Stomach and intestinal conditions: gastritis, irritable bowel syndrome (IBS), indigestion.
  • Management of chronic digestive disorders and interpretation of tests (endoscopy, ultrasound, labs).
General internal medicine and preventive care:
  • Respiratory infections – cough, colds, bronchitis.
  • Lab test analysis, therapy adjustments, medication management.
  • Adult vaccinations – planning, contraindications assessment.
  • Cancer prevention – screening strategies and risk assessment.
  • Holistic approach – symptom relief, complication prevention, and quality of life improvement.
Dr Biriukova combines internal medicine with specialist insight, offering clear explanations, personalised treatment plans, and comprehensive care tailored to each patient.
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Doctor

Sviatoslav Chekhun

Oncology 13 years exp.

Dr. Sviatoslav Chekhun is a medical oncologist with international clinical and research experience, specializing in modern medical oncology and a personalized approach to cancer treatment.

Currently (since 2025), he works as a Medical Oncologist at Institut Català d’Oncologia (Girona, Spain). Previously, he completed his residency in Medical Oncology and was involved in clinical research at Hospital Universitari Germans Trias i Pujol.

Dr. Chekhun has a strong academic and scientific background. He served as a lecturer in Internal Medicine at O.O. Bohomolets National Medical University and conducted research in experimental oncology at the R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology.

Earlier in his career, he worked as a medical oncologist at the Kyiv City Clinical Oncological Center and contributed to regulatory evaluation of medicinal products at the State Expert Center of the Ministry of Health of Ukraine.

When to consult Dr. Chekhun:

  •  for diagnosis or clarification of a cancer diagnosis
  •  to obtain a second opinion on an existing treatment plan 
  •  when you need a personalized treatment strategy 
  •  for interpretation of test results, CT, MRI, PET-CT, and biopsies 
  •  when choosing between treatment options (chemotherapy, targeted therapy, immunotherapy) 
  •  in case of doubts about treatment strategy or disease progression 

Consultation format

Dr. Chekhun provides online consultations, where you can receive:

  •  expert second opinion 
  •  detailed case review 
  •  recommendations based on current international treatment guidelines 
  •  personalized treatment and follow-up plan 

Important:
Prescription and monitoring of medications must be carried out by your treating physician in an in-person (offline) setting. An online consultation does not replace a face-to-face visit but helps you make more informed decisions about your treatment.

Dr. Sviatoslav Chekhun combines clinical practice, research, and international experience, enabling him to provide patients with modern, evidence-based approaches in oncology.

Get GASTROFRENAL 100 mg HARD CAPSULES Prescription Online

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Frequently Asked Questions

Is a prescription required for GASTROFRENAL 100 mg HARD CAPSULES?

GASTROFRENAL 100 mg HARD CAPSULES requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.

What is the active substance in GASTROFRENAL 100 mg HARD CAPSULES?

The active ingredient in GASTROFRENAL 100 mg HARD CAPSULES is cromoglicic acid. This information helps identify medicines with the same composition but different brand names.

How much does GASTROFRENAL 100 mg HARD CAPSULES cost in pharmacies?

The average pharmacy price for GASTROFRENAL 100 mg HARD CAPSULES is around 93.67 EUR. Prices may vary depending on the manufacturer and dosage form.

Who manufactures GASTROFRENAL 100 mg HARD CAPSULES?

GASTROFRENAL 100 mg HARD CAPSULES is manufactured by Alfasigma Espana S.L.. Pharmacy brands and packaging may differ depending on the distributor.

Which doctors can assess the use of GASTROFRENAL 100 mg HARD CAPSULES online?

Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether GASTROFRENAL 100 mg HARD CAPSULES is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.

How to buy GASTROFRENAL 100 mg HARD CAPSULES in Spain?

Spain has a well-developed healthcare infrastructure across major cities such as Madrid, Barcelona, Valencia, and Seville. Pharmacies are widely available and operate under strict regulations, ensuring access to prescribed medications.

You can buy GASTROFRENAL 100 mg HARD CAPSULES in Madrid, Barcelona, Seville, or Valencia at any local pharmacy with a valid prescription.

To obtain a prescription, you can use Oladoctor:

What are the alternatives to GASTROFRENAL 100 mg HARD CAPSULES?

Other medicines with the same active substance (cromoglicic acid) include GASTROFRENAL 200 mg HARD CAPSULES, ASACOL 1 G SUPPOSITORIES, ASACOL 1600 mg GASTRO-RESISTANT TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.

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