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CYTOTEC 200 micrograms tablets

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About the medicine

How to use CYTOTEC 200 micrograms tablets

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This page provides general information and does not replace a doctor’s consultation. Always consult a doctor before taking any medication. Seek urgent medical care if symptoms are severe.

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Introduction

Leaflet: Information for the user

Cytotec 200 micrograms tablets

Misoprostol

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.

  • Keep this leaflet, you may need to read it again.
  • If you have any further questions, ask your doctor or pharmacist.
  • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
  • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

Contents of the pack

  1. What Cytotec is and what it is used for
  2. What you need to know before you take Cytotec
  3. How to take Cytotec
  4. Possible side effects
  5. Storage of Cytotec
  6. Contents of the pack and other information

1. What Cytotec is and what it is used for

Misoprostol is a prostaglandin that belongs to a group of medicines called anti-ulcer medicines. It is indicated in adults for the treatment of duodenal ulcer and for the prevention of gastrointestinal lesions induced by the administration of non-steroidal anti-inflammatory drugs in long-term treatments.

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2. What you need to know before you take Cytotec

Do not takeCytotec

  • if you are a woman of childbearing age and are not using an effective contraceptive method to avoid becoming pregnant (see section "Pregnancy" for more information).
  • if you are pregnant, if you plan to become pregnant or do not have a negative pregnancy test, as misoprostol increases uterine tone and contractions during pregnancy, which can cause an abortion.
  • if you are allergic to misoprostol, to other prostaglandins or to any of the other components of this medicine (listed in section 6).

Warnings and precautions

Consult your doctor or pharmacist before starting to take Cytotec

  • if you are pregnant or plan to become pregnant (see subsection "Pregnancy" below). Due to the risk to the fetus, treatment with Cytotec should be discontinued immediately,
  • if you are a woman of childbearing age (see subsection "Pregnancy" below). Due to the risk to the fetus, it is essential to use effective contraceptive methods while taking Cytotec,
  • if you are a woman of childbearing age, as treatment with misoprostol should not begin until a possible pregnancy has been ruled out. You should use an adequate contraceptive method during treatment with this medicine. If you suspect pregnancy, you should discontinue treatment with misoprostol and consult your doctor,
  • if you are being treated with non-steroidal anti-inflammatory drugs (NSAIDs), there is a possibility that gastrointestinal bleeding, ulceration, or perforation may occur despite treatment with misoprostol. You should take this possibility into account even in the absence of gastrointestinal symptoms. If you are a patient prone to diarrhea, for example, if you have irritable bowel syndrome,
  • if you have dehydration,
  • if you have heart or circulatory disease, including high blood pressure.

Taking Cytotec with other medicines

Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.

The use of antacids containing magnesium during treatment with misoprostol should be avoided, as they may worsen the possible diarrhea induced by it.

The concomitant administration of misoprostol with non-steroidal anti-inflammatory drugs, in rare cases, produces swelling in the extremities (peripheral edema) and alteration of biochemical tests (elevation of transaminases).

Taking Cytotec with food and drinks

Cytotec should be taken during or after meals and before bedtime with a glass of water.

Pregnancy, breastfeeding, and fertility

If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Pregnancy

Do not take Cytotec if you are pregnant or planning to become pregnant. Your doctor will inform you of the risks if you become pregnant, as Cytotec can cause spontaneous abortion, premature birth, or birth defects. Pregnancies exposed to misoprostol during the first trimester have been associated with an approximately 3-fold increased risk of birth defects, particularly facial paralysis, limb malformations, cerebral and cranial anomalies. If you are exposed to Cytotec during pregnancy, consult your doctor. If you decide to continue the pregnancy, you will be closely monitored prenatally and periodic ultrasound examinations will be performed, paying special attention to the limbs and head.

Cytotec is contraindicated in pregnant women as it induces uterine contractions associated with abortions, premature births, birth defects, and fetal death. Therefore, pregnancy should be ruled out before starting to use this medicine, and an adequate contraceptive method should be used during treatment with it.

Misoprostol is excreted in breast milk and should not be administered to breastfeeding mothers, as it may have adverse effects on the infant.

Driving and using machines

Although no effects are expected, if dizziness occurs, do not drive or use hazardous machinery.

Cytotec contains castor oil and sodium

This medicine may cause stomach upset and diarrhea because it contains castor oil.

This medicine contains less than 1 mmol of sodium (23 mg) per tablet; this is, essentially "sodium-free".

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3. How to take Cytotec

Follow exactly the administration instructions of this medicine indicated by your doctor or pharmacist. In case of doubt, consult your doctor or pharmacist again.

The recommended dose in adults and elderly patients is:

For the prevention of gastrointestinal lesions induced by non-steroidal anti-inflammatory drugs (NSAIDs) in patients with long-term treatment: 1 tablet (200 micrograms of misoprostol) 2 to 4 times a day, during or after meals and at bedtime. The maximum recommended daily dose is 2 to 4 tablets (400 to 800 micrograms of misoprostol).

For the treatment of duodenal ulcer: 4 tablets (800 micrograms of misoprostol) per day divided into 4 doses, for a minimum period of 4 weeks, even if symptoms have disappeared before. Your doctor may indicate to continue treatment for up to 8 weeks.

Use in children and adolescents

The safety and efficacy in children under 18 years have not been established.

Patient with renal impairment

If you have kidney problems (renal failure), your doctor may recommend a lower dose.

Cytotec is administered orally. The tablets should be swallowed whole with a sufficient amount of liquid during or after meals or before bedtime.

The score line should not be used to divide the tablet

If you take more Cytotec than you should

You may experience the following symptoms: sedation, tremor, convulsions, difficulty breathing, abdominal pain, diarrhea, fever, palpitations, low blood pressure or slower heartbeats.

If you have taken more misoprostol than you should, consult your doctor, pharmacist, or call the Toxicology Information Service, phone: 91 562 04 20, indicating the medicine and the amount taken. It is recommended to take the package and the leaflet of the medicine to the healthcare professional.

If you forget to take Cytotec

In case of forgetting a dose, take the medicine as soon as possible, continuing the treatment as prescribed. Do not take a double dose to make up for forgotten doses.

If you stop taking Cytotec

Do not stop treatment without consulting your doctor, as there is a risk of suffering a gastrointestinal lesion.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

4. Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them.

Diarrhea is the most frequent side effect. It usually appears in the first days of treatment and is transitory. To reduce the risk of diarrhea, it is recommended to take the medicine with food.

The reported side effects are classified according to their frequency as:

Very common(may affect more than 1 in 10 people):

  • diarrhea,
  • rash.

Common(may affect up to 1 in 10 people):

  • dizziness, headache,
  • abdominal pain, constipation, indigestion, gas, nausea, and vomiting,
  • birth defects (fetal malformations). If you become pregnant during treatment, stop taking Cytotec immediately and seek medical attention.

Uncommon(may affect up to 1 in 100 people):

  • vaginal bleeding (including bleeding after menopause), bleeding between periods, menstrual disorders, and uterine cramps,
  • fever.

Rare(may affect up to 1 in 1,000 people):

  • excessive or prolonged menstrual bleeding (menorrhagia), painful menstruation (dysmenorrhea),
  • uterine rupture (after administration of prostaglandins in the second or third trimester of pregnancy, mainly in women with previous deliveries or with a cesarean section scar). Seek urgent medical attention.

Frequency not known(cannot be estimated from the available data):

  • allergy,
  • amniotic fluid embolism in the mother's bloodstream, which can cause cardiac failure, abnormal uterine contractions, fetal death, abortion, premature birth, retention of the placenta in the uterus after delivery, uterine bleeding,
  • chills.

Reporting of side effects

If you experience any side effects, talk to your doctor or pharmacist, even if they are not listed in this leaflet. You can also report them directly through the Spanish Pharmacovigilance System for Human Use Medicines: https://www.notificaram.es. By reporting side effects, you can help provide more information on the safety of this medicine.

5. Storage of Cytotec

Store below 30°C. Store in the original packaging to protect it from light.

Keep this medicine out of the sight and reach of children.

Do not use this medicine after the expiry date which is stated on the packaging after EXP. The expiry date is the last day of the month stated.

Medicines should not be disposed of via wastewater or household waste. Return the packaging and any unused medicine to a pharmacy. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.

6. Contents of the pack and other information

Composition of Cytotec

  • The active substance is misoprostol. Each tablet contains 200 micrograms of misoprostol.
  • The other components (excipients) are: hypromellose, microcrystalline cellulose, sodium carboxymethylcellulose (type A) (potato starch), hydrogenated castor oil. See section 2 "Cytotec contains castor oil".

Appearance of the product and packaging contents

Cytotec 200 mcg is presented in the form of white to off-white, hexagonal, scored tablets, with the marks "SEARLE" and "1461" on one side. Each pack contains 40 tablets.

Marketing authorisation holder and manufacturer

Marketing authorisation holder

Pfizer, S.L.

Avda. de Europa, 20 B. Parque Empresarial La Moraleja. 28108 Alcobendas, Madrid.

Manufacturer

Piramal Pharma Solutions (Dutch) B.V.

Bargelaan 200

2333 CW

Leiden

Netherlands

Date of last revision of this leaflet:06/2018

Detailed and updated information on this medicine is available on the website of the Spanish Agency for Medicines and Health Products (AEMPS) http://www.aemps.es/

Online doctors for CYTOTEC 200 micrograms tablets

Discuss questions about CYTOTEC 200 micrograms tablets, including use, safety considerations and prescription review, subject to medical assessment and local regulations.

5.0 (4)
Doctor

Tomasz Grzelewski

Dermatology 21 years exp.

Dr Tomasz Grzelewski is an MD, PhD specialist in allergy, paediatrics, general practice and sports medicine, with a clinical focus on dermatology, endocrinology, allergology and sports-related health. He has more than 20 years of clinical experience and completed his medical training at the Medical University of Łódź, where he defended his PhD thesis with distinction. His doctoral research was recognised by the Polish Society of Allergology for its innovative contribution to the field. Throughout his career, he has gained extensive expertise in diagnosing and managing a wide range of allergic and paediatric conditions, including modern allergen desensitisation techniques. For five years, Dr Grzelewski served as the Head of two paediatric departments in Poland, managing complex clinical cases and leading multidisciplinary teams. He also worked in medical centres in the United Kingdom, gaining experience across both primary care and specialist environments. With over a decade of telemedicine experience, he has provided online consultations across Europe and is valued for his clear, structured and evidence-based medical guidance. Dr Grzelewski is actively involved in clinical programmes focused on modern anti-allergic therapies. As a Principal Investigator, he leads research projects on sublingual and oral allergen desensitisation, supporting evidence-based progress in allergy treatment for both children and adults. In addition to his background in allergology and paediatrics, he completed dermatology studies through the Cambridge Education Group (Royal College of Physicians of Ireland) and a Clinical Endocrinology course at Harvard Medical School. This advanced training enhances his ability to manage skin manifestations of allergies, atopic conditions, urticaria, endocrine-related symptoms and complex immunological reactions. Patients commonly seek his care for: 

  • seasonal and perennial allergies
  • allergic rhinitis and chronic nasal symptoms
  • asthma and breathing difficulties
  • food and medication allergies
  • urticaria, atopic dermatitis and skin reactions
  • recurrent infections in children
  • sports-related health questions
  • general family medicine concerns

Dr Tomasz Grzelewski is known for his clear communication style, structured medical approach and ability to explain treatment options in a concise and accessible way. His multidisciplinary background across allergy, paediatrics, dermatology and endocrinology allows him to provide safe, up-to-date and comprehensive care for patients of all ages.

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Doctor

Hocine Lokchiri

General medicine 21 years exp.

Dr. Hocine Lokchiri is a French consultant with over 20 years of experience in General and Emergency Medicine. He works with adults and children, helping patients with urgent symptoms, infections, sudden health changes and everyday medical concerns that require timely evaluation. His background includes clinical practice in France, Switzerland and the United Arab Emirates, which allows him to navigate different healthcare systems and manage a wide range of conditions with confidence. Patients value his calm, structured approach, clear explanations and evidence-based decision-making.

Online consultations with Dr. Lokchiri are suitable for many situations when someone needs quick medical guidance, reassurance or a clear next step. Common reasons for booking include:

  • fever, chills, fatigue and viral symptoms
  • cough, sore throat, nasal congestion, breathing discomfort
  • bronchitis and mild asthma flare-ups
  • nausea, diarrhoea, abdominal pain, digestive infections
  • rashes, allergic reactions, redness, insect bites
  • muscle or joint pain, mild injuries, sprains
  • headache, dizziness, migraine symptoms
  • stress-related symptoms, sleep disturbances
  • questions about test results and treatment plans
  • management of chronic conditions in stable phases
Many patients reach out when symptoms appear suddenly and cause concern, when a child becomes unwell unexpectedly, when a rash changes or spreads, or when it’s unclear whether an in-person examination is necessary. His emergency medicine background is particularly valuable online, helping patients understand risk levels, identify warning signs and choose safe next steps.

Some situations are not suitable for online care. If a patient has loss of consciousness, severe chest pain, uncontrolled bleeding, seizures, major trauma or symptoms suggesting a stroke or heart attack, he will advise seeking immediate local emergency services. This improves safety and ensures patients receive the right level of care.

Dr. Lokchiri’s professional training includes:

  • Advanced Trauma Life Support (ATLS)
  • Basic and Advanced Cardiac Life Support (BLS/ACLS)
  • Pediatric Advanced Life Support (PALS)
  • Prehospital Trauma Life Support (PHTLS)
  • eFAST and critical care transthoracic echocardiography
  • aviation medicine
He is an active member of several professional organisations, including the French Society of Emergency Medicine (SFMU), the French Association for Emergency Physicians (AMUF) and the Swiss Society of Emergency and Rescue Medicine (SGNOR). In consultations, he works with clarity and precision, helping patients understand their symptoms, possible risks and the safest treatment options.
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Doctor

Daniel Cichi

Family medicine 24 years exp.

Dr Daniel Cichi is a family medicine doctor with over 20 years of clinical experience. He provides online consultations for adults, supporting patients with acute symptoms, chronic conditions, and everyday health concerns that require timely medical guidance. His background includes work in emergency care, ambulance services, and family medicine, which allows him to assess symptoms quickly, identify warning signs, and help patients choose the safest next steps – whether that means home care, treatment adjustment, or in-person evaluation. Patients commonly consult Dr Daniel Cichi for: 

  • acute symptoms: fever, infections, flu-like illness, cough, sore throat, shortness of breath;
  • chest discomfort, palpitations, dizziness, fatigue, and blood pressure concerns;
  • digestive problems: abdominal pain, nausea, diarrhoea, constipation, reflux;
  • sexually transmitted infections, erectile dysfunction;
  • muscle, joint, and back pain, minor injuries, post-traumatic symptoms;
  • chronic conditions: hypertension, diabetes, high cholesterol, thyroid disorders, weight loss, hair loss;
  • review and interpretation of lab tests, imaging reports, and medical documents;
  • medication review and treatment adjustment;
  • medical advice while travelling or living abroad;
  • second opinions and guidance on whether in-person care is needed.

Dr Cichi’s consultations are structured and practical. He focuses on clear explanations, risk assessment, and actionable recommendations, helping patients understand their symptoms and make informed decisions about their health.

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€55
5.0 (144)
Doctor

Yevgen Yakovenko

General surgery 12 years exp.

Dr. Yevgen Yakovenko is a licensed surgeon and general practitioner in Spain and Germany. He specialises in general, paediatric, and oncological surgery, internal medicine, and pain management. He offers online consultations for adults and children, combining surgical precision with therapeutic support. Dr Yakovenko works with patients across different countries and provides care in Ukrainian, Russian, English, and Spanish.

Areas of medical expertise:

  • Acute and chronic pain: headaches, muscle and joint pain, back pain, abdominal pain, postoperative pain. Identifying the cause, selecting treatment, and creating a care plan.
  • Internal medicine: heart, lungs, gastrointestinal tract, urinary system. Management of chronic conditions, symptom control, second opinions.
  • Pre- and postoperative care: risk assessment, decision-making support, follow-up after surgery, rehabilitation strategies.
  • General and paediatric surgery: hernias, appendicitis, congenital conditions, both planned and urgent surgeries.
  • Injuries and trauma: bruises, fractures, sprains, soft tissue damage, wound care, dressing, referral when in-person care is required.
  • Oncological surgery: diagnosis review, treatment planning, and long-term follow-up.
  • Obesity treatment and weight management: a medical approach to weight loss, including assessment of underlying causes, evaluation of comorbidities, development of a personalised plan (nutrition, physical activity, pharmacotherapy if needed), and ongoing progress monitoring.
  • Imaging interpretation: analysis of ultrasound, CT, MRI, and X-ray results, surgical planning based on imaging data.
  • Second opinions and medical navigation: clarifying diagnoses, reviewing current treatment plans, helping patients choose the best course of action.

Experience and qualifications:

  • 12+ years of clinical experience in university hospitals in Germany and Spain.
  • International education: Ukraine – Germany – Spain.
  • Member of the German Society of Surgeons (BDC).
  • Certified in radiological diagnostics and robotic surgery.
  • Active participant in international medical conferences and research.

Dr Yakovenko explains complex topics in a clear, accessible way. He works collaboratively with patients to analyse health issues and make evidence-based decisions. His approach is grounded in clinical excellence, scientific accuracy, and respect for each individual.

If you are unsure about a diagnosis, preparing for surgery, or want to discuss your test results – Dr Yakovenko will help you evaluate your options and move forward with confidence.

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€50
5.0 (2)
Doctor

Svetlana Kolomeeva

Cardiology 18 years exp.

Dr. Svetlana Kolomeeva is a general practitioner and internal medicine doctor providing online consultations for adults. She helps patients manage acute symptoms, chronic conditions, and preventive care. Her clinical focus includes cardiovascular health, hypertension control, and managing symptoms like fatigue, weakness, sleep issues, and overall low energy.

Patients commonly seek her help for:

  • High blood pressure, headaches, dizziness, swelling, palpitations.
  • Diagnosis and management of hypertension, arrhythmias, and tachycardia.
  • Metabolic syndrome, excess weight, high cholesterol.
  • Chronic fatigue, insomnia, poor concentration, anxiety.
  • Respiratory symptoms: colds, flu, sore throat, cough, fever.
  • Digestive issues: heartburn, bloating, constipation, IBS symptoms.
  • Chronic conditions: diabetes, thyroid disorders.
  • Interpretation of lab tests and medical reports, therapy adjustment.
  • Second opinion and decision-making support.
  • Cardiovascular disease prevention and metabolic risk reduction.
  • Long-term follow-up and dynamic health monitoring.

Dr Kolomeeva combines clinical expertise with personalised care. She clearly explains diagnoses, guides patients through symptoms and treatment options, and provides actionable plans. Her consultations are designed not only to address current complaints but also to stabilise chronic conditions and prevent future complications. She supports patients through every stage of care – from first symptoms to ongoing health management.

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€55

Frequently Asked Questions

Is a prescription required for CYTOTEC 200 micrograms tablets?
CYTOTEC 200 micrograms tablets requires a prescription in Spain. You can check with a doctor online whether this medicine may be appropriate for your situation.
What is the active substance in CYTOTEC 200 micrograms tablets?
The active ingredient in CYTOTEC 200 micrograms tablets is misoprostol. This information helps identify medicines with the same composition but different brand names.
How much does CYTOTEC 200 micrograms tablets cost in pharmacies?
The average pharmacy price for CYTOTEC 200 micrograms tablets is around 10.49 EUR. Prices may vary depending on the manufacturer and dosage form.
Who manufactures CYTOTEC 200 micrograms tablets?
CYTOTEC 200 micrograms tablets is manufactured by Pfizer S.L.. Pharmacy brands and packaging may differ depending on the distributor.
Which doctors can assess the use of CYTOTEC 200 micrograms tablets online?
Doctors such as Family doctors, Psychiatrists, Dermatologists, Cardiologists, Endocrinologists, Gastroenterologists, Pulmonologists, Nephrologists, Rheumatologists, Hematologists, Infectious disease physicians, Allergists, Geriatricians, Paediatricians, Oncologists may assess whether CYTOTEC 200 micrograms tablets is appropriate, depending on your situation and local regulations. You can book an online consultation to discuss your symptoms and possible next steps.
What are the alternatives to CYTOTEC 200 micrograms tablets?
Other medicines with the same active substance (misoprostol) include ALAPANZOL 40 mg GASTRO-RESISTANT TABLETS, ANAGASTRA 20 mg GASTRO-RESISTANT TABLETS, ANAGASTRA 40 mg GASTRO-RESISTANT TABLETS. These may have different brand names or formulations but contain the same therapeutic ingredient. Always consult a doctor before switching or starting a new medicine.
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